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  • 10/29/2010 CURRICULUM VITAE Fung-Lung Chung Office: Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, NW, Washington, DC 20057-1465 (202)687-3021 Home: 302 Oak Knoll Terrace, Rockville, MD 20850 (301)315-2666 EDUCATION: Chung-Yuan College of Sciences & Engineering, Taiwan Bio-organic Chemistry, 1968 - 1971, B.S. University of Utah, Salt Lake City, Utah Medicinal Chemistry, 1973 - 1978, Ph.D. Columbia University, New York, NY Comprehensive Cancer Center College of Physicians and Surgeons Staff Associate, 1979 - 1980 Postdoctoral Fellow, 1978 - 1979 PROFESSIONAL EXPERIENCE: 2004 – Pres Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC Tenured Professor, Department of Oncology. 2008 – Pres Co-Leader, Carcinogenesis, Biomarkers, and Epidemiology Program 1981 – 2004 Institute for Cancer Prevention, American Health Foundation Cancer Center (NCI-designated), Valhalla, NY. 1996 – 2004 Program Leader, Mechanisms of Carcinogenesis. 1995 – 2004 Chief, Division of Carcinogenesis and Molecular Epidemiology. 1990 – 1995 Associate Chief, Division of Chemical Carcinogenesis. 1985 – 1995 Head, Section of Nucleic Acid Chemistry. 1981 – 1984 Associate Research Scientist. 1993 – 2001 Memorial Sloan-Kettering Cancer Center, New York, NY. Adjunct Associate Member. 1992 – 2004 Adjunct Professor, New York Medical College, Valhalla, NY. HONORS: 2008 Session Chair, International Symposium on Novel Strategies and Targeted Prevention and Treatment of Cancer, New Delhi, India 2006 Tea Council of the USA, Scientific Advisory Panel, New York, NY. 2004 Chair, AACR Program Committee on Chemical Carcinogenesis, Orlando, FL. 1
  • 10/29/2010 2003 Organizer and Co-chair of the Symposium on Chemistry and Mechanisms of Tea in Disease Prevention at the 226th American Chemical Society National Meeting in New York City. 2001 Organizer and Chair of the Symposium on DNA and Protein Modifications by Aldehydic Compounds from Lipid Peroxidation at the 222nd American Chemical Society National Meeting in Chicago. 1999 Featured on the cover of Cancer Research, Vol. 59, July 1. 1996 Chair of the Poster Discussion Session on Oxygen Radicals at the AACR Annual Meeting in Washington, DC. 1995 Chair of the Session on Chemical Carcinogenesis and Cancer Prevention at the 6th SCBA International Symposium, Vancouver, B.C. 1992 Chair of the Poster Discussion Session on Dietary Carcinogenesis/Chemoprevention at the AACR Annual Meeting in San Diego, CA. 1990 Chair of the Mini-Symposium on Detection of DNA Adduct at the AACR Annual Meeting in Washington, DC. 1982 NCI, Young Investigator Award PROFESSIONAL SOCIETIES: 1986 – Pres American Association for the Advancement of Science 1983 – Pres American Association for Cancer Research 1978 – Pres American Chemical Society PROFESSIONAL SERVICE: 2007 – Pres American Cancer Society Scientific Review Committee, Regular Member. 2003 – Pres NIH Scientific Review Committee Ad Hoc member of Chemo- and Dietary Prevention Study Section, Division of Research Grants. 1990 – Pres NIH Review Committee for Program Projects and Cancer Center Support Grants. 1996 – 2004 Program Leader, Mechanisms of Carcinogenesis Program, AHF Cancer Center Grant from the NCI (rated as an outstanding program). 1992 – 2004 Senior Advisory Committee, IFCP. 1990 – 2004 American Cancer Society Scientific Review Committee, Ad Hoc Member. 2
  • 10/29/2010 2003 Participant of IARC handbook on Cancer Prevention, vol. 9: Cruciferous Vegetables, Isothiocyanates and Indoles. International Agency for Research on Cancer, World Health Organization. 2003 AACR Program Committee, Washington, D.C. 2001 NCI Lung Cancer Progress Review Group (PRG). 1990 – 1994 NIH Scientific Review Committee, Member of Chemical Pathology Study. Section, Division of Research Grants. EDITORIAL BOARD: 2008 – Pres Editorial Board of Lung Cancer: Targets and Therapy 2003 – Pres Editorial Board of Molecular Nutrition and Food Research. 1997 Editorial Member of Journal of Cellular Biochemistry, Chemoprevention Supplements. 1994 – 1997 Editorial Board of Chemical Research in Toxicology. 1993 – 1995 Editorial Board of Oncology Reports, an International Journal. INVITED LECTURES: Selected invited lectures since 2003: AAIM (American Association of Integrative Medicine) National Forum. Chicago, IL. Nov. 2003 Department of Pharmacological Sciences, “Endogenous DNA adducts from Enals as Lipid Peroxidation Products.” SUNY, Stony Brook. NY. Oct. 2003. Invited seminar speaker. Fred Hutching Cancer Center, “Chemoprevention of lung cancer by isothiocyanates.” Seattle, WA. Sept. 2003 Invited seminar speaker. Symposium on “Chemistry and Mechanism of Tea in Disease Prevention”, ACS national meeting. New York, NY. Aug. 2003 Tea Expo on “Take me to Tea.” Symposium on Tea and Health. Providence, RI. Nov. 2004. Symposium on “Polyphenols as antioxidants” at American Chemical Society National Meeting in Washington, DC. Aug. 2005. 3
  • 10/29/2010 Symposium of Agricultural and Food Chemistry Award to Dr. C.T. Ho. The 230th ACS National Meeting, Washington, DC. Aug. 2005. Scientific Meeting at Tea Council of America, “Recent progress on tea and cancer research.” New York, NY. Feb. 2006. Special lecture for Taiwanese American Science of Technology Association (TASTA), “Tea in Lung Cancer Prevention: Studies from animals to humans.” Bethesda, MD. Jun. 2006. Seminar at the University of Kentucky, Department of Pharmacology and Toxicology, Knoxville, KY. Nov. 2006. M.D. Anderson Cancer Center, “Mechanism based Chemoprevention of Lung Cancer by Isothiocyanates: Studies from Animals to Humans,” Houston, TX. Jan. 2007. Invited seminar speaker. Shanghai Cancer Institute, Shanghai, China, .”Phytochemicals in Cancer Prevention”. April 2007 Symposium on Cancer Chemoprevention, The 12th World Congress on Advances in Oncology, “Covalent Binging to Tubulin: A Mechanism of Cell Growth Arrest and Apoptosis by Isothiocyanates” Crete, Greece, Oct. 2007 The 9th International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis, “Mechanisms of Prevention of Oral Cancer in Smokers: A Clinical Investigation” Jeju island, Korea, Dec. 2007 Seminar at Biochemistry and Biophysics Center, DIR/NHLBI/NIH Laboratory of Molecular Biophysics, Bethesda, MD., Oct. 2008 International Symposium on Novel Strategies for targeted Prevention and Treatment of Cancer, “ Cruciferous Vegetable- derived Isothiocyanates Covalently Bound to Tubulin: A Mechanism of Cell Growth and Apoptosis” New Delhi, India, Dec. 2008 International Conference on Cancer Prevention by Foods and Chemicals: Basic and Clinical Research. Taipei, Taiwan, April, 2009 Seminar at Uniformed Services University of Health Sciences, Armed Forces Radiobiology Research Institute, May 2009 4
  • 10/29/2010 The 12th SCBA International Symposium, Academia Sinica, Taipei, Taiwan, June 2009 Department of Pharmacology and Biochemistry, Penn State University, Hershey, PA, Nov 16 2009 International Symposium on herbal medicines and vaccines for cancer therapy, Academia Sinica, Taipei, Taiwan, December 2 2009 American Chemical Society 239th National Meeting, Symposium on Reactive Carbonyl Species and their Health Consequences, San Francisco, CA, March 20-24 2010 UNIVERSITY SERVICE: 2006 – Pres Tumor Biology Oversight Committee—Monthly meeting to evaluate teaching program in LCCC and review student performance. 2005 – 2007 Georgetown University Animal Care and Use Committee (GUACUC)—Monthly meeting to review protocols submitted by faculty in the medical school. TEACHING ACTIVITIES: Fall semesters (2004-Pres) TBIO 581: Topics in Molecular Epidemiology. Role: Course Director and Lecturer. TBIO 508: Cellular and Molecular Aspects of Transformed Cells. Role: Carcinogenesis Section Course Director and Lecturer. Spring semesters (2006-Pres) BCHB 540/RASC 540: Molecular Basis of Carcinogenesis. Role: Lecturer. Spring semester (2007-Pres) TBIO 540: Cancer Control and Prevention. Role: Lecturer. SCHOLARSHIP AND RESEARCH: A. Research Grants: Current: NIH/NCI 5
  • 10/29/2010 RO1-CA-100083 Principal Investigator Mechanisms of Chemoprevention by Isothiocyanates Total Direct: $1,160,309 2004-2009 NIH/NCI RO1-CA-113449 Principal Investigator Prevention of Human Oral Cancer in Smokers by Tea: A Mechanisms Study Total Direct: $1,051,442 2006-2011 NIH/NCI RO1-CA-43159 Principal Investigator Enals in Tumorigenesis Total Direct: $1,370,526 2006-2011 NIH/NCI RO1-CA-134892 Principal Investigator Lipid Peroxidation-Derived Cyclic Adducts in Hepatocarcinogenesis Total Direct: $1,855,606 2009-2014 History of Grant Support: (continued support since 1982) NCI, R23-CA-32271, Screening for Inhibitors of N-Nitrosamine Carcinogenesis, Principal Investigator, 1982-1985 AICR, Sinigrin as Anticarcinogen to Nitrosamines, Principal Investigator, 1984-1986 NCI, RO1 - CA-23901, Environmental Nitrosamines - Metabolism and Carcinogenesis. Co-Investigator, 1980-1987 NCI, RO1 - CA-41544, Glucosinolates and Environmental Nitrosamine Activation. Principal Investigator, 1986-1989 NCI, RO1 - CA-43159, Enals in Tumorigenesis, Principal Investigator, 1986-2005 NCI, PO1 - CA-46535, Isothiocyanates and Nitrosamine Carcinogenesis, Project Leader of Project 1, Structure-Activity Relationships for Inhibition, Principal Investigator (Program Director: S. S. Hecht), 1987-2002 NCI, RO1 - CA-51830, Endogenous Enals in Nitrosamine Carcinogenesis, Principal Investigator, 1990-1993 NCI, Chemoprevention Branch, DCPC, NO1-CN-85095-06, Chemoprevention of Tobacco-Specific Nitrosamine-Induced Lung Tumors In Rats With Substituted Isothiocyanates. Principal Investigator, 1991-1995 NCI, Chemoprevention Branch, DCPC, NO1-CN-85095-08, Chemoprevention of Lung Cancer In Strain A Mice, Principal Investigator, 1992-1995 Tea Trade Health Research Associates, Tea and Tobacco Carcinogenesis, Principal Investigator, 1994-1997 & 1998-2001 HEI, DNA Biomarkers for Auto Mechanics Exposed to Aldehydes, Principal Investigator, 1999-2001 6
  • 10/29/2010 NCI, RO13 , Modification of Proteins and DNA by aldehydes from lipid peroxidation, Principal Investigator, 2001-2002 NCI, RO13, Chemistry and Mechanisms of Tea in Disease Prevention, Principal Investigator, 2003-2004 B. Publications*: *Please see attached bibliography. PATENTS: U.S. patent 4,923,813 on “Monoclonal antibody-based immunoassay for cyclic DNA adducts resulting from exposure to crotonaldehyde and acrolein.” Date of patent: May 8, 1990. U.S. patent 5,114,969 on “Method of inhibiting lung tumors, arylalkyl isothiocyanates, and method of synthesizing same.” Date of patent: May 19, 1992. U.S. patent 5,231,209 on “Method of inhibiting lung tumors, arylalkyl isothiocyanates, and method of synthesizing same.” Date of patent: July 27, 1993. U.S. patent 5,391,568 on “Inhibition of lung tumorigenesis by administration of a polyphenol.” Date of patent: February 21, 1995. U.S. patent 6,433,011 on “Method for inhibiting formation of aberrant crypt foci in the colon of a mammal.” Date of patent: August 13, 2002. U.S. patent (pending approval) on “Compositions and methods for treating lung cancer.” 7