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Pharmaceutical processings in ay

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Pharmaceutical Processings in Ayurveda and way out with core by Anand Chaudhary, Associate Professor, Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu …

Pharmaceutical Processings in Ayurveda and way out with core by Anand Chaudhary, Associate Professor, Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi - email-anandayubhu@gmail.com

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  • 1. Anand Chaudhary Associate Professor Department of Rasa Shastra Faculty of Ayurveda  Institute of Medical Sciences  Banaras Hindu University Varanasiemail‐anandayubhu@gmail.com
  • 2. Questions /Contents 01‐ Are the principles of herbal drug processing and mineral  drug processing same ?02‐Are there any parameters to know the physical change  in source material ?03‐What are the reasons for selection of particular process  of particular drug ?04‐What is the basis of selection of particular drugs for  particular formulations  ? CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 3
  • 3. Contd.05 ‐What is the relevance of repetition cycles especially for  production of Bhasma and Khalviya rasa kalpa ?06‐Principles of Stability are based on what logic ? 07‐Is there any co relation between principles of  formulations applied to Ayurvedic drugs and modern  drugs ? CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 4
  • 4. Herbal Drug – Ayurvedic Medicine  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 5
  • 5. Authoritative Authentication  Classical considerations Contemporary  contemplations CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 6
  • 6. Sanitization & Storage  Separation Segregation  Sustainable      CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 7
  • 7. Processing CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 8
  • 8. Container Consensus  Primary dosage forms  Secondary dosage forms  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 9
  • 9. Comminution Size ReductionMechanical Pressure                          Solvency Procedures                      CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 10
  • 10. Extraction Universal Solvent  Other Solutions Suspensions  Nano suspensions  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 11
  • 11. Energy Agenda  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 12
  • 12. SolventsCME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 13
  • 13. Completion Criteria  As per different dosage forms CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 14
  • 14. Procurement & Packing  As per Prepared Medicaments CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 15
  • 15. Delivery & Dispensing  As per indications of Physicians CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 16
  • 16. Mineral Drug – Ayurvedic Medicine   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 17
  • 17. Individualistic  Identification Conventional  connotations  Current  conjectures   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 19
  • 18. Processing CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 20
  • 19. Contd .CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 21
  • 20. Adaptations Modification – Physical    (Heterogeneous to homogenous) Chemical  Conversion Enhancement CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 22
  • 21. Impacts Purification Reduction in adverse effects  Induction of trace elements Alteration in Constituencies CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 23
  • 22. Metallographic findings Metallographic figure of Raw Metallographic figure of ShodhitaSwarna Makshika (M= 400X). Swarna Makshika (M= 400X). CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 24
  • 23. Initial StrideCME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 25
  • 24. Marana• Sukshmikaran (Fine powdering)• Chakrika Nirmana (Pellet formation)‐ With other ingredients.• Samputi Karana (Sealing in earthen vessels)• Puta CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 26
  • 25. Intrinsic Worth • Maximum Temperature range• Duration of Maximum temperature• Self Cooling• Repetition of process  1. Hardness 2. Particle size 3. Chemical Constituents CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 27
  • 26. VividnessCME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 28
  • 27. Explicitness 1200 1000temperature 800 Temperature 600 (0C) 400 200 0 1 4 7 10 13 16 19 time in min. (1 = 15 units) CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 29
  • 28. Magnitude Conversion  Potentiation Elimination Safety CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 30
  • 29. MakshikaSEM Feature of Raw S. M SEM Feature of Bhasma S. M CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 31
  • 30. Lauha BhasmaNeetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffractionand Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine,2010, 1(3), 143-149 CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 32
  • 31. Rasa SindoorTransmission electron microscopy (TEM) images (a, b, and c) along withselected area electron diffraction pattern (SAED) pattern (d) showing thepresence of sub-micron size, agglomerated, and crystalline particles in the drugRasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 33
  • 32. Rasa SindoorScanning electron microscopy (SEM) image of the Rasa-Sindoorshowing the plate like porous surface morphology. Inset to the figureshows the tiny voids presents in the material, S K Singh et al ,2011, Deptof Physics ,BHU CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 34
  • 33. Miscellaneous  Procurement   Packing   Dispensing  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 35
  • 34. Recent Researches Manufacturing Characterization Safety & Efficacy CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 36
  • 35. ObservationsScientific Approach  Stakeholders   Deptt of AYUSH,GOI  Deptt of DST,GOI  Academic Institutes   Research Organizations  ??????? CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 37
  • 36. Characterizations  IIT ,Rooraki Kumar A  IIT, Mumbai Bellare Jayesh  IIT ,Kharagpur Roy SubratoCME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 38
  • 37. Safety  Schedule Y , D & C Rule  1945  Rule 170 , D & C Rule  1945 – 24 Dec , 2008CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 39
  • 38. Rays of Radiance  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 40
  • 39. Selective Selection Artificial Addition  Inherent   Innate  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 41
  • 40. Supervises Solubility Developmental Doctrine  Progressive  Preferences   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 42
  • 41. Probable  Postulation Bio accumulation  Bio detoxification  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 43
  • 42. Reductionist Relativity  Contour  Conversion Eternal  Endowment  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 44
  • 43. Procedural Principal  Blending   Thermodynamics CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 45
  • 44. Assertive Assumptions Visionary  Validation  Rational Realization  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 46
  • 45. Extended Elegance  Explanation  Elucidation CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 47
  • 46. Prominent  Paramount  Herculean  Herbal Metamorphic  Metal  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 48
  • 47. Absolve  Absorption Organic  Order   Actual  Accomplishment  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 49
  • 48. Pragmatic Paradigms Momentous   Mercury  Poise  Parada CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 50
  • 49. Authentic AuthenticityCME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 51
  • 50. Bhasma as Nano‐medicine Global  Guidance   Crucial  Clause  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 52
  • 51. Stop PressAdditional GMP  Additional Certification  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 54
  • 52. Enlighten EndorsementCausative Consultation  Comprehensive  communication  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 55
  • 53. Special Submission CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 56
  • 54. Exigency in Education CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 57
  • 55. Take Home Message  Indian Inheritance  Authoritative  Agenda  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 58
  • 56. Conclusion Ayurveda is Super Science!Rasa Shastra is Super Chemistry! All is Well  Dosage forms of Rasa Shastra & Bhaishjya Kalpana ‐ Super Pharmaceutics ?   CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 59
  • 57. Acknowledgement  Prof A Wele ,Head , Dept of Rasa Shastra,  College of Ayurveda, Bharati Vidyapeetha ,Pune All Team Rasa Shastra , BV ,Pune All Scholastic Scholars of Rasa Shastra at  Pune from 25/07/2011 to 30/07/2011  CME for Teachers  in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 60
  • 58. Thanks & All Good Wishes ‐‐‐‐‐ CME for Teachers  in Rasa Shastra , College of Ayurveda  ,Bharati Vidyapeetha,Pune 25 July ,2011 61