Your SlideShare is downloading. ×
0
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
C:\fakepath\erosion
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

C:\fakepath\erosion

1,391

Published on

Published in: Business, Technology
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
1,391
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
89
Comments
0
Likes
1
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. Non caries tooth loss Dental erosion
    Chu CH
    Faculty of Dentistry
    The University of Hong Kong
  • 2. Non caries tooth loss
    • Erosion is the loss of enamel and dentine by chemical means not involving bacteria.
    • 3. Abrasion is the loss of enamel and dentine by wear from surfaces other than teeth (e.g. tooth brushing).
    • 4. Attrition is the loss of enamel and dentine caused by wear of tooth against tooth.
  • Dental erosion
    Dental erosion, or erosive tooth wear, is now recognized as a major cause of tooth wear.
    (Smales and Kaidonis, 2006)
  • 5. Dental erosion
    Effects:
    Enamel thinning with exposure of dentin
    Unsightly appearance of teeth
    Tooth hypersensitivity
    Reduced chewing function.
    5. Pulpal involvement in advanced cases
  • 6. Dental erosion
    Significance:
    Aging population with more elderly retaining their teeth,
    Change in dietary habits (Cola drinks, red or white wine and fruit juices)
  • 7. Dental erosion
    Prevalence
    Limited longitudinal data are available
    5% Finnish (Jarvinen et al., 1991)
    7% Nigerians (Oginni and Olusile, 2002)
    13% Swedish (Lussi et al., 1991)
    15% Norwegian (Myklebust et al., 2003)
    46% Chinese adults (Hou et al., 2005)
    6%Chinese prechildren (Luo et al., 2005)
    No data in Hong Kong
  • 8. Dental erosion
    Questionnaire telephone survey (2008)
    Faculty of Dentistry & Social Science Research Center, University of Hong Kong
    Chinese adults
    Website http://hkupop.hku.hk/
  • 9. Age
    Successful Samples:514
  • 10. 92% Respondents aged 25-45 had symptoms of Dental Erosion
    Successful Samples:570; Age range: 25-45
  • 11. 72% Respondents reported their teeth turned yellow
    Successful Samples:520 (multiple responses)
  • 12. Q: How often would you consume non-water beverage and food like soft drinks, coffee, snacks, fruits, dessert, etc. in a day?
    36%
    Successful Samples:494
    36% Respondents* ate at least 6 times per day (Average 5.4 Times )
  • 13. 68% Respondents had dental check-upat least once every year
    Q: On average, how often do you go for dental check up in a year ?
    Average: 0.92 times
    SD:0.03
    Base:499
    Successful Samples:519
  • 14. Dental erosion
    73% did not know symptoms of erosion
    70% had never heard about erosion
    53% could not differentiate erosion and caries
    This lack of public knowledge about erosion has also been reported in the UK
    (Dugmore and Rock, Community Dent Health; 20:223-7)
  • 15. Dental erosion
    Sources:
    1. endogenous (eg gastric)
    2. exogenous (eg dietary)
  • 16. Dental erosion
    Sources: endogenous
    Bullimia
  • 17. Dental erosion
    Sources: endogenous
    GI reflux
  • 18. Dental erosion
    Sources: exogenous
    Coke Zero over indulgence
  • 19. Dental erosion
    Sources: exogenous
    Red wine drinker
  • 20. Dental erosion
    Sources: exogenous
    Seafood lovers
  • 21. Dental erosion
    Sources: exogenous
    Preserved Snacks
  • 22. Dental erosion
    Sources: exogenous
    GI reflux
  • 23. Dental erosion
    All carbonated drinks, including soda and some energy drinks, contain a lot of acid such as citric, phosphoric and carbonic acids which can rapidly dissolve enamel on teeth.
  • 24. Early erosive tooth wear
    Prevention
    Patient Education
  • 25. Prevention of erosion
    • Dietary acids and drinking habits
    • 26. Reflux and referral to gastroenterologists
    • 27. Preventing erosion
    • 28. Fluoride
    • 29. Dentine bonding agents
    • 30. The relationship between sensitivity and erosion
  • Mild cases of tooth wear
    • Dietary advice
    • 31. Fluoride toothpaste
    • 32. Low abrasive toothpaste
    • 33. Dentine bonding agents
    • 34. Avoid placing restorations
  • Moderate erosion
    • Prevent and Patient education
    • 35. Consider restorations only when concerns for appearance or sensitivity
    Composites, Onlays, Crowns
  • 36. Severe erosion
    Refer to specialist
  • 37. Dental erosion
    Regular Review is important
  • 38.
  • 39. Dentine HypersensitivityOpportunities for an optimized, evidence based management
  • 40. Definition of Dentine Hypersensitivity
    Dentine hypersensitivity is characterized by short, sharp pain arising from exposed dentine in response to external stimuli which cannot be ascribed to any other form of dental defect or disease.
    Correct differential diagnosis is key for management success!
    Addy M.,Int. Dent.J, 2002, Canadian Advisory Board, J of Can.Dent.Assoc., 2003
  • 41. Aetiology - Mechanism of Hypersensitivity
    Explained by Brännström’s Hydrodynamic Theory
    Short sharp pain associated with A-beta and A-delta nerve fibers stimulation
    Two phases* development:
    Lesion Localisation
    Lesion Initiation
    GINGIVAL RECESSION
    LOSS OF ENAMEL
    LESION LOCALISATION
    Exposure of dentine
    LESION INITIATION
    Opening of dentine tubules
    (removal of cementum or smear layer)
    *Dababneh et all. Br Dent J, 1999
  • 42. Aetiology - Mechanism of Hypersensitivity
    GINGIVAL RECESSION
    LOSS OF ENAMEL
    Abrasion
    Attrition
    Abfraction
    Erosion
    Fracture
    Incorrect tooth-brushing or flossing
    Periodontitis
    Periodontal procedures
    Gingival trauma (picking, hard foods)
    Crown preparation
  • 43. Dentine Hypersensitivity treatment options
    Occluding the dentine tubules
    Desensitising the nerves
  • 44. Desensitising of nerves – mechanism and clinical evidence*
    Buffering of membrane potential with potassium (K+) ions
    Symptomatic action
    Potassium salts delivered in at home products (toothpastes)
    Potassium nitrate (5%)
    Potassium citrate (5,5%)
    Potassium chloride (3,75%)
    Reduction in yield sensitivity measures – minimum 2 weeks of 2/day use
    Pain relief - 4-8 weeks of 2/day use
    Equivocal data on actual efficacy
    * Literature review in Cummins, J Clin Dent, 2009
  • 45. Dentine tubule occlusion - mechanism and clinical evidence*
    At home use (Toothpaste) - precipitation of insoluble metal compounds.
    Strontium chloride – reported less effective than potassium salts**
    Stannous fluoride – secondary effects (staining)**
    In office use
    Established desensitisers with HEMA or oxalate seal
    Desensitising pastes with calcium sodium phosphosilicate or CPP-ACP technologies
    High fluoride containing products with sensitivity relief as secondary benefit only (varnishes, toothpastes and gels)
    *Literature review in Orchardson, JADA, 2006; ** Cummins, J Clin Dent 2009
  • 46. Dentine Hypersensitivity treatment options - Current State
    2 widely used mechanisms* **
    desensitising toothpaste recognized as the “first option” recommendation – effective but slow (4-8 weeks) pain relief * **
    In office treatment approached usually for “severe cases”* **
    Stated need for new tested treatment options that should effectively occlude dentine tubules and mimic the natural desensitising process***.
    *Orchardsson, JADA, 2006, ** Cummins, J Clin Dent 2009, ***Markowitz, J of Oral Rehab., 2007
  • 47. Dentine Hypersensitivity treatment options - Current Needs
    Efficacy – fast, reliable action and long term effect
    Action based upon natural process of desensitisation
    Compatible with other active compounds
    No staining or other side effects
    Good taste
    Safe
  • 48. Introducing a new technology
    Over several decades, the State University of New York (SUNY) studied the role of saliva in oral health under the leadership of Dr. Israel Kleinberg.
    Arginine was identified as a key component of saliva and important to oral health
    Ortek Company, in collaboration with SUNY, developed a novel technology for dentine hypersensitivity associating arginine with calcium carbonate
    Colgate acquired the technology from Ortek in July 2007, and further developed the formulation by including sodium fluoride
  • 49. What is the Pro-Argin™ Technology?
    • Pro-Argin™ is a special technology consisting of Arginine and calcium carbonate
    • 50. It is proprietary to Colgate
  • Carbon
    Hydrogen
    Oxygen
    Nitrogen
    What is Arginine?
    Arginine is a natural amino acid and is an essential element in many biological processes
    Arginine is naturally found in saliva
    Arginine is compatible with fluoride
    US Food and Drug Administration has categorised arginine as safe in food.
  • 51. -
    +
    How does Pro-Argin™ Technology work against Dentine Hypersensitivity?
    +
    -
    Arginine
    • Arginine is a bipolar molecule having both positively and negatively charged groups. Arginine ispositively charged at physiological pH
  • How does Pro-Argin™ Technology work against Dentine Hypersensitivity?
    -
    -
    +
    -
    -
    -
    Like most natural surfaces, tooth surface, including the dentine, is negatively charged.
    At physiological pH in saliva, Arginine interacts with the calcium carbonate and adheres to the walls of dentine tubules and the dentine surface.
    -
    +
    Arginine
    -
    Dentine
  • 52. How does Pro-Argin™ Technology work against Dentine Hypersensitivity?
    Arginine promotes precipitation of calcium and phosphate ions to form a calcium-rich layer that plugs and seals the opening of dentine tubules.
    The plug shields dentine fluid from exposure to external stimuli.
    -
    -
    -
    Graphical representation, for illustration purposes only
    Pro-Argin™ Technology thus addresses the cause of dentine hypersensitivity.
  • 53. Pro-Argin™ Technology Documentation
    Mode of Action
    How the technology works
    In vitro tests
    Clinical Efficacy
    Hypersensitivity clinical studies
    Surface roughness study
  • 54. High powered microscope visualization
    Confocal Laser Scanning Microscopy (CLSM)
    Scanning Electron Microscopy (SEM)
    Atomic Force Microscopy (AFM)
    Chemical Analysis
    • Electron Spectroscopy for Chemical Analysis (ESCA)
    • 55. Energy dispersive X-ray spectroscopy (EDX)
    Confocal Dye Binding Experiments
    Acid Resistance
    Hydraulic conductance
    Pro-Argin™ Technology – Mode of Action Documentation – Dentine Occlusion
  • 56. Pro-Argin™ Technology – Mode of Action High powered microscope visualization
    Dentine tubules have diameter ~1 to 5 microns
    High powered microscopes are used to visualize the tubules
    Confocal Laser Scanning Microscope (CLSM)
    Scanning Electron Microscope (SEM)
  • 57. Pro-Argin™ Technology – Mode of Action High powered microscope visualization
    Arginine and CaCO3 are required for efficacy
    Compared occlusion of
    CaCO3
    8% Arginine/CaCO3/1450 ppm MPF
    8% Arginine/Dical/1450 ppm MPF
    8% Arginine/CaCO3
  • 58. Pro-Argin™ Technology – Mode of Action High powered microscope visualization: Confocal LSM
    CaCO3
    8% Arginine/dical/1450 ppm MPF
    8% Arginine/CaCO3
    8% Arginine/CaCO3/1450 ppm MPF
  • 59. Pro-Argin™ Technology – Mode of Action High powered microscope visualization (SEM)
    Dentine Occlusion – 8.0% Arginine/CaCO3
    Treated
    Baseline
    SEM Images – 10,000x Magnification
  • 60. AFM used to evaluate dentine surface
    Untreated dentine shows tubule completely open and helical structure of dentine collagen
    Treated dentine shows no helical structure – sign of protective layer at the surface of dentine
    Collagen
    Open Tubule
    Pro-Argin™ Technology – Mode of Action Atomic Force Microscopy
  • 61. Pro-Argin™ Technology – Mode of Action Atomic Force Microscopy
    Untreated Dentine Multiple Tubules
    Treated dentine Multiple Tubules
    Dentine tubule completely occluded and sealed by 8% Arg/CaCO3
  • 62. Open Tubule
    Untreated Dentine– Single Tubule
    Pro-Argin™ Technology – Mode of Action Atomic Force Microscopy
    Treated Dentine– Single Tubule
  • 63. Pro-Argin™ Technology – Mode of Action Chemical Analysis - ESCA
    ESCA is a surface analysis technique used for obtaining chemical information about the surfaces of solid materials
    Utilizes an x-ray beam to excite a solid sample resulting in the emission of photoelectrons
    Energy analysis of these photoelectrons provides chemical information about a sample surface 
    ESCA has a sampling depth of approximately 30 Å
  • 64. Pro-Argin™ Technology – Mode of Action Chemical Analysis - ESCA
    Elementary analysis (by ESCA) of surface layer showed:
    Before treatment: high levels of carbon, oxygen and nitrogen, and low levels of calcium and phosphorus, consistent with demineralization of dentine and exposure of collagen matrix.
    After treatment: Increase in calcium, phosphorus and carbonate content confirms the composition of occluding layer deposited after application of the Pro-Argin™ Technology
    Decrease in nitrogen is due to coverage of collagen-containing dentine surface by occluding layer
    Increase in silicon is evidence that some silica from Pro-Relief™ Desensitising Polishing paste formula is deposited at the surface of dentine
  • 65. Pro-Argin™Technology– Mode of Action Chemical Analysis - ESCA
    16
    Legend
    14
    Before application
    12
    After application
    10
    Atomic %
    8
    6
    4
    2
    0
    CO3
    Ca
    P
    N
    Silica
    Chemical Analysis of Coating – ESCA = Electron Spectroscopy for Chemical Analysis*
  • 66. After evaluation of tubule occlusion by SEM, samples were analysed by EDX analysis in order to qualitatively determine the elemental composition of the occluding material as the sampling depth is higher than ESCA
    Analysis performed on occluded and a freeze-fractured face of the treated dentine disks
    Pro-Argin™ Technology – Mode of Action Chemical analysis - EDX
  • 67. Pro-Argin™ Technology – Mode of Action Chemical analysis - EDX
    Energy dispersive X-ray spectroscopy
  • 68. Pro-Argin™ Technology – Mode of Action Chemical analysis - EDX
    Energy dispersive X-ray spectroscopy
  • 69. Energy dispersive X-ray spectroscopy
    Pro-Argin™ Technology – Mode of Action Chemical analysis - EDX
    EDX analysis provided qualitative confirmation of the ESCA results
    Tubules occluded with arginine, calcium, carbonate, phosphate and silica
    Increase in silicon is evidence that some silica from Colgate® Sensitive Pro-Relief™ Desensitising Polishing Paste formula is deposited within the occluding layer
  • 70. Confocal Laser Scanning Microscope has two modes of operation
    Reflectance
    Shows hard surfaces
    Fluorescence
    Discloses substrate that binds fluorescent dye
    Used FITC dye that binds to amines
    (Functional group on arginine)
    Pro-Argin™ Technology – Mode of Action Dentine Occlusion
  • 71. Fluorescence
    Overlay
    Reflection
    Dentine Tubules 100% Open – Top view
    Pro-Argin™ Technology – Mode of Action Confocal Dye Binding
    Fluorescein isothiocyanate as dye
  • 72. Open tubules
    Overlay
    Reflection
    Fluorescence
    Dentine Tubules 100% Open – Side view
    Pro-Argin™ Technology – Mode of Action Confocal Dye Binding
  • 73. Pro-Argin™ Technology – Mode of Action Confocal Dye Binding
    Dye concentrated
    In tubule
    Fluorescence
    Reflection
    Overlay
    Treated Dentine – Top view
  • 74. Dye concentrated
    In tubule
    No open tubules
    Overlay
    Fluorescence
    Reflection
    Treated Dentine – Side view
    Pro-Argin™ Technology – Mode of Action Confocal Dye Binding
  • 75. Pro-Argin™ Technology – Mode of Action Confocal Dye Binding – Acid resistance
    Treatment of dentine surfaces with Colgate® Sensitive Pro-Relief™Desensitising Polishing Paste
    Subsequent treatment of occluded dentine samples with acidic soft drink
    Visualisation of dentine surface by 2 methods
    Confocal Laser Scanning Microscopy (CLSM) in reflectance mode
    CLSM using a fluorescent dye that adheres to surfaces, side view
  • 76. Pro-Argin™ Technology – Mode of Action Confocal Dye Binding – Acid resistance
    Before treatment
    Treated with Pro-Argin™ Technology 5xs
    2nd Acid Challenge (24 hours later)
    1 minute Acid Challenge
  • 77. Pro-Argin™ Technology – Mode of Action Confocal Dye Binding – Acid resistance
    Open tubules
    Open tubules
    Overlay
    Reflection
    Fluorescence
  • 78. Pro-Argin™ Technology – Mode of Action Confocal Dye Binding – Acid resistance
    Treated with 8.0% Pro-Argin™ Technology 5x
    Untreated
    Open tubules
    Acid Challenge-
    treated with
    Acidic drink for 1 min
    Second Acid Challenge (24 hours later) - treated with
    Acidic drink for 1 min
    Tubule occlusion by the Pro-Argin™ technology is resistant
    to acid from common beverages
  • 79. Pro-Argin™ Technology – Mode of Action Hydraulic Conductance
    Hydraulic conductance (Pashley et al) is used to measure inhibition of fluid flow in dentine tubules
    Effective occlusion agents reduce flow
    Hydraulic conductance experiments were conducted with Colgate Sensitive Pro-Relief™ Desensitising Polishing Paste (Pro-Argin™ formula)
  • 80. Pro-Argin™ Technology – Mode of Action Hydraulic conductance
    Pro-Argin™ Technology significantly reduced fluid flow in dentine tublules
  • 81. Pro-Argin™ Technology – Mode of Action Summary
    The arginine interacts with the calcium carbonate at physiological pH to form a positively charged agglomerate which is attracted by electrostatic forces to negative surfaces, including dentine
    This agglomerate promotes the formation of a calcium-rich mineral layer on the dentine surface to occlude the tubules.
    The occlusion protects dentinal fluid from exposure to external stimuli, thus stopping fluid movement in the tubules.
    This blocking of the fluid movement addresses the cause of pain and discomfort.
    The occluding layer resists acid attacks, such as provoked by certain acid beverages.
  • 82. Pro-Argin™ Technology Documentation
    Mode of Action
    How the technology works
    In vitro tests
    Clinical Efficacy
    Hypersensitivity clinical studies
    Surface roughness study
  • 83. Pro-Argin™ Technology Clinical Documentation
    Hypersensitivity Measurements Methodology
    In-Office desensitising (Prophylaxis) Paste containing 8% Arginine and Calcium Carbonate
    Colgate supported independent Clinical Documentation
    Ortek Clinical Documentation
    Toothpaste formula containing arginine and 1450 ppm fluoride as MFP in a calcium carbonate base
  • 84. Hypersensitivity Measurements Methodology
    Dentine Hypersensitivity (DHS) improvements for a tested product are usually compared to negative &/or positive controls in order to establish product efficacy.
    Double-blind randomized parallel groups
    DHS is generally may be measured following the application of stimuli of known intensity:
    Tactile
    Air blast
    Thermal
  • 85. Hypersensitivity Measurements Methodology
    Tactile stimulation
    Pressure stimulation based assessment
    Electronic Force Sensing Probe (Yeaple Probe) calibrated once daily
    Explorer tip stroked perpendicular to surface beginning at pre-set force of 10g and increasing by 10g increments until patient expresses discomfort.
    Scored as force (g) required to elicit discomfort
    Non-sensitive if no discomfort upon 50g of force.
  • 86. Hypersensitivity Measurements Methodology
    Air blast stimulation
    Evaporative stimulus-based assessment
    One second of air delivered at 1cm distance from the surface
    From standard dental unit syringe at 60psi (±5) and 70°F(±3)
    Examiner scores subject response using Schiff Cold Air Sensitivity Scale, where:
    “0” No subject response to stimulus
    “1” responds but will continue
    “2” responds and moves or requests discontinuation
    “3” Painful response to stimulus, discontinuation requested
  • 87. Pro-Argin™ Technology Clinical DocumentationHypersensitivity Clinical Research Methodology
    Fully compliant with American Dental Association Acceptance Guidelines for approval of desensitising products
    Reviewed by the US Food and Drug Administration (FDA)
    Also utilized in published research testing the effectiveness of desensitising products
  • 88. Pro-Argin™ Technology Clinical DocumentationHypersensitivity Clinical Research Methodology
    Colgate Sensitive Pro-Relief™ Desensitising Polishing Paste with Pro-Argin™ Technology
    8% arginine in a calcium carbonate/silica prophy base
    No fluoride
    Toothpaste formula containing arginine and 1450 ppm fluoride as MFP in a calcium carbonate base
  • 89. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Study design for post-scaling application1
    Objectives
    Compare the efficacy in reducing hypersensitivity after a single post scaling application, as the final polishing step in a dental prophylaxis
    Assess the duration of relief over 4 and 12 weeks.
    Methodology
    Study conducted in San Francisco, California
    68 subjects (50% female)
    Test: Colgate Sensitive Pro-Relief™ Paste n=32
    Negative Control: Nupro n=36
    Mean age 36 years (24-56)
    Double blind, parallel group controlled study
    Tactile and air blast scores at baseline, immediate after product application, at 4 and 12 weeks.
    All used Crest anti cavity toothpaste and soft brush for duration of study.
    1 Schiff T et al , (2009) Am.J of Dent, 22, Special Issue A, 8A-15A
  • 90. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Post-scaling application - Tactile results1
    p < 0.05
    p < 0.05
    Yeaple Probe Pressure
    Test product
    Control product
    1 Schiff T et al , (2009) Am.J of Dent, 22, Special Issue A, 8A-15A
  • 91. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Post-scaling application - Air Blast Results1
    p < 0.05
    p < 0.05
    Schiff Scores
    Test product
    Control product
    1 Schiff T et al , (2009) Am.J of Dent, 22, Special Issue A, 8A-15A
  • 92. Post-scaling application1
    Conclusions:
    Colgate® Sensitive Pro-Relief™ desensitising paste provides a statistically significant reduction in dentine hypersensitivity as compared to a control prophylaxis paste immediately after a single application following dental scaling. This relief lasts for 4 weeks.
    Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    1 Schiff T et al , (2009) Am.J of Dent, 22, Special Issue A, 8A-15A
  • 93. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Study design for pre-scaling application2
    Objective
    Compare the efficacy in reducing hypersensitivity when applied before professional prophylaxis
    Methodology
    Study conducted in Langhorn, Pennsylvania
    45 subjects (33 female)
    Test: Colgate Sensitive Pro-Relief ™ Paste n=22
    Negative Control: Nupro n=23
    Mean age 45 years (23-66)
    Double blind, parallel group controlled study
    Tactile and air blast scores at baseline,
    Two 3 second applications of test or control product with prophy cup
    Reassess sensitivity after completion of scaling and polishing with Nupro prophy paste
    2 Hamlin D et al, (2009) Am J of Dent, 22, Special Issue A, 16A-20A
  • 94. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Pre-scaling application - Tactile Results2
    p < 0.05
    Yeaple Probe Pressure
    Test product
    Control product
    2 Hamlin D et al, (2009) Am J of Dent, 22, Special Issue A, 16A-20A
  • 95. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Pre-scaling application - Air Blast Results2
    p < 0.05
    Schiff Scores
    Test product
    Control product
    2 Hamlin D et al, (2009) Am J of Dent, 22, Special Issue A, 16A-20A
  • 96. Conclusions:
    When applied prior to a scaling, Colgate® Sensitive Pro-Relief™ desensitising paste with 8 % arginine and calcium carbonate provides a statistically significant reduction in dentine hypersensitivity measured after scaling compared to a control prophylaxis paste.
    Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    Pre-scaling application2
    2 Hamlin D et al, (2009) Am J of Dent, 22, Special Issue A, 16A-20A
  • 97. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    ORTEK Sponsored Studies
    Immediate Relief
    Negative controlled Study
    Reductions in sensitivity after dental prophylaxis procedure
    Tactile: 53% improvement compared to 2% for the negative control
    Air blast: 37% improvement compared to 6% for the negative control
    Thermal: 37% improvement compared to 13% for the negative control
    2. Immediate and Lasting (28 days) Relief
    Monadic-design Study
    Reductions in sensitivity immediately after dental prophylaxis procedure
    Tactile: 84% improvement from baseline
    Air blast: 72% improvement from baseline
    Reductions in sensitivity 28 days after dental prophylaxis procedure
    Tactile: 88% improvement from baseline
    Air blast: 68% improvement from baseline
  • 98. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office product
    In vitro testing3 of surface roughness
    Composite
    Porcelain
    Amalgam
    Gold
    Enamel
    No significant alteration of surfaces
    3 Garcia-Godoy F et al, (2009) Am J of Dent, 22, Special Issue A, 21A - 24A
  • 99. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – In office productConclusions
    Significant immediate and lasting (28 days) tactile and air blast dentine hypersensitivity relief when applied as a single treatment after tooth scaling procedure, as the final polishing step in a dental prophylaxis.
    Significant tactile and air blast dentine hypersensitivity relief when applied as a single treatment before professional prophylaxis (scaling and polishing) procedure.
    No significant effect on surface roughness on the following substrates: resin composite, porcelain, amalgam, gold and human dental enamel.
  • 100. Study design4
    Objectives
    Compare the efficacy in reducing hypersensitivity after brushing application after 2, 4 and 8 weeks.
    Methodology
    Study conducted in private practice, Rome, Italy
    80 patients (24 males, 56 females)
    40 subjects in each group
    mean age of 42.2 y (± 10.6y)
    Test products:
    Test Formula: 8% Arginine/CaCO3/1450 ppm fluoride (as MFP)
    Positive Control: 3.75%KCl / 1450 NaF
    Double blind, parallel group controlled study
    Tactile and air blast scores at baseline, 2, 4 and 8 weeks
    Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    4 Docimo R et al (2009) J Clin Dent 20 (Spec Iss): 17-22
  • 101. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    Tactile Stimulation Results4
    p < 0.05
    p < 0.05
    p < 0.05
    Yeaple Probe Pressure
    Test formula
    Control product
    4 Docimo R et al (2009) J Clin Dent 20 (Spec Iss): 17-22
  • 102. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    Air Blast Stimulation Results4
    p < 0.05
    p < 0.05
    Schiff Scores
    p < 0.05
    Test formula
    Control product
    4 Docimo R et al (2009) J Clin Dent 20 (Spec Iss): 17-22
  • 103. Docimo R et al 4
    Conclusions:
    Pro-Argin™ Technology was shown to effectively reduce tactile and air blast hypersensitivity compared to both the baseline values and to a positive control toothpaste* containing 3.75% KCl when used twice daily for two, four and eight weeks.
    Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    * Sensodyne Total Care F toothpaste
    4 Docimo R et al (2009) J Clin Dent 20 (Spec Iss): 17-22
  • 104. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    Study Design5
    Objectives
    Compare the efficacy in reducing hypersensitivity after brushing application after 3 days, 2, 4 and 8 weeks.
    Methodology
    Study conducted in clinical research centre, Mississauga, Canada.
    77 patients (25 males, 52 females)
    38 test and 39 control subjects
    mean age of 35.2 y ± 10.6)
    tested products
    Test formula: 8% Arginine /CaCO3/ 1450 ppm Fluoride (MFP)
    Positive Control: 3.75%KCl / 1450 NaF
    Double blind, parallel group controlled study
    Tactile and air blast scores at baseline, 3 days, 2, 4 and 8 weeks
    5 Ayad F et al (2009) J Clin Den (Spec Iss) 10-16.
  • 105. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    Tactile Stimulation Results5
    p < 0.05
    p < 0.05
    p < 0.05
    Yeaple Probe Pressure
    Test formula
    Control product
    5 Ayad F et al (2009) J Clin Den (Spec Iss) 10-16.
  • 106. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    Air Blast Stimulation Results5
    p < 0.05
    p < 0.05
    p < 0.05
    Schiff Scores
    Test formula
    Control product
    5Ayad F et al (2009) J Clin Den (Spec Iss) 10-16.
  • 107. Ayad et al5
    Conclusions:
    Pro-Argin™ Technology was shown to effectively reduce tactile and air blast hypersensitivity compared to both the baseline values and to a positive control toothpaste* containing 3.75% KCl when used twice daily for two, four and eight weeks.
    Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula
    * Sensodyne Total Care F toothpaste
    5 Ayad F et al (2009) J Clin Den (Spec Iss) 10-16.
  • 108. Pro-Argin™ Technology Clinical Documentation Clinical Research Results – Test Formula : Summary
    Clinical data from two independent clinical trials showed show that the Pro-Argin™ Technology was shown to effectively deliver a sensitive benefit as compared to a leading desensitising toothpaste containing 2% potassium ion as the desensitising agent.
  • 109. 100
    Pro-Argin™ Technology Conclusions
    Pro-Argin™ Technology is an innovative and proprietary technology combining the key ingredients Arginine, an amino acid, and insoluble calcium carbonate.
    Occludes tubules rapidly and effectively to treat the cause of tooth sensitivity. Tubule occlusion is calcium rich and acid resistant.
    Provides fast relief and long lasting protection from hypersensitivity.
    Is compatible with fluoride and provides no secondary unpleasant effects.
    Provides clinically superior sensitivity relief compared to other leading desensitising technologies (3.75% potassium chloride equivalent to 2% potassium).
    Represents a reliable solution for treatment of dentine hypersensitivity of various aetiology.
  • 110.
  • 111.
  • 112.
  • 113. Colgate Sensitive Pro-Relief Desensitizing In-Office Paste
  • 114. Colgate Sensitive Pro-Relief Desensitizing In-Office Paste
    Clinically proven to deliver instant relief that lasts four weeks after a single application
    Fast and easy application using a rotary cup
  • 115. With
  • 116. With
  • 117. Reduces sensitivity pain for a comfortable dental procedure
    With
  • 118. Fast and easy to use
    Fill a rotary cup with paste.
  • 119. Fill a rotary cup with paste.
    At low to moderate speed polish whole dentition. On sensitive areas apply product for 3 seconds and then repeat.
    Fast and easy to use
  • 120. Proof of clinical efficacy
  • 121. Post-procedure instant and lasting relief study
    Controlled study
    68 male and female subjects (between 24 and 56 years of age) with established dentin hypersensitivity
    Schiff T et al. Am J Dent. 2009;22(Spec Iss A):8A-15A.
  • 122. Post-procedure instant and lasting relief study
    Controlled study
    68 male and female subjects (between 24 and 56 years of age) with established dentin hypersensitivity
    Products tested
    Pro-ArginTM technology desensitizing paste
    Negative control: pumice prophylaxis paste
    Schiff T et al. Am J Dent. 2009;22(Spec Iss A):8A-15A.
  • 123. Post-procedure instant and lasting relief study
    Product A or B
    Scaling
    Day 28
    Day 0
    (Immediate)
    Baseline
    Controlled study
    68 male and female subjects (between 24 and 56 years of age) with established dentin hypersensitivity
    Products tested
    Pro-ArginTM technology desensitizing paste
    Negative control: pumice prophylaxis paste
    Product applied after scaling procedure
    Evaluations at baseline, immediately after application, 28 days, 3 months
    Schiff T et al. Am J Dent. 2009;22(Spec Iss A):8A-15A.
  • 124. Post-procedure instant and lasting relief study
  • 125. Post-procedure instant and lasting relief study
    Effects on dentin hypersensitivity
    Tactile sensitivity scores
    Test paste
    Control paste
    Schiff T et al. Am J Dent. 2009;22(Spec Iss A):8A-15A.
  • 126. Post-procedure instant and lasting relief study
    Effects on dentin hypersensitivity
    Tactile sensitivity scores
    Air blast sensitivity scores
    Test paste
    Control paste
    Test paste
    Control paste
    Schiff T et al. Am J Dent. 2009;22(Spec Iss A):8A-15A.
  • 127. Post-procedure instant and lasting relief study
    Effects on dentin hypersensitivity
    Tactile sensitivity scores
    Air blast sensitivity scores
    149.6%
    reduction
    Test paste
    Control paste
    Test paste
    Control paste
    79%
    reduction
    40.6%
    reduction
    34.1%
    reduction
    Schiff T et al. Am J Dent. 2009;22(Spec Iss A):8A-15A.
  • 128.
  • 129.
  • 130.
  • 131. Plugs and seals open tubules
  • 132. Plugs and seals open tubules
  • 133. Shown to be more effective than the control toothpaste with potassium salt
  • 134. Air blast sensitivity score
    Shown to be more effective than the control toothpaste with potassium salt
    Brushing twice daily over a period of 8 weeks with Colgate® Sensitive Pro-Relief™ Toothpaste with Pro-Argin™ Technology is significantly (p<0.05) more effective in reducing sensitivity than using the control toothpaste (with potassium ions).
    Colgate Sensitive Pro-Relief™ Toothpaste
    Positive control: Toothpaste with 2% potassium ion
    Docimo R et al. J Clin Dent. 2009;20(Spec Iss):17-22.
  • 135. Air blast sensitivity score
    Shown to be more effective than the control toothpaste with potassium salt
    Sensitivity relief
    Brushing twice daily over a period of 8 weeks with Colgate® Sensitive Pro-Relief™ Toothpaste with Pro-Argin™ Technology is significantly (p<0.05) more effective in reducing sensitivity than using the control toothpaste (with potassium ions).
    Colgate Sensitive Pro-Relief™ Toothpaste
    Positive control: Toothpaste with 2% potassium ion
    Docimo R et al. J Clin Dent. 2009;20(Spec Iss):17-22.
  • 136.
  • 137.
  • 138.
  • 139. Shown to provide instant relief with direct application and continued relief with subsequent twice-daily brushing
  • 140. Shown to provide instant relief with direct application and continued relief with subsequent twice-daily brushing
    3
    2
    Air blast sensitivity scores
    1
    0
    Baseline
    Immediate
    3-day
    When applied directly to the sensitive tooth with a fingertip and gently massaged for 1 minute, Colgate® Sensitive Pro-Relief™ Toothpaste provides instant sensitivity relief compared to the positive and the negative control. The relief was maintained after 3 days of twice-daily brushing.
    Colgate Sensitive Pro-Relief™ Toothpaste
    Nathoo S et al. J Clin Dent. 2009;20(Spec Iss):123-130.
  • 141. Shown to provide instant relief with direct application and continued relief with subsequent twice-daily brushing
    3
    2
    Air blast sensitivity scores
    1
    0
    Baseline
    Immediate
    3-day
    When applied directly to the sensitive tooth with a fingertip and gently massaged for 1 minute, Colgate® Sensitive Pro-Relief™ Toothpaste provides instant sensitivity relief compared to the positive and the negative control. The relief was maintained after 3 days of twice-daily brushing.
    Colgate Sensitive Pro-Relief™ Toothpaste
    Positive control: Toothpaste with 2% potassium ion
    Nathoo S et al. J Clin Dent. 2009;20(Spec Iss):123-130.
  • 142. Shown to provide instant relief with direct application and continued relief with subsequent twice-daily brushing
    3
    2
    Air blast sensitivity scores
    1
    0
    Baseline
    Immediate
    3-day
    When applied directly to the sensitive tooth with a fingertip and gently massaged for 1 minute, Colgate® Sensitive Pro-Relief™ Toothpaste provides instant sensitivity relief compared to the positive and the negative control. The relief was maintained after 3 days of twice-daily brushing.
    Colgate Sensitive Pro-Relief™ Toothpaste
    Positive control: Toothpaste with 2% potassium ion
    Negative control: Toothpaste with 1450 ppm fluoride only
    Nathoo S et al. J Clin Dent. 2009;20(Spec Iss):123-130.
  • 143. Shown to provide instant relief with direct application and continued relief with subsequent twice-daily brushing
    3
    2
    Air blast sensitivity scores
    Sensitivity relief
    1
    0
    Baseline
    Immediate
    3-day
    When applied directly to the sensitive tooth with a fingertip and gently massaged for 1 minute, Colgate® Sensitive Pro-Relief™ Toothpaste provides instant sensitivity relief compared to the positive and the negative control. The relief was maintained after 3 days of twice-daily brushing.
    Colgate Sensitive Pro-Relief™ Toothpaste
    Positive control: Toothpaste with 2% potassium ion
    Negative control: Toothpaste with 1450 ppm fluoride only
    Nathoo S et al. J Clin Dent. 2009;20(Spec Iss):123-130.
  • 144. Colgate Sensitive Pro-Relief™ Toothpaste
  • 145. Colgate Sensitive Pro-Relief™ Toothpaste
    Colgate Sensitive Pro-Relief™ Toothpaste is the first toothpaste for at-home use and is clinically proven to provide instant and lasting sensitivity relief
  • 146. Colgate Sensitive Pro-Relief™ Toothpaste
    Colgate Sensitive Pro-Relief™ Toothpaste is the first toothpaste for at-home use and is clinically proven to provide instant and lasting sensitivity relief
    Works instantly when applied directly to the sensitive tooth
  • 147. Colgate Sensitive Pro-Relief™ Toothpaste
    Colgate Sensitive Pro-Relief™ Toothpaste is the first toothpaste for at-home use and is clinically proven to provide instant and lasting sensitivity relief
    Works instantly when applied directly to the sensitive tooth
    Contains fluoride for caries prevention
  • 148. A breakthrough in dentin hypersensitivity relief
  • 149. A breakthrough in dentin hypersensitivity relief
    An in-office treatment for instant sensitivity relief in one fast and easy step
  • 150. A breakthrough in dentin hypersensitivity relief
    An in-office treatment for instant sensitivity relief in one fast and easy step
    A daily-use toothpaste as follow-up treatment for long-lasting relief
  • 151. A breakthrough in dentin hypersensitivity relief
    An in-office treatment for instant sensitivity relief in one fast and easy step
    A daily-use toothpaste as follow-up treatment for long-lasting relief
    The first toothpaste to be clinically proven to offer instant relief when applied directly

×