Autoimmune diseases overview

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an introduction to a jungle of autoimmune diseases

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  • Autoimmune diseases (AIDs) may be classified as organ-specific or systemic (non-organ-specific). There is a spectrum of AIDs including some that exhibit intermediate features.
  • Autoimmune diseases overview

    1. 1. Autoimmune rheumatic diseases And related conditions
    2. 2. Pick an organ, any organ . . .Autoimmunity can affect ANY organ/organ system in the human body Autoimmune Uveitis Multiple Sclerosis Psoriasis Sjogren’s Syndrome Pemphigus Systemic Lupus Erythematosus Rheumatic Fever Diabetes Autoimmune Hepatitis Addison’s Disease Autoimmune Oophoritis Ulcerative Colitis Rheumatoid Arthritis Autoimmune hemolytic Anemia
    3. 3. Autoimmunity ClassificationCan be classified into clusters that are either organ-specific or systemic
    4. 4. 4
    5. 5. Historical Perspective The Virgin with Canon van The Painter’s Family Der Paele, 1436 Jacob Jordaens (1593-1678) Jan van Eyck (1385-1440) Evidence of: Evidence of: Rheumatoid Arthritis Temporal (Giant Cell) Arteritis
    6. 6. CDC: Census Bureau 2004
    7. 7. Multiple Factors Contribute to theDevelopment of Autoimmune diseases Nature Reviews Immunology, 2007
    8. 8. Multiple Cell Types and Cytokine Signaling Pathways Involved in Chronic Inflammatory Arthritis Modified from Choy, E. H.S. et al. N Engl J Med 2001;344:907-916 Key cytokines in Chronic Naï ve T cell Inflammatory Arthritis: TNF-α IL-1 IFN-γ IL-6 OPGL (RANK-ligand) IL-17
    9. 9. Rheumatoid Arthritis is Systemic Inflammatory Disease
    10. 10. SLE is a Systemic Inflammatory Disease
    11. 11. Sjogren Syndrome
    12. 12. Therapeutic StrategiesReagents that blunt inflammation but don’t have effects on disease progression: Aspirin Nonsteroidal anti-inflammatory drugs (NSAIDs) Non-selective and selective COX-2 antagonists Steroids (prednisone)Disease Modifying Anti-Rheumatic Drugs (DMARDs): Broad Acting: Methotrexate Hydroxychloroquin Azathoprine Cyclophosphamide Cyclosporin More selective biologics: TNF antagonists IL-6R antagonists IL-1R antagonists anti-B cell (CD20) therapy costimulatory inhibitors (CTLA4-Ig) Intravenous Immunoglobulin (iv Ig)
    13. 13. Biological Therapeutics Targets, Rationale, Status
    14. 14. Reumatologi Klinik Bandung 2013 14
    15. 15. Selamat menikmati workshop Update on autoimmune diseases Advances on the treatment for RA Autoimmune diseases in opthalmology The role of cyclosporine in psoriasis Clinical experience in Cyclosporine + Mtx in the Th/ of RA The role of cyclosporine in uveitis treatment

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