Issues of neuro ageing ksr-ppt


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Issues of neuro ageing ksr-ppt

  1. 1. Issues of Neuro ageing –Specific Ayurvedic Approach Prof. Dr. K. Shiva Rama Prasad M.D.(Ay) COP (German), M.A, Ph.D. (Jyotish) Prof.,H.O.D PG (Kayachikitsa), DGM Ayurveda Memorial College, SV Savadi Road, Gadag, 09448746450 / 09290566566 / 1 09290566566
  2. 2. • A man rises from India makes Thursday as Holiday rules all and takes them to long way in to stars to start new civilization - Nostradamus• We are getting started an initiation to make the Prophecies true / 2 09290566566
  3. 3. • Life is a Journey and the Death is a Stage.Think ! • Life is the sum of the functions that resist death. • Xavier Bichat 1771-1802 French surgeon, Paris • Aging is a natural process of being and ultimately the being is subjected for death. / 3 09290566566
  4. 4. • The ageing is of either physical (Body) or psychological (Mental) maturity• The organic process of growing older and showing the effects of increasing age is under the influence of fourth dimension - Time / 4 09290566566
  5. 5. Man took all refusal age portions than got 100 years to become “Shatayu” - Living like them • All Beings• Mother refused but nature • Man wants provide Life more years• Man 30 • Donkey 20 years refuse years • Dog 15 years• Donkey refuse 30 years • Monkey 15• Dog 30 years refuse years • Snake 20 years refuse• Monkey 30 years• Snake 30 years / 5 09290566566
  6. 6. Do we live like animals Sharing Animal instincts• If not . . . We have to know how to live like HUMAN • Such of rejuvenating method at present offers . . . • , , , Take one capsule twice daily or walk 100km, Please. . . / 6 09290566566
  7. 7. Objectives regarding thought/concept• Ayurveda doesn’t have description of Brain as Organ or even physiology & Pathology described in organ specific. So, Ayurveda doesn’t have Brain.• To understand and postulate whether ageing is physical or psychological• Attributing and isolating of the psychological ageing in terms of Psycho-Neuro (Brain) ageing• Finding factors / medicaments for retarding / regulating the Neuro-ageing / 7 09290566566
  8. 8. Internal Environment in Ayurveda• The “kena jalena phalati” “Kapha” – represents the Intracellular compartment• The “slisha alingana” “Shleshma” - represents the Intercellular compartment• The “poshana” “Bala” - represents the Interstitial (Blood) compartment• Apart from – the dual antagonistic qualities of “Sheeta : Ushna” & “Snigdha : Asnigdha” controls the internal environment in Ayurveda / 8 09290566566
  9. 9. •Ayurveda definesbio-availability andsustenance of toxicfree tissue buildingand maintenance byBio-fire, through outthe life span andultimately a voluntarytermination ofbiological needs -Marana. “If Mahamarichadi Taila Nasya A lizard cuts its tail accidentally is done at the “Pradhame can grow once Vayasi” (puberty) of lady – again – can even after attain the old age such task thought by the breast never drops”. Human - Bhavamishra / 9 09290566566
  10. 10. Classification LIFE depends on of Death Death = Cessation Glucose = Rasa Unction = sneha Influencing factors Nutritional deficiency, Systemic Mitochondrial Aging, Cellular Free Radicals rise, Caloric Restriction Beejabhaga Avayava •Apoptotic Mechanism •Tolemere Cardiac Respiratory Cerebral repeated loss •Loss of defensive mechanism Neuro degeneration Cessation Absence of Lower cognitive function Heartbeat breath Verbal & memory loss / 10 09290566566
  11. 11. Death• Death is – The cessation of life i.e. cessation of integrated tissue and organ functions or loss of heartbeat, absence of breathing and cerebral death. / 11 09290566566
  12. 12. • Frailty, The state of • Brain death being weak in health may very well or body - especially be a distinct, from old age is a physiological common entity but this phenomenon or concept of process of biological death is not aging is a complex accepted in phenomenon, many cultures depending on a and much manifold of different anthropological parameters, including evidence exists nature of the to demonstrate organism, lifestyle, this. diet, and so forth. Paul Gill, British anthropologist / 12 09290566566
  13. 13. • Ayurveda believes the re-birth and Karma Vipaka, thus the care for death and old age is not focused as we never care for Sunset as we are conformed of next day sunrise.• The prime goal is to alleviate suffering, and not to prolong life. If treatment does not alleviate suffering, but only prolongs life, that treatment should be stopped. • Christian Barnard 1922-2001 • Pioneer South African heart surgeon / 13 09290566566
  14. 14. • Thought is life • Thoughtlessness is Death (The cessation of life) • Body without thought is functionless • Thought without body is motionlessSequence • Human functions with Body (Hardware) Brain (software) of Death are co-axial components • The sequence of the death starts from – lungs – heart – brain – mind – and ends with soul • Death is manifested by the loss of heartbeat, by the absence of spontaneous breathing, and by cerebral death. / 14 09290566566
  15. 15. • A clinical syndrome characterized by the permanent loss of cerebral and brain stem function,• manifested by absence of responsiveness to external stimuli,• absence of cephalic reflexes, and apnea.• An isoelectric electroencephalogram for at least 30 minutes supports the diagnosis. Cerebral Death (Brain death) / 15 09290566566
  16. 16. Centenarians Symptoms of Menopause & Andropause• Centenarians – Incidence is 1:10000 – Achieving exceptional ages is by genetic variations – Survival advantage is through multifactor• Menopause and Andropause – Hot flashes – Mood swings – Irritability – Depression – Increased risk of osteoporosis, Respiratory, cardiovascular disease – Age-associated diseases / 16 09290566566
  17. 17. • Neurodegenerative diseases• Progressive impairment• A consequence of ongoing neuronal cell death• Brain cell Apoptotic mechanisms• Elderly experience includes – – steeper decline in cognitive function – lower cognitive performance – Disturbed endogenous estradiol (Sukra) levels Observations of Brain Ageing / 17 09290566566
  18. 18. 10 visible signs of Ageing 1. Hair loss 2. Eyes (Visual disturbances) 3. Ears (Hearing loss) 4. Lost Teeth 5. Wrinkled Facial skin 6. Dropped Breasts 7. Dry loose Body skin 8. Thin Buttocks 9. Raised Veins 10. Weak Muscles and bones / 18 09290566566
  19. 19. Prominent Seven Signs of Ageing1. Lines and wrinkles2. Uneven skin texture3. Uneven skin tone4. Appearance of pores5. Blotches and age spots6. Dry skin7. Dullness / 19 09290566566
  20. 20. Gender Differences of Ageing / 20 09290566566
  21. 21. Real Seven Signs of observance 1. Emotional maturity appears 2. Wisdom, self-confidence, self- esteem develops 3. Owning your own house fulfills 4. Sense of perspective on life inclines 5. Sexual confidence deprives 6. Career develops 7. Financial security obtains / 21 09290566566
  22. 22. Brain / Neuro Ageing• Brain (Mastaka Majja) size decreases with advancing age; after the age of 60 years, its size declines by 5 to 10%• Brain Aging is associated with a progressive decline in the synthesis of neurotransmitters and a decline in their corresponding receptors (? function of Pranavata) / 22 09290566566
  23. 23. Brain / Neuro Ageing• A major functional change is slower reaction times, which may be the result of a slower nerve conduction or trans- synaptic speed• Visual acuity tends to decrease with age progression & Diminished ability of the lens - reduced ability to distinguish colors• Anatomic changes, such as tissue laxity is witnessed / 23 09290566566
  24. 24. Brain / Neuro Ageing• Sleep patterns change with advancing age - older adults are more wakeful during the night and spend much more time in bed - a more fragmented pattern, with frequent awakenings in late life / 24 09290566566
  25. 25. Brain / Neuro Ageing• Neuropsychiatric aspects of Age-related symptoms of benign senescence, slowed reaction time, postural hypotension, vertigo or giddiness, presbyopia, presbycusis, stiffened gait, and sleep difficulties / 25 09290566566
  26. 26. AGE-RELATED PHYSIOLOGIC CHANGES IN THE CENTRAL NERVOUS SYSTEM1) Neuroanatomic changes – Brain atrophy (? Majja kshaya) – Decreased neuron counts (? Vata Kshaya) – Increased neuritic plaques – Increased lipofuscin and melanin (? Sneha kshaya)2) Neurotransmitter changes (? Gati nirodha) – Decline in cholinergic transmission – Decreased dopaminergic synthesis – Decreased catecholamine synthesis3) Neurophysiologic changes – Decreased cerebral blood flow – Electrophysiologic changes (slowing of alpha rhythm, increased latencies in evoked responses) / 26 09290566566
  27. 27. NEUROPSYCHIATRIC MANIFESTATIONS OF AGE-RELATED PHYSIOLOGIC CHANGESSystem ManifestationCognition Forgetfulness Processing speed declines throughout adult life Neuropsychological declines: selective attention, verbal fluency, retrieval, complex visual perception, logical analysisReflexes Stretch reflexes lose sensitivity Decreased or absent ankle reflexes Decreased autonomic and righting reflexes, postural instabilitySensory Presbycusis (high-frequency hearing loss), tinnitus Deterioration of vestibular system, vertigo Presbyopia (decreased lens elasticity) Slowed pupil reactivity, decreased upgaze Olfactory system deterioration Decreased vibratory sensationGait and Gait stiffer, slowed, forward flexed balance Increased body sway and mild unsteadinessSleep Decreased sleep efficiency, fatigue Increased awakenings, insomnia Decrease in sleep stages 3 and 4 / 27 Sleep duration more variable, more09290566566 naps
  28. 28. Sequential Loss of Biological Qualities in AgingDecades Years Losses (Vagbhata) Losses (Sharangdhara)First 0-10 Balya (Boyishness) BalyaSecond 11-20 Vrddhi (Growth) VriddhiThird 21-30 Prabha (Luster) Chhabi (Beauty)Fourth 31-40 Medha (Intellect) MedhaFifth 41-50 Twaca (Skin) TwacaSixth 51-60 Sukra (Sexual Ability) Drsti (Vision)Seven 61-70 Drsti (Vision) Sukra (Sexual Ability)Eighth 71-80 Srotrendriya (Audition) Vikram (Strength)Ninth 81-90 Mana (Psyche) Buddhi (Wisdom)Tenth 91-100 Sparshanendriya (Psychomotor Karmendriya (Locomotor function) Activity) oÉÉsrÉÇ uÉ×ήuÉïmÉÑqÉåïkÉÉ iuÉaSìÖ̹ zÉÑ¢üÌuÉ¢üqÉÉæ oÉÑή: MüqÉåïÎlSìrÉÇ cÉåÌiÉ eÉÏÌuÉiÉÇ SzÉiÉÉå ¾ûxÉåiÉç zÉÉ.xÉÇ.mÉÔ.6/20 / 28 09290566566
  29. 29. Ayurvedic sevenstages of Ageing • loss of Prabha (luster) @ 20 + • Medha (Intellect) @ 30 + • Twak (Wrinkling skin) @ 40 + • Sukra (estrogens) @ 50 + • Drusti (vision) @ 60 + • Vikrama (strength) and Srotram (Hearing) @ 70+ • Buddhi (wisdom) and Manas (psyche) @ 80+ • The seven step ageing includes - intellect, Vision, Sukra and wisdom, are of Brain / psycho-neuro connected. / 29 09290566566
  30. 30. Influencing factors• Nutritional deficiency (Rasa)• Mitochondrial Aging (Pitta)• Free Radicals rise (Ama)• Caloric Restriction (Vata)• Beejabhaga Avayava (Genetically) / 30 09290566566
  31. 31. Forces acting on cell injury Cell Bubble Pressure (Vata)Intra capsule temperature (Pitta) Mass resistance (Kapha) Surface tension External forces – Cytosolic calcium (Vata) pressure (Gravity), Oxygen toxicity (Pitta) Temperature & Free Radicles (Kapha) Mass resistance Ischemia (Rakta) / 31 09290566566
  32. 32. Factors influencing Longevity• Contemporary system – Environmental – Genetic characteristics• Ayurveda – Jaati (Race/ genetical) – Desha (Geographical / environmental) – Prakruti (constitution) and – Ahara (Food) / 32 09290566566
  33. 33. • Vata ageing is catabolic that develops Vata in Kapha inversely proportional is anabolic Neuro-ageing• Vata controls the mind which has a referral / functional seat as Brain• Physical ageing refers Kampa, Vepadhu, etc diseases of physical Brain dysfunctions• Chanchalya and deprived functions of the Manas are of psycho-neuro dysfunctions / 33 09290566566
  34. 34. • Pitta, relates with Jara and Jarana• Jara understood as “Paka” i.e. conversional Pitta in process• Dhatupaka, probably Neuro-ageing identified as technical term with reference to tissue ageing• Tissues are growing older and transformed from active building state to the morbid state• Morbid melancholic state is death• Retardation of ageing or slowing the Dhatupaka, termed as Rasayana / 34 09290566566
  35. 35. Ribosomes & Telomeres •Telomeres are the physical ends of linear eukaryotic chromosomes. •Telomeres are composed of short repeated DNA sequences and their• Ribosomes make the associated proteins stuff of life. They are •Many human somatic cells do not the protein factories express sufficient telomerase in every living activity to prevent telomere repeat creature, and they loss, resulting in cell senescence or churn out all proteins ranging from bacterial death when telomeres shorten to a toxins to human critical length. digestive enzymes. •telomere length checkpoint for aging and cell growth is also seen Ageing makes telomerase components deleted, and Rasayana is replacement of cell telomerase components / 35 09290566566
  36. 36. Rasayana understood as -• Retardation of Necrobiosis (the normal degeneration and death of living cells [as in various epithelial cells])• Retardation of Cytokinesis = Organic process consisting of the division of the cytoplasm of a cell following karyokinesis bringing about the separation into two daughter cells• Bio availability = Retardation of Bio- division by supply of abundant requisite nutrients for long term cell maintenance / 36 09290566566
  37. 37. • Rasayana is evolution by natural selection works through differential reproductive success. (Pumsavana, Vajikarana – Eugenics)• Rasayana by managing the flow, distribution, and rate of consumption of finite supplies of glucose (Rasa) and fat (Sneha) (Sequential tissue Progression)• Increased circulating glucose benefits the basic metabolic function of important tissues such as the brain (Rasa Parinama vada) & acts as Rasayana / 37 09290566566
  39. 39. Sheeta Rasayana Ushna Rasayana Seeta Rasayana with Sheeta Ushna Rasayana with Ushnaveerya dravya is considered as veerya dravya is considered asmedical cell Hibernation. cell fluid regulation. Here the cell becomes Here the cell becomesinactivate temporarily with inactivate temporarily withminimal input of nutrients. minimal cell fluid nutrients. In further the body organ In further the body organcomplex sustains life and bio- complex sustains life and bio-energy resources are regulated energy resources are regulated The cell temperature The body temperature regulations from externalregulations from external environment is made to regulateenvironment is necessary to cell mitosis and inactivation ofregulate cell mitosis and cytokines.inactivation of cytokines. The Pippali – is the best of The Amla – is the best of such. such. / 39 09290566566
  40. 40. Bio Psychological Rasayana Sphere Model For Psychosomatic apotheosis Psychological Personality Sphere factors Endocrinal Immune system Genetic Neurotransmitters Emotions MotivationBiologicalSphere factors Social support Stressful life events social norms Social Sphere factors / 40 09290566566
  41. 41. D R. P E R R I C O N E’S 7 Secrets to Beauty, Health, and Longevity• Jump-start cellular metabolism• Not to fanatically count calories to maintain weight & what have to do is learn how to control our blood sugar.• Prevent bone loss & stimulate new bone growth• Rejuvenate from underlying tissue but not superficial• A robust sex life enhances cellular health• Right form of exercise will restore balance, unity, and harmony between mind and body.• Mental and physical stress Control is the key to a long, healthy, and happy life. / 41 09290566566
  42. 42. Mandukaparani Latin - Centella asiatica Kannada - Vondelaga English - Indian Pennywort Parts used - whole plant (panchanga)PropertiesMedhya, rasayana, smrutipradha, (Cha. Chi.1)PittaharaNervine tonic, tranquilizer, improves concentration, intelligence &memoryUsesEpilepsy, Insomnia, lack of concentration, anxiety and related disorders / 42 09290566566
  43. 43. Natural food materials for Vayasthapana (Stagnated ageing) zÉÏiÉÉåSMÇü mÉrÉ: ¤ÉÉæSìÇ xÉÌmÉïËUirÉåMüzÉÉå̲zÉ: ̧ÉzÉxxÉqÉxiÉqÉjÉuÉÉ mÉëÉYmÉÏiÉÇ xjÉÉmÉrÉå²rÉ: xÉÑ.ÍcÉ. 27/4 ¤ÉÏUbÉ×iÉÉprÉÉxÉÉå UxÉÉrÉlÉqÉç – cÉ xÉÔ 25/40 Vayasthapana according to Dosha predominance Four major dietetic ingredients . . .1) Vata Dugdham2) Pitta Ghrutam3) Kapha Madhu4) Rakta Sheetalodaka AjÉ qÉÉÇxÉUxÉÇ xÉÌmÉï: ÍxÉ®Ç xÉ ¤ÉÏUÍqÉwrÉiÉå / 43 09290566566
  44. 44. Upastambha in Rasayana • Ahara – Brahmacharya – Nidra • The food (Rasa) according to Dosha predominance is prescribed as Rasayana • Celibacy retards the productivity not only of semen conservation but also cell division – thus becomes Ayushya • Accepted Sleep schedule is a proved bio-resting phase of minimal psycho-somatic activity by which enhances the longevity / 44 09290566566
  45. 45. Assessment of Rasayana Kashyapa • Rasayana lakshana – Deerghayu – Smruti – Medha – Arogya – Tarunaya Vaya – Vaksiddhi – Shareera Kanti • Dhatu karma – Preenana – Jeevana – Lepa – Snehana – Dharana – Poorana / – Garbhotpatti 45 09290566566
  46. 46. qÉåkÉÉMüUuÉaÉïqÉç –xÉiÉiÉÉkrÉrÉlÉÇ uÉÉS: mÉUiÉl§ÉÉuÉsÉÉåMülÉqÉçiÉ̲±ÉcÉÉrÉïxÉåuÉÉ cÉ oÉÑήqÉåkÉÉMüUÉå aÉÑ(aÉ)hÉ: xÉÑ ÍcÉ 28/24AÉrÉÑwrÉuÉaÉïqÉç –AÉrÉÑwrÉÇ pÉÉãeÉlÉÇ eÉÏhÉåï uÉåaÉÉlÉÉÇ cÉÉÌuÉkÉÉUhÉqÉçoÉë¼cÉrÉïqÉÌWÇûxÉÉ cÉ xÉÉWûxÉÉlÉÉÇ cÉ uÉeÉïrÉåiÉç – xÉÑ ÍcÉ 28/24 / 46 09290566566
  47. 47. • Continuous learning, discussion, learning unknown & being with learned makes ones to never attain “Brain Ageing” or Brain Death.• Insulin production and regulation in the body is directly proportional to the ageing• Methika modakam regulates the Insulin• Regulated Rasa – preenana – makes brain ageing retarded• Disturbed endogenous estradiol (Sukra) level correction (eg: Papaya) is first choice in retarding Brain ageing / 47 09290566566
  48. 48. • Rasayana is obtained by stem cell researches and cell reprogramming by Ushna Rasayana• Rasayana in terms of Telomeres replacement is achieved by the “Ashwagandha” etc as Aushadha or Shatavari as Ahara-Aushadha (Sheeta) Rasayana• Bio Psychological Rasayana Sphere Model or phyto-mineral-bio-available medicine for Psychosomatic apotheosis regulation is necessary for achieving long standing brain function• The role Sheeta/ Ushna Rasayana chosen under Ayurveda internal environment identity is very important in modulating Medhya (Brain) Rasayana / 48 09290566566
  49. 49. It’s from HAVE Knowledge Communicate your questions Dr. K.Shiva Rama Prasad doctorksrprasad@aol.in23/02/200807-03-2008 / 50 09290566566