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ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS
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ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS

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Pierre Guiot, Director Research and Development, Tevan B.V., The Netherlands

Pierre Guiot, Director Research and Development, Tevan B.V., The Netherlands

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  • 1. TBLI CONFERENCE ASIA 2008 BANGKOK, THAILAND Tevan BV – the Netherlands CEO : M.L. GAETHOFS Website: www.tevan.com R&D : Dr. Ir. P. GUIOT
  • 2. ENVIRONMENTALLY FRIENDLY OXIDATIVE AGENTS CHLORINE FREE TEVAN®SIL = HERLISIL® AND CHLORINE AND METAL FREE TEVAN® QA TEVAN® PANOX TEVAN® PANOXO
  • 3. 1. PHYSICAL, CHEMICAL and BIOLOGICAL ASPECTS
  • 4. HYDROGEN PEROXIDE A NATURAL GERM KILLER  Cells involved into the immune system produce hydrogen peroxide  Hydrogen peroxide is thus a natural germ killer  Outside of the immune system hydrogen peroxide needs synergy
  • 5. 2. PREVIOUS SYNERGY PEROXIDE, SILVER SALT
  • 6. PREVIOUS SYNERGY WITH SILVER  Silver modifies proteins  WHO recommendation =  0.1 mg Ag / L water  Catalase is thus neutralized  Ag body retention rate =  0-10%  Hydrogen peroxide can exert its full action  Calculus of Ag2S are formed which are  Silver adsorbs on the germ’s eliminated from the membrane and modifies the body membrane potential  Nevertheless, silver is considered as a heavy metal and its future is questionable vs annex 1 of 98/8/EEC (Ag is already banned in E and P)
  • 7. HERLISIL® Registered in B, NL, F, E, P, GB, D, CH, PL, Ma, Tun, Eg Species Organisms Concentrations Times Norms Bacteria -Pseudomonas 14% 5 min. EN 1276 areuginosa -Staphilococcus aureus -Escherichia coli -Enterococcus hirea -Legionella pneumophila 0.1% 5 min. EN 1276 -Legionella pneumophila 2% 5 min. EN 13 623 -Legionella pneumophila 0.02% 24 hours EN 13 623 -Listeria monocytogenes 0.05% 5 min. NF T 301 -Escherichia coli 0.25% 15 min. IMO Fungi -Aspergillus niger 15% 15 min. EN 1650 -Candida albicans Spores -Bacillus subtilis 10% 20 min. NF T 72 231 -Bacillus cereus -Clostridium sporogenes -Bacillus subtilis 1% 60 min. NF T 72 231 -Bacillus cereus -Clostridium sporogenes Amoeba -Naegleria fowleri 10% 60 min. - Virus -Enterovirus polio 2% 15 min. NF T 72 180 -Orthopox virus -Human adenovirus
  • 8. TEVAN®SIL WELLS REHABILITATION  CLEANING with TEVAN® RAPID TWB (mix of organic and mineral acids, surfactants)  DECONTAMINATION with TEVAN® SIL @ 200 ppm, 24 hours.  RESULTS Problems due to E. coli and Pseudomonas presence are solved
  • 9. TEVAN® SIL IN COOLING TOWER PIPES ‘EFFECT ON BIOFILM’  Tevan® Sil @ 100 ppm for 18 hours  and then @ 500 ppm for 1 additional hour within the glass made pipe’s flow  @ DSM, NL
  • 10. TEVAN® SIL ON REVERSE OSMOSIS MEMBRANES @ VITENS, NL A constant injection of TEVAN® SIL @ 3 ppm prevents membrane clogging and enables a constant water flow in the water installations
  • 11. 3. OTHER SYNERGIES
  • 12. OTHER SYNERGIES Quaternary ammoniums Adsorption on membranes Peracids Oxidizes SH, NH2, Open double bonds Fatty oxo amines Active wetting agents (innovative) Essential oils (terpenic skeleton) Active fragrances (innovative)
  • 13. 3.1. TEVAN® QA’s PEROXIDE, QUATERNARY AMMONIUM
  • 14. TEVAN QA 250 ® Species Organisms Concentrations Times Norms Bacteria -Pseudomonas 4% 5 min. EN 1276 aeruginosa -Staphilococcus aureus -Escherichia coli -Enterococcus hirea -Lactobacillus brevis 3% 5 min. Derived from EN 1276 -Pediococcus damnosus Mycobacteria -Mycobacterium 10% 30 min. NF T 72 301 tuberculosis Fungi -Candida albicans 4% 5 min. EN 1276 Yeasts -Saccharomyces 3% 5 min. Derived from EN 1650 cerevisiae -Saccharomyces diastaticus
  • 15. MULTI INDUCED EVAPORATION TECHNOLOGY  Aerosolisation of TEVAN® QA 80 with CLIM O’ MEDIC enabled good results in laboratories and manufacturing places
  • 16. TEVAN® QA 80 @ Glaxo Smith Kline, Belgium  Treatment of clean rooms and SAS used for vaccines manufacturing in B, F, D, H, USA, CND  Aerosolisation @ 12 g / m3  Droplets of < 10 µm  A Δ Log reduction of 6 is required and obtained for very resistant germs  TEVAN® QA 80 ranked first among 25 products
  • 17. TEVAN® QA 80 @ Bayer Crop Science, Belgium  Aerosolisation  Metatecta Cy. device = Clim’O Medic®  Rooms = from 50 to 150 m3  Droplets = 5-10 µm  Time = 45 min.  RT  Dispersed amount = 10 g / m3  Δ Log > 7 even under tables and inside cabinets  For: – Bacteria = Gram-negative Agrobacterium
  • 18. TEVAN® QA 80 @ Virco (Johnson & Johnson), Belgium  Aerosolisation  Metatecta Cy. device = Clim’O Medic®  Rooms = 60 m3  Droplets = 5-10 µm  Time = 45 min.  RT  Dispersed amount = 10 g/m3  For : HIV’s DNA which is destroyed at 96 %
  • 19. 3.2. TEVAN® PANOX PEROXIDE, PERACID, FATTY OXO AMINE INNOVATIVE: COMBINATION OF 3 ACTIVES
  • 20. TEVAN® PANOX Registered in F, GB, D, CH PASTEUR INSTITUTE FRANCE, 2005/2006 test results Species Organisms Concentrations Times Norms Bacteria -Pseudomonas 0.1% 5 min. EN 1276 aeruginosa -Staphilococcus aureus -Escherichia coli -Enterococcus hirea -Legionella pneumophila -Legionella pneumophila 0.05% 60 min. EN 1276 -Legionella pneumophila 0.02% 24 hours EN 1276 -Legionella pneumophila 1% 5 min. EN 13 623 -Legionella pneumophila 0.02% 24 hours EN 13 623 -Salmonella typhi 0.1% 10 min. EN 1276 Fungi -Aspergillus niger 2% 15 min. EN 1650 -Candida albicans -Tricophyton 0.5% 10 min. EN 1650 mentagrophytes Spores -Bacillus subtilis 5% 30 min. NF T 72 301 -Bacillus cereus -Clostridium sporogenes Mycobacteria -Mycobacterium terrae 3% Δlog5 5 min. AOAC Δlog6 10 min. (FDA approved in USA) Δlog7 20 min. Minntech lab. Virus -Enterovirus polio 2% 15 min. NF T 72 180 -Orthopox virus -Human adenovirus
  • 21. TEVAN® PANOX Study on biofilm at TNO, NL Control Test  A biofilm hosting Pseudomonas aeruginosa was formed on a  A biofilm hosting Pseudomonas aeruginosa was formed on a stainless steel coupon of 0.8 µm roughness stainless steel coupon of 0.8 µm roughness   A 5 min. treatment with TEVAN® PANOX 1% in water was A 5 min. water treatment was achieved achieved  The coupon was rinsed with 1 m3 water / m2 surface / hour  The coupon was rinsed with 1 m3 water / m2 surface / hour  The biofilm stayed on the coupon  The biofilm was removed from the coupon
  • 22. TEVAN® PANOX Study on biofilm at TNO, NL Control Test  After a 5 min. water treatment followed by a water rinsing  After a 5 min. treatment with a 1% concentration of TEVAN® (1 m3 water / m2 surface / hour), the stainless steel coupon PANOX followed by a water rinsing (1 m3 water / m2 surface / (0.8 µm roughness) was dyed with syto 9 and propidium hour), the stainless steel coupon (0.8 µm roughness) was  The Pseudomonas aeruginosa colonies are well apparent dyed with syto 9 and propidium  The Pseudomonas aeruginosa colonies are removed
  • 23. TEVAN® PANOX NATURAL WATER EXTRACTION @ Nestlé Waters Vittel, France  Strains tested and methods used are specific to Nestlé  Product was at 2% with 30 min. contact  A Δlog reduction of 5.5 is obtained for all strains  TEVAN® PANOX is the best product ever tested by Nestlé
  • 24. TEVAN® PANOX Spore forming bacteria Clostridium perfringens on working surfaces in slaughterhouses @ Wouters, NL Formulation @ 0.33% overnight Location After 1 week After 3 weeks After 5 weeks treatment treatment treatment cfu/100 cm2 cfu/100 cm2 cfu/100 cm2 Slaughter place 0 0 0 Carving place 0 0 0 Conditioned >900 0 0 meat warehouse
  • 25. MULTI INDUCED EVAPORATION TECHNOLOGY  Aerosolisation of TEVAN® PANOX with CLIM O’ MEDIC enabled good results in laboratories and hospital rooms
  • 26. TEVAN® PANOX Aerosolisation @ 33% @ Virco (Johnson & Johnson), Belgium • Device = Clim’O Medic® (Metatecta Cy.) • Room = 60 m3 • RT • Droplets = 5-10 µm • Amount = 10 g/m3 • For : HIV’s DNA which is destroyed at 100%
  • 27. TEVAN® PANOX Aerosolisation @ 33% @ Heilig Hart Hospital with the help of the University of Louvain B Floor, S aureus ΔLog > 7  Hospital room including walls, A niger ΔLog > 6 bath room = 50 m3 ceiling  Device = Clim’O Medic G stearo ΔLog > 5 (Metatecta) in the bedroom itself Within the S aureus ΔLog > 7  RT = 220C bedroom A niger ΔLog 3.5 !  Time = 30 minutes cabinet G stearo ΔLog >5  Droplets = 5 – 10 µm  Dispersion = 16 g / m3 Within the S aureus ΔLog 3 !  Organisms = Staphylococcus bathroom A niger ΔLog 3.5 ! aureus, Aspergillus niger, Geobacillus cabinet G stearo ΔLog >5 stearothermophilus
  • 28. TEVAN® PANOX DEFRA approved disinfectant since early 2007 DEFRA = UK DEPARTMENT of ENVIRONMENT, FOOD and RURAL AFFAIRS Disease Organism TEVAN® PANOX Foot & mouth Aphtovirus 1% Poultry Paramyxovirus 2% Newcastle General Salmonella 1%
  • 29. 3.3 TEVAN® PANOXO PEROXIDE, PERACID, FATTY OXO AMINE, ESSENTIAL OIL INNOVATIVE: COMBINATION OF 4 ACTIVES
  • 30. TEVAN® PANOXO RTU for SURFACE TREATMENTS PASTEUR INSTITUTE FRANCE, 2005/2006 test results Species Organisms Concentrations Times Norms Bacteria -Pseudomonas 20% 5 min. EN 1276 aeruginosa -Staphilococcus aureus -Escherichia coli -Enterococcus hirea -Salmonella typhi 10% 10 min. EN 1276 Fungi -Aspergillus niger 40% 15 min. EN 1650 -Candida albicans -Tricophyton 40% 10 min. EN 1650 mentagrophytes Spores -Bacillus subtilis 80% 30 min. NF T 72 301 -Bacillus cereus -Clostridium sporogenes Virus -Enterovirus polio 60% 30 min. NF T 72 180 -Orthopox virus -Human adenovirus
  • 31. TEVAN PANOXO GEL® Innovative RTU for vertical surface and ceiling treatments, test 1 Surface Time Result Plastic 30 min. Doesn’t PVC sag Galvanized 30 min. id. steel Stainless 30 min. id. steel Copper 30 min. id. Aluminum 30 min. id. Porcelain 30 min. id.
  • 32. TEVAN® PANOXO GEL @ CENTER PARK KEMPERVENNEN, NL Innovative RTU FOR WALL AND CEILING CLEANING, test 2  Walls presenting black fungal marks  Application of TEVAN® PANOXO GEL @ RT for 30 minutes  Rinse off  No mark anymore
  • 33. TEVAN® PANOXO RTU in agriculture (fungus fusarium oxysporum on tulip bulbs) @ ACN, NL Ultrasonic generator, droplets 1µm ,250C, RH 70%, 40 min. Assays Average cfu’s In original uncontaminated water 0.5 In contaminated water 25.33 On rinsed and dried contaminated bulbs 14.33 Treatments Formaline 1% 4.83 Formaline 10% 1.33 Jet 5 1% 1.08 TEVAN® PANOXO 1
  • 34. 4. COMPARISON, APPLICATIONS, CONCLUSIONS, REFEREES
  • 35. DISINFECTING AGENTS COMPARISON Quats Phenolics Aldehydes Chlorine Hydrogen Stabilized peroxide hydrogen peroxide Spectrum Semi broad* Broad Broad Semi broad* Broad Broad Contact time Short Long Long Short Long Short Efficacy Semi good* Poor Good Semi good* Poor Good Toxicity Moderate Moderate High Moderate Low Low Residue Yes Yes Yes Yes No No Corrosion Low Moderate Low High Low Low to Moderate** Environment Poor Poor Poor Poor Good Good Odour No Yes Yes Yes No Yes/No** Biodegradation 70% 85% 90% 100% 100% in 20 days in 20 days in 20 days seconds seconds Action on biofilm No No No No Yes*** Yes*** • * More and more germs are presenting resistance • ** Depending on the ingredients • *** H2O2 produces micro turbulences through the production of gaseous oxygen • Source: Tevan BV compilation 2003
  • 36. SYNERGISED HYDROGEN PEROXIDE APPLICATION FIELDS  WATER SYSTEMS  Drinking waters (public, domestic, transport carriers)  Industrial waters (cooling towers, air conditioning, sprinklers)  Waste waters  Still waters  Sport & Recreation (swimming pools, fountains)  AGRICULTURE  Transport materials  Watering devices, irrigation, hydroponic cultures  Seeds, bulbs  Vegetables, fruits, flowers  Greenhouses  LIVESTOCK  Potable water distribution for animals  Aquaculture  SURFACES and DEVICES  Hospital theatres, medical tools, dentistry, clean rooms / broilers, hatcheries, stables, pigsties, etc.  Metallurgy  FOOD and BEVERAGE  Breweries, dairies, slaughterhouses, vintage barrels, soft drinks  Baker’s & confectioner’s
  • 37. SOME NUMBERS  From Kaiser http://www.hkc22.com/waterdisinfection.html  Water world market in 2010 = 412 billion $  From Ecodis:  Water disinfection = 7.95 billions $  From the biocides information services:  Global biocides market = 84 billions $  In aquaculture = 9.42 billions $  For metallic surfaces = 9.15 billions $  In cooling towers = 87.3 millions $  From Herli-France  31 255 wells in France  From society statistics for nosocomial diseases:  1.71 billions $ spent in USA and still 20 000 deaths/Y  Nosocomial diseases in France:  800 000 infections and 10 000 deaths/Y
  • 38. REFEREES  Du Pont de Nemours, Belgium for Tevan® Sil in cooling towers water  Générale des Eaux, France for Tevan® Sil in drinking water distribution systems  Veolia, France for Tevan® Sil in drinking water distribution systems  Saur, France for Tevan® Sil in drinking water distribution systems  Grampian, UK for Tevan® Sil in water systems for broilers  Culligan, UK for Tevan® Sil in water softeners  Glaxo-Smith-Kline in all Europe for Tevan® QA 80 for clean rooms  City of Saarbrücken, Germany for Tevan® P.A.C. in drinking water distribution systems presenting to high levels in coli and in proteus
  • 39. CONCLUSIONS  Tevan® disinfecting agents and Herlisil®: a Superior Approach to Oxidative Treatments  1. Broad activity spectrum: destroys or inhibits virtually all viruses, bacteria, fungi, algae & protozoa's  2. Speed: active within short contact time (minutes)  3. No known development of resistance in micro-organisms  4. Active on biofilms  5. 100% degradable + non-toxic for the environment and superior organisms  6. No residual byproducts  7. Persistence of action after product application  8. Active on broad pH range  9. Selective action: targeting of specific micro-organisms  10. Long-term stability (stable up to 960C)  11. Weak corrosive effect on water pipes and other facilities  12. Formulations come so far in 3 different forms: liquid, aerosol, gel  13. Applicable to all environments: water, air, surfaces, instruments, etc.
  • 40. UNDER DEVELOPMENT FROM DIAGNOSTIC TO TREATMENT AND PREVENTION FAST DIAGNOSTIC (1 hour max.) USING BIOCHEMICAL LUMINESCENCE Determination of: - Overall pollution (COD measurement) - Biological pollution (ATP measurement) - Toxic pollution - Specific pollution (specific germs determination) SAFE AND ENVIRONMENTAL FRIENDLY TREATMENT AND PREVENTION - Use of chlorine and metal free formulations based on natural actives.
  • 41. UNDER DEVELOPMENT WATER FILTRATION &DISINFECTION Principle: filtration on active coal combined with metallic silver – Homogeneous carbon particle size = 1 mm – Homogeneous porosity in the particles = 20-30 A – Thin layer of Ag0 deposition (cold plasma technique at 9000C) – At the boundary Ag0/carbon, silver carbides are formed (Ag2C, AgC, AgC2) – The silver is not released from the carbon filter into the filtered water – The silver plays the role of disinfectant – The adsorption capacity is huge (2000 m2 / g as per BET measurements) Forecasted applications: - Legionella pneumophila (air conditioning) - Pseudomonas solanacearum (affecting vegetables in greenhouses) – Bulkodoria solanacearum (affecting vegetables in greenhouses) – Aquaculture (shrimps, fishes) – Livestock

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