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PRINCIPLES OF PHARMACEUTICALS PROCESSINGOF HERBAL AND MINERAL DRUGS Anand Chaudhary Associate Professor Department of Rasa Shastra Faculty of Ayurveda Institute of Medical Sciences Banaras Hindu University Varanasi email-anandayubhu@gmail.com
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Questions /Contents01- Are the principles of herbal drug processing and mineral drug processing same ?02-Are there any parameters to know the physical change in source material ?03-What are the reasons for selection of particular process of particular drug ?04-What is the basis of selection of particular drugs for particular formulations ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 3
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Contd.05 -What is the relevance of repetition cycles especially for production of Bhasma and Khalviya rasa kalpa ?06-Principles of Stability are based on what logic ?07-Is there any co relation between principles of formulations applied to Ayurvedic drugs and modern drugs ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 4
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Herbal Drug – Ayurvedic Medicine CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 5
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Authoritative Authentication Classical considerations Contemporary contemplations CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 6
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Sanitization & Storage Separation Segregation Sustainable CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 7
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Processing Mass transfer Solubility Herbal Comminution ExtractionCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 8
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Container Consensus Primary dosage forms Secondary dosage forms CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 9
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Comminution Size ReductionMechanical Pressure Solvency Procedures CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 10
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Extraction Universal Solvent Other Solutions Suspensions Nano suspensions CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 11
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Energy Agenda Natural Intrinsic Extrinsic FormulationsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 12
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Solvents Aqueous Oleaginous Alcohol Oil Ghee EthylCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 13
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Completion Criteria As per different dosage formsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 14
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Procurement & Packing As per Prepared MedicamentsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 15
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Delivery & Dispensing As per indications of PhysiciansCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 16
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Mineral Drug – Ayurvedic Medicine CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 17
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Individualistic Identification Conventional connotations Current conjectures CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 19
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ProcessingShodhan – Specific Bhavana – Bravura Marana – Magnificent CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 20
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Contd . Jarana Satvapatan Amritikaran LohitikaranCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 21
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Adaptations Modification – Physical (Heterogeneous to homogenous) Chemical Conversion Enhancement CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 22
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Impacts Purification Reduction in adverse effects Induction of trace elements Alteration in Constituencies CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 23
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Metallographic findingsMetallographic figure of Raw Metallographic figure of ShodhitaSwarna Makshika (M= 400X). Swarna Makshika (M= 400X). CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 24
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Initial StrideCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 25
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Marana• Sukshmikaran (Fine powdering)• Chakrika Nirmana (Pellet formation)- With other ingredients.• Samputi Karana (Sealing in earthen vessels)• Puta CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 26
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Intrinsic Worth• Maximum Temperature range• Duration of Maximum temperature• Self Cooling• Repetition of process 1. Hardness 2. Particle size 3. Chemical Constituents CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 27
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VividnessCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 28
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Explicitness 1200 1000temperature 800 Temperature 600 (0C) 400 200 0 1 4 7 10 13 16 19 time in min. (1 = 15 units) CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 29
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Magnitude Conversion Potentiation Elimination Safety CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 30
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MakshikaSEM Feature of Raw S. M SEM Feature of Bhasma S. M CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 31
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Lauha BhasmaNeetu Singh et al , Chemical Characterization of Lauha Bhasma by X-Ray Diffractionand Vibrating Sample Magnetometry International Journal of Ayurvedic Medicine,2010, 1(3), 143-149 CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 32
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Rasa SindoorTransmission electron microscopy (TEM) images (a, b, and c) along withselected area electron diffraction pattern (SAED) pattern (d) showing thepresence of sub-micron size, agglomerated, and crystalline particles in the drugRasa-Sindoor. S K Singh et al 2011 ,dept of Physics, BHU CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 33
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Rasa SindoorScanning electron microscopy (SEM) image of the Rasa-Sindoorshowing the plate like porous surface morphology. Inset to the figureshows the tiny voids presents in the material, S K Singh et al ,2011, Deptof Physics ,BHU CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 34
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Miscellaneous Procurement Packing Dispensing CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 35
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Recent ResearchesManufacturingCharacterizationSafety & Efficacy CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 36
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ObservationsScientific Approach Stakeholders Deptt of AYUSH,GOI Deptt of DST,GOI Academic Institutes Research Organizations ??????? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 37
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Characterizations IIT ,Rooraki Kumar A IIT, Mumbai Bellare Jayesh IIT ,Kharagpur Roy SubratoCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 38
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Safety Schedule Y , D & C Rule 1945 Rule 170 , D & C Rule 1945 – 24 Dec , 2008CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 39
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Rays of RadianceCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 40
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Selective SelectionArtificial Addition Inherent Innate CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 41
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Supervises SolubilityDevelopmental Doctrine Progressive Preferences CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 42
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Probable PostulationBio accumulation Bio detoxification CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 43
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Reductionist RelativityContour Conversion Eternal Endowment CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 44
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Procedural Principles Blending ThermodynamicsCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 45
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Assertive AssumptionsVisionary Validation Rational Realization CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 46
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Extended Elegance Explanation ElucidationCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 47
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Prominent ParamountHerculean Herbal Metamorphic Metal CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 48
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Absolve AbsorptionOrganic Order Actual Accomplishment CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 49
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Pragmatic ParadigmsMomentous Mercury Poise Parada CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 50
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Authentic AuthenticityCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 51
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Bhasma as Nano-medicineGlobal Guidance Crucial Clause CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 52
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Stop PressAdditional GMP Additional Certification CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 54
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Enlighten EndorsementCausative Consultation Comprehensive communication CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 55
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Special SubmissionCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 56
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Wisdomnary VisionCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 57
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Exigency in EducationCME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 58
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Take Home MessageIndian Inheritance Authoritative Agenda CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 59
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ConclusionAyurveda is Super Science!Rasa Shastra is Super Chemistry! All is Well Dosage forms of Rasa Shastra & Bhaishjya Kalpana - Super Pharmaceutics ? CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 60
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Acknowledgement Prof A Wele ,Head , Dept of Rasa Shastra, College of Ayurveda, Bharati Vidyapeetha ,Pune All Team Rasa Shastra , BV ,Pune All Scholastic Scholars of Rasa Shastra at Pune from 25/07/2011 to 30/07/2011 CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 61
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Thanks & All Good Wishes ----- CME for Teachers in Rasa Shastra , College of Ayurveda ,Bharati Vidyapeetha,Pune 25 July ,2011 62
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