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  • 2. 139 PROFESSIONAL ACTIVITIES Dr. David J. Brenner Chairperson Columbia University Radiation Safety Committee Program Committee, Fourth International Workshop: Microbeam Probes of Cellular Radiation Response, Killiney Bay, Dublin, July 1999 Member National Council on Radiation Protection and Measurements (NCRP) Joint Task Force on Vascular Radiation Therapy NCRP Committee 1-6 on Risk Linearity American Society of Therapeutic Radiology and Oncology (ASTRO), Refresher Course Program Committee Radiation Research Society Program Committee American Statistical Association Radiation Meeting Program Committee Dr. Gloria Calaf Appointed Adjunct Professor, Univerisity of Tarapaca, Arica, Chile; Department of Biology and Health (since December 1998) Teaching Postdoctoral Degree Course, “Biology of cancer and inflammatory processes,” University of Tarapaca (November 24-27, 1998) Dr. Charles R. Geard Member American Society of Therapeutic Radiology and Oncology (ASTRO) Environmental Mutagen Society Radiation Research Society Advisory Committee on Radiobiology, Brookhaven National Laboratory Associate Member, Radiobiology Advisory Team (AMRAT) of the Armed Forces Radiobiology Research Institute (AFRRI) Columbia University, Faculty Council (Voting Member) Editorial Work Editorial Board, International Journal of Radiation Biology. Reviewer International Journal of Radiation Oncology, Biology and Physics Radiotherapy and Oncology British Journal of Cancer Clinical Cancer Research, Mutagenesis
  • 3. 140 Mutation Research Radiation Research Ad Hoc Reviewer of Grant Proposals American Cancer Society National Institutes of Health Dr. Eric J. Hall Member American Board of Radiology Radiotherapeutic Written-Test Committee National Academy of Sciences American Society of Therapeutic Radiology and Oncology (ASTRO) Radiation Research Society International Stereotactic Radiosurgery Society Member of the Board American Radium Society President Program Committee Chairman International Association of Radiation Research President Elect Columbia University, College of Physicians & Surgeons Cancer Center, Internal Advisory Committee/Executive Committee Columbia-Presbyterian Medical Center: Chairman, Joint Radiation Safety Committee Chairman, Radioactive Drug Research Committee National Council on Radiation Protection and Measurements: Member of Council Member, Committee 1 Editorial Work International Journal of Radiation Oncology Biology Physics International Journal of Brachytherapy Dr. Haiying Hang Member Radiation Research Society
  • 4. 141 Dr. Tom K. Hei Adjunct Professor Department of Radiological Health Sciences, Colorado State University, Fort Collins, Colorado Department of Ion Beam Bioengineering, Chinese Academy of Sciences, Hefei, China Chairman Ad hoc review panel, Chemical Pathology Study Section, 1998, 1999 Member: Chemical Pathology Study Section, 1998- present Ad hoc review panel, Metabolic Pathology Study Section, 1999 Ad hoc review panel, National Science Foundation, 1999 Radiation Research Society American Association for Cancer Research Environmental Mutagen Society Oxygen Society Student Mentoring Ph.D. candidate, Department of Ion Beam Bioengineering, Chinese Academy of Sciences, China Master degree students, Environmental Heath Sciences, Columbia University School of Public Health. New York City high school science students for Intel Science project Reviewer British Journal of Cancer Cancer Research Carcinogenesis Occupational and Environmental Medicine International Journal of Radiation Biology Radiation Research Mutagenesis Environmental Health Perspective ICRERTT Fellowship- International Union Against Cancer Research Grant Council- Government of Hong Kong Vision of Tomorrow Foundation Editorial Work Section editor, Advances in Space Sciences
  • 5. 142 Dr. Howard B. Lieberman Reviewer Grants Chairman, NIH Radiation Study Section Manuscripts Biotechniques Gene International Journal of Radiation Oncology, Biology, and Physics Nucleic Acids Research Radiation Research Member Advisory Board, Summer Research Program for NYC Secondary School Science Teachers, Columbia University American Association for the Advancement of Science American Society for Microbiology Environmental Mutagen Society Genetics Society of America Radiation Research Society Elected Biology Councilor Chairman, Web-Site Committee Chairman, Michael Fry Research Award Selection Committee Sigma Xi Theobald Smith Society Stephen A. Marino Member Columbia University Radiation Safety Committee Radiation Research Society Sigma Xi Guest Scientist Brookhaven National Laboratories, Upton, NY Dr. Tej K. Pandita Member American Association for the Advancement of Science. American Association of Cancer Research. Radiation Research Society The American Society of Microbiology NIH Study section
  • 6. 143 Reviewer Cancer Research Clinical Cancer Research Cytogenetics and Cell Genetics Carcinogenesis FASEB Journal International Journal of Radiation Biology Mutation Research Oncogene Oncology Reports Proceedings of National Academy of Science, USA. Radiation Research
  • 7. 144 THE COLUMBIA COLLOQUIUM AND LABORATORY SEMINARS At intervals of approximately one month during the academic year, a regular colloquium has been held to discuss ongoing research. Dr. Tej Pandita organized them and scheduled the speakers. These have been attended by the professional staff, graduate students, and senior technical staff of this Laboratory and RARAF, as well as by scientists from other departments of the College of Physicians & Surgeons interested in collaborative research. Attention has focused on recent findings and future plans, with special emphasis on the inter-disciplinary nature of our research effort. During the year, we have been pleased to welcome a number of visitors who have presented formal seminars and/or spent time discussing ongoing research with various members of the Laboratory. These have included Drs. Carol Griffin, Medical Research Council, Harwell, UK, Brian Ponnaiya, University of California, San Francisco, Yuxin Yin, Princeton University, Princeton, NJ, Adayabalam Balajee, National Institutes of Health, Bethesda, MD, R. Kucherlapati, Albert Einstein College of Medicine, NY, Joel Bedford, Colorado State University, Ft. Collins, CO, Terry Ashley, Yale University School of Medicine, New Haven, CT, Sally Amundson, National Cancer Institute, Bethesda, MD, Tracy Ruscetti, Los Alamos National Laboratory, Los Alamos, NM, Jun- Jie Chen, Dana Farber Cancer Institute, Boston, MA, Jai Parkash, Haverford College, Haverford, PA, Simon J. Hall, The Mount Sinai Medical Center, New York, Srikumar Chellappan, Columbia University, New York, Carmel Hensey, Dept. of Genetics & Development, Columbia University, Jan K. Kitajewski, Dept of Pathology, Columbia University, and Basil Worgul, Dept. of Ophthalmology, Columbia University.
  • 8. 145 PUBLICATIONS Azbaid AH, Dymnikov AD, and Martinez, G. The optimal construction of an electrostatic quadruplet as focusing microprobe system. Nucl. Instr.and Meth. B158, 61-65 (1999). Brenner DJ, Does fractionation decrease the risk of breast cancer induced by low-LET radiation? Radiat. Res. 151:225-9 (1999). Brenner DJ, The relative effectiveness of exposure to 131 I at low doses. Hlth. Phys. 76:180-185 (1999). Brenner DJ and Hall EJ. Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 43:1095-101 (1999). Brenner DJ, Leu C-S, Beatty JF, Shefer RE, Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devices. Phys. Med. Biol. 44:323-33 (1999). Brenner DJ and Sachs RK, A more robust biologically based ranking criterion for treatment plans. Int. J. Radiat. Oncol. Biol. Phys. 43: 697 (1999). Calaf G, Russo J, Tait L, Estrada S, and Alvarado ME. Morphological phenotypes in neoplastic progression of human breast epithelial cells. J. Submicroscopy Cytology and Pathology. Vol. 32, n.1 (January 2000). Dymnikov AD. Matrix methods in periodic focusing systems. Nucl. Instr. and Meth. A427:6-11 (1999). Dymnikov AD and Garcia G. High-frequency focusing system for nuclear microprobes. Nucl. Instr.and Meth. B158:85-89 (1999). Hall EJ, Miller RC, and Brenner DJ. Radiobiological Principles in Intravascular Therapy. Cardiovasc. Radiat. Med. 1:42-47 (1999). Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, Sawant SG, and Pandita TK. A preliminary report: Frequency of A-T heterozygotes amongst prostate cancer patients with severe late responses to radiation therapy. Can J Sci Amer 4: 385-389 (1998). Hei TK, Liu SX, and Waldren CA. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species. Proc. Natl. Acad. Sci., 95: 8103-8107 (1998).
  • 9. 146 Hei TK, Piao CQ, Wu LX, Willey JC, and Hall EJ. Genomic instability and tumorigenic induction in immortalized human bronchial epithelial cells by heavy ions. Advances in Space Research 22: 1699-1707 (1999). Johnson KL, Brenner DJ, Geard CR, Nath J, Tucker JD, Chromosome Aberrations of Clonal Origin in Irradiated and Unexposed Individuals: Assessment and Implications. Radiat Res 152:1-5 (1999). Kharbanda S, Pandey P, Morris PL, Whang Y, Xu Y, Sawant S, Zhu L, Kumar N, Yuan Z, Weichselbaum R, Sawyers CL, Pandita TK, and Kufe D. Functional role for the c-Abl tyrosine kinase in meiosis. Oncogene 16: 1773-1777 (1998). Martinez G, Azbaid AH, Dymnikov AD. The numerical synthesis of an optimal microprobe focusing system. Nucl. Instr.and Meth. A 427, 344-349 (1999). Miller RC, Randers-Pehrson G, Geard CR, Hall EJ, and Brenner, DJ. The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc. Natl. Acad. Sci. USA 1999: 18-22 (1999). Okayasu R, Takashashi S, Yamada S, Hei TK, and Ullrich RL. Asbestos and DNA double strand breaks. Cancer Research 59:298-300 (1999). Okayasu R, Wu LJ, and Hei TK. Biological effects of naturally occurring and man- made fibers: In vitro cytotoxicity and mutagenesis in mammalian cells. British J. Cancer 59: 298-300 (1999). Pandita TK, Westphal CH, Anger M, Sawant SG, Geard CR, Pandita RK, and Scherthan H. Atm inactivation results in aberrant telomere clustering during meiotic prophase. Mol. Cell. Biol. 19:5096-5105 (1999). Piao CQ, Willey JC, and Hei TK. Alterations of p53 in tumorigenic human bronchial epithelial cells correlate with metastatic potential. Carcinogenesis 20:1529-1533 (1999). Rakovitch E, Mellado W, Hall EJ, Sawant SG, Geard CG, Newman RN, and Pandita TK. Penclomedine-induced DNA fragmentation and p53 accumulation correlates with reproductive cell death in colorectal carcinoma cells with different status of p53. Oncology Reports 6:161-165 (1999). Rakovitch E, Mellado W, Hall EJ, Pandita TK, Sawant SG, and Geard CR. Pacitaxel sensitivity correlates with p53 status and DNA fragmentation but not G2/M accumulation. Int. J. Radiat. Oncol. Biol. Phys. 44:1119-1124 (1999). Sawant SG, Gregiore V, Umbricht CB, Cvilic S, Sukumar S, and Pandita TK. Telomerase activity as a measure for monitoring radiocurability of tumor cells. FASEB J. 13:1047-1054 (1999).
  • 10. 147 Smilenov LB, Dhar S, and Pandita TK. Altered telomere nuclear matrix interactions and nucleosomal periodicity in cells derived from individuals with ataxia telangiectasia before and after ionizing radiation treatment. Mol. Cell. Biol. 19:6963-6971 (1999). Smilenov LB, Mellado W, Roa PH, Umbricht CB, Sukumar S, and Pandita TK. Cloning and chromosomal localization of Chinese hamster telomeric protein chTRF1: A potential role in chromosomal instability. Oncogene 17: 2137-2142 (1998). Smith LG, Miller RC, Richards BS, Brenner DJ, Hall EJ, Investigation of hypersensitivity to fractionated low-dose radiation exposure. Int. J. Radiat. Oncol. Biol. Phys. 45:187-192 (1999). Waldren C, Vannais D, Drabek R, Gustafson D, Kraemer S, Lenarczek M, Kronenberg, A, Hei TK, and Ueno A. Analysis of mutant quantity and quality in human hamster hybrid AL cand AL-179 cells exposed to gamma-rays and HZE-Fe ions. Advances in Space Research 22(4): 579-585 (1998). Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, Nolan GP, Zhang H, Gulyas S, Hill RP, and Benchimol S. Analysis of genomic integrity and p53 dependent G1 checkpoint in telomerase induced extended life span fibroblast (TIELF) cells. Mol. Cell. Biol 19: 2373-2379 (1999). Wu LJ, Randers-Pehrson G, Waldren CA, Geard CR, Yu ZY, and Hei TK. Targeted cytoplasmic irradiation by alpha particles induces gene mutations. Proc. Natl. Acad. Sci. U.S.A. 96: 4959-4964 (1999). Xu A, Wu LJ, Santella R, and Hei TK. Role of oxyradicals in mutagenicity and DNA damage induced by asbestos in mammalian cells. Cancer Research 59:5922-5926 (1999). Zhou HN, Zhu LX, Li KB, and Hei TK. Radon, tobacco-specific nitrosamine, and mutagenicity. Mutation Research 870(430):145-153 (1999).