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Seizures / Febriles Seizures                                   Dr. Kalpana Malla                                       MD ...
Topics•   Seizure***•   Causes / Classification•   Neonatal seizures•   Febrile seizures***•   Epilepsy & Specific epilept...
Seizures in children• Common neurological disorder in children• Do not constitute diagnosis-Is symptom of  underlying CNS ...
Definition- Seizure :• Paroxysmal alteration in behavior due to any  transient brain pathology-cerebral  dysrhythmias, Tra...
• 10% of children have seizure• Most seizures are provoked by somatic  disorders originating outside brain – like –  high ...
Terminology• Fit :-       Clinical manifestation of cerebral       dysrhythmia              - Maybe convulsive-GTC        ...
Terminology• Convulsion:-• Tonic clonic motor component of seizure• When child shows sudden episode of  decerebrate postur...
Terminology• Epilepsy : Two 0r more unprovoked seizure occurring at  an interval greater than 24 hrs apart– recurrent fits...
• What are nonepileptic conditions  that may mimic seizures?
Seizure Mimicers1.   Breath-holding spells   1. Benign paroxysmal vertigo2. Cough Syncope             2. Benign paroxysmal...
Mimicking seizuresJitteriness   –   Absence of abnormal gaze movements   –   Provoked by passive flexion or extension   – ...
Mechanisms• Exact cause unknown• Basis-Failure of mechanism that aborts S1. Excessive persistent excitation - by  excitato...
Mechanisms3.Significant neuronal burst discharge-  usually by voltage dependent calcium  currents4.Arise from areas of neu...
Causes of seizures1. Febrile convulsions**2. Epilepsy**3. Infections- Meningitis**, encephalitis*, brain  abscess**,Cerebr...
Causes6. Metabolic –  Hypocalcemia, Hypoglycemia, Hypomagne  semia, Dyselectrolytemia, Inborn errors of  metabolism7. Toxi...
Causes8.Renovascular-  Acute nephritis, Hypertensive  encephalo[athy, Hemolytic –Uremic syndrome9.Arterio-venous malformat...
Febrile Seizures
Febrile Convulsion**Most common seizure disorder with excellent  prognosis• Definition:-  Seizure occurring with temp ≥38o...
Febrile Convulsion•   Incidence – 3-5%•   Autosomal dominant pattern of inheritance•   Chromosome 19p & 8q.•   Thus , fami...
PATHOGENESIS• Due to temporary impairment of the balance  between the convulsant and anticonvulsant  system of brain• Thre...
PATHOGENESIS• Studies in children suggests – that the  cytokine network is activated and may have a  role in the pathogene...
Causes - Febrile Convulsion1.ARI-URTI(Otitis media )2.LRTI3.Viral fever- Roseola and Influenza A , other  fever with rash4...
Typical F. Convulsion1. Age- 6months – 5 yrs peak 14 - 18 months2. With rapid rise of temp ≥38oC ,within 24 hrs  of onset ...
Typical F. Convulsion5. Positive family history ( 50%) - AD in some  families6. One seizure attack at each episode7. No re...
Criteria for Diagnosis• Above features plus• M>F• Infections: 90% of the cases are due to viral  infections, Common infect...
Classification• SIMPLE- Age group-6months – 5 yrs peak 14 - 18 months- GTCS- <10 MIN- Single in 24 hrs1 fit per febrile ep...
Classification• ATYPICAL/ COMPLEX    - > 15 MIN    - >1 Episode per fever - Occurs more than once in 24 hrs    - Focal    ...
Risk factor for 1st episode•   + family history•   After immunization – DPT , MMR.•   INFECTIONS esp Herpes virus•   Fe def
Risk Factors for Recurrent Febrile• Younger than 18 months• Duration of fever (i.e., shorter duration of fever  before sei...
Risk factors for devp of epilepsy1.+ family history2. 1st F .seizure before age 9 month3. Atypical F. seizure4. Delayed mi...
AAP Practice Parameter• Lab testing - identifying source of fever            - part of routine evaluation• Do blood glucos...
Investigations - AAP Practice Parameter• EEG: not needed for first simple febrile seizure  but done in complex febrile sei...
Hospital care1.Position –semi prone –ABC2. Control fever-antipyretics, tepid sponge3.Control convulsion-Diazepam IV/PR4. I...
Treatment• Home management• Reduction of body temp-        - PCM/Ibuprofen        -Tepid water sponging
Treatment5.prophylaxis-  - Intermittent with oral diazepam -0.3mg   /kg/ dose TID   clobazam, midazolam –effective - Long ...
SEIZURE PROPHYLAXIS•   Intermittent   • Continuous•   Diazepam       • Valproate•   Clobazam       • No role of•   Midazol...
• Criteria for Prophylactic anticonvulsant  therapy:  1. <18mo with previous abnormal     development or abnormal neurolog...
• Continuous daily prophylaxis given with  Sodium Valproate 30- 60mg/kg/day in two  divided doses to be continued for at l...
Patient Education• Counsel on the benign nature of febrile seizures• Reassured that simple febrile seizures do not lead to...
Prognosis• 50% with single F. convulsion have no  recurrence even if untreated• 30-50% have recurrence• 40% in 1st episode...
Thank youDownload more documents and slide shows on The Medical Post               [ www.themedicalpost.net ]
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Seizures - Febrile Seizures

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  1. 1. Seizures / Febriles Seizures Dr. Kalpana Malla MD Pediatrics Manipal Teaching HospitalDownload more documents and slide shows on The Medical Post [ www.themedicalpost.net ]
  2. 2. Topics• Seizure***• Causes / Classification• Neonatal seizures• Febrile seizures***• Epilepsy & Specific epileptic syndromes***• Status epilepticus• Drug therapy in epilepsy
  3. 3. Seizures in children• Common neurological disorder in children• Do not constitute diagnosis-Is symptom of underlying CNS disorder
  4. 4. Definition- Seizure :• Paroxysmal alteration in behavior due to any transient brain pathology-cerebral dysrhythmias, Transient ischemic or anoxic attacks (faints) - excessive and abnormal discharge from cortical neurons**May be manifested as Transient, involuntary alteration or loss of consciousness, abnormal motor activity, behavioral abnormalities, sensory disturbance or autonomic dysfunction
  5. 5. • 10% of children have seizure• Most seizures are provoked by somatic disorders originating outside brain – like – high fever, toxins, hypoxia, arrhythmias, psychogeni c etc.• Less than 1/3rd of seizures are caused by epilepsy
  6. 6. Terminology• Fit :- Clinical manifestation of cerebral dysrhythmia - Maybe convulsive-GTC - Maybe nonconvulsive – absence or complex partial
  7. 7. Terminology• Convulsion:-• Tonic clonic motor component of seizure• When child shows sudden episode of decerebrate posturing which is followed by clonic jerking-**all convulsions are not epilepsy
  8. 8. Terminology• Epilepsy : Two 0r more unprovoked seizure occurring at an interval greater than 24 hrs apart– recurrent fits due to repeated primary cerebral dysrhythmias
  9. 9. • What are nonepileptic conditions that may mimic seizures?
  10. 10. Seizure Mimicers1. Breath-holding spells 1. Benign paroxysmal vertigo2. Cough Syncope 2. Benign paroxysmal torticollis of infancy3. Tics 3. Hereditary chin trembling4. Acute dystonia 4. Narcolepsy5. Pseudoseizures 5. Day dreaming6. Benign myoclonus 6. Hysteria7. Night terrors 7. Migraine
  11. 11. Mimicking seizuresJitteriness – Absence of abnormal gaze movements – Provoked by passive flexion or extension – Movement to and fro shorter duration – Normal EEG – No increase in blood pressure or heart rate• No postictal phase after these episodes
  12. 12. Mechanisms• Exact cause unknown• Basis-Failure of mechanism that aborts S1. Excessive persistent excitation - by excitatory neurotransmitters -- glutamate, aspartate, acetylcholine also N- methyl-d-aspartate (NMDA)2. Ineffective recruitment of inhibition - dominant inhibitory neurotransmitter gamma aminobutyric acid (GABA)
  13. 13. Mechanisms3.Significant neuronal burst discharge- usually by voltage dependent calcium currents4.Arise from areas of neuronal death- these regions promote development of hyperexcitable synapses that promote seizure
  14. 14. Causes of seizures1. Febrile convulsions**2. Epilepsy**3. Infections- Meningitis**, encephalitis*, brain abscess**,Cerebral malaria4. ICSOL**5. Cerebral ischemia, trauma
  15. 15. Causes6. Metabolic – Hypocalcemia, Hypoglycemia, Hypomagne semia, Dyselectrolytemia, Inborn errors of metabolism7. Toxic – Uremia, Hepatic encephalopathy, Reye’s syndrome, Lead ,phenothiazine Strychnine poisoning, Shigelosis, Tetanus
  16. 16. Causes8.Renovascular- Acute nephritis, Hypertensive encephalo[athy, Hemolytic –Uremic syndrome9.Arterio-venous malformation10. Hysterical conversion reaction
  17. 17. Febrile Seizures
  18. 18. Febrile Convulsion**Most common seizure disorder with excellent prognosis• Definition:- Seizure occurring with temp ≥38oC in absence of detectable CNS infections but there may be association of acute extra cranial infections and high environmental temperatures
  19. 19. Febrile Convulsion• Incidence – 3-5%• Autosomal dominant pattern of inheritance• Chromosome 19p & 8q.• Thus , family history imp.
  20. 20. PATHOGENESIS• Due to temporary impairment of the balance between the convulsant and anticonvulsant system of brain• Threshold level of anticonvulsant system in these genetically predisposed children is lower
  21. 21. PATHOGENESIS• Studies in children suggests – that the cytokine network is activated and may have a role in the pathogenesis of febrile seizures• Other suggestion - endogenous pyrogens, such as interleukin 1, increasing neuronal excitability & causing seizures
  22. 22. Causes - Febrile Convulsion1.ARI-URTI(Otitis media )2.LRTI3.Viral fever- Roseola and Influenza A , other fever with rash4.UTI5. Gastroenteritis
  23. 23. Typical F. Convulsion1. Age- 6months – 5 yrs peak 14 - 18 months2. With rapid rise of temp ≥38oC ,within 24 hrs of onset of fever3.Should not last more than 10 min4. Generalized not focal
  24. 24. Typical F. Convulsion5. Positive family history ( 50%) - AD in some families6. One seizure attack at each episode7. No residual weakness of limb or disability except a brief period of drowsiness8.EEG between and after seizure is normal9.Extracranial infection may be + but no CNS infection
  25. 25. Criteria for Diagnosis• Above features plus• M>F• Infections: 90% of the cases are due to viral infections, Common infections are URTI, Otitis Media, Pneumonia, UTI and Roseola• Recurrence: 30- 50% under 1 year. Frequency decreases after 5 yrs of age.
  26. 26. Classification• SIMPLE- Age group-6months – 5 yrs peak 14 - 18 months- GTCS- <10 MIN- Single in 24 hrs1 fit per febrile episode- Brief / no post ictal phenomenon- EEG - N
  27. 27. Classification• ATYPICAL/ COMPLEX - > 15 MIN - >1 Episode per fever - Occurs more than once in 24 hrs - Focal - + family history - Pre existing CNS disorder - Delayed devl or regression- - Followed by Todd paralysis, but no significant other- reason or CNS infection can not be found - EEG may remain abnormal for 2wks or more• Continuous prophylaxis therapy may be given
  28. 28. Risk factor for 1st episode• + family history• After immunization – DPT , MMR.• INFECTIONS esp Herpes virus• Fe def
  29. 29. Risk Factors for Recurrent Febrile• Younger than 18 months• Duration of fever (i.e., shorter duration of fever before seizure - higher risk of recurrence)• Complex febrile seizure at onset• Family history of epilepsy• Family history of febrile seizures• Height of fever (i.e., the lower the peak fever, the higher the rate of recurrence)
  30. 30. Risk factors for devp of epilepsy1.+ family history2. 1st F .seizure before age 9 month3. Atypical F. seizure4. Delayed milestones5. Abnormal neurological findingsRisk of epilepsy increases to 9% from 1% if above factors are ++
  31. 31. AAP Practice Parameter• Lab testing - identifying source of fever - part of routine evaluation• Do blood glucose in all patients• Blood Studies: No indication for routine testing of electrolytes, calcium, magnesium, CBC• Neuroimaging: No need to perform in routine evaluation of first febrile seizure
  32. 32. Investigations - AAP Practice Parameter• EEG: not needed for first simple febrile seizure but done in complex febrile seizure• LP: should be “strongly considered” in < 12 mos and “considered” between 12-18 mos.• If older than 18 mo, rely on meningeal S&S• Also consider LP if prior antibiotic treatment
  33. 33. Hospital care1.Position –semi prone –ABC2. Control fever-antipyretics, tepid sponge3.Control convulsion-Diazepam IV/PR4. Infection should be looked for and treated - LP? - CBC?• Parents reassurance
  34. 34. Treatment• Home management• Reduction of body temp- - PCM/Ibuprofen -Tepid water sponging
  35. 35. Treatment5.prophylaxis- - Intermittent with oral diazepam -0.3mg /kg/ dose TID clobazam, midazolam –effective - Long term prophylaxis- sodium valproate
  36. 36. SEIZURE PROPHYLAXIS• Intermittent • Continuous• Diazepam • Valproate• Clobazam • No role of• Midazolam phenytoin/CBZ/Ph enobarbitone
  37. 37. • Criteria for Prophylactic anticonvulsant therapy: 1. <18mo with previous abnormal development or abnormal neurological signs 2. Atypical febrile seizure 3. Recurrent febrile seizure 4. High level of parental anxiety
  38. 38. • Continuous daily prophylaxis given with Sodium Valproate 30- 60mg/kg/day in two divided doses to be continued for at least 2 fit free years or until child is 6 yr old, whichever comes earlier.
  39. 39. Patient Education• Counsel on the benign nature of febrile seizures• Reassured that simple febrile seizures do not lead to neurological problems or developmental delay• If their child has another seizure -• To call for assistance if the seizure lasts longer than 10 minutes or if the postictal period lasts longer than 30 minutes
  40. 40. Prognosis• 50% with single F. convulsion have no recurrence even if untreated• 30-50% have recurrence• 40% in 1st episode have > one or more further convulsions,10% will have multiple attacks• 1% with no risk factors and 9% with risk factors develop epilepsy by age 7 yrs
  41. 41. Thank youDownload more documents and slide shows on The Medical Post [ www.themedicalpost.net ]
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