EEG Variants By IM


Published on

EEG variants, are always to be recognized while interpreting the EEG one must be aware of these. Major and most common EEG is variants are discussed in the stated presentation.
Syed Irshad Murtaza.

  • Be the first to comment

No Downloads
Total views
On SlideShare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide

EEG Variants By IM

  2. 2. INTRODUCTION• The term “normal variant pattern” refers to thoserhythms or waveforms that have features reminiscentof either inter-ictal or ictal EEG abnormalities.• However, these patterns have been found in asubstantial proportion of tracings from healthy subjectsand, therefore,• are not currently thought to represent pathologicalentities. It is, therefore, vital that such patterns be• appropriately recognized by the EEG reader as normalvariants and not erroneously confused for pathologicalpatterns.
  3. 3. TYPES OF EEG VARIANTS• There are four main types of EEGvariants.• 1. Rhythmic patterns.• 2. Epileptiform patterns.• 3. Lambda and lambdoids.• 4. Age-related variants.
  4. 4. 1. RHYTHMIC VARIANT PATTERNS• There are six main types of rhythmic variant EEGpatterns:• 1. Alpha variant.• 2. Mu rhythm.• 3. Rhythmic temporal theta burst of drowsiness(“psychomotor variant”).• 4. Subclinical rhythmic electrographic (theta)discharges in adults (SREDA).• 5. Midline theta rhythm.• 6. Frontal arousal rhythm (FAR).
  5. 5. 1. Alpha Variant• This pattern was described first by Goodwin in 1947.• There are two types of alpha variants,• “Slow or Sub-Harmonic” alpha rhythm and• “Fast or Harmonic” alpha rhythm.”• 1. The slow (sub-harmonic) alpha variant appears as anabrupt rhythm usually at half the frequency of the patient’smore typical waking background rhythm, and often ofgreater voltage• 2. The fast (harmonic) alpha variant may appear as anotched or bifurcated form of the patient’s usual wakingbackground rhythm, so that a superimposed harmonicrhythm of twice the alpha frequency occurs. Alpha variantsare blocked with eye opening and exhibit a posteriorpredominance, just as with normal alpha rhythms.
  6. 6. CONT’D• Alpha variants vary in their prevalencewithin a subject’s tracing, alternating withperiods of normal-appearing alphaactivity. Alpha variants have beenregarded as a physiological variation of themore familiar posterior background alphaactivity, and do not predict increasedconvulsive tendency.
  7. 7. 2. Mu Rhythm• Numerous terms have been applied to the mu rhythm, includingarcade, comb, and wicket rhythms, owing to its morphology.Individual waveforms have an arciform morphology. This occurs inwaking over the central regions, especially the C3, Cz, and C4contacts.• It is closely associated with the sensorimotor cortex, hence theterm “mu,” for motor. Mu exhibits a frequency in the alpharange, typically at 9 to 11 Hz. Niedermeyer observed this rhythm inapprox 14% of adolescents’ EEG tracings, and less often in youngerchildren and the elderly.• Similar to the alpha activity of the occipital cortex, it exhibitsphysiological reactivity. It attenuates with contralateral limbmovement or just planned movement of the contralateral limb.• With direct cortical recording methods, a 20-Hz beta activity may beobserved from the sensorimotor cortex, with similar reactivity.
  8. 8. • Thus, the scalp-recorded mu is likely a subharmonicof this underlying rhythm.• Mu is usually observed bilaterally with shiftingpredominance; it may, however, be asymmetricaland asynchronous. Mu activity is augmented in thesetting of a focal skull breach.• This could, for instance, explain some instances ofhighly lateralized mu rhythms. Exclusively• lateralized mu should raise a suspicion of anabnormality in the hemisphere lacking mu activity.• Sometimes, focal mu activity in the setting of a bonydefect of the skull may be so sharp and• of higher voltage as to falsely mimic anepileptogenic focus.
  9. 9. .3. Rhythmic Temporal Theta Bursts ofDrowsiness (“Psychomotor Variant”)• Gibbs et al. called this pattern the“psychomotor variant” because it wasthought to represent a temporal lobe orpsychomotor seizure.• This concept has been more recentlydiscarded because this pattern is observed inasymptomatic healthy individuals and exhibitspoor correlation with patients with truetemporal lobe or psychomotor seizures.
  10. 10. CONT’D• This pattern has also been called “rhythmicmid-temporal discharges” describing itscharacter, location, and frequency.• This pattern may be present in waking or earlydrowsiness and usually in tracings of adults andadolescents. It wanes with deepening sleep.• As its name implies, this particular patternsfound in the mid-temporal head regions, butcan spread parasagittally. It is comprised of 5-to 7-Hz rhythms in bursts or trains lastingoften longer than 10 s and sometimesbeyond a minute.
  11. 11. • This variant rhythm can exhibit variablemorphologies, but is often sharply contoured.• It is usually monomorphic; it does not evolvesignificantly in frequency or amplitude, asoccurs in most ictal patterns. Rhythmic mid-temporal discharges can occur bilaterally orindependently with shifting hemisphericpredominance. This pattern is uncommon; itsincidence is approx 0.5%, according to Gibbset al.
  12. 12. 4.SubclinicalRhythmicElectrographicDischargesin Adults(SREDA)• This variant pattern involves sharply contoured 5- to 7-Hz activitieswith a wide distribution, mainly over temporo-parietal derivations. Itis usually bilateral, but can be asymmetrically disposed.• SREDA can appear as repetitive monophasic sharp waves or as asingle discharge followed seconds later by sharp waves that graduallyaccelerate to form a sustained, rhythmic train of theta activity. Thismay last from 20 s to several minutes, usually 40 to 80 s.• Because of its duration and evolution, SREDA can easily bemisinterpreted as an ictal pattern, even by experienced readers.Nevertheless, SREDA has not been shown to have any consistent• correlation with seizures. SREDA is more typically seen in olderadults, and more common at rest, drowsiness, or duringhyperventilation.
  13. 13. 5. Midline Theta Rhythm• The midline theta rhythm is most prominent at Czbut may spread to nearby contacts. This• 5- to 7-Hz frequency exhibits either a smooth, arc-shaped (mu-like) or spiky appearance. The• duration is variable and it tends to wax and wane.It is more common in wakeful and drowsy• states and reacts variably to limbmovements, alerting, and/or eye opening. Thisrhythm is• now regarded to be a nonspecificvariant, although it once was considered a markerof an
  14. 14. 6. Frontal Arousal Rhythm• FAR involves trains of 7- to 10-Hz activities in thefrontal head regions. These rhythms• may be notched and may last up to 20 s. FAR hasbeen described as an uncommon rhythm• that appears during sleep-to-waketransitions, especially in children. FAR disappearsonce the• subject is fully awake. This pattern was, at onetime, associated with children with minimal• cerebral dysfunction, but this specific association hasbeen subsequently doubted. This pattern• is still considered to be a nonspecific finding withoutpathological significance.
  15. 15. 2. EPILEPTIFORM VARIANT PATTERNS• There are 4 major types of epileptiformvariant patterns:• 1. 14- and 6-Hz positive bursts.• 2. Small sharp spikes (benign epileptiformtransients of sleep [BETS]).• 3. 6-Hz spike and wave (phantom spike andwave).• 4. Wicket spikes.
  16. 16. Fourteen- and 6-Hz Positive Bursts• Previously called “14- and 6-Hz positive spikes” or“ctenoids,” these variants occur as bursts of rhythmicarched waves, similar to sleep spindles, with a smoothnegative component and a spike-like positive component.As the name implies, these trains occur at 14 and 6 Hz.• The bursts last only 0.5 to 1 s. Such bursts are best capturedon referential montages (because of the greater inter-electrode distances).• They are maximal at the posterior temporal head regions• and usually occur independently from bilateralhemispheres with shifting predominance.• This variant appears in 10 to 58% of healthy subjects, but isinfluenced by age, montage, and duration of drowsinessand sleep.• More prevalent in children and adolescents.
  17. 17. 2. Small Sharp Spikes/BETS• As these names imply, small sharp spikes or BETSare low in amplitude (~50 µV) and brief (~50 ms).• Their morphology can be monophasic or diphasic.When diphasic, the ascending limb is quite abruptand the descending limb slightly less so They mayexhibit a subtle following slow wave.• BETS are isolated and sporadic.• They appear during drowsiness and light sleep inadults.• They are usually unilateral but can appearindependently (and rarely synchronously) frombilateral regions.
  18. 18. Cont’d• On a transverse montage, their field oftenillustrates a transverse oblique dipole (oppositepolarities across the opposing hemispheres), anatypical finding in bona fide epileptiformdischarges..Other distinguishing features BETS and epileptiformactivity are that BETS do not run in trains, distortthe background, or coexist with rhythmicslowing, and BETS diminish with deepeningsleep, whereas epileptiform discharges worsen withdeeper sleep stages.White et al. reported the incidence of BETS to becomparable in healthy subjects (24%) as insymptomatic patients (20%). Thus, BETS seemunrelated to the diagnosis of epilepsy.
  19. 19. 4. SIX HZ SPIKE AND WAVE(“PHANTOM” SPIKE AND WAVE• These rhythms have a frequency ranging from 5-to 7-Hz. They occur in brief bursts lasting 1 to 2sec, rarely up to 3 to 4 sec.• The spike component can be difficult torecognize because it is not only very brief butalso of very low amplitude and, thus, has afleeting quality.• This subtle characteristic has given rise to thepithy term, “phantom” spike and wave.
  20. 20. Cont’d• By contrast, its slow-wave component isbroader in duration, higher in amplitude, andmore widespread in distribution.• This pattern appears in waking or drowsiness inadolescents and adults. However, it is absent• from slow-wave sleep. Silverman reported itsoverall incidence to be 2.5%. It usually has a• diffuse, bilaterally synchronous distribution. Attimes, it is asymmetric or more regional.
  21. 21. Cont’d• Phantom spike and wave can appear quite similarto the 6-Hz positive spike burst.• Infrequently, a transition may be seen on thesame subject’s EEG between these two types ofvariants.• This pattern is thought by most to represent abenign finding. However, its morphology may beeasily confused with an epileptiform pattern. Itsfailure to persist into slow wave sleep and itsmonomorphic quality permit its distinction frombona fide epileptiform discharges.
  22. 22. Wicket Spikes• This variant pattern appears as single spike-likewaves or as intermittent trains of arc-likemonophasic waves at 6- to 11-Hz (Fig. 6).Amplitudes range from 60 to 200 µV.• Wicket spikes commonly appear from temporalchannels and can be bilateral and synchronousor with shifting predominance. They occurmainly in drowsiness and light sleep in adultsolder than 30 yr of age.
  23. 23. Cont’d• When wicket spikes occur in isolation, they maybe mistaken for an epileptiform discharge.Several features help differentiate isolatedwicket spikes from pathological spikes. A similarmorphology of the isolated wicket spike to thosein a later train or cluster argues for the variantpattern and against an epileptiform discharge.The absence of a following slow-wave argues forthe variant and against an epileptiformdischarge. An unchanged background alsoargues more for the variant and against anepileptiform event.
  24. 24. 3. LAMBDA AND LAMBDOIDS• . Lambda:• Lambda waves are sharp monophasic or biphasicwaveforms that resemble the Greek letter lambda.They have a duration of 160 to 250 ms, an amplitudeof 20 to 50 µV, and usually appear over bi-occipitalleads, although occasionally may be unilateral .• Lambda waves depend on rapid saccadic eyemovements with eyes open. This variant pattern isusually generated when the patient scans a complexpatterned design in a well-illuminated room, forinstance, dotted ceiling tiles in the laboratory.
  25. 25. Cont’d• They block by staring at a featureless white surface orby closing the eyes. They are much more common inchildren 2 to 15 yr of age than in adults.• Slow lambda of youth, also known as shut-eyewaves and posterior slow wave transients• associated with eye movements, are associatedwith eye blinks in children. They appear over• occipital channels as single, broad monophasicor diphasic, mainly surface negative waves.• These morphologies last 200 to 400 ms andhave an amplitude of 100 to 200 µV. They may• be asymmetric. They are usually found inchildren younger than 10 yr of age.
  26. 26. Lambdoids• Lambdoids, also called positive occipital sharptransients of sleep (POSTS) have a check mark(biphasic) morphology with initial surface positivityand often appear in trains up to 4 to 5 Hz .• POSTS are usually synchronous but can beasymmetric in size. There are most commonly seenbetween 15 and 35 yr of age, and usually in lightsleep. They may appear before the alpha rhythmcompletely evaporates in drowsiness. POSTS are acommonly encountered variant pattern on routineEEGs.
  27. 27. Slow lambdoids• Slow lambdoids of youth, also known as cone-shaped waves or O-waves, are highvoltage, diphasic slow transients seen over theoccipital contacts and frequently with theoccipital delta activity in deeper sleep states• As the name implies, they are cone-shaped.They can be seen up to 5 yr of age.
  28. 28. AGE-DEPENDENT VARIANTS• Posterior slow waves of youth, also calledyouth waves, posterior fusedtransients, and sail waves, aretriangular, 2- to 4-Hz waveforms thatcoexist with other waking backgroundrhythms.• They commonly form a complex thatconsists of the slow delta component withsuperimposed and following fasterrhythms of the waking background
  29. 29. Con’t• They are best seen over the posterior headregions in waking. These waves are occasionallyasymmetric.• These waveforms behave just like normal wakingbackground rhythms in that they block with eyeopening, increase with hyperventilation, anddisappear in drowsiness.• Youth waves usually appear between the ages of 8to 20 yr, maximally in early adolescence.• Hyperventilation-induced slowing refers to abuild-up of diffuse theta and delta activities inresponse to hyperventilation for several minutesduring the EEG.
  30. 30. • This build-up may beabrupt or gradual and isoften rhythmic and of high amplitude (up to500 µV); it should resolve within 1 min aftercessation of the patient’s hyperventilationeffort.• This slowing is more prominent posteriorly inchildren and more anteriorly in young adults.This phenomenon is highly age dependent. It isextremely common in children andadolescents, becoming less common in youngadults and thought by many to be uncommonafter the age of 30 yr. Focal slowing orepileptiform activity evoked during hyperven-• tilation is, however, pathological in nature.
  31. 31. • Temporal theta in the elderly is a commonly encountered age-dependent pattern. This is a 4- to 5-Hz activity involving temporalchannels and is thought by some to represent a subharmonic of the8- to 10-Hz background rhythm common in the elderly.However, this rhythm is distinct from the alpha rhythm in that itpersists with eye opening and even into drowsiness and light sleep.Hyperventilation augments this pattern’s voltage and persistence.• Temporal theta in the elderly usually occurs as very brief fragmentslasting only two to three waves, rarely more than seven. Some haveobserved them to be more prevalent over the left hemisphere.Their significance remains controversial. Some regard thesewaveforms as normal variants but others have suggested that theymay signify underlying vascular insufficiency, possibly subclinical innature. Low-voltage intermittent temporal theta activity inasymptomatic elderly individuals has been estimated to occur withan incidence of approx 35%.
  32. 32. • REVIEW QUESTIONS• 1. Alpha variant may:• A. Be a subharmonic (slow) frequency of normal alpha.• B. Be a harmonic (fast) frequency of normal alpha.• C. Block with eye opening.• D. Be sporadic, intermingling with normal alpha or maypredominate.• E. All the above.• 2. Mu has features that may include:• A. Predominantly found at the C3 and/or C4 contacts.• B. An arciform appearance.• C. Blocking with contralateral upper extremity use or planned use.• D. More common in adults vs children.• E. All of the above.
  33. 33. • 3. Which one of the following statements concerning the psychomotorvariant pattern is false?• A. It is also known as rhythmic temporal theta bursts of drowsiness.• B. It is typically seen in patients with temporal lobe (“Psychomotor”)epilepsy.• C. It usually exhibits a 5- to 7-Hz frequency.• D. It usually occurs in restful wakefulness or in drowsiness.• E. None of the above is false.• 4. The 14- and 6-Hz positive bursts (14- and 6-Hz positive spikes orctenoids) are best des-• cribed as:• A. More common in children and adolescents, declining in prevalence withadvancing age.• B. Maximal over the posterior temporal regions, especially on referentialmontage.• C. Similar in morphology to sleep spindles with a sharp, spike-like positivecomponent and a• smooth, rounded negative phase.• D. Exhibiting a brief duration of 0.5 to 1 s.• E. All of the above.
  34. 34. • 5. BETS (small sharp spikes) typically:• A. Have an amplitude of 50 µV and a duration of 50 ms.• B. May be monophasic or diphasic with an abrupt ascent and a steepdescent.• C. May include a diminutive following slow wave.• D. Appear in isolation, not in trains.• E. All of the above.• 6. Which of the following statements regarding phantom spike andwave are true?• A. It persists into slow-wave sleep.• B. This pattern often presents in lengthy trains up to 40 to 80 s.• C. It resembles the 6-Hz positive spike burst variant, and both maycoexist in the same tracing.• D. The pattern is fleeting or “phantom-like,” in that it may be easilyblocked by eye opening.• E. All of the above.
  35. 35. • THANKYOU………….• “Nomatterhowbadthingsare,youcanalwaysmakethingsworse.”―RandyPausch