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Pharmaceutical ac

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  • 1. PRINCIPLES OF PHARMACEUTICALS PROCESSINGOF HERBAL AND MINERAL DRUGS Anand Chaudhary Associate Professor Department of Rasa Shastra Faculty of Ayurveda Institute of Medical Sciences Banaras Hindu University Varanasi email-anandayubhu@gmail.com
  • 2. Ayurvedic Astuteness
  • 3. Questions /Contents01- Are the principles of herbal drug processing and mineral drug processing same ?02-Are there any parameters to know the physical change in source material ?03-What are the reasons for selection of particular process of particular drug ?04-What is the basis of selection of particular drugs for particular formulations ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 3
  • 4. Contd.05 -What is the relevance of repetition cycles especially for production of Bhasma and Khalviya rasa kalpa ?06-Principles of Stability are based on what logic ?07-Is there any co relation between principles of formulations applied to Ayurvedic drugs and modern drugs ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 4
  • 5. Herbal Drug – Ayurvedic Medicine CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 5
  • 6. Authoritative Authentication Classical considerations Contemporary contemplations CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 6
  • 7. Sanitization & Storage Separation Segregation Sustainable CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 7
  • 8. Processing Mass transfer Solubility Herbal Comminution ExtractionCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 8
  • 9. Container Consensus Primary dosage forms Secondary dosage forms CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 9
  • 10. Comminution Size ReductionMechanical Pressure Solvency Procedures CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 10
  • 11. Extraction Universal Solvent Other Solutions Suspensions Nano suspensions CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 11
  • 12. Energy Agenda Natural Intrinsic Extrinsic FormulationsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 12
  • 13. Solvents Aqueous Oleaginous Alcohol Oil Ghee EthylCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 13
  • 14. Completion Criteria As per different dosage formsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 14
  • 15. Procurement & Packing As per Prepared MedicamentsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 15
  • 16. Delivery & Dispensing As per indications of PhysiciansCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 16
  • 17. Mineral Drug – Ayurvedic Medicine CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 17
  • 18. Classical Connotation
  • 19. Individualistic Identification Conventional connotations Current conjectures CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 19
  • 20. ProcessingShodhan – Specific Bhavana – Bravura Marana – Magnificent CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 20
  • 21. Contd . Jarana Satvapatan Amritikaran LohitikaranCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 21
  • 22. Adaptations Modification – Physical (Heterogeneous to homogenous) Chemical Conversion Enhancement CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 22
  • 23. Impacts Purification Reduction in adverse effects Induction of trace elements Alteration in Constituencies CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 23
  • 24. Metallographic findingsMetallographic figure of Raw Metallographic figure of ShodhitaSwarna Makshika (M= 400X). Swarna Makshika (M= 400X). CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 24
  • 25. Initial StrideCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 25
  • 26. Marana• Sukshmikaran (Fine powdering)• Chakrika Nirmana (Pellet formation)- With other ingredients.• Samputi Karana (Sealing in earthen vessels)• Puta CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 26
  • 27. Intrinsic Worth• Maximum Temperature range• Duration of Maximum temperature• Self Cooling• Repetition of process 1. Hardness 2. Particle size 3. Chemical Constituents CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 27
  • 28. VividnessCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 28
  • 29. Explicitness 1200 1000temperature 800 Temperature 600 (0C) 400 200 0 1 4 7 10 13 16 19 time in min. (1 = 15 units) CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 29
  • 30. Magnitude Conversion Potentiation Elimination Safety CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 30
  • 31. MakshikaSEM Feature of Raw S. M SEM Feature of Bhasma S. M CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 31
  • 32. Lauha BhasmaNeetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffractionand Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine,2010, 1(3), 143-149 CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 32
  • 33. Rasa SindoorTransmission electron microscopy (TEM) images (a, b, and c) along withselected area electron diffraction pattern (SAED) pattern (d) showing thepresence of sub-micron size, agglomerated, and crystalline particles in the drugRasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 33
  • 34. Rasa SindoorScanning electron microscopy (SEM) image of the Rasa-Sindoorshowing the plate like porous surface morphology. Inset to the figureshows the tiny voids presents in the material, S K Singh et al ,2011, Deptof Physics ,BHU CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 34
  • 35. Miscellaneous Procurement  Packing  Dispensing CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 35
  • 36. Recent ResearchesManufacturingCharacterizationSafety & Efficacy CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 36
  • 37. ObservationsScientific Approach Stakeholders  Deptt of AYUSH,GOI  Deptt of DST,GOI  Academic Institutes  Research Organizations  ??????? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 37
  • 38. Characterizations  IIT ,Rooraki Kumar A  IIT, Mumbai Bellare Jayesh  IIT ,Kharagpur Roy SubratoCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 38
  • 39. Safety  Schedule Y , D & C Rule 1945  Rule 170 , D & C Rule 1945 – 24 Dec , 2008CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 39
  • 40. Rays of RadianceCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 40
  • 41. Selective SelectionArtificial Addition Inherent Innate CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 41
  • 42. Supervises SolubilityDevelopmental Doctrine Progressive Preferences CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 42
  • 43. Probable PostulationBio accumulation Bio detoxification CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 43
  • 44. Reductionist RelativityContour Conversion Eternal Endowment CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 44
  • 45. Procedural Principles Blending ThermodynamicsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 45
  • 46. Assertive AssumptionsVisionary Validation Rational Realization CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 46
  • 47. Extended Elegance Explanation ElucidationCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 47
  • 48. Prominent ParamountHerculean Herbal Metamorphic Metal CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 48
  • 49. Absolve AbsorptionOrganic Order Actual Accomplishment CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 49
  • 50. Pragmatic ParadigmsMomentous Mercury Poise Parada CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 50
  • 51. Authentic AuthenticityCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 51
  • 52. Bhasma as Nano-medicineGlobal Guidance Crucial Clause CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 52
  • 53. Exceptional Embodiment
  • 54. Stop PressAdditional GMP Additional Certification CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 54
  • 55. Enlighten EndorsementCausative Consultation Comprehensive communication CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 55
  • 56. Special SubmissionCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 56
  • 57. Wisdomnary VisionCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 57
  • 58. Exigency in EducationCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 58
  • 59. Take Home MessageIndian Inheritance Authoritative Agenda CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 59
  • 60. ConclusionAyurveda is Super Science!Rasa Shastra is Super Chemistry! All is Well Dosage forms of Rasa Shastra & Bhaishjya Kalpana - Super Pharmaceutics ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 60
  • 61. Acknowledgement Prof A Wele ,Head , Dept of Rasa Shastra, College of Ayurveda, Bharati Vidyapeetha ,Pune All Team Rasa Shastra , BV ,Pune All Scholastic Scholars of Rasa Shastra at Pune from 25/07/2011 to 30/07/2011 CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 61
  • 62. Thanks & All Good Wishes ----- CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 62