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Concentrating Asacol for the improved treatment of Crohn's Disease

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  • 1. Concentrating Asacol for the improved treatment of Crohn’s disease
    Gustavo Perez Caballero
  • 2. What is Crohn’s disease?
    It’s a form of inflammatory bowel disease.
    It usually affects the intestines, but may occur anywhere from the mouth to the end of the rectum.
  • 3. What is the cause of Crohn’s?
    The exact cause is unknown.
    It’s linked to a problem with the body's immune system response.
    The result is an overactive immune response that leads to chronic inflammation.
  • 4. What is Asacol?
    Asacol is an anti-inflammatory drug used to treat inflammation of the digestive tract ulcerative colitis and mild-to-moderate Crohn's disease.
    Asacolis a bowel-specific aminosalicylatedrug that acts locally in the gut and has its predominant actions there, thereby having few systemic side effects.
  • 5. Asacol side-effects
    Commonly:
    Diarrhea, Nausea, Cramping, Flatulence.
    Uncommonly:
    Headache, Exacerbation of the colitis, Hypersensitivity reactions, Hair Loss, Interstitial nephritis.
    Rarely:
    Acute pancreatitis, Hepatitis, Nephrotic syndrome, Blood disorders.
  • 6. Hypothesis
    That one of the concentrated Asacol pills will be enough to repress Crohn’s disease for the whole day.
  • 7. Objectives
    To improve the Asacol pill so that it can be taken once daily or even once every 2 or 3 days.
    Currently a normal person has to take 6 pills of Asacol per day to allow it to be effective.
  • 8. Objectives (cont.)
    The thing is most health insurance companies don’t cover the pill.
    For example a person whose insurance wont cover the treatment and has to take six pills a day must pay the hefty amount of 700 to 800 dollars every 4 to for 5 weeks.
    So this proposal will save people both time and money.
  • 9. Methodology
    I will have my control group and my experimental group, control being 5 sets of 5 mice taking the normal Asacol treatment and my experimental being 5 sets of 5 mice taking the more concentrated type of Asacol.
    I will observe them over a period of time to watch for any side-effects and see if there are any effects on offspring.
    After which if there is no change in genes and presents no danger to humans I will test it on willing humans with the disease.
  • 10. Expected Results
    After numerous observations I expect that the mice in the concentrated Asacol group show more improvement in rectal bleeding and stool frequency than in the normal treatment.
    I also expect that it wont damage the offspring in anyway so that I can test it on willing humans with the disease.
  • 11. References
    1. http://www.drugs.com/asacol.html
    Asacom,07/27/2010, Cerner Multum, Inc. ('Multum’)
    2. http://www.medicinenet.com/crohns_disease/article.htm
    Jay W. Marks, MD,Crohn'sDisease, 12 Jul 1996
    3. http://www.webmd.com/ibd-crohns-disease/crohns-disease/tc/crohns-disease-treatment-overview
    2005-2011, WebMD,Healthwise
    4. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001295/
    George F Longstreth, MD, Department of Gastroenterology, 12/13/2010, A.D.A.M., Inc.