Annual Report 2007/2008
Department of Oncology
August 2008
Chair: Gerald Batist, MD
Prepared by: Gayle A. Shinder, PhD
1
Department of Oncology Annual Report 2007/2008
Message from the Chair
We were pleased to have been invited to write a pape...
Department of Oncology Annual Report 2007/2008
the FRSQ Image Bank. Dr. Neil MacDonald received the 2007 Statesman Award f...
Department of Oncology Annual Report 2007/2008
lymphedema research, pain management, quality of life and bereavement, and ...
Department of Oncology Annual Report 2007/2008
PAUL ALLISON
1. Research Grants (new and ongoing)
Developing a team to addr...
Department of Oncology Annual Report 2007/2008
PhD Students
Larissa Vilela, January 2005 – present (Supervisor)
Reem Alans...
Department of Oncology Annual Report 2007/2008
Bone Health Research), FRSQ
Committee member: Conseil d’administration, Fon...
Department of Oncology Annual Report 2007/2008
Formal small group teaching to ICM students.
3. Presentations
On-site cytot...
Department of Oncology Annual Report 2007/2008
Clinical Research
1. Adjuvant and neoadjuvant trials in breast cancer (part...
Department of Oncology Annual Report 2007/2008
Osama Hussein, PhD Committee : Breast cancer metastases to bone, Supervisor...
Department of Oncology Annual Report 2007/2008
Lecture to Surgery Residents, “High Risk Breast Cancer Patients”, Dept surg...
Department of Oncology Annual Report 2007/2008
resonance magnétique; $60,000/per annum (renewable for 3rd yr), PI-Martel S...
Department of Oncology Annual Report 2007/2008
Title: MUHC within the McGill University Dept of Oncology and the McGill RU...
Department of Oncology Annual Report 2007/2008
2. Research grants (new and on-going)
CEACAM1 signaling in epithelial cell ...
Department of Oncology Annual Report 2007/2008
Sarah LeBlanc M.Sc. (2009)
Post-Doctoral Fellows
Anne-Laure Nouvion 2006-20...
Department of Oncology Annual Report 2007/2008
6. External Committees and Boards
Panel Member
Canadian Institutes for Heal...
Department of Oncology Annual Report 2007/2008
Member of McGill University’s Harassment and Sexual Harassment Committee (2...
Department of Oncology Annual Report 2007/2008
Synthesis of Parathyroid Hormone? Richardson K, Payne RJ, Hier MP, Black MJ...
Department of Oncology Annual Report 2007/2008
5. External Committees and Boards
M. Hier
“Head and Neck Plenary Session”, ...
Department of Oncology Annual Report 2007/2008
3. Education and Research Training
PhD Students
Melissa Mui
Chi Ying (There...
Department of Oncology Annual Report 2007/2008
Utility of #D Ultrasound for assessing cachexia through measurement of musc...
Department of Oncology Annual Report 2007/2008
10/03-06/04 2008 Matthias Haas (visiting)
Oncology Residents
09/07-18/11 20...
Department of Oncology Annual Report 2007/2008
Editorial co-author, “Optimism Matters in the Treatment of Cancer: Montreal...
Department of Oncology Annual Report 2007/2008
Small group facilitator, Professionalism Seminar, McGill University, Postgr...
Department of Oncology Annual Report 2007/2008
Grant for New Investigators $55,371 (2005 – 2006); $56,956 (2006 – 2007); $...
Department of Oncology Annual Report 2007/2008
Dawn Allan Ph.D
Dr. Javad Shahidi (Iran): Quality of life of people with ad...
Department of Oncology Annual Report 2007/2008
Institute of Canada Sociobehavioural Cancer Research Network
Director, Pall...
Department of Oncology Annual Report 2007/2008
Association of Surgical Education Meeting (Toronto) April 2008
American Soc...
Department of Oncology Annual Report 2007/2008
Training volunteers to act as research assistants, and to facilitate coping...
Department of Oncology Annual Report 2007/2008
Canadian Organization Of Medical Physics: Radiation And Technical Standards...
Department of Oncology Annual Report 2007/2008
6. Invited Presentations
Terapia hypofracionada: o futuro da radioterapia? ...
Department of Oncology Annual Report 2007/2008
Exploring the pathogenic and therapeutic implications of aberrant splicing ...
Department of Oncology Annual Report 2007/2008
McGill University Medical Genetics Elective
2006-2007 Marta McCrum
Aspasia ...
Department of Oncology Annual Report 2007/2008
Medical Genetics
Unit 8 small group teaching in medical genetics
Format: Le...
Department of Oncology Annual Report 2007/2008
Scientific Advisory Committee, Breast Cancer Family Registry (NIH)
Member, ...
Department of Oncology Annual Report 2007/2008
Improving breast cancer mortality: have genetic markers helped? The 2008 CL...
Department of Oncology Annual Report 2007/2008
RO1CA81310, approx. $1.3 million [US$ 870,000], 2000-03; renewed 2004-07, a...
Department of Oncology Annual Report 2007/2008
A randomised controlled evaluation of HPV testing for cervical cancer scree...
Department of Oncology Annual Report 2007/2008
Oral Diseases
Public Library of Science (PLoS) – Medicine
Salud Pública de ...
Department of Oncology Annual Report 2007/2008
University of Washington, Department of Pathology, Seattle, USA (evaluation...
Department of Oncology Annual Report 2007/2008
Member, Scientific Committee, XVIII IEA World Congress of Epidemiology, Por...
Department of Oncology Annual Report 2007/2008
Steering Committee Member, HPV-040 Vaccination Study, National Public Healt...
Department of Oncology Annual Report 2007/2008
“Research at McGill’s Division of Cancer Epidemiology” Seminar at the Facul...
Department of Oncology Annual Report 2007/2008
“What new proofs are needed to foster universal implementation of HPV vacci...
Department of Oncology Annual Report 2007/2008
“Epidemiologic issues in implementing HPV vaccination” Lecture at the Sub-S...
Department of Oncology Annual Report 2007/2008
Evaluation of new radiotherapy technologies.
2. Research Grants (new and on...
Department of Oncology Annual Report 2007/2008
Pediatric Radiation Oncology, Montréal.
5. External Committees and Boards
C...
Department of Oncology Annual Report 2007/2008
Co-Chair, Tumor Board, Montreal Children’s Hospital
Ad hoc member Promotion...
Department of Oncology Annual Report 2007/2008
2. Education and Training
Undergraduate Teaching
ICM-B (Introduction to Cli...
Department of Oncology Annual Report 2007/2008
Participating in an 8 Week Ambulatory Cancer Nutrition Rehabilitation (CNR)...
Department of Oncology Annual Report 2007/2008
ICM-B-50-60 hours per year
Osler Fellowship-Physician Apprenticeship Course...
Department of Oncology Annual Report 2007/2008
study of the effects of changing lifestyle and environmental conditions on ...
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
Annual Report 2007/2008 Department of Oncology
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Transcript of "Annual Report 2007/2008 Department of Oncology"

  1. 1. Annual Report 2007/2008 Department of Oncology August 2008 Chair: Gerald Batist, MD Prepared by: Gayle A. Shinder, PhD 1
  2. 2. Department of Oncology Annual Report 2007/2008 Message from the Chair We were pleased to have been invited to write a paper describing the past, present and future of the McGill Department of Oncology. This paper, entitled The McGill University Department of Oncology: Structure depicts the shape of evolving knowledge, and co-authored by me and Dr. Gayle Shinder, was published in Current Oncology 15(3): 28-35, 2008. It describes the changes that we’ve all made in how we function, which reflects the rapid evolution of both cancer care and research to interdisciplinarity. A very strongly positive response has come from across Canada, and I believe that the leadership McGill held in first creating the Department persists in the innovations we’ve created since its inception. There were two new Department of Oncology faculty appointments in the 2007/2008 academic year: Dr. Thomas Jagoe joined as an Assistant Professor in November 2007 and began his tenure as the Director of the Cancer Nutrition-Rehabilitation Program, replacing Founding Director, Dr. Neil MacDonald, who continues to play an active role in the Program. Dr. François DeBlois joined Medical Physics as an Assistant Professor in May 2008. In addition, in May 2008 Dr. Golda Tradounsky, from Palliative Care, became a Faculty Lecturer. The academic year also saw the departures of Dr. Ala-Eddin Al Moustafa, who was involved in cancer genetics research, and Dr. Tarek Bismar who was an academic Pathologist at the Jewish General Hospital. Two faculty members were awarded tenure as of June 1, 2007: Dr. Robin Cohen (Palliative Care) who was also promoted to Associate Professor, and Dr. Frank Verhaegen (Medical Physics). Dr. Paul Allison, an Associate Member, was appointed the Dean of the Faculty of Dentistry. The 5 year term began on June 1st . There were also several administrative staff changes. Pamela Hodgson joined Palliative Care as a Research Assistant while Sara Marcil-Johnson became Palliative Care’s new Administrative and Student Affairs Coordinator, replacing Lucy Saunders who was in that position since August 2007 when she replaced Marie-José Martirene. Mary Jane MacDonald, the administrative coordinator for the Cancer Nutrition-Rehabilitation Program, retired in January 2008 and was replaced, in May, by Christine Sgherri. Kingsley Cheung, who was responsible for the Department of Oncology website maintenance left in April 2008 and was replaced, in May, by Jasper Palfree. A number of Department faculty members received awards and honours: Dr. Paul Allison received the 2007 Howard Katz Award for Excellence in Teaching; Dr. Gerald Batist received the Minda de Gunzburg Chair in Oncology, McGill University in 2007; Dr. Nicole Beauchemin was on the 2007 “Faculty Honour List for Educational Excellence”; Dr. Bernard Lapointe was the recipient of the 2007 Canadian Hospice Palliative Care Association Award of Excellence; Dr. Carmen Loiselle, with her colleague, Lynne McVey, received 2nd place prize at the Regional Order of Nurses Competition for Clinical Innovation/3M. in Montreal on May 26, 2008 for Technology and intensive care units: Health information and support are just as present. In addition, the photo she submitted for the Fonds de la recherche en santé du Québec (FRSQ) Scientific Photo Competition (November 2007) was one of 33 chosen to become part of 2
  3. 3. Department of Oncology Annual Report 2007/2008 the FRSQ Image Bank. Dr. Neil MacDonald received the 2007 Statesman Award from the American Society of Clinical Oncology; Dr. Morag Park was inducted as a Fellow of the Royal Society of Canada; Dr. Ervin Podgorsak received a 2007 Fellowship from The American College of Medical Physics (ACMP) and in 2008 was the recipient of a Gold Medal from the Canadian Organization of Medical Physicists (COMP); Dr. Shafaat Rabbani received the 2008 Outstanding Achievement Award from the Society of American Asian Scientists in Cancer Research; Dr. Janusz Rak was awarded an Honorary Professorship at Masaryk University, Czech Republic (in progress 2008); In 2007 Dr. Marc Tischkowitz received the Fanconi Anemia Research Fund Discovery Award and also received the FRSQ Chercheur-bousier clinicien Junior 1 award; Dr. Anna Towers was given the 2007 Ethel Lilian Creller Award from the MUHC Research Institute; and Dr. Te Vuong received the Hebert S. Lang Oncology Surgery award as well as a CIHR Investigator Salary Award (2007). The Division of Cancer Epidemiology was pleased to announce awards given to two of its trainees: Andrea Spence, a PhD student, received a merit award for the best paper presented at the 60th Anniversary Celebration of the NCIC while Dr. Marie-Hélène Mayrand, was awarded a McGill Principal’s Dissertation Fellowship. In 2007, the Oncology Summer Scholarship Program awarded a summer research bursary to Vincent Lavallée for the project entitled “Comparing ectopic and endogenous replication in normal vs. tumor cells” under the guidance of Dr. Maria Zannis-Hadjopoulos. This year’s Department of Oncology Retreat was held on March 13-14, 2008 at the Château Vaudreuil. Talks ranged from basic research studies in tumour suppression, angiogenesis, and DNA replication to clinical studies on cancer nutrition and rehabilitation as well as radiation therapy. A highlight of the retreat was the “Being Mindful-How to Stay Awake on the Job” meditation presentation given by Dr. Thomas Hutchinson from the Department of Oncology’s McGill Programs in Whole Person Care. Through Dr. Hutchinson’s expert guidance, the attendees were able to try their hand at Mindfulness Meditation, a practice that many cancer patients use as a method of relaxation. The McGill Centre for Translational Research in Cancer/Montreal Centre for Experimental Therapeutics in Cancer held its Fifth Annual Meeting on December 3-4, 2007. On the first day presentations focused on prostate cancer, ovarian cancer, muscle wasting, vitamin D hybrid molecules and radiopharmaceutical chemistry. The second day was devoted to presentations from the CIHR Training Program trainees who presented on a variety of research areas. In Fall 2006 the inaugural edition of Palliative Care Research News reported on the research interests of the members of the Division of Palliative Care. The second edition of the Newsletter, which came out in Fall 2007, followed up with research findings from the studies conducted on nutritional interventions for anorexia-cachexia, prognostic indicators of cancer cachexia, exercise in patients with non-small cell lung cancer, 3
  4. 4. Department of Oncology Annual Report 2007/2008 lymphedema research, pain management, quality of life and bereavement, and pediatric palliative care. The Visiting Professors in Oncology Program had another successful year with presentations covering areas such as acute myeloid leukemia, colorectal cancer, breast cancer, radiation oncology, psychosocial oncology and mind-body medicine. The Programme Québecois de lutte contre le cancer evaluations of the tumour site teams at the McGill teaching hospitals continued in 2007/2008. The Table d’oncologie of RUIS McGill continued to meet on a monthly basis, tackling a range of policy and service issues related to the RUIS. It’s been a very busy and productive year, with the expanding mandate in cancer care related to the RUIS structure added to our strong and growing academic programs. We continue to develop new interdisciplinary and interprofessional programs, such as the Nursing Oncology program and Geriatric Oncology this past year. Plans to team with Pathology and other Departments will evolve during the next year. Gerald Batist, MD 4
  5. 5. Department of Oncology Annual Report 2007/2008 PAUL ALLISON 1. Research Grants (new and ongoing) Developing a team to address oral health disparities in Canada. PI: Drs. Paul J Allison and Christophe Bedos, Co-investigators: T.Barnett, C.Bell, J.Feine, R.Harrison, D. Matthews, M.McNally, B.Nicolau M.Raynault, J.Veronneau, C.Wyatt. Canadian Institutes of Health Research. $121,750. January 2008 – December 2008 À L'écoute Les Uns Des Autres – Implantation d'un programme visant à améliorer les compétences des professionnels de la santé buccodentaire pour entrer en relation et soigner les personnes en situation de pauvreté. PI: Dr. Christophe Bedos, Co- investigators: P.J. Allison, G. Arbour, A. Charbonneau, J. Coté S. Dupéré, C. Erdelyon, M-M. Jacob, I. Laurin, C. Loignon, L. Whitmore. Ministère de Développement économique, innovation et de l’Exportation; Réseau de recherche en santé buccodentaire et osseuse. $299,950. April 2008 – March 2011 Changing Demographics: The Oral Health of our Aging Population. PI: Drs Debora Matthews and Joanne Clovis. Co-investigators: P.J. Allison, M. Filiagi, S. Kirkland, H. Lawrence, M. McNally. Health Canada (Office of the Chief Dental Officer); Nova Scotia Health Research Foundation & CIHR, $280,701. February 2008 – January 2011 Réseau de recherche en santé bucco-dentaire et osseuse. PI: P.J.Allison, Co- investigators: C. Bedos, R. St.Arnaud, M.Rouabhia, J-P. Goulet, J. Henderson. Fonds de Recherche en Santé du Québec, $1,800,000. April 2007 – March 2011 The life course approach to studying the etiology of head and neck cancer: HeNCe life study. PI: B. Nicolau, Co-investigators: P.J.Allison, R. Burk, F. Coutlée, E. Franco, G. Humphris, J. O’Loughlin, A. Sacker, N. Schlecht. Canadian Institutes of Health Research, $476,000, October 2006 – September 2010 Personnes en situation de pauvreté : Une étude de leur trajectoire dans le système de soins buccodentaires au Québec PI: C.P. Bedos, Co-investigators: P.J.Allison, J-M Brodeur, B. Nicolau, L. Richard, Canadian Institutes of Health Research, $211,437. April 2006 – March 2009 A randomised controlled trial of the effectiveness of a coping strategies intervention for people with head and neck cancer. Principal Investigator: P.J.Allison, Co- investigators: L.J.Edgar, J.S.Feine, E.L.Franco, B.F.Nicolau, R.D.Rajan. Canadian Institutes of Health Research, $471,139. April 2005 – March 2009 2. Education and Research Training Master’s Students Hawazin Elani, January 2007 – present (Supervisor) 5
  6. 6. Department of Oncology Annual Report 2007/2008 PhD Students Larissa Vilela, January 2005 – present (Supervisor) Reem Alansari, January 2006 – present (Co-supervisor) Nora Makinsi, September 2007 – present (Supervisor) Violet D’Souza, September 2007 – present (Supervisor) Postdoctoral Fellows Christine Loignon, May 2006 – present (Co-supervisor) Katia Muller, September 2006 – present (Supervisor) Saul Paiva, March 2007 – February 2008 (Supervisor) 3. Scientific Reviews Editorial boards Journal of Dental Research Oral Oncology Journal reviewer Community Dental Health Journal of Dental Research Quality of Life Research Social Science and Medicine Oral Oncology Preventive Medicine Community Dentistry & Oral Epidemiology Canadian Medical Association Journal Journal of the Canadian Dental Association Health & Quality of Life Outcomes Grant reviewer NCIC operating grant review panel K – Supportive Care, Palliative Care and Psychosocial Issues (Oct 2005 – present day) NIH-NIDCR special grants panel 4. Conference Organization Member, Local Organising Committee: “International Association for Dental Research” annual scientific meeting, Toronto, July 2008 5. External Committees and Boards Director: Réseau de recherche en santé bucco-dentaire et osseuse (Network for Oral and 6
  7. 7. Department of Oncology Annual Report 2007/2008 Bone Health Research), FRSQ Committee member: Conseil d’administration, Fondation de l’Ordre des dentistes du Québec Committee member: Advisory Board, CIHR Clinician Scientist Training Program in Oral Health Research 6. Invited Presentations P.J.Allison & J.Veronneau : Intervention pour prevenir la carie de la petite enfance : resultats d’un projet de recherche. Presented to the 9e Colloque de santé dentaire publique du Québec, Montréal, June 2007 P.J.Allison : Recommendations et initiatives issues des actes du colloque « Pour un meilleur acces aux soins dentaires pour les personnes defavorisees au Quebec » place de la sante dentaire publique. Presented to the 9e Colloque de santé dentaire publique du Québec, Montréal, June 2007 P.J.Allison : L’acces aux soins dentaires au Quebec. Presented at the « Colloque Acces sante » organised by the Insitut quebecopis de la deficiance intellectuelle, Saint Georges, Quebec, November 2007 P.J.Allison : Comment utiliser la science en pratique clinique? Presented to the 28e Journées Scientifiques du CNEOC (Collège Nationale des Enseignants Odontologie Conservatrice), Clermont Ferrand, France, May 2008. 7. Hospital and University Activities Faculty of Education University Tenure Committee DAWN ANDERSON 1. Summary of New and Ongoing Research Ongoing project on the potential benefit of cytotechnician screening in thyroid biopsy evaluation. Co-Investigator at St. Mary’s for a new study on the effect of pre-operative dietary changes on pain following breast cancer surgery (Dr. Yoram Shir PI) 2. Education and Training Postgraduate Surgical Education Coordinator for St. Mary’s Hospital- supervising, advising and evaluating the surgical residents, family medicine residents and surgical oncology fellows who rotate through the surgical service at SMH, as well as mentoring ICM students to review case reports and supervising residents and students who choose electives at SMH 7
  8. 8. Department of Oncology Annual Report 2007/2008 Formal small group teaching to ICM students. 3. Presentations On-site cytotechnician screening improves efficient management of thyroid nodules D. Anderson, M. Prevost. Ville Marie Medical Center, Montreal, Canada 4. Continuing Education Activities Attended ECCO 14 the European Cancer Conference in Barcelona, September 2007. Attended the meetings of the Société d’Oncologie de Montréal Attended a CHUM-organized day-long update on Melanoma, May 2008,. 5. University and Hospital Activities Surgical Grand Rounds at SMH including advising the Chief resident on appropriate topics. Recording secretary for the St. Mary’s Interdisciplinary Thyroid Rounds, where patients are presented pre and/or post operatively to a team made up from surgery, endocrinology, pathology, medical oncology and nuclear medicine. Lower GI Tumor Board at the Montreal General Hospital. St. Mary’s weekly Tumor Board. Ville Marie Breast Cancer weekly Clinico-Pathology Rounds . Member of the General Surgery Residency Committee. Member of the Surgical Oncology Residency Training Committee MARK BASIK 1. Summary of New and Ongoing Research Basic research 1. Mechanisms of resistance to herceptin 2. Stromal-tumor cell interactions in breast cancer 3. Genomics of breast cancer: new amplicon discovery 4. Discovery of novel tumor suppressor genes in breast cancer 5. Serum proteomics 6. The role of the CXCR4/SDF-1 axis in breast cancer 8
  9. 9. Department of Oncology Annual Report 2007/2008 Clinical Research 1. Adjuvant and neoadjuvant trials in breast cancer (participating in NSABP and other clinical trials) 2. Research Grants (new and ongoing) Ongoing DARPP32 in resistance to trastuzumab in breast cancer, PI : M. Basik, co-applicant : W. Miller. Cancer Research Society $ 60000/year 2006-8 The Discovery of Novel Tumor Suppressor Genes in Breast Cancer. PI: M. Basik; co- applicants: P. Tonin, S.Mader, C.Rancourt. Quebec Breast Cancer Foundation $ 138 000/year 2004-2008 Multi-investigator grant (total amount $1 500 000 total) Targeting Carcinoma-associated fibroblasts in breast cancer, PI: M. Basik. Weekend to End Breast Cancer, $50000 (2007-8) New Predictive markers for therapy in breast cancer, PIs: M. Basik, M Park, Terry Fox Research Institute $ 163000 1 year (2008-9) 3. Education and Research Training Saima Hassan: PhD student, Dept Experimental Surgery, McGill University 07/2004- present; Role of stromal cell derived factor-1 in breast cancer metastasis Abdel Hosein : PhD student, Dept Pharmacology, McGill University, 06/2004-present : targeting tumor stroma for cancer therapeutics. Aline Mamo : Postdoctoral fellow, Dept Oncology, McGill University, 05/2005-present, Discovery of novel tumor suppressor genes in breast cancer Adriana Aguilar: Postdoctoral fellow, Dept Oncology, McGill University, 03/2005- present, Discovery and validation of novel markers predictive of response to cancer therapy using protein microarrays. Sophie Hamel : MSc Student, Dept Experimental Medicine, McGill University, 01/2006- present : Mechanisms of resistance to herceptin. Marie-France Savard; Undergraduate student, dept Biochemistry, Universite de Montreal, 06/2007-08/2007: Genomic changes in breast cancer PhD Committees Patrick Fok, PhD defense committee, Supervisor : Josephine Nalbantoglu, Dept of Experimental Medicine, McGill University, May 2008. “The identification of protein- protein interactors of the Coxsackievirus and adenovirus receptor (CAR) and Their impact on cell migration” 9
  10. 10. Department of Oncology Annual Report 2007/2008 Osama Hussein, PhD Committee : Breast cancer metastases to bone, Supervisor; Svetlana Komarova, faculty of Dentistry, McGill University May 2008 4. Scientific Reviews Journal Reviews Cancer Research International Journal of Cancer Mutation Research Grant Reviews CIHR operating grant Invited member of Evaluating Committee CIHR Team Grants, Fall 2007 5. External Committees and Boards Member of strategy committee for position paper for Genome Canada on treatment optimization (2007) Invited researcher to meeting about State of Genomics in Quebec organized by Genome Quebec, Montreal, August 24, 2007. 6. Invited Presentations Cancers Héréditaires: sein et côlon”. Led workshop seminar at the Annual Congress of the Association Québécoise de Chirurgie. La Malbaie, Qc, May 31, 2007. “Screening for Breast Cancer”, Thursday Evening Learning Series, McGill University Faculty of Medicine, January 24,2008. “The Genomic Landscape of Cancer”, presentation at the Annual Retreat of the Department of Oncology of McGill University, March 14, 2008. “Reverse-phase Protein microarrays: validation and discovery”, invited speaker at the Genome Quebec conference “Rendez-Vous Proteomique 2008”, McGill University, April 10, 2008. “Tumor banking in cancer research”, Invited speaker at the First International Conference on “Translational Research in Oncology”, Forli, Italy, May 14, 2008. 7. Continuing Education Activities attended or lectured Discovering and validating novel targets and markers in breast and colon cancer », Seminar in the course. Genomic Medicine » given to 4th year Medical students, McGill University. 2007/03 Lecture to Oncology Fellows, “Surgical Principles of Melanoma”, McGill University. 2008/04 Lecture on Breast Disease to 3rd year Surgical Clerks, Jewish General Hospital. 2008/05 10
  11. 11. Department of Oncology Annual Report 2007/2008 Lecture to Surgery Residents, “High Risk Breast Cancer Patients”, Dept surgery, McGill University. 2008/05 8. Hospital and University Activities Medical Director, Inter-disciplinary breast cancer team, Segal Cancer Center (obtained level IV accreditation from Ministry of Health, Québec) GERALD BATIST 1. Summary of New and Ongoing Research The Quebec - Clinical Research Organization in Cancer (Q-CROC) is a Quebec oncology research consortium that is also active in oncology care. Q-CROC operates as a network, bringing together basic and clinician researchers, oncologists, surgeons and pathologists, amongst others. It was created by Dr Gerald Batist (Director of the Segal Cancer Centre) and Dr Luc Bélanger (Director of the Centre de Recherche Clinique et Évaluative en Oncologie). It is Q-CROC's firm intention to establish a province-wide translational and clinical research infrastructure in oncology in Quebec. By working together toward a common goal, members of Q-CROC will bring about major changes and improvements, for the ultimate well-being of patients. 2. Research Grants (new and ongoing) Canadian Institutes of Health Research, partnership with FRSQ, Montreal Centre for Experimental Therapeutics in Cancer, Strategic Training Program , G. Batist - P.I., Co- Invs. W. Miller, M. Alaoui-Jamali, J. Galipeau, C. Rancourt, et al. 6yrs., average operating $262,500 (Total : $1,455,000+ $120,000FRSQ). 2002-2009 Canadian Institutes of Health Research,Regulation of glutathione and related enzymes: dissection of the Nrf-2 master regulator and generation of novel potential chemopreventive molecules. $100,655/yr. 04/2006-03/2009 The Cancer Research Society, research grant, Cullin3 regulates the proliferation of breast cancer cells, a potential novel target for therapeutic intervention, Co-PI/ Weimin Miao, 2yrs - $60,000 per annum ($120,000) 09/2006-08/2008 Canadian Institutes of Health Research, GD2 gangliosides and Small Cell Lung Cancer, one year(Aug.1/06 to July 31/07). Partners: Mimetogen Pharmaceuticals Inc. $250,000(non-renewable) 08/2006-2007 Canadian Institutes of Health Research, EphB2, a novel target for gamma-secretase inhibitors (GSIs) in cancer therapy, P.I.- G. Batist,Co-PI: M. Kandouz, $150,000 per annum ($450,000). 07/2007-2010 FQRNT, Team grant, Title of Grant: Plateforme pour les interventions médicales ciblées par des dispositifs propulsés par gradients générés par un système d'imagerie par 11
  12. 12. Department of Oncology Annual Report 2007/2008 resonance magnétique; $60,000/per annum (renewable for 3rd yr), PI-Martel Sylvain. 04/2007-2008 National Institutes of Health(NIH), Title of project: MRI-Based Tumor Trgeting Enhancement with Magnetotactic Bacterial Carriers, PI- Martel Sylvain, Co-PIs - Batist G, Beaudoin G, Aloyz R. Amount:$405,000, 09/2008-2010. 3. Education and Training Andrew Bier, Ph.D. Student 2001- Mustapha Kandouz, Ph.D. Student, 2001- Khadijia Haidara, Ph.D. Student, 2003- 4. Scientific Reviews Editorial Boards Associate Editor, J. Cellular Pharmacology, Springer-Verlag Editorial Board, Journal of Liposome Research, Marcel Dekker Editorial Board, Molecular Cancer Therapeutics, AACR Member, Montreal Gazette "Board of Contributors" Ad hoc Reviews Cancer Research Journal of Biological Chemistry Biochemical Pharmacology Journal of Clinical Oncology Cancer Chemotherapy and Pharmacology 5. External Committees and Boards Membre, FRSQ comité évaluatif, Centre de recherche, CHUM Scientific Advisory Committee, Israel Cancer Research Fund Investigational New Drug Committee, National Cancer Institute of Canada Member, Scientific Advisory Board, Les Laboratoires Aeterna (Aeterna Zentaris). Member, Scientific Advisory Board, Thallion Pharmaceuticals Inc(Ecopia) Member, Scientific Advisory Board, Immunotec Inc., 6. Invited Presentations Queen’s University Cancer Research Inst. Annual Retreat, Invited speaker, title: “Chemoprevention and chemotherapy resistance: the importance of context”. 7. Hospital and University Activities MUHC Cancer Care Mission Retreat (Dr. Jeremy Sturgeon), Mont-Tremblant 12
  13. 13. Department of Oncology Annual Report 2007/2008 Title: MUHC within the McGill University Dept of Oncology and the McGill RUIS: how best can we work together? NICOLE BEAUCHEMIN 1. Summary of New and Ongoing Research 1) Modifiers of colon cancer. Dr. Philippe Gros, Dept. of Biochemistry, McGill University. 2) Evaluation of colon cancer pathology in transgenic and knockout mice. Dr. Victoria Marcus, MUHC pathologist, McGill University. 3) Investigation into the insulin resistance phenotype of Ceacam1-/- mice. Dr. Emile Lévy, Centre de Recherche, Hôpital Ste-Justine, Montréal. 4) Investigations into the altered fat metabolism in Ceacam1-/- mice. Dr. Roland Savard. Dept. of Biologie, UQAM, Montréal. 5) Immunology and infections with MHV of Ceacam1-/- mice. Dr. Lucie Lamontagne. Dept. of Biologie, UQAM, Montréal. 6) The role of the tyrosine phosphatase SHP-1 in metabolism. Dr. André Marette, Centre de Recherche du CHUL. Ste-Foy Qué. 7) Phenotypes of an endothelial-specific transgenic mouse model for CEACAM1, Dr. Christoph Wagener, Dept. of Clinical Biochemistry, Univ. of Hamburg, Hamburg, Germany. 8) The role of CEACAM1 in endothelial progenitor cells. Dr. Suleyman Ergun, Essen University, Germany. 9) Mice Resistant to mouse hepatitis viral infections. Dr. Kathryn V. Holmes, Dept. of Microbiology, Univ. of Colorado, Denver, CO. 10) Analyses of brain-tropism of MHV in Ceacam1-/- targeted mice. Dr. Susan Weiss, Department of Microbiology, Univ. of Pennsylvania School of Medicine, Philadelphia, USA. 11) Development of a Humanized CEACAM1-targeted mouse. Dr. Scott Gray- Owen, Dept. of Microbiology, Univ. of Toronto, Toronto, Canada. 12) The functions of CEACAM1 in platelets. Dr. Denise Jackson. Austin Research Institute. Melbourne Australia. 13) The role of CEACAM1 in dendritic cells. Drs. Robert Kammerer and Wolfgang Zimmerman. Klinikum der Universität München. Munich Germany. 14) The role of CEACAM1 in insulin receptor signaling. Dr. Sonia M. Najjar. Medical College of Ohio. Toledo Ohio. 15) The role of CEACAM1 in graft versus host disease. Dr. Marcel R.M. van den Brink. Memorial Sloan-Kettering Cancer Center. New York. N.Y. 16) The role of CEACAM1 in immune responses of M cells. Drs. H. Kiyono and O. Igarashi. Institute of Medical Science, The University of Tokyo. Tokyo, Japan. 17) The role of CEACAM1 in lung tissue. Dr. Bob Scholte, Cell Biology Dept. Eramus University Medical Centre, Rotterdam, The Netherlands. 18) The role of CEACAM1 in T lymphocytes. Dr. Richard Blumberg, Harvard University. 13
  14. 14. Department of Oncology Annual Report 2007/2008 2. Research grants (new and on-going) CEACAM1 signaling in epithelial cell adhesion and motility Canadian Institutes for Health Research PI: Nicole Beauchemin $128,664./yr, 2003-2007 Involvement of mouse biliary glycoproteins (CEACAM1) in tumor development and metastasis, PI: Nicole Beauchemin, Cancer Research Society Inc. $60,000./yr 2005-2007 CEACAM1 in colon cancer progression, PI: Nicole Beauchemin, National Cancer Institute of Canada, $113,050./yr 2005-2008 Genetic control to susceptibility of carcinogen-induced colon cancer (PI: Philippe Gros, co-PI: Nicole Beauchemin) Miriam and Saul Goldberg Innovative Research $ 15,000./yr 2007-2008 Metabolic functions of the PTPase SHP-1 in insulin target tissues (co-PI with: André Marette & Kathryn Siminovitch) Canadian Institutes for Health Research $136,515./yr 2007-2012 Genetic control to susceptibility of carcinogen-induced colon cancer (PI: Philippe Gros, co-PI: Nicole Beauchemin) National Cancer Institute of Canada $123,000./yr 2007-2010 CEACAM1 as a regulator of normal and tumor angiogenesis. PI: Nicole Beauchemin Canadian Institutes for Health Research $141,480./yr 2007-2011 Involvement of mouse biliary glycoproteins (CEACAM1) in tumor development and metastasis. PI: Nicole Beauchemin Cancer Research Society Inc. $60,000./yr 2007- 2009 (declined) CEACAM1 in colon cancer progression PI: Nicole Beauchemin Canadian Institutes for Health Research $177,253./yr 2008-2012 Coordinator for the McGill Cancer Centre, the Segal Cancer Centre and the MUHC CIHR Training Grant Letter of Intent. Full grant to be submitted on Nov. 1, 08. $325,000/yr for 6 years. 3. Education and Research Training Undergraduate Students Sarah Leblanc Winter 2007 (Biochemistry) Denitza Roudeva Autumn 2007 (Biochemnistry) Justin Drager Autumn-Winter 07-08 (Biochemistry) Samantha Benlolo Summer 2008 (Biochemistry) Graduate Students Nelly Leung Ph.D. (2008) (Biochemistry) Anne-Marie Charbonneau-Allard M.Sc. (2007) (Biochemistry) 14
  15. 15. Department of Oncology Annual Report 2007/2008 Sarah LeBlanc M.Sc. (2009) Post-Doctoral Fellows Anne-Laure Nouvion 2006-2010 Ph.D. Institute de Chimie-Biologie, Lyon Azadeh Arabzadeh 2008-2012 Ph.D. University of Ottawa Graduate students on whose supervisory committees I currently serve. 1. RAC Nelly Leung, Dept. of Biochemistry 2001- 2. RAC Melanie Chagnon, Dept. of Biochemistry 2003- 3. RAC Patrick Fok, Montreal Neurological Institute, 2004-2006 4. RAC Valérie Hudon, Dept. of Biochemistry, 2004- 5. RAC Ghada Kurban, Dept. Biochemistry, 2004- 6. RAC for Charles Meunier, Dept. of Biochemistry, 2006- 7. RAC Malika Oubaha, IRCM, student of J.P. Gratton, 2006- 8. RAC Kataryna Jesien, Dept. of Medicine, IRCM, 2007- 9. GAC Shun Li, Royal Victoria Hospital, student of Dr. P. Brodt, 2007- 10. GAC and RAC for Sami Bouahia, Dept. of Biochemistry, May 2007- 11. GAC and RAC for David Grote, Dept. of Biochemistry, April 2007- 12. GAC for Alana Nguyen, Dept. of Biochemistry, April 2007- 13. GAC for Karen Doody, Dept. of Biochemistry, September 07- 14. GAC & RAC Patricia McDonald, Dept. of Experimental Medicine, May 2008- 15. Ph.D. Oral Defense for Pierre-Luc Tremblay, Laval University, November 2007. 16. Ph.D. Oral Defense for Nelly Leung, Dept. of Biochemistry, December 2007. 4. Scientific Reviews Journal Reviews Nature Reviews Immunology Oncogene X 4 Molecular Cell Biol. Experimental Medicine and Biology Colon Cancer Metastasis J. Biol. Chem. Grant Reviews Canadian Institutes for Health Research NSERC 5. Conference Organization Organizer of the McGill Cancer Centre seminar series 2005-2008 Co-organizer of the Angiogenesis-Metastasis Research Group 2006-present: meeting once/month of 20 research groups from the Montreal region interested in these topics. 15
  16. 16. Department of Oncology Annual Report 2007/2008 6. External Committees and Boards Panel Member Canadian Institutes for Health Research, Palliative Care committee 2 days/year National Cancer Institute of Canada, Panel J 2 days/year 7. Invited Presentations and Workshops CEACAM1 as a regular of normal and tumor angiogenesis. Angiogenesis and Metastasis Research Group. January 2007. CEACAM1: entre l’adhésion cellulaire, le cancer du côlon et l’angiogénèse. Invited talk at the Centre de Recherches de l’Hotel Dieu, Québec, Qc, May 25 2007. La tyrosine phosphatase SHP-1 régule négativement l’homéostasie du glucose. Invited talk at the Symposium de physiopathologie de l’intestin. Sherbrooke June 2007. Intestinal Tumor Progression Is Promoted by Decreased Apoptosis and Dysregulated Wnt Signaling in Ceacam1-/- Mice. Invited talk at the 17th CEA International Workshop. Los Angeles California, Sept. 2007. CEACAM1, a cell adhesion molecule that functions as an inhibitor of tumor progression and a modulator of neo-angiogenesis. Invited talk at the Sunnybrook Health Sciences Centre. Toronto, December 2007. CEACAM1, a cell adhesion molecule that functions as an inhibitor of tumor progression and a modulator of neo-angiogenesis. Invited talk at the McGill Cancer Centre. Montreal, March 2008. Colon Cancer Susceptibility Gene Loci. Canadian Cancer Society, May 2008. 8. University Committees Member of an Ad Hoc Faculty Postgraduate Promotions Review committee, Faculty of Medicine, since November 2003-2008. Member of the Dept. of Oncology Promotions Committee, 2 meetings per year since 2006-. Member of the Faculty of Medicine Admissions committee, 2 weeks/year of interviews of potential Medicine students, 2007-present. Member of MUHC Lutte Contre le Cancer (Colorectal) team (2006-…). Presentation at McGill University Grantsmanship meeting (2007-…). 16
  17. 17. Department of Oncology Annual Report 2007/2008 Member of McGill University’s Harassment and Sexual Harassment Committee (2007). This was a 6- month involvement for one of the worse cases to happen at McGill University. It required 3 months of non-stop work on my own, with the help of the University lawyers. Member of McGill University’s committee on Policy on the Care and Use of Animals in Scientific Research and Teaching (2007-08). 9. Involvement in the community Member of the Institutional Review Board at the Ville-Marie Breast Clinic. Meetings once/month for evaluation of clinical trial protocols. (2004-…). Actively involved in speaking engagements to volunteers of the Canadian Cancer Society. Oct. 4, 2007: interview for TeleQuebec, Une pillule, une petite granule. Oct. 11, 2007: 45 min talk for employees of Canadian Public Security for Canadian Cancer Society. Oct. 23, 2007: one hour radio interview for Radio-Centre Ville on breast cancer. Nov. 6, 2007: meeting with large donors for the Canadian Cancer Society. Nov. 8, 2007: invited speaker for Canadian Cancer Society donors of the Mauricie region. Jan. 15, 2008: meeting with donors of Canadian Cancer Society at Cossette Communications. May 6, 2008: meeting with large donors for the Canadian Cancer Society. MARTIN BLACK and MICHAEL HIER 1. Summary of New and Ongoing Research 1) A phase 3 randomized trial of chemotherapy with or without panitumumab in patients with metastatic and/or recurrent squamous cell carcinoma of the head and neck (McG0723) 2) A phase 2,randomized trial of chemoradiation with or without panitumumabin subjects with unresected ,locally advanced squamous cell carcinoma of the head and neck (McG0735) 3) Can Post-parathyroidectomy Hypocalcemia Be Attributed to Research Abnormal 17
  18. 18. Department of Oncology Annual Report 2007/2008 Synthesis of Parathyroid Hormone? Richardson K, Payne RJ, Hier MP, Black MJ, Tamilia M 4) Defining Success Following Parathyroidectomy for Primary Hyperparathyroidism Rotstein D, Payne RJ, Hier MP, Black MJ, Tamilia M 5) Radiation Therapy Oncology Group, RTOG 0514 Establishment Of A Head And Neck Cancer Tissue/Specimen Repository 6) Radiation Therapy Oncology Group, RTOG 0522 A Randomized Phase Iii Trial Of Concurrent Accelerated Radiation And Cisplatin Versus Concurrent Accelerated Radiation, Cisplatin, And Cetuximab (C225) [Followed By Surgery For Selected Patients] For Stage Iii And Iv Head And Neck Carcinomas 7) Radiation Therapy Oncology Group, RTOG 0615 A Phase Ii Study Of Concurrent Chemoradiotherapy Using Three-Dimensional Conformal Radiotherapy (3d-Crt) Or Intensity-Modulated Radiation Therapy (Imrt) + Bevacizumab (Bv) For Locally Or Regionally Advanced Nasopharyngeal Cancer NCI-supplied agent: Bevacizumab (NSC 704865; IND 79211) 8) Phase Ii Study Of Peri-Operative Brachytherapy ± Intenisty Modulated Radiotherapy (Imrt) With Or Without Chemotherapy For Carcinoma Of The Oral Tongue Investigators: Dr. Boris Bahoric Radiation Oncologist, Dr. Michael Hier ENT Surgeon, Dr. Martin Black ENT Surgeon. 2. Research Grants (new and ongoing) The life course approach to the aetiology of squamous cell carcinoma in the upper aerodigestive tract. P.J.Allison, EL Franco, R Fuhrer, G Humphris. Collaborators: M.Black, M.Hier. Canadian Institutes of Health Research. $434,063. Oct 2004 - Sept 2007 A randomized controlled trial of the effectiveness of a coping strategies intervention for people with head and neck cancer. P.J.Allison, LJ Edgar, JS Feine, EL Franco. Collaborators: M.Black, M.Hier. Canadian Institutes of Health Research. $471,139. April 2005 – March 2009 3. Education and Research Training Dr Limor Kalmovitch. H&N fellow from Isreal finishing Sept/08 4. Scientific Reviews (M. Hier and M Black) Editorial Board Can. Journal of Otolaryngology Reviewer Head and Neck Surgery 18
  19. 19. Department of Oncology Annual Report 2007/2008 5. External Committees and Boards M. Hier “Head and Neck Plenary Session”, Chairman, 61st Annual Meeting of the Canadian Society of Otolaryngology/Head and Neck Surgery. Montreal, Quebec, May 14, 2007 M Black Retired as Surgeon in chief …JGH in 2007…15years 6. Invited Presentations M. Black Community Mini-Med presentation – “Update in Head and Neck Surgery” YMHA, Montreal. 2007 “Thyroid Cancer Update”, Jewish General Hospital in conjunction with Hope & Cope, 2007 M Hier Non-Melanoma Skin Cancer, Chair: M. Hier Panel: J. Chaplin, J. Harris, N. Jha, C. Keeling, C. Moore, M. Taylor, H. Seikaly, M. Sapijaszko, J. Yoo. Presented at the Canadian Society of Otolaryngology – Head and Neck. Surgery, 62nd Annual Meeting, June 1 -4, 2008, Jasper, Alberta. 7. Hospital and University Activities Many many committees at university and the hospitals PHILIP BRANTON 1. Summary of New and Ongoing Research Our studies continue on 2 projects. In the first we are examining the degradation of proteins by the adenovirus E4orf6-E1B55K complex and studies focus on identifying the target proteins, especially those involved in mRNA transport. In the second we continue work on the adenovirus E4orf4 protein that kills cancer cells specifically. We are working on the mechanism of action, especially on the inhibition of PP2A by E4orf4. 2. Research Grants (new and ongoing) Major Grants Mechanism of oncogenic transformation by human adenovirus, Canadian Institutes of Health Research (CIHR), $204,000/yr, 1998-2009 Mechanism of action of the adenovirus death protein E4orf4 and their targets, National Cancer Institute of Canada (NCIC), $150,000/yr, 2004-2009 19
  20. 20. Department of Oncology Annual Report 2007/2008 3. Education and Research Training PhD Students Melissa Mui Chi Ying (Theresa) Cheng Postdoctoral Fellows Paola Blanchette Suiyang Li 4. Scientific Reviews Journal Reviews MCB J Virology Oncogene 5. Conference Organization DNA Tumor Virus Meeting, Madison, WI 2008 6. External Committees and Boards Scientific Director, CIHR Institute of Cancer Research (until July 31, 2008) 7. Hospital and University Activities Advisor for the Terry Fox Research Institute MARTIN CHASEN 1. Summary of New and Ongoing Research Principal Investigator, The Value Of The Egg (Electrogastrogram) In Patients With The Anorexia/Cachexia Syndrome (Ethical approval, October 2005) Co-Investigator, NCIC Sociobehavioural Cancer Research Network-Clinical Trials Group. Cancer Pain Classification Project: Pilot and Feasibility Phase Co-Investigator, Phase II Study of Neoadjuvant Taxotere, Cisplatin, and 5-Fluorouracil in Patients With Gastric or Gastroesophageal Junction Adenocarcinoma Co-Investigator, A Double-Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Orexigenic Therapy with delta-9-Tetrahydrocannabinol (THC) in Advanced Cancer Patients with Chemosensory Abnormalities A Phase 2, Open-Label, Multi-Center Study with AVRll8 in Anorectic Patients with Recurrent or Advanced Malignancies Principal Investigator 20
  21. 21. Department of Oncology Annual Report 2007/2008 Utility of #D Ultrasound for assessing cachexia through measurement of muscle volume changes Gut Brain Axis Phenotype –Cachexia Assessment Trial (GUBRA-CAT) 2. Reasearch Grants (new and ongoing) NCIC Sociobehavioural Cancer Research Network: Cancer Pain Classification Project: Pilot and Feasibility Phase ($45,000) Expanding the Role of Pre-operative Rehabilitation: The Impact of a Multidisciplinary Program of Improving Nutritional Reserve and Exercise Capacity on Post-operative Complications after Major Thoracic Cancer Surgery ($20,000) – Co-investigator—Research Institute of the McGill University Health Centre (awarded) Sept 2007-Sept 2008 Evaluation of a 12-week comprehensive exercise program following adjuvant therapy for breast cancer ($10,000)—Co-investigator—Research Institute of the McGill University Health Centre (awarded) Towards an understanding of cancer cachexia—Linking molecular mechanisms with novel treatment options ($2,000,000)—Co-investigator—Terry Fox Research Institute TFRI (Montreal) (awarded) 3. Education and Training Undergraduate: Medical students ICM (Introduction to Clinical Medicine): Introduction to Oncology Feb-June 2007 1-3 students, 1-2 days/week—clinic tutorial/ward rounds Feb-June 2008 1-3 students, 1-3 days/week—clinic tutorial/ward rounds Courses/lectures (undergraduate) Oct. 2007 Lecture (1 hr.) entitled, “Spirituality”, McGill University School of Physical and Occupational Therapy, Course # POTH 446: Current Topics in Rehabilitation: Cancer Rehabilitation Jan 2008 ICM--Introduction to Clinical Medicine Class 2010: Professional Skills (Course # IMED 301) Jan 2008 Introduction to Clinical Sciences (ICS) Evidence Based Medicine Universal Precautions (Course # INDS 301) May 2008 Group leader (ranked highest by students), “Spirituality, Religious Adherence and Medicine”, (Course # INDS 120, “Physicianship I”- 1st year medical and dental students) Electives (R2, R3 & R4 medical students) 30/07-26/08 2007 Michael Palumbo (McGill) 20/08-12/10 2007 Shermaine Ye Yun Pan (visiting) 23/03-06/06 2007 Soumaya El Fahmy (visiting) 19/11-16/12 2007 Andries Petrus Dippenaar (visiting) 21
  22. 22. Department of Oncology Annual Report 2007/2008 10/03-06/04 2008 Matthias Haas (visiting) Oncology Residents 09/07-18/11 2007 Ashley Davidson 13/02-30/06 2008 Giovanna Speranza Lectures (post-graduate) Jan 25, 2008 Lecture (2 hr.) entitled, “Chemotherapy for Oesophagus Cancer”, Faculty of Medicine, Medical Oncology Feb 26, 2008 Lecture (1hr.) entitled, “Chemotherapy for patients with head and neck cancer”, for ENT residents, Royal Victoria Hospital May 21, 2008 Lecture (1hr) entitled, “Cancer Rehabilitation”, for surgical residents, Royal Victoria Hospital May 21, 2008 Lecture (1hr) entitled, “Spiritual Care of the Terminally Ill”, for surgical residents, Royal Victoria Hospital 4. Scientific Reviews Editorial Boards Editorial Manager/Peer Review, Journal of Cancer Survivorship: Research and Practice Section editor of section Cancer Rehabilitation and Survivorship in Current Oncology Journal Reviews Supportive Care in Cancer Journal of the National Cancer Institute Annals of Oncology 5. External Committees and Boards Member, Palliative Care Working Group, European Society of Medical Oncology Member, Board of Directors of the Canadian Society of Palliative Care Physicians Member, Eyes on the Prize.org Medical Advisory Panel Member, ESMO Palliative Care Working Group for the European Society of Medical Oncologists, Budapest, Hungary Foundation Board Member Miriam Home, Montreal Member, Advisory Board Abbott North American Ensure Health Care Professionals 6. Invited Presentations Television interview, “Healthy Living”, Radio-Canada (Télé journal), Montreal. Sept. 28, 2007 Hôpital Charles Lemoyne, Montreal, “Cancer – Nutrition Rehabilitation: It Really Works!” Oct. 26, 2007 22
  23. 23. Department of Oncology Annual Report 2007/2008 Editorial co-author, “Optimism Matters in the Treatment of Cancer: Montreal Patients do not have to Navigate this often Terrifying Journey Alone,” the Montreal Gazette, Montreal Nov. 4, 2007 Organizer, Inaugural Steven and Lillian Vineberg Lecture: Dr. Stephen Sagar, “Complimentary Therapies—New Horizons in Cancer Care”, Gelber Centre, Montreal Nov. 5, 2007 Department of Radiation, Montreal General Hospital, Montreal, “Cancer – Nutrition - Rehabilitation: It Really Works!” Nov. 12, 2007 Department of Continuing Medical Education, Faculty of Medicine, McGill University, “Cancer Rehabilitation”, as part of the Thursday Evening Learning Series, By Special Request, Fall 2007 Session. Dec 13, 2007 McGill Oncology Research Retreat, “Cancer Nutrition and Rehabilitation: Current Status”, Montreal. March 13, 2008 Invited faculty/speaker, Cancer Education Committee for the 2008 ASCO Annual Meeting, Education Session entitled, “The Path to Self-Healing. Delivering Bad News: An Opportunity for Healing the Patient and Physician.” Chicago, Illinois May 30-June 3, 2008 7. Continuing Education Activities attended or lectured The 5th Annual Advanced Learning in Palliative Medicine, Ottawa, Canada (May 8-10, 2008) 8. Hospital and University Activities Member, Upper GI Site-Specificity Committee, McGill University Health Centre Member, Palliative Care Site-Specificity Committee, McGill University Health Centre Member of Institutional Review Board of the Faculty of Medicine, McGill University Supervisor, Clinical Teaching McGill medical students and R3-R4 elective students (McGill University and visiting students), Medical Oncology, Royal Victoria Hospital, MUHC Faculty-observer, McGill Internal Medicine Residency Training Program using the McGill Simulation Centre (Jan 11 & April 5, 2007) Examiner, McGill Internal Medicine Residency Training Program Royal Victoria Hospital, R1 & R2 Oral Examinations 23
  24. 24. Department of Oncology Annual Report 2007/2008 Small group facilitator, Professionalism Seminar, McGill University, Postgraduate Core Competencies Program for R2s in all disciplines Small group facilitator (15 first-year students from McGill Faculty of Medicine), Inter- professional Cultural Competence Seminar as part of the Joint Inter-professional Curriculum Committee from the McGill Educational Initiative on Inter-professional Collaboration (Funded by Health Canada) Faculty-observer, McGill Internal Medicine Residency Training Program using the McGill Simulation Centre (Jan 17, 2008: Academic half day) Small group facilitator (students within the Faculty of Medicine Schools of PT, OT, Nursing, Medicine, Dentistry and Communication Sciences and Disorders ), Cultural Awareness Workshop, Developing Cultural Competence: Raising Awareness & Building Knowledge for Effective Health Care Practice, The McGill Educational Initiative on Interprofessional Collaboration: Partnerships for Patient and Family-Centred Practice Co-attending, Royal Victoria Hospital 10 Medicine Clinical Teaching Unit Rounds. ROBIN COHEN 1. Research Grants (new and ongoing) Strategic Training Program in Palliative Care Cancer Research. Robin Cohen (PI). Canadian Institutes of Health Research/National Cancer Institute of Canada - #STI- 63286. $1,800,000 04/2003 – 03/2009 GRISIM: Groupe de recherche interuniversitaire en soins infirmiers de Montréal. Investigator. (P.I.s: Celeste Johnston and Nicole Richard) FRSQ/Newton Foundation/MSSS $2,000,000 04/2004 – 03/2008 Family caregiving in palliative and end-of-life care: A new emerging team. Co-principal investigator with K.I. Stajduhar, University of Victoria. Canadian Institutes of Health Research- #129692 $1,361,361 2004 – 2009 A national cancer pain research network to improve the classification, assessment, and management of difficult cancer pain problems. Co-investigator. (P.I.s: N.A. Hagen, University of Calgary, R.L. Fainsinger, University of Alberta, P.M. Brasher, Alberta Cancer Board) Canadian Institutes of Health Research- # 129697 $1,363,586 2004 – 2009 Quality of life in cancer patients admitted to an acute palliative care unit and their caregivers: a prospective study of self-report and proxy-for-patient ratings Co- Investigator. (P.I.: Jennifer Jones) National Cancer Institute of Canada – CCS Research 24
  25. 25. Department of Oncology Annual Report 2007/2008 Grant for New Investigators $55,371 (2005 – 2006); $56,956 (2006 – 2007); $62,614 (2007 – 2008) Measuring the quality of end-of-life care provided in inpatient health care settings (Co- investigator) (P.I. Kelli Stajduhar) Michael Smith Foundation for Health Research HSPRSN Research Operating Grant $99,796 05/2006 – 04/2008 An evaluation of Canada’s compassionate care benefit from a family caregiver’s perspective (P.I. A Williams, co-investigators: Stajduhar K, Crooks V, Allan D, Cohen SR , Brazil K.) Canadian Institutes of Health Research (CIHR) $169,729 09/2006 – 08/2009 Safety in home care: Perspectives from clients, family members, caregivers, and providers. (P.I: Lang A, co-investigators: Cohen SR, Easty AC, Lachance JA, Germain D, Stajduhar KI, Williams AM) Canadian Institutes of Health Research (CIHR) $53, 237 04/2007-03/2010 An anthropology of bereavement: a sociocultural analysis of parental grief and mourning. (P.I.: Macdonald, ME, co-investigators: Mitchell L, Stephenson PH, Cadell SA) (collaborator: Cohen SR) Social Sciences and Humanities Research Council (SSHRC) $75,000. 04/2007-03/2010 2. Education and Research Training Ph D Students Anita Mehta: Family caregivers of palliative care patients at home: The pain management process Marianne Olivier- d’Avignon: Development of a needs profile for siblings of terminally ill children Lisa Chan: The experience of end-of life-care on an end-stage medical in-patient unit Shuling Chen: Spirituality & Palliative Care in Chinese Canadians Réjeanne Dupuis: Nursing leadership in palliative care Christopher MacKinnon: Spirituality and ethnicity in palliative care Postdoctoral Students Mary Rykov, Ph.D. The impact of music therapy on patients and families on palliative care units Melissa Henry, Ph.D. Meaning Making Intervention for women with newly diagnosed advanced ovarian cancer 25
  26. 26. Department of Oncology Annual Report 2007/2008 Dawn Allan Ph.D Dr. Javad Shahidi (Iran): Quality of life of people with advanced cancer and their family carers Traugott Roser Ph.D.: Spirituality in palliative care Nadine Bernier Ph.D.: Projet sur les facteurs facilitant et contraignants la prestation de services aux proches de maladies en fin de vie Winter 2007, NUR2 705 Instructor: Robin Cohen A required course for the interdisciplinary Psychosocial Oncology Option in the Faculty of Graduate Studies and Research, Palliative Care in Cancer 3. Scientific Reviews Editorial Boards Journal of Palliative Care American Journal of Hospice and Palliative Care Ad Hoc Reviews Journal of Pain and Symptom Management Journal of Palliative Care Palliative Medicine Psycho-oncology Quality of Life Research Grant Reviews Panel Member: National Cancer Institute of Canada, Clinical Fellowships , July 1-2006- June 30-2008. 4. Congress and Workshop Organization 17th International Congress on Care of the Terminally Ill, Montreal, September 22-26, 2008, Executive and Organizing Committee Oct 2006- Sept 2008 • Determining Congress content and schedule • Sole Organizer of Research Program. • Chair of Research Abstract Review Committee. • Chair all Research Fora European Association for Palliative Care 5th Research Forum, Trondheim, Norway, May 28-31, 2008. Scientific Committee, March 2007 – May 2008 5. External Committees Director, Quebec Research Satellite Centre of the National Cancer 26
  27. 27. Department of Oncology Annual Report 2007/2008 Institute of Canada Sociobehavioural Cancer Research Network Director, Palliative Care Research Team of the National Cancer Institute of Canada Sociobehavioural Cancer Research Network Founding Member, Quebec Pain Research Initiative 6. Invited Presentations and Workshops (National and International) Cohen SR, Fyles G, Viola R, Lachance J, Leis A, Brown KS, Porterfield P. Predicting carer experience in the first six months of bereavement. 9th World Congress of Psycho- Oncology, London, England, September 16-20, 2007. 7. Hospital and University Activities Hospital Wellness Centre, Jewish General Hospital, Research Advisory Board, Member. McGill Founding Member, McGill Pain Centre McGill Department of Oncology Clinical Trials Operations, Supportive Care Section, Member ANNA DEROSSIS 1. Research Training Mc Gill Undergraduate Breast Surgery Elective Director/Supervisor (undergraduate students) Surgical Oncology Fellowship Site Coordinator (SMBD JGH) 2. External Committees and Boards Medical Council of Canada Examiner 3. Invited Presentations Derossis AM. International Society of Surgery, International Surgery Week 2007, Montreal, Quebec. Panel: “Is Breast Cancer the same Disease in Asia as in the West?; Breast Cancer in Canada”. August 2007. 4. Continuing Education Activities Attended International Society of Surgery Meeting (Montreal) August 2007 Searching the literature for evidenced-based teaching and learning (McGill) November 2007 27
  28. 28. Department of Oncology Annual Report 2007/2008 Association of Surgical Education Meeting (Toronto) April 2008 American Society of Breast Surgeons Meeting (New York) May 2008 Lectured Faculty Development, Faculty of Medicine, McGill University, “Life as a Physician Series”, Derossis AM, November 2007. Faculty Development, Faculty of Medicine, McGill University, “Designing Successful Workshops” (Workshop Leader), Derossis, AM., December 2007. Department of Surgery, McGill University, “Breast Cancer in Canada: Changes in Presentation and Management”, Derossis AM, Surgical Grand Rounds, March 2008. 5. Hospital and University Activities SMBD - Jewish General Hospital, Department of Surgery, Surgical Education Director McGill University, Faculty of Medicine, Faculty Development Committee Member LINDA EDGAR 1. Research Grants (new and ongoing) PI. Working with The Wellness Community of America and the BC Cancer Agency , Hope & Cope is a partner in researching cultural differences and generic composition of patient education for cancer treatment and survivorship. $10,000.00 2008 -2009 Co-Investigator with Paul Allison, PI, A randomized controlled trial of the effectiveness of a coping strategies intervention for people with head and neck cancer. CIHR. $480,000.00. 2005-2009 PI. In house funding. Evaluating the Wellness Center for its impact on psychological factors and goal attainment. Hope and Cope Research Fund. 2005- 2. Education and Training Inhouse Examiner for PhD thesis, School of Nursing, McGill. Adjunct Professor, Brock University, Ontario – Lead Professor for 4th year Bac. Nursing Program Course on Applied Nursing Research. Developed web site on coping with cancer. www.Copingwellwithcancer.com Developed and taught The Cancer Coach Program now in use by CCAC. 28
  29. 29. Department of Oncology Annual Report 2007/2008 Training volunteers to act as research assistants, and to facilitate coping workshops at the JGH Hope & Cope Wellness Centre. 3. Scientific Reviews Journal reviewer for International Journal of Nursing Studies 4. External Committees and Boards Director of Support, Colorectal Cancer Association of Canada. Consulting and training Functions. 10 hours/week Presented at Advocacy Training for the Canadian Colorectal Cancer Association 1day Consultant and Presenter, for Staff at McNally House, a newly built hospice, Grimsby, Ontario.7 days. Consulted with Cancer Care Ontario on developing Care pathways for specific cancer sites. MICHAEL EVANS 1. Education and Research Training McGill University Graduate Courses 563-613B Health Physics 563-603 B Laboratory In Radiation Therapy Dawson CEGEP Laboratory In Radiation Oncology M.Sc. Thesis: A Dosimetric Analysis Of The Varian Enhanced Dynamic Wedge Factor For Symmetric And Asymmetric Configurations. Richard Benson, 2008 Medical Physics Resident Supervision Eric Reynard, M. Sc. 2007 – Present Gabriella Stroian, Ph.D. 2007 – Present Krum Asiev, M. Sc. 2007 – Present Ismail Dahlawi, M. Sc. 2008 - Present 2. External Committees and Boards Canadian College Of Physicists In Medicine (Ccpm), Board Member And Chief Examiner C.C.P.M., Fellowship Examination (Oral) Committee C.C.P.M., Membership Examination (Oral) Committee 29
  30. 30. Department of Oncology Annual Report 2007/2008 Canadian Organization Of Medical Physics: Radiation And Technical Standards Advisory Committee: Canadian Medical Association Conjoint Committee On Accreditation Site Visit : Mcmaster University / Mohawk Institute, Hamilton Ontario, 2008 3. Invited Presentations M.D.C. Evans, An Overview Of Brachytherapy At Mcgill University. Workshop On The Role Of Hdr Brachytherapy In Multi-Modality Treatment Of Rectal Carcinoma. Montreal, October 19 – 21, 2007. 4. Hospital and University Activities Hospital Committees McGill University Health Center: Radiation Safety Committee McGill University Health Center: Radiation Oncology Qa Committee McGill University Health Center: Med. Physics Qa Committee McGill University Health Center: Med. Physics Radiation Safety Committee SERGIO FARIA 1. New and Ongoing Research With Dr. Te Vuong reviewing the MUHC experience in Rectal cancer and Anal Canal cancer. Reviewing with our fellow in GU tumors (Nicholas Rene) changes in Testosterone levels after hypofractionation 2. Education and Training Dr Wael El-Sheshtawy Dr Nicholas Rene 3. Scientific Reviews Journal Reviews International Journal of Radiation Oncology Biology and Physics Radiotherapy & Oncology 4. Conference Organization Workshop - 6 MV vs 18 MV and Heterogeneity correction in Lung Cancer. Does it matter? CARO –ACRO meeting 2007, October 13, 2007, Toronto, Ontario 5. External Committees and Boards NCIC- National Cancer Institute of Canada: Member, Lung Disease Site Committee RTOG – Radiotherapy Oncology Group: Member, Lung Disease Site Committee 30
  31. 31. Department of Oncology Annual Report 2007/2008 6. Invited Presentations Terapia hypofracionada: o futuro da radioterapia? Oral presentation at the Curso avançado de Uro Oncologia November 30, 2007-12-09. Campinas, Sao Paulo, Brazil Como conduzir a recidiva bioquímica pós radioterapia? Oral presentation at the Curso avançado de Uro Oncologia November 30, 2007-12-09. Campinas, Sao Paulo, Brazil Hypofractionation in prostate cancer. Oral presentation at the 1st ALATRO – Asociacion Latinoamericana de Terapia Radiante Oncologica, Mesa de Cancer de Prostata 4 – 7 December, 2007-12-09 Montevideo, Uruguay Nodule pulmonaire inopérable. Vaut-il la peine de l’irradier ? Comment? Soiree de Pneumoligie de la Rive Sud 15 Janvier 2008 Brossard, Quebec, Canada The challenge of scoring late radiation induced lung toxicity. Radiation Oncology Research Retreat, on May 30, 2008, Montreal,Quebec, Canada 7. Hospital and University Activities McGill University: Member, Lung Cancer Committee Member, Genito-Urinary Tumor Board, Montreal General Hospital, Montreal Member, Lung Cancer Tumor Board, Montreal General Hospital, Montreal Member, Lung Cancer Tumor Board, Jewish General Hospital, Montreal WILLIAM FOULKES 1. Summary of New and Ongoing Research 1) Finding out PALB2 cause breast cancer 2) Investigation of an Inuit family with a recessive cancer syndrome 3) Investigation of a new aneuploidy-related cancer syndrome 4) Variation in the breast cancer transcriptome 5) Cyclin E and breast cancer 6) Basal breast cancer and BRCA1 2. Research Grants (new and ongoing) Systematic Characterization of Dasatinib Sensitivity and Resistance in Breast Cancer Cells: Rationale for Patient Selection and Treatment Design. Susan G Komen BrCa Foundation 31
  32. 32. Department of Oncology Annual Report 2007/2008 Exploring the pathogenic and therapeutic implications of aberrant splicing in breast cancer. U.S. Army Medical Research and Materiel Command Toward the biological treatment of BRCA1-related breast cancer: EGF, EGFR and tyrosine kinase inhibitors. Canadian Breast Cancer Research Alliance The 3D telomeric signature(s) of DCIS. Susan G Komen BrCa Foundation BRCA1, CDC4, Cyclin E, and Chromosomal Instability in Breast Cancer. Canadian Breast Cancer Research Alliance Risk factor analysis of hereditary breast and ovarian cancer. Canadian Breast Cancer Research Alliance The Genetic of Prostate Cancer: The ICPCG Study. National Institutes of Health (NIH) 3. Education and Training Graduate Students Name: Tayma Khalil (Raquel Aloyz: co-supervisor) Department: Human Genetics Years: 2005-2007 Degree: MSc Topic: CDC4 in hereditary breast cancer Name: Lili Li Department: Human Genetics Years: 2007- Degree: PhD Postdoctoral Fellows Ahmet Yilmaz, 2006-2008 Martin Couillard, 2008-2010 Supervision of McGill University Genetic Counselling M.Sc. students 2005-2007 Jennifer MacLean Marilyn Richard Nassim Taherian Teresa Tiberg 2006-2008 Danna Loder Karine Bedard Rachel Vanneste Stephanie Neuert 32
  33. 33. Department of Oncology Annual Report 2007/2008 McGill University Medical Genetics Elective 2006-2007 Marta McCrum Aspasia Karalis Cristina Stanculescu 2007-2008 Nga Man Lau Royal College Resident Trainees Nicholas Ah Mew 2002-7 Philippe Campeau 2003-8 Maha Al-Awadi 2004-9 Khalid Al-Thihli 2004-9 Mouna Ben Amor 2004-9 Ahmed Alfares 2006-11 Daniela D'Agostino 2006-11 Sébastien Lévesque 2007-10 (entering at RIII level) Asparia Karalis 2007-12 Graduate And Undergraduate Courses 516-614B Environmental Carcinogenesis Department: Medicine (Div. Experimental Medicine) Format: Lecture Title: Cancer Genetics/Prevention Role: Lecturer Level: MSc Program Time: One 2 hour session Years: 1996-1999, 2003, 2005 516-0635D Experimental and Clinical Oncology Department: Medicine Format: Lecture Title: Cancer Genetics Role: Lecturer Level: MSc program Time: 1.5 hour seminar Years: 2002- 521-690B Inherited Cancer Syndrome Department: Department of Human Genetics Format: Lecture Title: Cancer Genetics Role: Lecturer Level: MSc program Time: Four 2 hour sessions Years: 2003, 2005, 2007 33
  34. 34. Department of Oncology Annual Report 2007/2008 Medical Genetics Unit 8 small group teaching in medical genetics Format: Lecture Role: Lecturer Level: Medical Students Time: One 2 hour lecture and 4 small group sessions, 3 hours each Years: 1977- 4. Scientific Reviews Journal Reviews Journal of Medical Genetics International Journal of Cancer British Journal of Cancer Breast Cancer Research Nature Genetics Lancet Journal of the National Cancer Institute Cancer Research Clinical Cancer Research European Journal of Cancer American Journal of Human Genetics Lancet Oncology Human Mutation Oncogene Gastroenterology Prostate Journal of Clinical Pathology Oncology Research Molecular and Cellular Probes Canadian Journal of Oncology Grant Reviews Canadian Institute for Health Research, Genetics Panel 5. Conference Organization Second International Symposium on Hereditary Breast and Ovarian Cancer, Montreal Oct 17-19, 2007. (www.odon.ca/brca/). Co-sponsored by the Program in Cancer Genetics and the Hereditary Breast and Ovarian Cancer Foundation (www.hboc.ca). Role: Scientific Director of Conference. 6. External Committees and Boards International Committees Member, Steering Committee, International Prostate Cancer Genetics Collaborative Group (representing Eastern Canada) 34
  35. 35. Department of Oncology Annual Report 2007/2008 Scientific Advisory Committee, Breast Cancer Family Registry (NIH) Member, Advisory Board, Conseil d’Évaluation des technologies de la santé du Québec, 7. Invited Presentations International BRCA1 and sporadic basal-like breast cancers: similarities and differences. Triple Negative Breast Cancer Conference, San Antonio, TX, USA. December 11th 2007 How should we study special populations-Ashkenazim, Minorities? BCFR Scientific Conference, San Antonio, TX, USA. December 12th 2007 From the bedside to the bench and back again: short stories that end up as novels, Breakthrough Breast Cancer Research Centre Seminar. London, UK. March 13th 2008 National New developments in breast cancer genetics. Winnipeg, Manitoba. May 10, 2007 Samuel Lunenfeld Research Institute Seminar. Toronto, Ontario. November 8th , 2007 Prevention/risk factors: Non-modifiable factors and hereditary breast cancer (Chair) CBCRA Reasons for Hope Fifth Scientific Conference. Vancouver, British Columbia. April 25-27, 2008 Local/Provincial Hereditary breast cancers - Guidelines for treatment options to women at high risk: what id the evidence behind? 42nd World Congress of the International Society of Surgery, International Surgical Week. Palais des Congrès. Montreal, Quebec. August 28th , 2007 Is breast cancer the same disease in Asia as in the west? – Analysis and summary. 42nd World Congress of the International Society of Surgery, International Surgical Week Palais des Congrès. Montreal, Quebec. August 30th , 2007 Les aspects génétiques du cancer du sein. Découvrir de nouveaux sommets, 28ième Congrès Annuel de la société québécoise de biologie clinique. Mont-Tremblant, Qc. October 11th , 2007 BRCA1/2 mutations: helping you and your loved ones deal with the hand you are dealt BRCA: New Frontiers in Research and Practice, Second International Symposium on the Hereditary Breast and Ovarian Cancer Susceptibility Genes. Hotel Delta, Montreal, Qc October 17th , 2007 From the bedside to the bench and back again: translating cancer genetics. 1st Annual Canadian Human Genetics Conference. Manoir St-Sauveur, St-Sauveur, Qc. April 10th , 2008 35
  36. 36. Department of Oncology Annual Report 2007/2008 Improving breast cancer mortality: have genetic markers helped? The 2008 CLIMOA Annual Scientific Meeting. Sofitel Montreal, Montreal, Qc. May 12th , 2008 Institutional DNA repair and cancer susceptibility. Radiation Science Seminar. Montreal General Hospital. January 5th , 2007 Genetics of pheochromocytoma and other paragangliomas. MUHC Cancer Genetics Services. MUHC January 12, 2007 The role of medical genetic services in the management of pediatric cancer patients and their families. Joint meeting of the Departments of Medical Genetics and Pediatric Hematology/Oncology, Montreal Children’s Hospital. January 17th , 2008 It is a short walk from the clinic to the laboratory, but sometimes you get lost on the way. MUHC Urology seminar. MUHC, April 1st , 2008 8. Hospital and University Activities Member, Curriculum Committee, Department of Human Genetics Member, Fellowship Committee, Department of Human Genetics Member, Standing Committee, Department of Human Genetics Member, Management Committee, Department of Oncology EDUARDO FRANCO 1. Research Grants (new and ongoing) In brief, my research program covers the molecular epidemiology and prevention of cervical cancer and human papillomavirus-associated diseases, upper aero-digestive tract cancers, and childhood tumours; studies of epidemiologic methods for evaluating efficacy of cancer screening strategies; the impact of measurement error in epidemiology; and studies of societal and clinical influences on the survival of cancer patients. The titles of funded research projects are listed below: As PI Biomarkers of cervical cancer risk (E Franco, F Coutlée, G Matlashewski, M. Pollak, M Roger) Canadian Institutes of Health Research (CIHR grant #MOP-42532, $418,119, 2000-04; renewed 2005-08, $313,587). Antioxidant nutrients among a Brazilian population (A Giuliano, E Franco [co-Pis], J Marshall, D Roe, L Villa, N Craft) National Institutes of Health (NCI Grant # 36
  37. 37. Department of Oncology Annual Report 2007/2008 RO1CA81310, approx. $1.3 million [US$ 870,000], 2000-03; renewed 2004-07, approx. $1.2 million). Efficacy trial of HPV versus Pap testing for screening cervical cancer precursors (E Franco, F Coutlée, S Ratnam, S Walter, E Duarte, I Rodrigues, R Rajan, M Steben). Canadian Institutes of Health Research (CIHR grant #MCT-54063, $1,071,837, 2002- 08). PAP Cytology Screening Failure: Influences of the Patient, Physician, and Laboratory (E Franco, E Duarte-Franco, F Coutlée, A Ferenczy, P Ghadirian, M Dawes, M Deschamps, P Drouin). Canadian Institutes of Health Research (grants # IHS-61108, $48,545, 2002- 03 and MOP-64454 $312,945, 2003-08). HPV infection and transmission among couples through heterosexual activity (the HITCH cohort) (E Franco, F Coutlée, J Hanley, P Tellier). Canadian Institutes of Health Research (grant# 68893, $546,544, 2004-09). CIHR Team in HPV infection and associated diseases (E Franco, F Coutlée [co-PIs], M Roger, G Matlashewski, P Brassard, Z Rosberger, A Al-Moustafa, J Archambault, P Davies, B Duval, R Rajan). Canadian Institutes of Health Research (grant #83320, $2,546,941, 2007-13). As Co-investigator Characterization of the human papillomavirus infection among a population of Inuit women in Québec. (P Brassard, E Franco, F Coutlée, M Roger). Canadian Institutes of Health Research (CIHR grant #MOP57749, $496,752, 2002-08). Development and validation of new statistical methods for modeling intermediate events in CIHR training program in applied Oral Health Research (J Feine, P Allison, E Franco, W Fraser, M Frenette, D Grenier, A Kolta, G Lavigne, J Lund, M Mckee). Canadian Institutes of Health Research (grant #QTA-68723, $1.76M, July 2004 –June 2010). Molecular analysis of HPV infection in precancerous and cancerous lesions of the uterine cervix (F Coutlée, E Franco, G Matlashewski). Canadian Institutes of Health Research (grant# MOP-67155, $289,371, 2004-07). The psychosocial impact of Pap versus HPV testing on Canadian women screened for cervical cancer (Z Rosberger, P DiDio, E Duarte, E Franco, B Knauper, MH Mayrand). Canadian Institutes of Health Research (grant# pending, $160,000, 2005-08). A randomized controlled trial of the effectiveness of a coping strategies intervention for people with head and neck cancer (P Allison, LJ Edgar, J Feine, E Franco, B Nicolau, R Rajan). Canadian Institutes of Health Research (grant #MCT-75475, $471,139, April 2005 – March 2009). 37
  38. 38. Department of Oncology Annual Report 2007/2008 A randomised controlled evaluation of HPV testing for cervical cancer screening (A Coldman, P Davies, R Martin, J Matsic, D Van Niekerk, G Ogilvie, T Ehlen, G Stuart, E Franco, S Peacock, M Krajden), Canadian Institutes of Health Research (grant #TBA, $6,268,935, 2006-13). The life course approach to studying the etiology of head and neck cancer: HeNCe life study (B Nicolau, P Allison, R Burk, F Coutlée, E Franco, G Humphris, J O’Loughlin, A Sacker, N Schlecht), Canadian Institutes of Health Research (grant # MOP-81172, $478,236, 2006-10). Industry support (non-peer-reviewed unrestricted grants) (amounts in Canadian dollars) Support for the Canadian Cervical Cancer Screening Trial (Merck-Frosst Co., $75,000, 2004-08). Support for the HPV infection and transmission among couples through heterosexual activity (the HITCH cohort) (Merck-Frosst Co., $472,072, 2006-09) 2. Education and Research Training H Trottier. Epidemiology of cervical cancer. Postdoctoral fellow, Department of Oncology, McGill University, Montreal, 2004-08. M-H Mayrand. Efficacy trial of HPV testing in cervical cancer screening. Ongoing PhD research, Department of Epidemiology & Biostatistics, McGill University, Montreal, 2002-07 (FRSQ and NCIC scholarships). A Spence. Determinants of cervical cancer screening failure. Ongoing PhD research, Department of Epidemiology & Biostatistics, McGill University, Montreal, 2001-09. T Dang-Tan. Childhood cancer surveillance. Ongoing PhD research, Department of Epidemiology & Biostatistics, McGill University, Montreal, 2002-08 (CIHR scholarship). S Lau. Natural history of ASCUS cervical cytological abnormalities. Ongoing MSc research (part-time student), Department of Epidemiology & Biostatistics, McGill University, Montreal, 2002-07. A. Burchell. Behavioural determinants of HPV transmissibility. Ongoing PhD research, Department of Epidemiology & Biostatistics, McGill University, Montreal, 2003-08 (Tomlinson and NCIC scholarships). A De Pokomandy. Anal intraepithelial neoplasia in HIV-infected men. Ongoing MSc research, Department of Epidemiology & Biostatistics, McGill University, Montreal, 2005-08. 3. Scientific Reviews Editorial Boards Cancer Detection and Prevention Cancer Epidemiology, Biomarkers and Prevention Epidemiology 38
  39. 39. Department of Oncology Annual Report 2007/2008 Oral Diseases Public Library of Science (PLoS) – Medicine Salud Pública de México HPV Today (Scientific Committee Member) Manuscript Reviews American Journal of Epidemiology American Journal of Obstetrics & Gynecology American Journal of Tropical Medicine & Hygiene British Medical Journal Cancer Causes and Control Cancer Detection and Prevention Cancer Epidemiology, Biomarkers and Prevention Cancer Research Epidemiology European Journal of Obstetrics & Gynecology and Reproductive Biology International Journal of Cancer Journal of Adolescent Health Journal of Medical Virology Journal of Infectious Diseases Lancet Oral Oncology Preventive Medicine Public Library of Science-Medicine Regulatory Toxicology and Pharmacology Scandinavian Journal of Infectious Diseases Sexually Transmitted Diseases Grant reviews (internal) National Institutes of Health, Epidemiology of Cancer [EPIC] panel, Bethesda, USA: Member (2008) (3 written critiques). Scottish Government Health Department, Edinburgh, Scotland (2008) (1 written critique) Cancer Research UK, London, England (2008) (5 written critiques) Fundação para a Ciência e a Tecnologia, Lisbon, Portugal (2008) (3 written critiques) Faculty evaluations University of California at Los Angeles, Department of Epidemiology, Los Angeles, USA (evaluation of Dr Haroutune Armenian promotion to professor-in-residence), September 2007. University of Washington, Department of Epidemiology, Seattle, USA (evaluation of Dr Steve Hawes’ promotion to Associate Professor), September 2007. 39
  40. 40. Department of Oncology Annual Report 2007/2008 University of Washington, Department of Pathology, Seattle, USA (evaluation of Dr Long-Fu Xi’s promotion to Associate Professor), September 2007. Johns Hopkins University, Departments of Epidemiology and Infectious Diseases, Baltimore, USA (evaluation of Dr Patti Gravitt’s promotion to Associate Professor), December 2007. Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, USA (Evaluation of Dr. Stephen Schwartz’s 5-year report and plan, December 2007). Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, USA (Evaluation of Dr. Margaret Madeleine’s promotion to Assistant Member), April 2008. University of Washington, Department of Epidemiology, Seattle, USA (evaluation of Dr Rachel Winer’s recruitment dossier to Assistant Professor), May 2008. Other scientific review work Judge for prize of best paper in the journal Salud Publica de Mexico (annual). Judge for Rothman prize, given to best article published in the journal Epidemiology (annual). Oregon Evidence-based Practice Center, Agency for Health Care Research and Quality, Rockville, USA. Screening for Cervical Cancer: A Systematic Evidence Review for the US Preventive Services Task Force (2008) 5. Conference Organization Member, International Scientific Committee, 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China (November 2007). Member, Candidacy Planning Committee (subsequently, Local Organizing Committee), World Cancer Congress of the Union Internationale Contre le Cancer, Montreal, Canada (winning bid for 2012). Member, Local Organizing Committee, International Papillomavirus Conference, Montreal, Canada (July 2010). Member, 60th Anniversary Cancer Research Conference Program Committee, National Cancer Institute of Canada, Toronto (November 2007). Member, Program Committee, EUROGIN 2007 Congress, European Research Organization on Genital Infection and Neoplasia, Monte-Carlo, Monaco (October 2007). 40
  41. 41. Department of Oncology Annual Report 2007/2008 Member, Scientific Committee, XVIII IEA World Congress of Epidemiology, Porto Alegre, Brazil (September 2008). Member, Program Committee, EUROGIN 2008 Congress, European Research Organization on Genital Infection and Neoplasia, Nice, France (November 2008). Organizer and Instructor, Satellite Workshop “Reading, writing, and publishing in Epidemiological and Clinical Research”, 7th Scientific Meeting, IEA-Eastern Mediterranean Region, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia (November 29, 2007). Co-Organizer and Lecturer, Satellite Course “Epidemiologic Research and New Directions” in conjunction with the XVIII IEA World Congress of Epidemiology, Porto Alegre, Brazil (September 20-21, 2008). 6. External Committees and Boards National National Cancer Institute of Canada, Toronto: Member, Awards-in-Excellence Committee (2005-08). National Cancer Institute of Canada, Toronto: Member, Governance and Nominating Committee (2007-). Canadian Institutes of Health Research, Ottawa, Canada: Member (2007-08), Michael Smith Prize in Health Research Committee. Canadian Institutes of Health Research, Ottawa, Canada: Member (2008), Meetings, Planning and Dissemination Grant Program. Clinical Medicine and Basic Biology Working Group, National Cancer Institute of Canada’s Prevention Initiative, Toronto, Canada (2006-08) Member, National Infectious Agents Committee, Primary Prevention Action Group, Canadian Partnership Against Cancer, Vancouver, Canada (2007-). Co-Chair, HPV Prevention Network, International Centre for Infectious Diseases, Winnipeg, Canada (2007-). Member, Environment Cancer Fund Advisory Board, Cancer Research Society, Toronto, Canada (2006-) International National Institutes of Health, Epidemiology & Disease Control-2 Study Section (renamed Epidemiology of Cancer [EPIC] panel in 2003), Bethesda, USA: Member (2002-07). 41
  42. 42. Department of Oncology Annual Report 2007/2008 Steering Committee Member, HPV-040 Vaccination Study, National Public Health Institute, Helsinki, Finland (2007-11) Member, External Advisory Committee, Cancer Control and Population Sciences, University of Puerto Rico Comprehensive Cancer Center, San Juan, USA (2007-). Member, Expert committee on burden of HPV-related disease and health economics, Sabin Institute, Washington, USA (2007-). Member, Steering Committee, HPV Vaccine Global Forum and Communities of Practice, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland (2007-). Member, Nominating Committee, International Epidemiological Association (2005-) Chair, World Congress Advisory Committee, International Epidemiological Association (2005-) 7. Invited Presentations National “New paradigms in primary and secondary cervical cancer prevention” Keynote plenary lecture, 63rd Annual Clinical Meeting, Society of Obstetricians and Gynaecologists of Canada, Ottawa, Canada (June 22, 2007). “Cervical cancer screening in the era of HPV vaccination” Keynote plenary lecture, 63rd Annual Clinical Meeting, Society of Obstetricians and Gynaecologists of Canada, Ottawa, Canada (June 22, 2007). “Expected impact of vaccination on screening practices: Theoretical concerns and research opportunities” Lecture at the HPV Master Class of the Canadian Association for Immunization Research and Evaluation, Ottawa, Canada (September 22, 2007). “HPV testing in cervical cancer screening” Grand Rounds Seminar at McMaster University, Hamilton, Canada (September 28, 2007). “New Primary and Secondary Prevention Strategies for Cervical Cancer Prevention” Lecture to the Alberta Cancer Board Provincial/Regional Medical Laboratory Meeting, Banff, Canada (October 17, 2007). “What’s the fuss about infectious diseases? Infections and cancer” Café Scientifique, Canadian Institutes of Health Research, Montreal, Canada (January 22, 2008). “Arguments for and against HPV vaccination: Separating sensible from silly” Seminar to the Merck HPV Club, Toronto, Canada (February 4, 2008). 42
  43. 43. Department of Oncology Annual Report 2007/2008 “Research at McGill’s Division of Cancer Epidemiology” Seminar at the Faculty Retreat of the Department of Oncology, McGill University, Montreal, Canada (March 13, 2008). International “Presente, futuro y recomendaciones de la aplicación de la vacuna 16-18 para VPH” Plenary Lecture, VI International and XI National Conference of the Mexican Association of Colposcopy and Pathology, Acapulco, Mexico (July 20, 2007). “Las vacunas y los cambios en las politicas de salud: Sinergismo en las estrategias preventivas” Plenary Lecture, VI International and XI National Conference of the Mexican Association of Colposcopy and Pathology, Acapulco, Mexico (July 20, 2007). “La vacuna VPH 16/18: de la investigación a la realidad” Keynote plenary lecture, 3rd Regional Congress of the Pediatric College of Puebla, Puebla, Mexico (July 20, 2007). “Avances en vacunas en la prevención del HPV” Symposium lecture, Congreso Internacional, Hospital Aleman, Buenos Aires, Argentina (August 9, 2007). “Epidemiology of Cervical Cancer in Latin American Countries” Lecture at the Latin American HPV Master Class and Clinical Workshop, São Paulo, Brazil (August 16, 2007). “Expected impact of HPV vaccination on Screening for cervical cancer” Lecture at the Latin American HPV Master Class and Clinical Workshop, São Paulo, Brazil (August 16, 2007). “Rastreamento. Uma nova geracao livre do cancer? Symposium lecture, XII Congresso Paulista de Obstetrícia e Ginecologia, São Paulo, Brazil (August 17, 2007). “Diagnóstico: Citologia e métodos moleculares” Symposium lecture, XII Congresso Paulista de Obstetrícia e Ginecologia, São Paulo, Brazil (August 18, 2007). “Expected impact of HPV vaccination on current screening practice” Lecture at the Middle East and North Africa HPV Master Class and Clinical Workshop, Cairo, Egypt (September 6, 2007). Co-Moderator and Speaker “Impact of Mandatory and/or Universal Immunization for HPV on the Epidemiology of Cervical Cancer” Policy Workshop, Annual Meeting of the American College of Epidemiology, Fort Lauderdale, USA (September 17, 2007). “The burden of HPV-related diseases” Plenary lecture, EUROGIN 2007 Conference on New Strategies of Cervical Cancer Prevention: The Reality of Hpv Vaccines, Monte- Carlo, Monaco (October 4, 2007). 43
  44. 44. Department of Oncology Annual Report 2007/2008 “What new proofs are needed to foster universal implementation of HPV vaccines?” Plenary lecture, EUROGIN 2007 Conference on New Strategies of Cervical Cancer Prevention: The Reality of Hpv Vaccines, Monte-Carlo, Monaco (October 5, 2007). “HPV testing as a more logical screening approach following vaccination” Plenary lecture, EUROGIN 2007 Conference on New Strategies of Cervical Cancer Prevention: The Reality of Hpv Vaccines, Monte-Carlo, Monaco (October 6, 2007). Rapporteur “Screening approach for vaccinated population” Plenary session, EUROGIN 2007 Conference on New Strategies of Cervical Cancer Prevention: The Reality of Hpv Vaccines, Monte-Carlo, Monaco (October 6, 2007). Chair, Scientific Session 12: Epidemiology. EUROGIN 2007 Conference on New Strategies of Cervical Cancer Prevention: The Reality of Hpv Vaccines, Monte-Carlo, Monaco (October 6, 2007). “The value of HPV testing in cervical cancer screening” Plenary session, Symposium on HPV and Cervical Cancer, Hong Kong, China (November 1, 2007). “Epidemiology of HPV infection” Lecture, Fogarty Symposium, 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China (November 5, 2007). Co-Chair, Scientific Session: Epidemiology I, 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China (November 6, 2007). “Impacto de la vacuna VPH en el cribado del cancer de cervix” Keynote lecture, XIX Congreso Annual, Asociación Española de Patología Cervical y Colposcopia, Oviedo, Spain (November 17, 2007). “Cancer Epidemiology at a Crossroads: Time for Reappraisal” Keynote lecture, 7th Scientific Meeting of the International Epidemiological Association, Eastern Mediterranean Region, Riyadh, Saudi Arabia (November 28, 2007). “Perspectivas en tamización de cáncer de cuello uterino” Keynote lecture, Programa Evento Socialización y Recomendaciones Tamización de Cancer de Cuello Uterino, Ministerio de la Protección Social, Instituto Nacional de Cancerología, Bogota, Colombia (December 17, 2007: via teleconference; travel cancelled due to snow storm). “HPV DNA testing: a more logical cervical cancer screening strategy for the era of HPV vaccination?” Plenary lecture, 1st Scientific Meeting of the Hellenic HPV Society, Thessaloniki, Greece (January 26, 2008). “Confidence in implementing universal HPV vaccination: What additional proofs are needed?” Plenary lecture, 1st Scientific Meeting of the Hellenic HPV Society, Thessaloniki, Greece (January 26, 2008). 44
  45. 45. Department of Oncology Annual Report 2007/2008 “Epidemiologic issues in implementing HPV vaccination” Lecture at the Sub-Saharan Africa HPV Master Class and Clinical Workshop, Johannesburg, South Africa (February 26, 2008). “Cervical Cancer Prevention in Latin America: Gaps in Knowledge and Research Priorities” Plenary lecture, Congreso Internacional de Colposcopia en la Practica Medica, Mexico City, Mexico (April 4, 2008). “Scientific Merit of Arguments Against HPV Vaccination: An Epidemiologic Perspective” Plenary lecture, Congreso Internacional de Colposcopia en la Practica Medica, Mexico City, Mexico (April 4, 2008). “Human papillomaviruses and neoplasia: New prevention strategies” Session lecture, American Association for Cancer Research Annual Meeting 2008, San Diego, USA (April 12, 2008). “Molecular epidemiology of HPV infection and cervical cancer” Seminar at the Division of Epidemiology, School of Public Health, University of California, Berkeley, USA (April 15, 2008). 8. Hospital and University Activities University Member, Management Committee, Department of Oncology (2001-) Member, Committee on Multidisciplinary Oncology Residency/Fellowship Curriculum Chair, Faculty Promotion Sub-committees, Department of Oncology (2003-present). Chair, Student Funding Committee, Department of Epidemiology and Biostatistics Member, Comprehensive PhD Exam Committee, Department of Epidemiology and Biostatistics Member, Search Committee, Director of Surgical Oncology, Department of Oncology CAROLYN FREEMAN 1. Summary of New and Ongoing Research Clinical research in paediatric tumours especially brain tumours. Use of radio-sensitising and biological agents in pediatric brain tumours. Development of new radiotherapy treatment techniques. 45
  46. 46. Department of Oncology Annual Report 2007/2008 Evaluation of new radiotherapy technologies. 2. Research Grants (new and ongoing) Radiotherapy co-PI of grant from National Institute of Health (USA) for clinical pediatric oncology research studies (per case funding). 1980 - present National Childhood Cancer Foundation (NCCF): ~ $20,000.00/yr. Co-Chair CNS Strategy Committee, Children’s Oncology Group. 2001 - 2008 National Cancer Institute of Canada $61,960/yr. (With Seuntjens, J. (PI), Verhaegen, F., Shenouda, G. and Podgorsak, E.) Monte Carlo-based modulated electron beam inverse treatment planning and delivery. 2005-2008 Canadian Medical Protective Association $31,000. (Role PI, with Parker, W., Gingras, C., Podgorsak, E., Daly, M., and Shenouda, G.) Development of a comprehensive system for classifying, recording and analysing radiation events. 2007-2008 3. Scientific Reviews Editorial Boards Associate Editor, Perez: Principles and Practice of Radiation Oncology 5th edition, 2007 Associate Editor, International Journal of Radiation Oncology, Biology and Physics Member, Editorial Board, Pediatric Blood and Cancer Section Editor (Radiation Oncology), Current Oncology Ad Hoc Reviews Ad hoc reviewer, Societé française de lutte contre le cancer (translational research) 4. Conference Organization Member of Scientific Committee, Second International Congress on Pediatric Radiation Oncology, Barcelona, Spain. 2007 Judge of Resident Poster Award session, Annual Meeting of the Canadian Association of Radiation Oncologists, Toronto, October 2007 Moderator of poster session, Annual Meeting of the Canadian Association of Radiation Oncologists, Toronto, October 2007 Co-organiser and co-moderator of session on adult-type tumours seen in paediatric oncology practice, Annual Meeting of SIOP, Mumbai, November 2007 Abstract reviewer. SIOP 2008 Berlin Chair of Scientific and Local Organizing Committees, Third International Congress on 46
  47. 47. Department of Oncology Annual Report 2007/2008 Pediatric Radiation Oncology, Montréal. 5. External Committees and Boards Chair, Radiotherapy Advisory Committee, Radiotherapy Technology Training Program, Dawson College Chair, Medical Advisory Board, Sarah Cook Fund Co-Chair, Brain Tumor Strategy Committee, Children’s Oncology Group Member, Brain Tumour Core Committee, Pediatric Oncology Group, now the Children’s Oncology Group Member, Board of Directors, Quality Assurance Review Centre, Rhode Island (NIH funded) Member, Data Monitoring and Safety Committee, SIOP PNET - 4 Member, Data Monitoring and Safety Committee, UKCCSG Study on Low Grade Gliomas Member, Manpower Committee, Canadian Association of Radiation Oncologists Membre, Comité de direction, Direction de la lutte contre le cancer, MSSS Membre, Groupe conseil de lutte contre le cancer, MSSS Membre, Comité d’évaluation de la mise en oeuvre des équipes interdisciplinaires de lutte contre le cancer, MSSS Member of Board of Directors, Pediatric Radiation Oncology Society Member of Board of Directors, Canadian Radiation Oncology Foundation 6. Invited Presentations Guest lecture. “Children’s Oncology Group CNS studies.” Meeting of the International Pediatric Radiation Oncology Society. Barcelona, June 2007. Educational course. “Medulloblastoma.” Annual meeting of the International Society of Paediatric Oncology. Mumbai, October 2007. 7. Continuing Education Activities lectured “Radiotherapy in the treatment of sarcomas.” Oncology Level 2 course. McGill University Health Centre. January 2008. 8. Hospital and University Activities Co-chair, McGill Télé-oncologie committee 47
  48. 48. Department of Oncology Annual Report 2007/2008 Co-Chair, Tumor Board, Montreal Children’s Hospital Ad hoc member Promotions Review Committee Member, Tumor Board, Montreal Children's Hospital Member, Radiation Safety Committee, Montreal General Hospital/McGill University Health Centre Member, Medical/Clinical Advisory Committee, Montreal General Hospital/McGill University Health Centre Member, Oncology Quality Improvement Committee, McGill University Health Centre Member, Medical Advisory Committee, Cedars Cancer Institute Member, Board of Directors MUHC Research Institute BRUNO GAGNON 1. Research Grants (new and ongoing) Co-Investigator (PI: P. Gagnon). Étude de faisabilité pour le traitement du delirium hyperactif chez les patients atteints de cancer avancé par l’haloperidol à dose différentielle. Funded by CIHR through NET Grant ($1.3million): Developing, evaluating, and implementing new interventions in palliative care. CIHR. 2007-2009 Co-Investigator (CO-PIs: J. Pelletier, N. MacDonald). Towards an understanding of cancer cachexia –Linking molecular mechanisms with novel treatment options. Terry Fox Research Institute (Montreal). 2007-present Chair. A Phase II study of methadone as a first line agent in the treatment on neuropathic pain. National Cancer Institute of Canada (NCIC) $120,000. 2007-present Principle Investigator. Patterns of care during the last six months of life of patients dying of cancer. CIHR: Operating Grant $411,610. 2004-present Principle Investigator. Les différents profiles de soins reçus par les patients mourant du cancer durant les six derniers mois de vie : une étude basée sur des banques de données administratives. Fonds de la recherche en santé du Québec (FRSQ) $30,000. 2004-2008 Principle Investigator. Characterizing cognitive failure, physical retardation and hypo- active delirium in advanced cancer patients: A Pilot Project. CIHR: Palliative and End of Life Care: A Pilot Project $80,160. 2004-2007 48
  49. 49. Department of Oncology Annual Report 2007/2008 2. Education and Training Undergraduate Teaching ICM-B (Introduction to Clinical Medicine) a day rotation to CNR clinic – for 1st and 2nd year students. 2008-present Research Trainees Mentored Dominique Elie, Dept. Pharmacie, U Laval. Primary supervisor P. Gagnon. May 2008 – present. 3. Scientific Reviews Editorial and Advisory Boards Member, Editorial Committee of Medicina Paliativa Member, Advisory Board of Medicina Paliativa Ass. Editor, Palliative Care, Pain Research & Management Ad hoc Reviews The Open Clinical Cancer Journal European Journal of Cancer Journal of Pain and Symptom Management Supportive Care Therapy Journal of Palliative Care 4. Invited Presentations and Workshops The next step in pain management. Comité d’éducation continue de La maison des soins palliatifs de la Rivière-du-Nord en association avec la compagnie Paladin-Laboratoires Inc. St. Jérome, Québec – 16 mai 2007. The next step in pain management. Paladin-Laboratoires Inc. Montréal, Québec – 28 septembre, 2007. The next step in pain management. Notre-Dame de la Merci, organisée par Paladin- Laboratoires Inc. Montréal, Québec – 1 novembre, 2007. La méthadone : Sa prescrire pour la douleur. CLSC St. Jean-sur-Richelieu, organisée par Dr. A.H. Dandavino. Laprairie, Québec – 12 décembre, 2007. Gagnon B. Un laxative sous-cutané? Pourquoi pas? Le traitement de la constipation réfractaire. 24 et 25 avril, 2008, 18e Congrès du Réseau des soins palliatifs du Québec : La vie qui prend son sens. Hôtel Hilton du Lac-Leamy et Ramada Plaza/Manoir du Casino, Gatineau, Québec. 5. Peer Reviewed Abstracts Eades M, Chasen M, Di Dio P, Lee V, Sharma R, Gagnon B. A Retrospective Descriptive Comparison of the Cancer Symptom Experience of Two Groups of Patients 49
  50. 50. Department of Oncology Annual Report 2007/2008 Participating in an 8 Week Ambulatory Cancer Nutrition Rehabilitation (CNR) Service. 20th Anniversary International Symposium of the Multinational Association of Supportive Care in Cancer. St Gallen, Switzerland. June 27-30, 2007. (Poster) MacDonald N, Kasymjanova G, Agulnik J, Pepe C, Kreisman H, Cohen V, Sharma R, Gagnon B, Small D. Influence of baseline inflammatory markers on the response to first line chemotherapy in advanced NSCLC. The 20th Anniversary Conference of the European Chapter on Combinatorial Optimization (ECCO). Limassol, Cyprus. May 24- 26, 2007. (Poster) MacDonald N, Kasymjanova G, Gagnon B, Sharma R, Baracos V, Droege W, Kreisman H. Markers of a chronic inflammatory state of influence patient successful trial completion. Data from cancer cachexia trial. 44th ASCO Annual Meeting. Chicago, Illinois. May 30 – June 3, 2008. Local Peer-reviewed abstracts Chasen M, Sharma R, Zhang X, Bhargava R, Gagnon B, Vigano A, MacDonald N. Electrogastrography in cancer patients. McGill University, Cancer Nutrition Rehabilitation Program, Department of Oncology, Montreal, Quebec, Canada. McGill University Health Center Research Institute 6th Annual Health Outcomes Axis Research Day, Montreal, Canada. May 24, 2007. (Oral) 6. Hospital and University Activities Clinical trial coordinator, Cancer Nutrition-Rehabilitation Program. Department of Oncology, McGill University. MUHC Clinical Trials Director Committee member of the MUHC-RI Studentship/Fellowship competition. Committee member of the MUHC-RI Pilot Project Review Committee. Member, Supportive Care Section Committee Meeting, Department of Oncology, McGill University. PHIL GOLD 1. Teaching and Training Lectures- Physiology-10 hours Seminars-Professionalism-9 hours Tutorials-Physiology-2 hours Small Groups-Biology of Cancer;Biochemistry;Immunology-12hours Clinical-80 hours per year 50
  51. 51. Department of Oncology Annual Report 2007/2008 ICM-B-50-60 hours per year Osler Fellowship-Physician Apprenticeship Course-24 hours 2. Scientific Reveiws Editorial Board Current Oncology, Deputy Editor 3. External Committees and Boards Chairman of Burroughs Wellcome Fund 4. Hospital and University Activities Executive Director, Clinical Research Centre and Office of Clinical Contracts of the RI- MUHC Progress of Office of Clinical Research; Phase I studies and development of a CRO by PPP under consideration Presently working strictly with pharmaceutical funds for clinical trials of all phases Mentoring of new staff initiated officially and actually ongoing Osler Physician Apprenticeship Program-Class of 2010 Auditing First Year Medicine MARK GOLDBERG 1. Summary of New and Ongoing Research The following projects are currently underway and most will be completed over the next five years: The most recently funded studies are: (1) “A longitudinal study of the health effects of air pollution”, funded by CIHR in the fall 2002 competition (PI: M. Goldberg; with Richard Burnett (Health Canada), and Kenneth Flegel, Nadia Giannetti, Michal Abrahamowicz, Robert Platt (McGill); 2003-2006). (2) A case-control study to investigate gene-environment interactions (funded by the Quebec Breast Cancer Foundation; with J. Simard and F. Durocher (Université Laval), F. Labrèche (Montreal Public Health Department), M.-É. Parent (INRS-Institut Armand-Frappier), B. Langholz (University of Southern California), and D. Sinnett (Université de Montréal)); (3) a study of traffic-related air pollution and socioeconomic gradients in the incidence of cancer (funded by CIHR; with Michael Jerrett (McMaster University), Nancy Ross (McGill), Nicolas Gilbert (Health Canada), Jeffrey Brook (Environment Canada), Renjun Ma (University of New Brunswick), Richard Burnett (Health Canada), Claire Infante-Rivard (McGill), and Jack Siemiatycki (Université de Montréal); (4) a cohort study of cancer incidence and mortality among adults from long-term exposure to outdoor air pollution (funded by CIHR, Paul Villeneuve(PI), Richard Burnett, Yang Mao); and (5) “A panel 51
  52. 52. Department of Oncology Annual Report 2007/2008 study of the effects of changing lifestyle and environmental conditions on signs and symptoms heart failure”. Studies for which I am a co-investigator are: (1) “Estimating the need for radiotherapy for cancer: A population-based requirements analysis” (funded by the Canadian Institutes of Health Research; William Mackillop, PI); (2) “Estimating age-, gender- and risk factor-specific incidence rates of stroke and heart disease using longitudinal cohorts created from linkage of survey and administrative databases” (funded by the Canadian Institutes of Health Research; Nancy Mayo, PI); and (3) a study in palliative medicine of patterns of care among cancer patients in end-of-life (Bruno Gagnon, PI (McGill)). 2. Research Grants (new and ongoing) As Principal Investigator “Implementation of an Automated Artificial Intelligence System for Extracting Data and Coding Pathology Reports for Use in the MUHC Tumour Registry”, Funded by the Canadian Partnership Against Cancer Corporation (Christine Boutin and Mark Goldberg, Co-PI), $160,000. 2008-2010 “Gene-environment interactions in postmenopausal breast cancer: A case-control study” Funded by the Quebec Breast Cancer Foundation ($1.5 million for three years; the project is 8 years and other funding will be sought in two years; Goldberg MS (PI), Jacques Simard, Francine Durocher (Université Laval), France Labrèche (Direction de la santé publique, Montréal), Marie-Élise Parent (INRS Institut Armand-Frappier), Bryan Langholz (University of Southern California), Daniel Sinnett (Université de Montréal)) 2004-2010 “Traffic-related air pollution and socioeconomic gradients in the incidence of cancer”. Funded by the Canadian Institutes of Health Research ($108,642/year, $58,734 equipment, Goldberg MS (PI) / BROOK, Jeffrey R / BURNETT, Richard T / GILBERT, Nicolas L / INFANTE-RIVARD, Claire / JERRETT, Michael L / MA, Renjun / ROSS, Nancy A / SIEMIATYCKI, Jack ) 2004-2008 “Longitudinal study of acute effects of ambient air pollution in susceptible populations”. Funded by the Canadian Institutes of Health Research ($68,948/year, $3,398 equipment; Mark Goldberg (PI), ABRAHAMOWICZ,Michal / BURNETT,Richard T / FLEGEL, Kenneth M /GIANNETTI, Nadia /PLATT, Robert W). This was ranked 2nd of 23 (score=4.17) in the CIHR population health review panel. 2003-2008 Research Contracts As Principal Investigator “A panel study of the effects of changing lifestyle and environmental conditions on signs and symptoms heart failure” Contract with Health Canada, $418,277.92. (Mark Goldberg, PI, with Amanda Wheeler, Nadia Giannetti, Eileen O'Meara, Nancy E. Mayo, James Brophy, Richard T. Burnett) 2006-10 52

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