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Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
Nanobiosensors
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Nanobiosensors

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Nanobiosensors

Nanobiosensors

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  • 1. Nanobiosensors
  • 2. tion A biosensor is a measurement system for the detection of an analyte that combines a biological component with a physicochemical detector, and a nanobiosensor is a biosensor that on the nano-scale size What is a Nanobiosensor?
  • 3. Nanobiosensor Transducer Detector Biological Recognition Element (Bioreceptor) Living biological system (cell, tissue or whole organism) Biological molecular species (antibody, enzyme, protein…)
  • 4. Functioning of Nanobiosensor Detector
  • 5. TYPES OF BIOSENSORS Optical Biosensors  Electrical Biosensors  Electrochemical Biosensors  Nanotube Based Biosensors  Nanowire Biosensors  Viral Nanosensors  Nanoshell Biosensors
  • 6. Optical Nanobiosensors A sensor that uses light to detect the effect of a chemical on a biological system. The small size of the optical fibers allow sensing intracelular intercelular physiological and biological parameter in micro- environment. Continued….
  • 7. Optical Nanobiosensors Two kind of fabrication methods for optical fiber tips 1) Heat and Pull Method 2) Chemical Etching
  • 8. Nanowire Field Effect Nanobiosensors (FET) Semiconductor channel (nanowire) of the transistor. The semiconductor channel is fabricated using nanomaterials such a carbon nanotubes,metal oxide nanowires or Si nanowires. Very high surface to volume radio and very large portion of the atoms are located on the surface Extremely sensitive to environment
  • 9. Piezo-Electric Biosensors Some piezo-electric devices utilize crystals, such as quartz, which vibrate under the influence of an electric field. The frequency of this oscillation depends on their thickness and cut. Very high surface to volume radio and very large portion of the atoms are located on the surface Extremely sensitive to environment.  Others use gold to detect the specific angle at which electron waves (surface plasmons) are emitted when the substance is exposed to laser light.  The change in frequency is proportional to the mass of absorbed material.
  • 10. Electrochemical Biosensors Amperometric for applied current: Movement of e- in redox reactions detected when a potential is applied between two electrodes. Potentiometric for voltage: Change in distribution of charge is detected using ion-selective electrodes, such as pH-meters. Conductimetric for impedance
  • 11. Applications of Nanobiosensors Biological Applications  DNA Sensors: Genetic monitoring, disease  Immunosensors: HIV, Hepatitis,other viral diseas, drug testing, environmental monitoring…  Cell-based Sensors: functional sensors, drug testing…  Point-of-care sensors: blood, urine, electrolytes, gases, steroids, drugs, hormones, proteins, other…  Bacteria Sensors (E-coli, streptococcus, other): food industry, medicine, environmental, other.  Enzyme sensors: diabetics, drug testing, other. Environmental Applications  Detection of environmental pollution and toxicity  Agricultural monitoring  Ground water screening  Ocean monitoring
  • 12. Future Applications of Nanobiosensors Cancer Monitoring Nanobiosensors play a very important role for early cancer detection in body fluids. The sensor is coated with a cancer-specific antibody or other biorecognation ligands. The capture of a cancer cell or a target protein yields electrical, optical or mechanical signal for detection. Identification of Biomarkers ↓ Validation of Cancer Biomarkers ↓ Cancer Biomarkers ↓ Ligands / Probes Developments ↓ Cancer Diagnostics Biosensor ← Detector ↓ Point of Care Cancer Diagnostics

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