SCD-HeFT trial - Summary & Results

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A study on sudden cardiac death in heart failure (SCD-HeFT) using randomized to conventional therapy for CHF plus placebo, conventional therapy plus amiodarone, or conventional therapy plus a conservatively programmed, shock- only, single-lead ICD

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SCD-HeFT trial - Summary & Results

  1. 1. SCD-HeFT (Sudden Cardiac Death inHeart Failure)
  2. 2. SCD-HeFT (Sudden Cardiac Death in Heart Failure)G Bardy (Seattle Institute for Cardiac Research, WA)American College of Cardiology 2004 Scientific Sessions• Population and treatment: 2521 patients with NYHA class 2-3 HF of either ischemic or nonischemic etiology and an LVEF <35% Randomized to conventional therapy for CHF plus placebo, conventional therapy plus amiodarone, or conventional therapy plus a conservatively programmed, shock- only, single-lead ICD Placebo and amiodarone were administered in a double-blind fashion• Primary end point: Death from any cause
  3. 3. SCD-HeFT: Results• Adding an ICD to standard therapy reduced the hazard ratio for five-year all- cause mortality by 23% vs placeboThree- and five-year all-cause mortality by treatment groupAll-cause mortality ICD (n=829) , % Amiodarone (n=845), % Placebo (n=847), %Three years 17.1 24.0 22.3Five years 28.9 34.1 35.8Hazard ratios at five years vs placebo for all-cause mortalityTherapy Hazard ratio (97.5% CI) pAmiodarone vs placebo 1.06 (0.86–1.30) 0.53ICD vs placebo 0.77 (0.62–0.96) 0.007
  4. 4. SCD-HeFT: Commentary*"Because MADIT II and SCD-HeFT were both similar in the risk reduction that theyreported, we would have to conclude that there is enough evidence to moveforward." - Dr Kim A Eagle"These results also emphasize the national need to continue to develop andimplement new methods to further identify patients who will benefit from life-savingICD therapy." - Dr Michael E Cain *All comments from The experts on SCD-HeFT: Implement now, but seek more discriminating ICD patient-selection criteria (http://www.theheart.org/article/221157.do)
  5. 5. Become a member of http://www.theheart.org Become a fan on Facebook: http://www.facebook.com/theheartorg Follow us on Twitter: http://www.twitter.com/theheartorgtheheart.org is the leading online source of independent cardiology news.We are the top provider of news and opinions for over 100 000 physicians.

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