IsoFlow™ Infusion Catheter Enabling Direct Delivery To Hard-to-reach Treatment Areas

Amy Cohen and Family

Search for a Cure Stop-flow technique for loco-regional delivery of antiblastic agents

Corporate Timeline 2002 Filing of Patent 2002 Amy Cohen Loses Cancer Battle 2009 U.S. Patent Issued 2002 2004 2006 2008 2010 2010 CE Mark Issues 2009 FDA 510(k) Marketing Clearance 7 years, 2 months

Market Opportunity Late Stage Cancer Treatment Pre-surgical Treatment of Cancer Direct Treatment of Disease Stroke Intervention Animal Health Other Applications Total Available Market >$1 Billion Market Segmentation

Late Stage Cancer Treatment

Pre-surgical Treatment of Cancer

Direct Treatment of Disease

Stroke Intervention

Animal Health

Other Applications

First Patient Use Dr. Osama Zaidat Vascular Neurologist

Recognition 2009 Healthcare Innovation Award for Oncology

Media and Market Momentum I meet a lot of Silicon Valley companies, but rarely do I come across a story as inspiring as this one. The fight against cancer just got a shot in the arm. It’s really quite the revolution.

IsoFlow: A New Weapon Against Cancer “ The IsoFlow catheter facilitates the use of regional infusion therapies, especially in cases of challenging arterial anatomy where it helps achieve these promises of targeted delivery. IsoFlow is a valuable addition to our treatment arsenal.” Dr. Michael Dake Stanford University School of Medicine