HOPE trial - Summary & Results

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A randomized, double-blinded study on heart outcomes prevention evaluation (HOPE) using patients with a history of vascular disease of with diabetes and at leat one other risk factor

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  • 1. HOPE (Heart Outcomes PreventionEvaluation)
  • 2. HOPE (Heart Outcomes Prevention Evaluation)S Yusuf (McMaster University, Hamilton, ON)European Society of Cardiology 1999 Congress• Population: 9541 people at least 55 years of age with a history of vascular disease or with diabetes and at least one other risk factor• Treatment: Patients were randomized in a double-blind manner to either the ACE inhibitor ramipril or placebo for 4 to 6 years• Primary outcome: Combined rate of CV death, MI, or stroke
  • 3. HOPE: Results• At the end of four years the primary end point was 22% lower in the ramipril group than in the placebo group (p<0.001)• The Data and Safety Monitoring Board terminated the study early because of the clear beneficial effect of ramiprilEvent rates and relative risks at four yearsOutcome Ramipril (%) Placebo (%) Relative risk pCombined end point 13.9 17.5 0.79 <0.001CV death 6 8 0.75 0.002MI 9.8 12 0.82 0.005Stroke 3.3 4.8 0.69 0.001
  • 4. HOPE: Commentary*"HOPE will have a major impact in the way patients are treated." - Dr Philip Aylward"If ramipril is used widely in appropriate patients, over one million prematuredeaths, heart attacks, and strokes would be prevented each year." - Dr Salim Yusuf *All comments from HOPE overwhelms cardiologists with benefits of ACE inhibitors (http://www.theheart.org/article/298385.do)
  • 5. Become a member of http://www.theheart.org Become a fan on Facebook: http://www.facebook.com/theheartorg Follow us on Twitter: http://www.twitter.com/theheartorgtheheart.org is the leading online source of independent cardiology news.We are the top provider of news and opinions for over 100 000 physicians.