A Journey from Patient Needs to Health Solutions

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Copyright - Jackie Oldham, Manchester Integrated Medicine and Innovative Technologies, University of Manchester, 2011

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A Journey from Patient Needs to Health Solutions

  1. 1. MIMIT innovation model: A journey from patient needs to (commercial) healthcare solutions. Jackie Oldham Director MIMIT Dr Roz Kelly and Dr Sian Taylor
  2. 2. MANCHESTER - INTEGRATING MEDICINE & INNOVATIVE TECHNOLOGY www.mimit.org.uk 1 st International Affiliate of
  3. 3. 1998 CIMIT: A formal consortium among 13 Boston institutions, International Affiliates, and in collaboration with TATRC/DoD In Collaboration with and support from the Telemedicine and Advanced Technology Research Center 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 A Center at VA Boston 2009 2010 International Affiliates
  4. 5. Established 1824 One of the country’s major research universities Annual income of £788million 40,000 students By 2015 £650million capital investment Most prolific in the UK for IP and invention disclosures
  5. 6. Established 2001 (amalgamation of six Trusts) Largest University NHS Teaching Trust in the UK 1,245 beds, 8,000 staff Annual turnover £483million
  6. 7. Major acute teaching Trust 4,300 staff 855 beds Annual turnover £211million Northwest Lung Research Unit (led by Ashley Woodcock) Shortlisted for NHS Hospital of the Year 2011
  7. 8. Largest cancer centre in Europe More than 40,000 patients per year 2,500 staff £173million annual turnover
  8. 9. 850 in patient beds 5,080 staff 400,000 patient per year 328million annual turnover One of the best hospitals in the NHS
  9. 10. NHS Greater Manchester Cluster Statutory functions of each of ten PCTs across greater Manchester
  10. 11. What is MIMIT ? <ul><li>Identifying & validating unmet clinical need </li></ul><ul><li>Creating partnerships to address that need (MAHSC, MIMIT/CIMIT & industry) </li></ul><ul><li>Providing pump-priming investment </li></ul><ul><li>Facilitating further levered investment </li></ul>A Unique Model for Fostering Innovation
  11. 12. MIMIT TM - Innovation Development Pathway Project Proposals Industry Engagement MIMIT Funding Site Miner dialogue with clinical community Clinical Unmet Need ILP targeted scoping or other introduction Dissemination of need To the widest group of scientists, engineers and designers. Validation of need Project award Optional Industry Funding or involvement Best Ideas Patients and Carers Six month review Facilitated Grant Funding Other Unmet Need Market Analysis Integration of need and solution Project Delivery License/spin out/other Operational/ Management team Forum
  12. 13. <ul><li>Clinical needs pull and is therefore market led. Clinical needs can be introduced via patients and industry as well as from the clinical community </li></ul><ul><li>A comprehensive clinical validation network that can quickly test market need and appetite, reducing partner risk </li></ul><ul><li>Expert intellectual property resources to identify and protect project outputs </li></ul><ul><li>Extensive affiliate network of regulatory experts, med tech designers and reimbursement professionals, NICE & National Technology Adoption centre </li></ul>What are the key features of MIMIT?
  13. 14. <ul><li>Specialist engineering capability including collaboration opportunities </li></ul><ul><li>Substantial community of world class scientists and engineers in multiple disciplines </li></ul><ul><li>Industry standard project management and design control ensuring efficiency and productivity with regulatory compliant and high value outputs </li></ul><ul><li>MIMIT funds projects and can maximise the value of other contributions. </li></ul><ul><li>MIMIT can act as facilitator to securing follow on research council, med tech VC and government funding. </li></ul>
  14. 15. <ul><li>Initiatives that promise great impact on patient care </li></ul><ul><li>Valid unmet need </li></ul><ul><li>Proposed technology innovation </li></ul><ul><li>Collaborative nature of the project </li></ul><ul><li>Concrete deliverables & measures of success </li></ul><ul><li>Longer term probability of clinical adoption </li></ul><ul><li>Short term probability of levering follow-on investment </li></ul>What do we look for?
  15. 16. <ul><li>Proactive scoping of unmet need </li></ul><ul><li>Community of ‘Site Miners’ </li></ul><ul><li>Focused workshops </li></ul><ul><li>Joint AHSC initiatives </li></ul><ul><li>Patient opinion – focus groups </li></ul><ul><li>(Stroke Association, Colostomy Care, </li></ul><ul><li>and Arthritis Research UK) </li></ul>Medicine Nursing Paediatrics Surgery Cancer care
  16. 17. <ul><li>Creating partnerships – Site Miners </li></ul>Imaging Computing Chemistry UMIP CIMIT TrusTECH Pharmacy & materials Photon Sciences Microfulidics & microfabrication
  17. 18. Christie Cancer urology, pathology medical physics, University of Manchester Chem eng, Tissue eng, Biomaterials, Polymer chem, Photon sciences, Biomed eng, Electrical & electronic eng, Manchester informatics, Mechanical and aerospace eng, Pharmaceutical sciences, Material sciences CMFT Rehab, renal medicine ENT/ head and neck surgery, maternal & foetal health, ophthalmic surgery, radiology, cardiovascular, nephrology, paediatric neurology Salford Rheumatology, diabetes, Dermatology, GI neurosciences, Salford PCT Vascular South Plastic surgery, vascular surgery, transfusion services, respiratory
  18. 19. Science Bridge Connections University of Manchester South Man CMFT Adults CMFT Children’s Tissue Engineering Chemical Eng & cardiovascular Med Pharmacy / biomaterials Mathematics Christie Wolfson Molecular Imaging/ neurology Rehab Science Plastic surgery Respiratory medicine Biomedical imaging ENT Anaesthetics Paediatric oncology Paediatric ICU Neurology Neonatology Terenghi Yuan El-deredy Parker Lionheart McCann Oldham McGrouther Woodcock Fowler Herholz Homer Coleman Makin Playfor Martland Tirelli Psychological Sciences Electrical Eng. Victor MIT Harvard Medical School Draper Lab Boston University Brigham Women’s Massachusetts General Boston Children’s Tissue Engineering Guttag Biomed Engineering Radiology Neurology Biomedical Engineering Rehabilitation Services Pathology & Health Sciences Laryngeal Surgery and Voice Rehab Anaesthetics Paediatric ICU Grinstaff Kikinis Schacter Trevejo Borenstein Zaman Stevenson Schoen Hillman Goldman Wolf Gaydecki Salford Royal Adult ICU Dark
  19. 20. Examples of projects
  20. 21. Cumulative disclosures 61 considered, 22 funded, 12 under consideration)
  21. 22. <ul><li>The outputs: </li></ul><ul><li>Patent filed </li></ul><ul><li>Medical Futures grant awarded </li></ul><ul><li>UMIP PoP funding awarded </li></ul><ul><li>i4i funding awarded >£1million </li></ul><ul><li>UK Centre for Tissue Regeneration </li></ul><ul><li>Sandra Downes, Georgio Terenghi, </li></ul><ul><li>Paul Kingham & </li></ul><ul><li>Gus McGrouther </li></ul><ul><li>The need: Surgical repair of severed peripheral nerves </li></ul><ul><li>The solution: Novel fabricated peripheral nerve conduits </li></ul>
  22. 23. <ul><li>The outputs: </li></ul><ul><li>Patents filed </li></ul><ul><li>UMIP PoP funding awarded </li></ul><ul><li>RCUK Science Bridges award </li></ul><ul><li>Industry collaboration </li></ul><ul><li>Maria Basanta, </li></ul><ul><li>Paul Dark & </li></ul><ul><li>Stephen Fowler </li></ul><ul><li>The need: Point of care testing for respiratory disease </li></ul><ul><li>The solution: Novel breath collection device </li></ul>
  23. 24. <ul><li>The outputs: </li></ul><ul><li>Aerospace engineering collaboration </li></ul><ul><li>Publication in high impact journals </li></ul><ul><li>Tissue engineered constructs under development </li></ul><ul><li>Ali Turan & </li></ul><ul><li>Xue-feng Yuan </li></ul><ul><li>The need: Aneurysms that cannot be treated with conventional stent grafts require custom solutions. </li></ul><ul><li>The solution: Novel computer simulation & tissue engineered constructs </li></ul>
  24. 25. <ul><li>The outputs: </li></ul><ul><li>SME collaboration </li></ul><ul><li>UMIP PoP funding awarded </li></ul><ul><li>Patent protected </li></ul><ul><li>Commercialisation strategy </li></ul><ul><li>Suresh Victor & </li></ul><ul><li>Patrick Gaydecki </li></ul><ul><li>The need: Can’t monitor EEG in pre term infants </li></ul><ul><li>The solution: Novel signal capture and processing device </li></ul>
  25. 26. <ul><li>The outputs: </li></ul><ul><li>Prototype moulds developed </li></ul><ul><li>MHRA approval being sought </li></ul><ul><li>Plan to go to clinical trial 2011 </li></ul><ul><li>Nicola Tirelli, </li></ul><ul><li>Saqhir Sadiq </li></ul><ul><li>& Brian Derby </li></ul><ul><li>The need: Conventional tear duct stents don’t work and dramatic surgery required </li></ul><ul><li>The solution: Novel tissue engineered stent </li></ul>
  26. 27. <ul><li>The outputs: </li></ul><ul><li>Prototype developed & undergoing clinical evaluation </li></ul><ul><li>Substantial follow on grant funding </li></ul><ul><li>UMIP PoP funding awarded </li></ul><ul><li>Patents filed and granted </li></ul><ul><li>Numerous publications </li></ul><ul><li>Hugh McCann & </li></ul><ul><li>Anthony Jones </li></ul><ul><li>The need: Treatment for chronic pain hampered by lack of knowledge of the brains' response </li></ul><ul><li>The solution: Real time pain assessment using electrical impedance tomography </li></ul>
  27. 28. <ul><li>The outputs: </li></ul><ul><li>Prototype developed </li></ul><ul><li>Exploratory testing underway </li></ul><ul><li>Medical Research Council Development Pathway funding </li></ul><ul><li>Mark Dickinson, </li></ul><ul><li>Paul Brenchley, </li></ul><ul><li>Andrea Murray, </li></ul><ul><li>Arianne Herrick, </li></ul><ul><li>Helen Young & </li></ul><ul><li>Titus Augustine </li></ul><ul><li>The need: Assessing response to anti-angiogenic and anti-fibrotic therapies </li></ul><ul><li>The solution: Development of optical coherence tomography as a clinical imaging tool </li></ul>
  28. 29. <ul><li>The outputs: </li></ul><ul><li>World wide patents granted </li></ul><ul><li>SME collaboration </li></ul><ul><li>UMIP facilitated licence agreement </li></ul><ul><li>>£5million venture capital funded </li></ul><ul><li>Global company expressions of interest </li></ul><ul><li>>£200k industry sponsored research funding </li></ul><ul><li>Bionow Healthcare Project of the Year 2010 </li></ul><ul><li>Femeda & </li></ul><ul><li>Jackie Oldham </li></ul><ul><li>The need: Solving stress incontinence </li></ul><ul><li>The solution: Novel ‘tampon like’ pelvic floor muscle stimulator </li></ul>
  29. 30. <ul><li>The outputs: </li></ul><ul><li>Extensive patient opinion sought </li></ul><ul><li>Three prototypes developed </li></ul><ul><li>Industry partnership established </li></ul><ul><li>Lou Harris, </li></ul><ul><li>Peter Fielden, </li></ul><ul><li>Shaheen Hamdy </li></ul><ul><li>& John New </li></ul><ul><li>The need: To overcome problems with ‘pancaking’ in colostomy bags </li></ul><ul><li>The solution: Development of a better colostomy bag </li></ul>
  30. 31. <ul><li>The Future for Healthcare Innovation: </li></ul><ul><ul><li>DRIVEN BY UNMET HEALTHCARE NEED (clinician and patient) </li></ul></ul><ul><ul><li>Partnership working including optimised opportunity for early industry collaboration </li></ul></ul><ul><ul><li>Close operational interface with Intellectual property offices </li></ul></ul><ul><ul><li>Rigorous process of project selection- output focussed </li></ul></ul><ul><ul><li>Rigorous innovation development pathway </li></ul></ul><ul><ul><li>Proactive facilitation of grant leverage </li></ul></ul>
  31. 32. MIMIT TM is supported by: Manchester Academic Health Science Centre (MAHSC)

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