Safety facts and side effects about trisodium citrate

1. Safety Facts And Side Effects About Trisodium Citrate
Trisodium Citrate, CAS# 68-04-2, is a organic chemicals manufactured through fermentation,
available as Colorless or white crystalline granule or crystalline powder odorless. Trisodium
Citrate is widely used as acidulants. It is widely accepted as safe food additive in many countries
with E number E331.
Is there some safety and/or health risk about Trisodium Citrate that consumers need to know?
Let's check out some basic facts about this ingredient.
GRAS Exemptions: Yes
Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is
generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and
Cosmetic Act (FFDCA) food additive tolerance requirements. Trisodium Citrate is perfectly safe for
using as food additives.
Suggested Dosage
As Trisodium Citrate is widely known as safe, there is no limit on dosage of intake. However, we
still recommend consumers to consult professionals before using large quantity of Trisodium
Citrate for long period.
Special Groups Precaution
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Trisodium Citrate could have any negative effects on these vulnerable
groups. It should be safe to use Trisodium Citrate in food for newborns and pregnant. However,
we still recommend consumers to consult professionals before using large quantity of Trisodium
Citrate for long period in food for newborns or pregnant.
General Side Effects
No significant side effects reported. Prolonged using of Trisodium Citrate may increase risk of
renal failure when used in large quantity. Trisodium citrate can cause allergy in specific group of
individuals.
Reported Health Issues
No health issues about Trisodium Citrate reported up to now.
Related Research
1. Loss of antimicrobial effect of trisodium citrate due to 'lock' spillage from haemodialysis
catheters. [Nephrol Dial Transplant. 2014 Apr]
Author: Schilcher G, Schneditz D, Ribitsch W, Horina JH, Hoenigl M, Valentin T, Rosenkranz AR,
Krause R.
2. Facile synthesis of alumina hollow microspheres via trisodium citrate-mediated hydrothermal

2. process and their adsorption performances for p-nitrophenol from aqueous solutions. [J Colloid
Interface Sci. 2013 Mar 15]
Author: Zhou J, Wang L, Zhang Z, Yu J.
3. Incompatibility of contrast medium and trisodium citrate. [Cardiovasc Intervent Radiol. 2013
Feb]
Author: Delcour C, Bruninx G.
4. Evaluation of interparticle interaction between colloidal Ag nanoparticles coated with
trisodium citrate and safranine by using FRET: spectroscopic and mechanistic approach. [J
Photochem Photobiol B. 2012 Aug 1]
Author: Mokashi VV, Gore AH, Sudarsan V, Rath MC, Han SH, Patil SR, Kolekar GB.
5. Trisodium citrate induced protein precipitation in haemodialysis catheters might cause
pulmonary embolism. [Nephrol Dial Transplant. 2012 Jul]
Author: Schilcher G, Scharnagl H, Horina JH, Ribitsch W, Rosenkranz AR, Stojakovic T, Polaschegg
HD.
Source: http://www.foodchemadditives.com/side_effects_info/618