Office: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University
Medical Center, 3800 Reservoir Road, NW, Washington, DC 20057-1465
Home: 302 Oak Knoll Terrace, Rockville, MD 20850 (301)315-2666
EDUCATION: Chung-Yuan College of Sciences & Engineering, Taiwan
Bio-organic Chemistry, 1968 - 1971, B.S.
University of Utah, Salt Lake City, Utah
Medicinal Chemistry, 1973 - 1978, Ph.D.
Columbia University, New York, NY
Comprehensive Cancer Center
College of Physicians and Surgeons
Staff Associate, 1979 - 1980
Postdoctoral Fellow, 1978 - 1979
2004 – Pres Lombardi Comprehensive Cancer Center, Georgetown
University, Washington, DC
Tenured Professor, Department of Oncology.
2008 – Pres Co-Leader, Carcinogenesis, Biomarkers, and Epidemiology
1981 – 2004 Institute for Cancer Prevention, American Health Foundation
Cancer Center (NCI-designated), Valhalla, NY.
1996 – 2004 Program Leader, Mechanisms of Carcinogenesis.
1995 – 2004 Chief, Division of Carcinogenesis and Molecular
1990 – 1995 Associate Chief, Division of Chemical Carcinogenesis.
1985 – 1995 Head, Section of Nucleic Acid Chemistry.
1981 – 1984 Associate Research Scientist.
1993 – 2001 Memorial Sloan-Kettering Cancer Center, New York, NY.
Adjunct Associate Member.
1992 – 2004 Adjunct Professor, New York Medical College, Valhalla, NY.
HONORS: 2008 Session Chair, International Symposium on Novel Strategies and
Targeted Prevention and Treatment of Cancer, New Delhi, India
2006 Tea Council of the USA, Scientific Advisory Panel, New York, NY.
2004 Chair, AACR Program Committee on Chemical Carcinogenesis,
2003 Organizer and Co-chair of the Symposium on Chemistry and
Mechanisms of Tea in Disease Prevention at the 226th American
Chemical Society National Meeting in New York City.
2001 Organizer and Chair of the Symposium on DNA and Protein
Modifications by Aldehydic Compounds from Lipid Peroxidation
at the 222nd American Chemical Society National Meeting in
1999 Featured on the cover of Cancer Research, Vol. 59, July 1.
1996 Chair of the Poster Discussion Session on Oxygen Radicals at the
AACR Annual Meeting in Washington, DC.
1995 Chair of the Session on Chemical Carcinogenesis and Cancer
Prevention at the 6th SCBA International Symposium,
1992 Chair of the Poster Discussion Session on Dietary
Carcinogenesis/Chemoprevention at the AACR Annual Meeting
in San Diego, CA.
1990 Chair of the Mini-Symposium on Detection of DNA Adduct at
the AACR Annual Meeting in Washington, DC.
1982 NCI, Young Investigator Award
1986 – Pres American Association for the Advancement of Science
1983 – Pres American Association for Cancer Research
1978 – Pres American Chemical Society
2007 – Pres American Cancer Society Scientific Review Committee, Regular
2003 – Pres NIH Scientific Review Committee Ad Hoc member of Chemo-
and Dietary Prevention Study Section, Division of Research
1990 – Pres NIH Review Committee for Program Projects and Cancer Center
1996 – 2004 Program Leader, Mechanisms of Carcinogenesis Program, AHF
Cancer Center Grant from the NCI (rated as an outstanding
1992 – 2004 Senior Advisory Committee, IFCP.
1990 – 2004 American Cancer Society Scientific Review Committee, Ad Hoc
2003 Participant of IARC handbook on Cancer Prevention, vol. 9:
Cruciferous Vegetables, Isothiocyanates and Indoles. International
Agency for Research on Cancer, World Health Organization.
2003 AACR Program Committee, Washington, D.C.
2001 NCI Lung Cancer Progress Review Group (PRG).
1990 – 1994 NIH Scientific Review Committee, Member of Chemical
Pathology Study. Section, Division of Research Grants.
2008 – Pres Editorial Board of Lung Cancer: Targets and Therapy
2003 – Pres Editorial Board of Molecular Nutrition and Food Research.
1997 Editorial Member of Journal of Cellular Biochemistry,
1994 – 1997 Editorial Board of Chemical Research in Toxicology.
1993 – 1995 Editorial Board of Oncology Reports, an International Journal.
Selected invited lectures since 2003:
AAIM (American Association of Integrative Medicine)
National Forum. Chicago, IL. Nov. 2003
Department of Pharmacological Sciences, “Endogenous DNA
adducts from Enals as Lipid Peroxidation Products.” SUNY,
Stony Brook. NY. Oct. 2003.
Invited seminar speaker.
Fred Hutching Cancer Center, “Chemoprevention of lung cancer
by isothiocyanates.” Seattle, WA. Sept. 2003
Invited seminar speaker.
Symposium on “Chemistry and Mechanism of Tea in Disease
Prevention”, ACS national meeting. New York, NY. Aug. 2003
Tea Expo on “Take me to Tea.” Symposium on Tea and Health.
Providence, RI. Nov. 2004.
Symposium on “Polyphenols as antioxidants” at American
Chemical Society National Meeting in Washington, DC. Aug.
Symposium of Agricultural and Food Chemistry Award to Dr.
C.T. Ho. The 230th ACS National Meeting, Washington, DC.
Scientific Meeting at Tea Council of America, “Recent progress
on tea and cancer research.” New York, NY. Feb. 2006.
Special lecture for Taiwanese American Science of Technology
Association (TASTA), “Tea in Lung Cancer Prevention: Studies
from animals to humans.” Bethesda, MD. Jun. 2006.
Seminar at the University of Kentucky, Department of
Pharmacology and Toxicology, Knoxville, KY. Nov. 2006.
M.D. Anderson Cancer Center, “Mechanism based
Chemoprevention of Lung Cancer by Isothiocyanates: Studies
from Animals to Humans,” Houston, TX. Jan. 2007. Invited
Shanghai Cancer Institute, Shanghai, China, .”Phytochemicals in
Cancer Prevention”. April 2007
Symposium on Cancer Chemoprevention, The 12th World
Congress on Advances in Oncology, “Covalent Binging to
Tubulin: A Mechanism of Cell Growth Arrest and Apoptosis by
Isothiocyanates” Crete, Greece, Oct. 2007
The 9th International Conference on Mechanisms of
Antimutagenesis and Anticarcinogenesis, “Mechanisms of
Prevention of Oral Cancer in Smokers: A Clinical Investigation”
Jeju island, Korea, Dec. 2007
Seminar at Biochemistry and Biophysics Center,
Laboratory of Molecular Biophysics, Bethesda, MD., Oct. 2008
International Symposium on Novel Strategies for targeted
Prevention and Treatment of Cancer, “ Cruciferous Vegetable-
derived Isothiocyanates Covalently Bound to Tubulin: A
Mechanism of Cell Growth and Apoptosis” New Delhi, India,
International Conference on Cancer Prevention by Foods and
Chemicals: Basic and Clinical Research. Taipei, Taiwan, April,
Seminar at Uniformed Services University of Health Sciences,
Armed Forces Radiobiology Research Institute, May 2009
The 12th SCBA International Symposium, Academia Sinica,
Taipei, Taiwan, June 2009
Department of Pharmacology and Biochemistry, Penn State
University, Hershey, PA, Nov 16 2009
International Symposium on herbal medicines and vaccines for
cancer therapy, Academia Sinica, Taipei, Taiwan, December 2
American Chemical Society 239th National Meeting, Symposium
on Reactive Carbonyl Species and their Health Consequences,
San Francisco, CA, March 20-24 2010
2006 – Pres Tumor Biology Oversight Committee—Monthly meeting to
evaluate teaching program in LCCC and review student
2005 – 2007 Georgetown University Animal Care and Use Committee
(GUACUC)—Monthly meeting to review protocols submitted
by faculty in the medical school.
Fall semesters (2004-Pres) TBIO 581: Topics in Molecular Epidemiology.
Role: Course Director and Lecturer.
TBIO 508: Cellular and Molecular Aspects of
Role: Carcinogenesis Section Course Director and
Spring semesters (2006-Pres) BCHB 540/RASC 540: Molecular Basis of
Spring semester (2007-Pres) TBIO 540: Cancer Control and Prevention.
SCHOLARSHIP AND RESEARCH:
A. Research Grants:
RO1-CA-100083 Principal Investigator
Mechanisms of Chemoprevention by Isothiocyanates
Total Direct: $1,160,309 2004-2009
RO1-CA-113449 Principal Investigator
Prevention of Human Oral Cancer in Smokers by Tea: A Mechanisms Study
Total Direct: $1,051,442 2006-2011
RO1-CA-43159 Principal Investigator
Enals in Tumorigenesis
Total Direct: $1,370,526 2006-2011
RO1-CA-134892 Principal Investigator
Lipid Peroxidation-Derived Cyclic Adducts in Hepatocarcinogenesis
Total Direct: $1,855,606 2009-2014
History of Grant Support: (continued support since 1982)
NCI, R23-CA-32271, Screening for Inhibitors of N-Nitrosamine Carcinogenesis,
Principal Investigator, 1982-1985
AICR, Sinigrin as Anticarcinogen to Nitrosamines, Principal Investigator, 1984-1986
NCI, RO1 - CA-23901, Environmental Nitrosamines - Metabolism and Carcinogenesis.
NCI, RO1 - CA-41544, Glucosinolates and Environmental Nitrosamine Activation.
Principal Investigator, 1986-1989
NCI, RO1 - CA-43159, Enals in Tumorigenesis, Principal Investigator, 1986-2005
NCI, PO1 - CA-46535, Isothiocyanates and Nitrosamine Carcinogenesis, Project Leader
of Project 1, Structure-Activity Relationships for Inhibition, Principal Investigator
(Program Director: S. S. Hecht), 1987-2002
NCI, RO1 - CA-51830, Endogenous Enals in Nitrosamine Carcinogenesis, Principal
NCI, Chemoprevention Branch, DCPC, NO1-CN-85095-06, Chemoprevention of
Tobacco-Specific Nitrosamine-Induced Lung Tumors In Rats With Substituted
Isothiocyanates. Principal Investigator, 1991-1995
NCI, Chemoprevention Branch, DCPC, NO1-CN-85095-08, Chemoprevention of Lung
Cancer In Strain A Mice, Principal Investigator, 1992-1995
Tea Trade Health Research Associates, Tea and Tobacco Carcinogenesis, Principal
Investigator, 1994-1997 & 1998-2001
HEI, DNA Biomarkers for Auto Mechanics Exposed to Aldehydes, Principal
NCI, RO13 , Modification of Proteins and DNA by aldehydes from lipid peroxidation,
Principal Investigator, 2001-2002
NCI, RO13, Chemistry and Mechanisms of Tea in Disease Prevention, Principal
*Please see attached bibliography.
U.S. patent 4,923,813 on “Monoclonal antibody-based immunoassay for cyclic DNA
adducts resulting from exposure to crotonaldehyde and acrolein.” Date of patent: May
U.S. patent 5,114,969 on “Method of inhibiting lung tumors, arylalkyl isothiocyanates,
and method of synthesizing same.” Date of patent: May 19, 1992.
U.S. patent 5,231,209 on “Method of inhibiting lung tumors, arylalkyl isothiocyanates,
and method of synthesizing same.” Date of patent: July 27, 1993.
U.S. patent 5,391,568 on “Inhibition of lung tumorigenesis by administration of a
polyphenol.” Date of patent: February 21, 1995.
U.S. patent 6,433,011 on “Method for inhibiting formation of aberrant crypt foci in the
colon of a mammal.” Date of patent: August 13, 2002.
U.S. patent (pending approval) on “Compositions and methods for treating lung