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Liposomes:  Improving drug delivery
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Liposomes: Improving drug delivery

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Liposomes: Improving drug delivery

Liposomes: Improving drug delivery

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Liposomes:  Improving drug delivery Liposomes: Improving drug delivery Presentation Transcript

  • Liposomes: Improving drug delivery
  • What is a liposome?
    Liposomes are closed vehicles having both lipophilic and hydrophilic portions.
    Size range is from 25nm to as much as 10mm.
    Made from naturally occuring phospholipids such as phosphatidylcholine , cholesterol.
    Also obtained from synthetic phospholipids like phosphatidylinositol.
  • Structure of liposome
    Hydrophilic
    Hydrophobic
    Spherical vesicles with a phospholipidbilayer
  • Cell Membrane
  • Advantages of Liposomes
    They can incorporate both hydrophobic and hydrophilic drugs in them.
    Their surfce can be modified to alter their biodistribution and pharmakokinetics.
    Alter drug distribution according to their size.
    Liposomes can be made to release the entrapped drugs at increased temperatures.
  • Advantages of Liposomes
    A number of anticancer and anti-microbiologic agents such as Cytosine, Arabinoside, Methotrexate, Doxorubicin, Dactinomycin and AmphotericinB are entrapped.
    These can be grafted with hydrophilic polymers such as PEG to reduce their uptake by macrophages.
  • Why Use Liposomes in Drug Delivery?
    Pharmokinetics - efficacy and toxicity
    • Changes the absorbance and biodistribution
    • Deliver drug in desired form
    • Multidrug resistance
    Protection
    • Decrease harmful side effects
    • Change where drug accumulates in the body
    • Protects drug
  • Why Use Liposomes in Drug Delivery?
    Release
    • Affect the time in which the drug is released
    • Prolong time -increase duration of action and decrease administration
    Dependent on drug and liposome properties:
    • Liposome composition, pH and osmotic gradient, and environment
  • Targeted Liposome delivery system
  • Preparation of targeted Liposomes
  • Modes of Liposome/Cell Interaction
    Adsorption
    Endocytosis
    Fusion
    Lipid
  • Medical Applications of Liposomes
    Chelation therapy for treatment of heavy metal poisoning
    Enzyme replacement
    Diagnostic imaging of tumors
    Cosmetics
    Study of membranes
    Localised delivery of drug is possible.
  • Medical Applications of Liposomes
    Used for tumor imaging.
    Ligand mediated targeted drug delivery by long circulating liposomes.
    Antibodies can be conjugated to PEG chains on PEG stabilized liposomes.
    To treat artherosclerosis or neointimal hyperplasia.
    For targeted gene delivery to specific cells.