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  • Why is data sharing important? Avoid duplication Eg Negative results Foster re-use of data Make more information available Add to cancer knowledge through synergy Discoveries are usually dependent on multiple facts being placed in context “ Collatable” cancer information is greater than the sum of the values of each item in isolation Summary: To make better use of the money, time and effort allocated to Cancer Research
  • NCRI context on Implementation Plan draft document moving target, still to be finalised requires input from Task Force members

About Us About Us Presentation Transcript

  • NCRI Informatics Initiative
  • The NCRI Partnership
  • Where does Informatics fit in with NCRI’s governance? NCRI Board Chair: Prof Sir Kenneth Calman NCRI Informatics Management Board Chair: Prof Sir Alex Markham Informatics Coordination Unit Interim Director: Alan Hogg
  • Beginning at the beginning: What is Cancer Informatics?
    • General: Using technology to make use of information relating to cancer cause, prevention and cure
      • Example: Looking for occurrences of a DNA base sequence within 3 billion base pairs of the Human Genome
    • NCRI Informatics: focus on using informatics to maximise the impact of cancer research
      • Coordination and guiding role
      • Primary concern is data sharing
  • The Informatics Problem A consequence of success
    • Think of all the types of data relevant to cancer
      • Biology, Animal Models, Genetics, Epidemiology, Clinical etc
    • Data Volumes
      • The sheer scale of data
      • Distribution
      • Indexing
    • Data Standards
      • Not all data contains all the elements needed
      • Ontology, Format, Mapping
    • Much research data isn’t accessible
    • There is no simple solution
  • Cancer Informatics Examples of what we can see today
    • USA
      • caBIG  moved from pilot to production status in 2007
    • NCRI Data Sharing policy
      • Agreed to by all Partners
    • Mature EBI services
      • Very widely used
    • UKCRC/CfH Simulations
      • Research Capability Program
    • NCRI Initiative demonstrators
      • Platform Reference Model (UCL)
        • How might cancer information resources be organised?
      • Imaging & Pathology
        • A practical problem integrating multiple sources
  • Towards Future Progress: NCRI Informatics Coordination Unit goals Willingness to share Ability to share Cultural Change through Community Alliances Help to build a Cancer Informatics Platform
    • Assessing standards
      • Maintaining and promoting “the Cancer InfoMatrix”
    • Hosting workshops (Examples)
      • Data Sharing, Genetic variation, Data Sharing
    • Demonstrator Projects
    • Helping to implement data sharing policy
    • Sample Publications and conferences
      • Joint UK/US Informatics Conference, NHS CAT
      • Parallel session at NCRI Conference
      • Cancer Informatics, Nature Biotechnology, Human Mutation
    • Presentations at external events
      • For example caBIG  Annual Meeting, LRF, Wellcome Data to Discovery meeting, UCL public lecture series, etc
    • Building an “Informatics Platform” with the community
    NCRI Informatics Coordination Unit Working with and for the community
  • What is “The Platform”? Informatics Platform ONcology Information eXchange NCRI ONIX Community Node Community Node Communit y Node Community Node Community User User Interface Data Source Data Service Data Service Data Source Data Source Data Source Data Service Informatics Platform Genomics Data Other Collaborators ONcology Information eXchange NCRI ONIX Imaging & Pathology Analysis Tools Community Node Community Node Proteomic Data NHS CfH Research Data Community Node (e.g caBIG TM ) Data Service Data Source Data Source Data Source Cancer Registries Community Node Community Node Community Node Community Node Community Node Tissue Banks Data Source Data Service
  • Platform Development Phase I Phase II Gate Review Gate Review Gate Review Gate Review Gate Review A complex plan with many deliverables and a well defined control process . 2007 2008 2009 2010 = Deliverable
  • Why Onix? Why not just use Google?
    • Disambiguation
      • E.g. “Cancer” isn’t about horoscopes or tropics in our context
    • Users are identified, so hosts can grant appropriate access
    • Access to thesauri in context
      • E.g. Breast cancer = Carcinoma of breast
    • Connected resources are designed to interoperate
      • E.g. To link clinical endpoints with information on genetic markers
    • Queries can be passed between multiple resources
    • Located data and tools have defined meanings
    • Sources are categorised to focus your research
      • E.g. Tissue bank, clinic, gene sequence, etc
    • Complex queries can be constructed
      • Lobular breast cancer Stage T2 and BRCA2 associated with ….
        • Published Papers, Gene Sequences, Proteomics, Clinical Trials, etc
    ONcology Information eXchange NCRI ONIX
    • Promoting national and international collaboration
      • Linking the UK cancer research community
      • Unifies cancer and non-cancer research teams, irrespective of size
      • Frees up researchers to focus more on the science
      • Integration of connected resources globally
      • Flexible but consistent infrastructure for future sources/services
    • Fostering a Data Sharing Culture
      • Makes resources more accessible
      • Reuse of resources (data and services) across multiple domains
      • Reduction of duplication, saves time and effort
      • Adoption of data standards and data sharing
    The Platform will increase the impact of research for the benefit of patients Benefits of the Platform
    • Plan calls for central coordination
      • Mainly Informatics Coordination Unit activities
    • Also many community and shared activities
      • For new platform resources to be linked by ONIX …
      • … and to adapt existing ones to connect
      • A new funding stream for community projects has been proposed
    • Informatics Management Board response
      • Issued an “Expressions of Interest” call to judge community interest
      • The response was of a very high quality
    • Finance Committee
      • To support this there is a “financing committee” to help raise funds
      • Initially Pharmaceutical companies are being approached
      • An industry “Informatics Summit” took place in Feb08
    Financial Support for the Platform
  • Summary
    • The NCRI Informatics Initiative is helping
      • To work with the UK and international community to build re-usable infrastructure
      • To change culture to make the infra-structure usable
    • We think it is in everyone’s best interest
      • But our approach is open and voluntary