Phosphodiesterase-Inhibitors by Aseem
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Phosphodiesterase-Inhibitors by Aseem

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Phosphodiesterase-Inhibitors by Aseem Phosphodiesterase-Inhibitors by Aseem Presentation Transcript

  • PHOSPHODIESTERASE INHIBITORS
  • Introduction • Isolated by UZONOV & WEISS in 1972 from Rat Brain • Therapeutic Action documented in 1977 • Inhibits Platelet Aggregation by promoting hydrolysis and degradation of cAMP and / or cGMP and release of Protein Kinase A
  • Subtypes Non-Selective CAFFEINE/THEOBROMINE/METHYLXANTHINES AMINOPHYLLINE / THEOPHYLLINE (BDs) PENTOXYFILLINE (Circulation enhancer DM / PVD) PDE-1 Inhibitors VINPOCETINE (Nootropic)
  • Subtypes PDE-2 I Erythro Hydroxy Nonyl Adenine (EHNA) (Investigtive for CCF) PDE-3 I MILRINONE (Inotrope – CCF) CILOSTAZOL (Arterial VD – Intermittent Claudication)
  • Subtypes PDE-4 I MESEMBRINE (SRI) ROFLUMILAST (COPD Exacerbations – FDA) DROTAVERINE (Anti-spasmodic / Tocolytic) Anti-inflamm / Anti-depressant
  • Subtypes PDE-5 I (ED – degradation of cGMP in CC) SILDENAFIL (VIAGRA) TADALAFIL (CIALIS) VARDENAFIL (LEVITRA)UDENAFIL AVANAFIL PAH BPH / PAH t1/2 PE tmax
  • Subtypes PDE-10 I PAPAVERINE (Papaver Somniferum) Gastro-Intestinal Vasodilator ED (Intracavernosal) Coronary Vasodilator
  • THANK YOU