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Four Michigan public universities, collaborating with private sector for-profit companies and state government agencies supporting technology commercialization and innovation, have successfully implemented methods for building and sustaining entrepreneurship, technology development and commercialization at emerging research institutions: distributing the cost, promoting best practices and affecting the cultural changes within institutions necessary for sustaining these activities. This program, led by Michigan Technological University has produced a model, termed U-TEAMED (Multi-University Technological and Expertise Assets Management for Enterprise Development). The emergent model offers guidance for identifying and capturing the important features of sustainable, faculty-led early-stage technology innovation and entrepreneurship education programs at emerging research institutions. Lessons include methods for securing revenue, sustaining faculty enthusiasm, anticipating IP and commercialization barriers derived from faculty-student collaborations, and creating an academic environment supportive of embedding technology innovation and entrepreneurship in academic curricula.