Nanobiosensors
tion
A biosensor is a measurement system for the
detection of an analyte that combines a biological
component with a phys...
Nanobiosensor
Transducer Detector Biological Recognition Element
(Bioreceptor)
Living biological system
(cell, tissue or w...
Functioning of Nanobiosensor
Detector
TYPES OF BIOSENSORS
Optical Biosensors
 Electrical Biosensors
 Electrochemical Biosensors
 Nanotube Based Biosensors
...
Optical Nanobiosensors
A sensor that uses light to detect the effect of a
chemical on a biological system.
The small siz...
Optical Nanobiosensors
Two kind of fabrication
methods for optical fiber
tips
1) Heat and Pull Method
2) Chemical Etching
Nanowire Field Effect Nanobiosensors
(FET)
Semiconductor channel (nanowire) of the transistor.
The semiconductor channel...
Piezo-Electric Biosensors
Some piezo-electric devices utilize
crystals, such as quartz, which vibrate under
the influence...
Electrochemical Biosensors
Amperometric for applied current: Movement of
e- in redox reactions detected when a potential ...
Applications of Nanobiosensors
Biological Applications
 DNA Sensors: Genetic monitoring, disease
 Immunosensors: HIV, He...
Future Applications of Nanobiosensors
Cancer Monitoring
Nanobiosensors play a very important role for early cancer
detect...
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Nanobiosensors

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Nanobiosensors

  1. 1. Nanobiosensors
  2. 2. tion A biosensor is a measurement system for the detection of an analyte that combines a biological component with a physicochemical detector, and a nanobiosensor is a biosensor that on the nano-scale size What is a Nanobiosensor?
  3. 3. Nanobiosensor Transducer Detector Biological Recognition Element (Bioreceptor) Living biological system (cell, tissue or whole organism) Biological molecular species (antibody, enzyme, protein…)
  4. 4. Functioning of Nanobiosensor Detector
  5. 5. TYPES OF BIOSENSORS Optical Biosensors  Electrical Biosensors  Electrochemical Biosensors  Nanotube Based Biosensors  Nanowire Biosensors  Viral Nanosensors  Nanoshell Biosensors
  6. 6. Optical Nanobiosensors A sensor that uses light to detect the effect of a chemical on a biological system. The small size of the optical fibers allow sensing intracelular intercelular physiological and biological parameter in micro- environment. Continued….
  7. 7. Optical Nanobiosensors Two kind of fabrication methods for optical fiber tips 1) Heat and Pull Method 2) Chemical Etching
  8. 8. Nanowire Field Effect Nanobiosensors (FET) Semiconductor channel (nanowire) of the transistor. The semiconductor channel is fabricated using nanomaterials such a carbon nanotubes,metal oxide nanowires or Si nanowires. Very high surface to volume radio and very large portion of the atoms are located on the surface Extremely sensitive to environment
  9. 9. Piezo-Electric Biosensors Some piezo-electric devices utilize crystals, such as quartz, which vibrate under the influence of an electric field. The frequency of this oscillation depends on their thickness and cut. Very high surface to volume radio and very large portion of the atoms are located on the surface Extremely sensitive to environment.  Others use gold to detect the specific angle at which electron waves (surface plasmons) are emitted when the substance is exposed to laser light.  The change in frequency is proportional to the mass of absorbed material.
  10. 10. Electrochemical Biosensors Amperometric for applied current: Movement of e- in redox reactions detected when a potential is applied between two electrodes. Potentiometric for voltage: Change in distribution of charge is detected using ion-selective electrodes, such as pH-meters. Conductimetric for impedance
  11. 11. Applications of Nanobiosensors Biological Applications  DNA Sensors: Genetic monitoring, disease  Immunosensors: HIV, Hepatitis,other viral diseas, drug testing, environmental monitoring…  Cell-based Sensors: functional sensors, drug testing…  Point-of-care sensors: blood, urine, electrolytes, gases, steroids, drugs, hormones, proteins, other…  Bacteria Sensors (E-coli, streptococcus, other): food industry, medicine, environmental, other.  Enzyme sensors: diabetics, drug testing, other. Environmental Applications  Detection of environmental pollution and toxicity  Agricultural monitoring  Ground water screening  Ocean monitoring
  12. 12. Future Applications of Nanobiosensors Cancer Monitoring Nanobiosensors play a very important role for early cancer detection in body fluids. The sensor is coated with a cancer-specific antibody or other biorecognation ligands. The capture of a cancer cell or a target protein yields electrical, optical or mechanical signal for detection. Identification of Biomarkers ↓ Validation of Cancer Biomarkers ↓ Cancer Biomarkers ↓ Ligands / Probes Developments ↓ Cancer Diagnostics Biosensor ← Detector ↓ Point of Care Cancer Diagnostics

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