Mechanical Properties of Proteins<br />Swapnil Khachane<br />
Take Away<br />What are proteins<br />Necessity of the study<br />Sarcomere and Titin<br />Go-like Model<br />Results<br /...
Purpose of the Study<br /><ul><li>Diseases
Injury/Trauma
Future Inventions</li></li></ul><li>Titin<br />Figure 1. Structure of Titin<br />From. Cieplak 2002<br />
Titin<br />Figure 2. Structure of Titin<br />From. Tshovorebova 2005<br />
Sarcomere in a Striated Muscle<br />Figure 3. Sarcomere<br />From. Cieplak 2002<br />
Go Like Model<br /><ul><li> Cα Atoms
Lennard Jones Potential
Equation of Motion</li></ul>From. Buehler 2008<br />
Results from the model<br />Figure 4. Force Displacement Curve for 1tit<br />From. Cieplak 2005<br />
Experimental Results<br />Figure 5. Force Displacement Curve for 3tit<br />From. Tshovorebova 2005<br />
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Mechanical Properties of Collagen Molecule

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Mechanical Properties of Collagen Molecule

  1. 1. Mechanical Properties of Proteins<br />Swapnil Khachane<br />
  2. 2. Take Away<br />What are proteins<br />Necessity of the study<br />Sarcomere and Titin<br />Go-like Model<br />Results<br />Summary<br />
  3. 3. Purpose of the Study<br /><ul><li>Diseases
  4. 4. Injury/Trauma
  5. 5. Future Inventions</li></li></ul><li>Titin<br />Figure 1. Structure of Titin<br />From. Cieplak 2002<br />
  6. 6. Titin<br />Figure 2. Structure of Titin<br />From. Tshovorebova 2005<br />
  7. 7. Sarcomere in a Striated Muscle<br />Figure 3. Sarcomere<br />From. Cieplak 2002<br />
  8. 8. Go Like Model<br /><ul><li> Cα Atoms
  9. 9. Lennard Jones Potential
  10. 10. Equation of Motion</li></ul>From. Buehler 2008<br />
  11. 11. Results from the model<br />Figure 4. Force Displacement Curve for 1tit<br />From. Cieplak 2005<br />
  12. 12. Experimental Results<br />Figure 5. Force Displacement Curve for 3tit<br />From. Tshovorebova 2005<br />
  13. 13. Experimental Results<br />Figure 6. Force Displacement Curve for 3tit<br />From. Tshovorebova 2005<br />
  14. 14. References<br /><ul><li>Sulkowska et al., Predicting the order in which contacts are broken during single molecule protein stretching experiments, Wiley-Liss Inc, 2007.
  15. 15. Cieplak et al. , Folding and Stretching in a Go-like Model of Titin.
  16. 16. Cieplak et al,. Stretching of proteins in the entropic limit. Phys Rev e 2004; 69: 011912.
  17. 17. Erickson HP. Protein biophysics - stretching single protein molecules: titin is a weird spring. Science 1997; 276: 1090-1092.
  18. 18. Tskhovrebova et al, Elasticity and unfolding of single molecules of the giant muscle protein titin. Nature 1997; 387: 308-312.
  19. 19. Dietz H,BerkemeierF,BertzM,Rief M. Anisotropic deformation response of single protein molecules. Proc NatlAcadSci USA 2006; 103: 12724-12728.
  20. 20. West et al, Mechanical Resistance of Proteins Explained Using Simple Molecular Models, Biophysical Journal, Volume 90, Issue 1, 287-297, 1 January 2006.
  21. 21. Ceiplak et al, Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment, Biochimica et BiophysicaActa (BBA) - Biomembranes
  22. 22. Volume 1758, Issue 4, April 2006, Pages 537-544.
  23. 23. Kil Ho Eom, The Mechanical Modeling of Proteins.
  24. 24. Yoon et al, Mesoscopic Model for Mechanical Characterization of Biological Protein Materials, Nano-Bio Research Center, Korea Institute of Science & Technology (KIST), Seoul 136-791, Republic of Korea.</li></li></ul><li>Thank You<br />
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