Nano Drug Delivery
IMPORTANCE OF NANOSIZE IN DRUG
DELIVERY
A new family of nanoscale
materials on the basis of
dispersed networks of cross-
l...
NEW NANOSCALE PLATFORMS
Nanotools have been utilized for medical
diagnostics via:
Fluorescent Imaging
Magnetic Resonance...
VARIOUS ROUTES OF DRUG
DELIVERY
Oral Adminisration- Tablets, Capsules, Liquids,
Mixtures
Nasal Route- Nasal drops, Aeros...
TARGETED DRUG DELIVERY
CONTINUED…
.
Targeted drug delivery is the most important goal of
pharmaceutical research and deve...
TARGETED DRUG DELIVERY
Drug targeting can be achieved by physical, biological,
or molecular systems that result in high c...
SPECIFIC ENZYMES AT THE TARGET ORGAN
Specific enzymes at the target organ activate the CDS to
drug (D) only at the site. I...
DRUG TARGETING BY SOFT DRUGS
Soft Drugs are novel active drugs strategically designed
to undergo singular metabolic deact...
VECTOR-MEDIATED DELIVERY
TO THE BRAIN
 The development of peptide-
based opioid analogs toward
clinically useful drugs is...
ORAL PEPTIDE DELIVERY
ORAL PEPTIDE DELIVERY
Peptide drug delivery has been of considerable interest over
recent decades due in part to rapid de...
TRANSDERMAL DRUG DELIVERY SYSTEM
Nanotechnology plays a promising role in transdermal
applications
Drugs made of nanopar...
TRANSDERMAL APPLICATIONS
Transdermal applications include dendrimers which are
extensively used to deliver drugs, vaccine...
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Nano drug delivery

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Nano drug delivery

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Nano drug delivery

  1. 1. Nano Drug Delivery
  2. 2. IMPORTANCE OF NANOSIZE IN DRUG DELIVERY A new family of nanoscale materials on the basis of dispersed networks of cross- linked ionic and nonionic hydrophilic polymers is being developed. Traditional nanotechnology for drug delivery mainly referred to those nanoscale vehicles which were mainly utilized to improve the drug bioavailability and minimize the side effects of the drug by holding or transporting the drug molecules to the desired locations.
  3. 3. NEW NANOSCALE PLATFORMS Nanotools have been utilized for medical diagnostics via: Fluorescent Imaging Magnetic Resonance Imaging (MRI) Scanning Electron Microscopy (SEM) Transition Electron Microscopy (TEM) Atomic Force Microscopy (AFM)
  4. 4. VARIOUS ROUTES OF DRUG DELIVERY Oral Adminisration- Tablets, Capsules, Liquids, Mixtures Nasal Route- Nasal drops, Aerosol Ophthalmic- Ointments, suspensions Vaginal and Rectal Route- Soppositories Parenteral Route- Injections
  5. 5. TARGETED DRUG DELIVERY CONTINUED… . Targeted drug delivery is the most important goal of pharmaceutical research and development. Drug targeting is defined in the broadest sense, that is, to optimize a drug’s therapeutic index by strictly localizing its pharmacological activity to the site or organ of action. This is an important distinction from the basic targeting concept, where the specific drug receptor is the target and the objective is to improve fit, affinity, and binding to the specific receptor that ultimately will trigger the pharmacological activity.
  6. 6. TARGETED DRUG DELIVERY Drug targeting can be achieved by physical, biological, or molecular systems that result in high concentrations of the pharmacologically active agent at the pathophysiologically relevant site. If successful, the result of the targeting would be a significant reduction in drug toxicity, reduction of the drug dose, and increased treatment efficacy.
  7. 7. SPECIFIC ENZYMES AT THE TARGET ORGAN Specific enzymes at the target organ activate the CDS to drug (D) only at the site. In the periphery or rest of the body, D is not formed due to the lack of activating enzymes or unfavorable rate processes
  8. 8. DRUG TARGETING BY SOFT DRUGS Soft Drugs are novel active drugs strategically designed to undergo singular metabolic deactivation after they achieve their therapeutic roles. In many instances, these kinds of compounds are ideal for producing specific action at the site of application without affecting the rest of the body. In the reversed targeting method using SDS, very significant distributional differences for a drug can be generated by involving drug metabolism in a retroactive manner in the design.
  9. 9. VECTOR-MEDIATED DELIVERY TO THE BRAIN  The development of peptide- based opioid analogs toward clinically useful drugs is still impeded by the limited access of these substances to the central nervous system (CNS) following peripheral or systemic administration Various strategies are evaluated for overcoming the cerebrovascular endothelium, which represents the morphological substrate of the BBB in vivo
  10. 10. ORAL PEPTIDE DELIVERY
  11. 11. ORAL PEPTIDE DELIVERY Peptide drug delivery has been of considerable interest over recent decades due in part to rapid developments in biotechnology and peptide synthesis, as well as the unique pharmacological activity of peptide drugs. Among barriers for oral drug absorption, metabolism is generally recognized as particularly significant for peptides and peptide-type drugs. For peptide-type drugs that have no intestinal instability and are dosed below their solubility limit, the fraction of the dose absorbed (not systemic availability) can be correlated with intestinal membrane permeability
  12. 12. TRANSDERMAL DRUG DELIVERY SYSTEM Nanotechnology plays a promising role in transdermal applications Drugs made of nanoparticles can efficiently delivered the drugs directly into the epidermis
  13. 13. TRANSDERMAL APPLICATIONS Transdermal applications include dendrimers which are extensively used to deliver drugs, vaccines, and chemotherapeutic agents for cancer therapy Some of the dendrimer based bionano applications include: gene delivery targeted cancer therapy in vivo diagnoses (MRI)  antiinfective agent delivery vaccine and peptide delivery

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