Cancer Interest/ Focus:
Planned Cancer Research Interactions/Collaborations:
UNIVERSITY OF MARYLAND PROGRAM IN ONCOLOGY
REQUEST FOR APPOINTMENT IN THE UNIVERSITY OF MARYLAND SCHOOL OF
MEDICINE PROGRAM IN ONCOLOGY
I hereby request membership/associate membership in the University of Maryland School of Medicine
Program in Oncology. I understand and accept the following obligations that such an appointment
1. Support the basic concept, mission, and goals of the Cancer Center.
2. Participate fully in respective research program, collaborative efforts, and communications
about research and patient care initiatives.
3. Provide the Cancer Center with the information necessary to maintain current information
about scientific activity and grant support in order to maintain the Center’s database on
4. Request funds in grant applications to support the shared resource services provided to them
by Cancer Center.
5. Attend cancer seminars and program meetings in areas of interest.
6. Report all funded activities to the Cancer Center at the time membership is granted, and as
requested by the Director
7. Include recognition of membership in the Program in Oncology and the Cancer Center on all
cancer-related academic papers, grants, journal articles, poster sessions, and/or abstracts.
8. Participate in cancer-related educational activities (both medical and graduate school)
sponsored by the Cancer Center.
9. Participate in the Cancer Center core grant program project and training application process as
10. Participate in seminars and conferences.
Applicant Name (please print): ______________________________________________
Applicant Signature: ______________________________________________________
Applicant Name: __________________________________________________
Program in Oncology Research Programs
Please indicate your primary (1) and secondary (2) interest by program.
Experimental Therapeutics Program
Contact: Douglas D. Ross, M.D., Ph.D., Professor, Department of Medicine
The unifying theme of the Program is to build translational clinical trials based on innovative and novel
laboratory research projects. The Program goals are to: identify cancer-specific targets that can be
exploited for cancer prevention or therapy, and translate these findings to clinical trials; rationally design
agents to combat cancer directed at specific targets identified; and conduct clinical trials that test the
efficacy of novel targeted anticancer therapeutic agents or improve the efficacy of existing agents, and
translate clinical findings to laboratory investigations. Major research areas of interest include: cancer
drug resistance; cell proliferations, signaling, growth factors, and apoptosis; angiogenesis; Computer-
Assisted Drug Design (CADD), screening and lead optimization; and clinical trials that specifically test
the efficacy of novel agents aimed at identified targets.
Tumor Immunology and Immunotherapy Program
Contact: Scott E. Strome, M.D., Chair, Department of Otorhinolaryngology--Head and Neck Surgery
The principal scientific goals of the Program are to develop, characterize, and apply immunological
approaches for the prevention, diagnosis, treatment and monitoring of premalignant and malignant
diseases and disease progression. The specific aims include the development and characterization
of molecular and immunologic strategies for manipulating the innate and adaptive immune
responses to malignancy; the design and conduct of preventive and therapeutic trials for selected
cancers utilizing these molecular/immunological strategies; and the development of an
immunological monitoring program to be used in conjunction with clinical outcomes to evaluate the
efficacy of immunotherapy and conventional therapies.
Hormone Responsive Cancers Program
Contact: Amy M. Fulton, Ph.D., Professor of Pathology
The overall goals of the Program are to understand the pathophysiological processes that determine the
behavior of malignancies of hormonally-responsive tissues, chiefly prostate and breast. These studies
address mechanisms by which hormone-refractory disease develops and identify novel targets. The
specific aims of the Program are to: identify mechanisms of de novo and acquired hormone-resistance;
identify novel diagnostic, prognostic and therapeutic targets; elucidate the biology of tumor angiogenesis
and develop therapeutic strategies; define the mechanisms mediating tumor invasion and metastasis and
develop therapeutic strategies; and identify causes and reduce cancer disparities.
Molecular and Structural Biology Program
Contact: Alan Tomkinson, Ph.D. Professor of Radiation Oncology
The overall goals of the Program are to understand the cellular processes that normally regulate cellular
proliferation and maintain genome stability and how these processes may contribute to cancer formation.
The research interests of the Program members can be divided into three broad areas: DNA damage,
repair and genome instability; RNA biology: and signal transduction. The specific aims include: gaining
molecular insights into cellular processes that regulate cellular proliferation and maintain genome
stability; evaluating proteins as novel therapeutic targets; and identifying small molecules that will serve
as lead compounds for the development of novel therapeutic agents.
Viral Oncology Program
Contact: Marvin S. Reitz, Jr., Ph.D. Professor, IHV and Department of Microbiology and Immunology
The overall goal of the Program is to understand how viral infections contribute to the development and
progression of cancers. This includes not only the mechanisms by which some viruses, such as
papillomavirus and some herpesviruses, contribute directly to tumorigenesis, but also more indirect
mechanisms, such as dysregulation of different aspects of immunity by human immunodeficiency virus
(HIV). These include the impairment of the control of tumorigenic viruses, the creation of
microenvironments that can facilitate the formation and/or maintenance of cancer, such as inflammation
and angiogenesis, and the abrogration of innate immunity against tumors.