Reporting on Scientific Journal Articles

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Reporting on Scientific Journal Articles

  1. 1. Reporting on Scientific Journal Articles Jeremy Moore, M.A. Senior Manager, Science Communications American Association for Cancer Research jeremy.moore@aacr.org
  2. 2. Why is Cancer Newsworthy?
  3. 3. Why is Cancer Newsworthy? • Number 1 cause of death, surpassing heart disease in 2010
  4. 4. Why is Cancer Newsworthy? • Number 1 cause of death, surpassing heart disease in 2010 • In the United States, it affects one in three women and one in two men
  5. 5. Why is Cancer Newsworthy? • Number 1 cause of death, surpassing heart disease in 2010 • In the United States, it affects one in three women and one in two men • Consequences both biological and psychological
  6. 6. Why is Cancer Newsworthy? • Money
  7. 7. Why is Cancer Newsworthy? • Money • Government Money – NCI Budget, 2009: $4.96 billion – NCI Budget, 2010: $5.1 billion
  8. 8. Why is Cancer Newsworthy? • Money • Government Money – NCI Budget, 2009: $4.96 billion – NCI Budget, 2010: $5.1 billion Budget Request for 2011 $5.26 Billion
  9. 9. Why is Cancer Newsworthy? • Money • Private Money
  10. 10. Why is Cancer Newsworthy? • Money • Private Money • Corporate and Philanthropic
  11. 11. Scientific Inquiry “In fact I have not failed 1,000 times. I have successfully discovered 1,000 ways not to make a light bulb.” --Thomas Edison
  12. 12. Scientific Inquiry • Cancer
  13. 13. Scientific Inquiry • Cancer • Out of control cell growth
  14. 14. Scientific Inquiry • Cancer • Out of control cell growth • More than 200 diseases
  15. 15. Cancer CURE?
  16. 16. Cancer CURE vs. CONTROL
  17. 17. Cancer: The Scientific Questions • Diagnosis
  18. 18. Diagnosis • Bladder Cancer • Pancreatic Cancer • Ovarian Cancer • Breast Cancer • Colon Cancer • Skin Cancer
  19. 19. Cancer: The Scientific Questions • Diagnosis • Screening
  20. 20. Screening • Questions surrounding PSA, Mammography, Colonoscopy
  21. 21. Sensitivity vs. Specificity Sensitivity • Correctly Identifying Who Is Sick Specificity • Correctly Identifying Who Is Not Sick
  22. 22. MicroRNA “The discovery of MicroRNA can be equated with the idea that we’ve known for years that cars existed and only recently discovered they have a transmission. It’s that fundamental.” Philip Sharp, Ph.D., Nobel Laureate from M.I.T.
  23. 23. MicroRNA News from Annual Meeting 2010 • miR-21 and miR-106a are associated with an overall poor prognosis and that overexpressions of miR-181b and miR-203 are associated with poor outcomes in blacks for colorectal cancer • MicroRNA-31 (miR-31) repressed specific tumor suppressors and, therefore, may be a novel pharmacologic target for lung cancer therapy and chemoprevention.
  24. 24. MicroRNA News from Annual Meeting 2010 • High levels of miR-21 were significantly correlated with poor response to Herceptin.
  25. 25. DNA Methylation Levels
  26. 26. Cancer: The Scientific Questions • Diagnosis • Screening • Personalized Medicine
  27. 27. Personalized Medicine
  28. 28. Cancer: The Scientific Questions • Diagnosis • Screening • Personalized Medicine • Prevention
  29. 29. Prevention “At least half of all cancer deaths are preventable by what we already know about healthy eating, exercise, maintaining appropriate weight, avoiding smoking and going for regular screenings.” Ernest T. Hawk, M.D., M.P.H. Vice President of the Division of Cancer Prevention and Population Sciences at The University of Texas M. D. Anderson Cancer Center.
  30. 30. Prevention • Healthy Living
  31. 31. Prevention • Healthy Living • Chemoprevention
  32. 32. Prevention
  33. 33. Scientific Inquiry 75 Clinical Trials & 11 Systematic Reviews Are Being Published Every Single Day Bastian H, Glaszio P, Chalmers I, et al. (2010). Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? PLOS Med 7 (9): e1000326. doi:10.1371/journal.pmed.1000326.
  34. 34. Journals to Watch • New England Journal of Medicine
  35. 35. Journals to Watch • New England Journal of Medicine • Journal of the American Medical Association
  36. 36. Journals to Watch • New England Journal of Medicine • Journal of the American Medical Association • Cancer
  37. 37. Journals to Watch • New England Journal of Medicine • Journal of the American Medical Association • Cancer • Journal of Clinical Oncology
  38. 38. Journals to Watch • Cancer Research
  39. 39. Journals to Watch • Cancer Research • Clinical Cancer Research
  40. 40. Journals to Watch • Cancer Research • Clinical Cancer Research • Cancer Epidemiology, Biomarkers & Prevention
  41. 41. Journals to Watch • Cancer Research • Clinical Cancer Research • Cancer Epidemiology, Biomarkers & Prevention • Cancer Prevention Research
  42. 42. Journals to Watch • Cancer Research • Clinical Cancer Research • Cancer Epidemiology, Biomarkers & Prevention • Cancer Prevention Research • Molecular Cancer Research • Molecular Cancer Therapeutics
  43. 43. NEWS FLASH • CANCER DISCOVERY
  44. 44. NEWS FLASH • CANCER DISCOVERY – Officially announcing next week
  45. 45. NEWS FLASH • CANCER DISCOVERY – Officially announcing next week – Editors in Chief, Jose Baselga, M.D, Ph.D. and Lewis Cantley, Ph.D.
  46. 46. NEWS FLASH • CANCER DISCOVERY – Officially announcing next week – Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis Cantley, Ph.D. – Will be the premier venue for the publication and broad dissemination of high impact research in all areas of cancer research
  47. 47. NEWS FLASH • CANCER DISCOVERY – Officially announcing next week – Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis Cantley, Ph.D. – Will be the premier venue for the publication and broad dissemination of high-impact research in all areas of cancer research. – First papers will be published online April 2011
  48. 48. NEWS FLASH • CANCER DISCOVERY – Officially announcing next week – Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis Cantley, Ph.D. – Will be the premier venue for the publication and broad dissemination of high-impact research in all areas of cancer research – First papers will be published online April 2011 – In Print July 2011
  49. 49. THE ANATOMY OF AN ABSTRACT • Conclusions, not titles
  50. 50. THE ANATOMY OF AN ABSTRACT • Conclusions, not titles • Goals
  51. 51. THE ANATOMY OF AN ABSTRACT • Conclusions, not titles • Goals • Population Samples
  52. 52. THE ANATOMY OF AN ABSTRACT • Statistics – P Values, anything less than .05 is significant
  53. 53. THE ANATOMY OF AN ABSTRACT • Statistics – P Values, anything less than .05 is significant – Hazard Ratios – HR=1.23, 95% CI, 1.05-1.10
  54. 54. THE ANATOMY OF AN ABSTRACT
  55. 55. FOLLOW THE NEWS • Subscribe to Newswise • Check Eurekalert
  56. 56. FOLLOW THE NEWS • Subscribe to Newswise • Check Eurekalert • Find a PR Person you trust
  57. 57. KEEP IN TOUCH Jeremy Moore Senior Manager, Science Communications Office: 267-646-0557 Cell: 609-519-0212 jeremy.moore@aacr.org
  58. 58. THANK YOU

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