Placenta Power: For Health and BeautyA useful guide for those seeking placenta-based remedies                   Kentaro Yo...
PrefaceThere are many things in life which bring us joy. Whatever it is that makes you happy, I’m sure we wouldall agree t...
Contents                                Placenta Power: For Health and BeautySection 1 – The Amazing Power of PlacentaWhat...
Liver FunctionsSection 5 – Examples of Treatment of Menopausal Disorders and Pre-Menopausal Disorders:Rheumatism, Atopic D...
Section 1The Amazing Power of Placenta
What is the Placenta?The placenta acts as an agent between the mother’s body and the embryo when a new baby is formed inma...
respiration and protein synthesis, breakdown of toxins, hormone secretion, and excretion of waste. Thefunctions performed ...
•   Proteins such as albumin, and globulin.    •   Fats and Fatty Acids such as cholesterol, phosphatidic acid, phosphatid...
□ Regenerative MedicineOn 7th January, 2001, Asahi Shimbun, a Japanese newspaper, carried the sensational headline, “CellR...
anti-obesity function. The discovery of Metastin is a further result of this continuing research into orphanreceptors.In t...
Many researchers have found that the placenta possesses a variety of medicinal effects, just like in thearticles above. Wh...
•   Other: fatigue, chills, weak constitution, recovery of strength during and after illness, muscularity,        and stre...
“if the tissues of plants and animals are refrigerated, the stimulus of the cold environment activates thetissue, inducing...
Placenta Extract and SafetyPlacenta Extract injections are extracted as a so called organ preparation, meaning safety issu...
Section 2Relieving Menopausal Disorders with Placenta
The Perimenopause is the 5 Year Period either side of the MenopauseWhile there are still many people who mistakenly think ...
So, why do menopausal disorders occur? In answering that question we must first understand therelationship between menstru...
Autonomic nerves are present in various bodily organs where they regulate the organ’s functions. The twomain types of auto...
extremely varied and wide-ranging. You might say there are as many experiences as there are people,from those who experien...
of the body is malfunctioning” as would be the norm in Western medicine, Kampo medicine emphasises“finding the body’s natu...
This chapter presents some very interesting clinical data from pharmaceutical companies examining theeffectiveness of “Mel...
(1) Psychological SymptomsA difference could already be seen between the Melsmon and placebo group after just four treatme...
Melsmon           12            9           5              5            0    31          21                 (38.8)       (...
Symptom                 Heavy Medium Light                    None         Points          (1) Flushed Head               ...
0~25 Points: You are bearing the menopause well. You should continue with your normal activities.26~50 Points: Pay attenti...
There are “acute symptoms of menopausal disorders” which arise from imbalance of the nervous systemduring the menopause, a...
Atrophic vaginitis is a degenerative disorder seen in post-menopausal women. It is an inflammationwhich arises due to the ...
You probably know the oxidising effect of airborne oxygen from when you leave an iron nail outside andit turns a red rusty...
In my clinic, there are often cases of patients with a combination of menopausal disorders andhyperlipidemia (excessive fa...
menopausal disorders and common diseases in that stage of life. Of the choices available at this time, I’msure you’ll agre...
Section 3                  Effective Treatment of Pre-Menopausal Disorders:Menstrual Irregularity, Chills, Stiff Shoulders...
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
Placenta power by Dr. Kentaro Yoshida, Japan
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Placenta power by Dr. Kentaro Yoshida, Japan

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An excellent book on Human Placental Extract by Dr. Kentaro Yoshida, Japan. This book is especially for the people who are non-technical on this subject and wants to have a first hand information on Human Placental Extract Therapy. All rights of the book is reserved with Dr. Kentaro Yoshida, and its been uploaded on http://placentrex.blogspot.com/ - the human placental extract blog for the general awareness on this subject.

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Transcript of "Placenta power by Dr. Kentaro Yoshida, Japan"

  1. 1. Placenta Power: For Health and BeautyA useful guide for those seeking placenta-based remedies Kentaro Yoshida Director of the Yoshida Clinic
  2. 2. PrefaceThere are many things in life which bring us joy. Whatever it is that makes you happy, I’m sure we wouldall agree that eternal health and youthfulness help us to make the most of life. Although this is easyenough to say, everyone knows eternal health and youth are considerably harder things to realise.Throughout history, whether in the East or the West, we hear of the futile struggles of the rich andpowerful to seek out life-extending elixirs whatever the cost.Well, here in the 21st century, while we still cant perform miracles of health and beauty, an "elixir" thatwill aid both health and beauty is just now coming into the limelight. That elixir is "Placenta Extract".Through the placenta, a material produced only at the time of birth in mammals, the mothers bodyprovides nutrition and oxygen to the growing infant, enabling the body to be formed and born. In humans,it is the placenta that causes a fertilised egg to grow to up to 3kg during pregnancy. In other words, theplacenta serves as a replacement for various internal organs for the infant embryo. This is why theplacenta demonstrates a variety of medicinal effects.When we are born, even though the outside environment changes our bodies are able to maintain a regularinternal environment, such as blood constituency and temperature; in other words, to maintain ahomeostatic state. Although of course, if the external environment remains abnormal for a long period wewould be unable to maintain a homeostatic state and we would fall ill.Homeostasis works to create a balance using the hormonal, nervous, and immune systems. We know thatthe placenta increases natural healing through hormonal regulation, nervous regulation, and immune-regulation, giving the body resistance against disease. We often hear that many modern diseases arecaused by free radicals. It is surprising to learn that the placenta has been confirmed to remove freeradicals, adding another form of attack to its ability to strengthen the body. In addition to these functions,the placenta acts to improve basic metabolism, strengthen the liver and counteract toxins, counterinflammation, accelerate the recovery of wounds, accelerate muscle formation, promote circulation,promote blood production, counter allergens, regulate the body, and improve the constitution.Another form of attack the placenta uses is its various growth abilities, such as the ability to accelerategrowth of the liver, as observed in the re-growth of cells and organs. This liver regenerative effect alonehas been shown in animal testing to be effective for almost all diseases other than cancer, such as hepatitis,cirrhosis of the liver, heart disease, stroke, and renal failure. You can see why the placenta is now viewedby many as a substance which will revolutionise modern medicine.However wonderful the functions and effects of the placenta, at childbirth it is excreted from the body.Nevertheless, we can make safe and effective use of the placenta for health and beauty by scientificallyprocessing it to produce Placenta Extract. Placenta Extract is made from natural ingredients which meansthere are no concerns about side effects, giving you peace of mind. Placenta Extract is especially effectivefor disorders of the nervous system, allergies, and lifestyle illnesses, which are often neglected by westernmedicine. It is also surprisingly effective for skin problems such as blemishes, wrinkles, and acne.Currently, Placenta Extract is approved for used in Japan in the form of injections (two varieties called"Melsmon" for menopausal disorders and failed lactation, and "Laennec" for liver disorders), as an oralmedicine, and also in health foods and make-up products.This book explains in detail what the placenta is, which diseases it is effective against (menopausal andpre-menopausal disorders, rheumatism, osteoarthritis, neuralgia, atopic skin complaints, bronchial asthma,hay fever, and liver disease) with real-life examples, and how the placenta is used in beauty products. Atthe end of the book you can find a list of medical organisations using Placenta Extract injections and oralmedicines, as well as manufacturers of make-up products using Placenta Extract.The placenta holds the key to the healthy development of an embryo, and even after we are fully grown,the placenta, in the form of Placenta Extract, plays an active role in the recovery from complaints anddisorders arising from day-to-day life. I sincerely hope that this book serves as a useful guide to PlacentaExtract, bringing its practical use within reach of all those who want to enjoy their lives in good health.August 2001Kentaro Yoshida, Director of the Yoshida Clinic
  3. 3. Contents Placenta Power: For Health and BeautySection 1 – The Amazing Power of PlacentaWhat is the Placenta?The Placenta Acts as a Substitute for an Embryos OrgansThe Many Constituents of the PlacentaThe Placenta is Amazing! Growth FactorsGrowth Factors will revolutionise 21st Century MedicineThe Medicinal Properties of PlacentaEffective Use of Placenta for Health and BeautyPlacenta is an Old and a New MedicineDr. Filatov, Dr. Kentaro Hieda, and NowThe Many Ways Placenta is usedPlacenta Extract and SafetySection 2 – Relieving Menopausal Disorders with PlacentaThe Perimenopause is the 5 Year Period around the MenopauseMenopausal Disorders are a General Malaise around the MenopauseWhy Menopausal Disorders OccurCommon Menopausal Disorders: Hot Flashes, Rushes of Blood, Excessive PerspirationHeavy and Light SufferersPlacenta as a TreatmentEffective Herbal MedicinesClinical Data Shows "Melsmon" is EffectiveUsing the "Simple Menopause Index"Illnesses Linked to the MenopausePrevention and Treatment of Osteoporosis, Atherosclerosis, and Atrophic VaginitisPrevention and Treatment of Breast Cancer and Uterine CancerSection 3 – Effective Treatment of Pre-Menopausal Disorders: Menstrual Irregularity, Chills, StiffShoulders, Sleeplessness, Constipation, Anaemia, etc.What Are Pre-Menopausal DisordersThe Link between Pre-Menopausal Disorders and StressSuppression of Emotions and Desires and an Out-of-Balance Nervous SystemTrend towards Those Susceptible to StressThe Link between Pre-Menopausal Disorders and DietDiet as the Cause of Irregular or Non MenstruationPre-Menopausal Disorders and Body Clock ProblemsIllnesses Linked to Pre-Menopausal DisordersPlacenta is Effective for Gynaecological IllnessesSection 4 – More Conditions Treatable with the Power of PlacentaChronic Rheumatoid Arthritis, Osteoarthritis, and NeuralgiaAtopic Skin ComplaintsBronchial Asthma and Hay Fever
  4. 4. Liver FunctionsSection 5 – Examples of Treatment of Menopausal Disorders and Pre-Menopausal Disorders:Rheumatism, Atopic Disorders, and Liver DiseaseMy menopausal disorders have calmed and my hormone levels have increasedIt helped me with my hot flashes, heavy perspiration, tiredness, and irritabilityMenopausal disorders and low-blood pressure both improved with twice weekly injectionsI have improved health and feel emotionally brighterI now have improved bodily and psychological resistance, and better physiological strengthI woke up refreshed the day after the injection, and am already feeling the effectsIt relieved a range of disorders like chills, stiff shoulders, constipation, and irregular menstruationI was treated for Hepatitis C, my wife for menopausal disorders and my daughter for menstrual painMy GOT and GPT went down from 3 to 2 figures, and there was no relapse of liver cancerI have Hepatitis C, but after 1 month my GOT dropped 103 to 27, and my GPT 85 to 28I was hospitalised in Taiwan with Hepatitis B, but felt dramatic effects from daily treatment over 2 weeksMy tests for fatty liver and high-blood pressure improved, and I feel greatMy bronchial asthma fits were reduced and my symptoms improvedMy rheumatism pain disappeared, but I will continue use it to maintain my healthThe pain from my osteoarthritis disappeared and now I even enjoy dancingIt worked for my knee pain. Evidence from more than 10 years of personal experienceIt improved my atopic skin disorder and I can now even use foundation creamMy contact dermatitis was cured in 1 month. My health is good and my skin clearMy poor vocal chords improved. Ive even been told I sound "rejuvenated"My incurable sarcoidosis was alleviated and there were no side-effectsSection 6 – Beauty Tips! Improve Your Skin with PlacentaPlacenta is Highly-Valued in the World of Beauty ProductsBlemishes Disappear with PlacentaWrinkles Improved with PlacentaAcne and Acne Scars ImprovedPlacenta Doesnt Distinguish Between Skin TypesWorks for Young, Mid-Life, and Elderly SkinPlacenta Stimulates Hair RestorationSection 7 – Placenta Questions and AnswersAfterword* Conditions Treatable with Placenta
  5. 5. Section 1The Amazing Power of Placenta
  6. 6. What is the Placenta?The placenta acts as an agent between the mother’s body and the embryo when a new baby is formed inmammals, enabling it to develop and grow using oxygen and nutrients from its mother.As you can see in Figure 1-1a below, the infant is connected to the mother by the umbilical cord. Theumbilical cord is very resilient and elastic and has blood vessels running inside it. The placenta begins toform in around the fifth week after conception and is fully grown by the 13th week. Let’s take a brief lookat that formation process.The process begins when the fertilised egg implants itself on the inner wall of the uterus. Then, countlesstiny hairs (villi) sprout from the surface of the fertilised egg, and those on the side of the uterine wallbegin to grow (the others are lost). This binds the egg to the wall, forming a flat cake shape. This is theplacenta.Figure 1-1a – Structure of the Placenta[Labels, top to bottom] Placenta, Umbilical CordAs well as connecting the mother and the embryo, the placenta also acts to separate them. Oxygen andnutrients flow into the placenta in the mother’s blood, and are then passed on into the embryo’s blood. Inthe other direction, waste products from the embryo’s blood are passed to the placenta and deposited inthe mother’s blood. The blood of the mother and embryo do not mix in this process. The embryo’s bloodcirculates in the embryo’s blood vessels in the villi while the mother’s blood merely fills the spacesbetween the villi [see Figure 1-1b]. This is why an embryo is not rejected even if the blood-type of themother and embryo are different. Also, if there are any abnormalities in the mother’s blood, the placentaacts as a protective barrier for the embryo.Figure 1-1b – Blood Circulation within the Placenta[Labels, left side, top to bottom] Mother’s Blood, Uterus, Mother’s Side, Uterus[Labels, right side, top to bottom, left to right] Amnion, Chorionic Sac, Intervillous Space, UmbilicalCord, Embryo’s Side, Umbilical Artery, Umbilical Vein, VillusThe size of the fertilised egg is initially only around 0.1mm in diameter, but around 280 days later atchildbirth the infant has grown to three or four kilograms and around 40cm in height. During this period,the placenta also grows to support the growing infant, reaching a size of 15 to 20cm in diameter, 1.5 to3cm in thickness, and around 500g in weight by the time of birth. The infant develops rapidly in this shortnine month period leading to birth, but the main driver behind this wonder is the placenta. It is primarilythanks to the placenta that mammals are able to undergo the process of live birth. Finally, after the birthof the child the placenta is expelled from the body as part of the birthing process.The Placenta Acts as a Substitute for an Embryos OrgansLet’s take a closer look at the growth of a fertilised egg.The fertilised egg implants itself into the uterus wall around one week after fertilisation, and there itbegins to separate into three layers of cell groups. Each of these three cell groups will form into a groupof organs. At around four weeks the three groups start to develop as follows: skin, brain, spinal cord, teeth,mouth, anus, etc., bones, muscles, blood vessels, kidneys, etc., and oesophagus, stomach, intestines, liver,bladder, etc. At around eight weeks, although still immature, these three groups are fixed and their growthwill be rapid.It is here where another of the placenta’s important roles comes into play. As well as providing nutrientsand oxygen to the embryo and protecting it, the placenta acts as a substitute for the immature organs asthey develop. In other words, the placenta carries out essential functions for the embryo such as
  7. 7. respiration and protein synthesis, breakdown of toxins, hormone secretion, and excretion of waste. Thefunctions performed by the placenta in place of organs can be summarised as follows. • Functions of the Lungs (Respiration) The embryo receives oxygen from its mother’s blood via the placenta. Also, carbon dioxide produced by the embryo is deposited in the mother’s blood, again via the placenta. • Functions of the Liver (Metabolism, Detoxification) An adult liver operates using up to 200 enzymes and around 500 chemical processes simultaneously (for detoxification functions such as protein synthesis). In an embryo, the liver does not possess enough enzymes to perform detoxification, so the placenta provides the missing functionality. The placenta also breaks down toxins, just like the liver. • Functions of the Kidneys (Excretion) The placenta processes the embryo’s waste matter and passes it into the mother’s bloodstream. • Functions of the Pituitary Gland and Ovaries (Endocrine System) A vigorously developing embryo needs large quantities of hormones, and it is the placenta which supplies them. Essentially, it provides the hormone secretion functions of endocrine organs such as the pituitary gland or the ovaries. • Functions of the Spleen (Immune System) The placenta acts as a barrier preventing the invasion of viruses and foreign substances. • Functions of the Small Intestines (Digestion) An embryo’s only source of protein is amino acids. In the placenta, serum proteins in the mother’s blood are digested and broken down into amino acids before being passed to the embryo. Neutral fats are also hydrolysed in the placenta and passed to the embryo.As you can see, the placenta acts as an agent for various organs for the undeveloped embryo. You mightcall it an all-purpose organ.Another important aspect of the placenta is its regulatory function. For example, the placenta prevents thetwo opposing problems of blood coagulation and bleeding. Think about when you accidentally cutyourself. Normally your blood needs to coagulate before the bleeding can stop. If the blood is preventedfrom coagulating bleeding wouldn’t stop. So, the placenta regulates the blood to create a balance betweenthe two functions, allowing them to co-exist. To put it another way, the placenta needs to preventcoagulation in order to supply blood to the embryo, but it also needs to prevent any bleeding in order toprotect the mother. Therefore, the placenta self-regulates to provide whichever function is required at thetime. This all-purpose organ constantly strives to maintain the status-quo, providing the regulatoryfunctions essential to life.The Many Constituents of the PlacentaWe have already mentioned a number of physiological aspects of the placenta, but the placenta containsnot only the three major nutrient groups: carbohydrates, proteins, and fats, but also a wide range ofnutrients such as minerals, vitamins, enzymes, and nucleic acids.□ Major Nutrients of the Placenta • Amino acids (the building blocks of proteins) such as leucine, lysine, valine, threonine, isoleucine, glycine, alanine, and arginine. • Active peptides (amino acid polymers called peptides): Many active peptides have been found to be the key to pharmacological activity.
  8. 8. • Proteins such as albumin, and globulin. • Fats and Fatty Acids such as cholesterol, phosphatidic acid, phosphatidylethanolamine, lauric acid, and palmitic acid. • Carbohydrates such as glucose, galactose, and sucrose. • Mucopolysaccharides such as hyaluronic acid, and chondroitin. • Vitamins such as vitamin B1, B2, B6, B12, C, D, E, and niacin. • Minerals such as calcium, sodium, potassium, phosphorus, magnesium, zinc, and iron. • Nucleic Acids such as DNA, RNA, and metabolic products. • Enzymes: Close to 100 varieties have been found including alkaline phosphatise, acid phosphatise, hyaluronidase, and adenosine triphosphate.The Placenta is Amazing! Growth FactorsThe placenta is known to possess various physiologically powerful growth factors, which are nowattracting a lot of attention.As mentioned earlier, the placenta makes up for many of the organs of an embryo. In just under 10months, a single fertilised egg is differentiated into the various organs and built into a full human body,and of course it is the placenta that lies behind this process of differentiation and growth. Central to thisprocess is the placenta’s cell activation growth factor, enabling an embryo to grow to up to 3kg inside theuterus. Placental growth factors are processes which promote cell activation, and therefore stimulate cellsand promote cell division. This causes the metabolism to increase as old cells are gradually replaced withnew ones. Not only that, but its effect is felt across the whole body. You could call placental growthfactors “stimulants” which switch on the process of cell division. It is important to note that even tinyquantities demonstrate this power.□ Main Growth Factors of the Placenta • Hepatocyte Growth Factor (HGF): Promotes growth of liver parenchymal cells and various tissues. • Nerve Growth Factor (NGF): Promotes growth of nerve cells (sensory and sympathetic ganglionic cells). • Epidermal Growth Factor (EGF): Promotes growth of skin, lungs, cornea, and tracheal epithelial cells. • Fibroblast Growth Factor (FGF): Promotes growth of human fibroblasts, glia cells, and vascular endothelial cells. • Insulin-like Growth Factor (IGF): Promotes growth of cartilage cells, and smooth muscle cells. • Growth Factors which Increase Immune Strength o Colony-Stimulating Factor (CSF): Promotes growth of stem cells such as immuno- competent cell granulocytes, and macrophages. o Interleukin-1 (IL-1): Promotes production of immune-competent cells (T-cells, B-cells, and NK-cells), thymus cells, and lymphokines. o Interleukin-2 (IL-2): Promotes growth of T-cells (helper T-cells, killer T-cells, and suppressor T-cells). o Interleukin-3 (IL-3): Promotes growth of hematopoietic cells, and mast cells. o Interleukin-4 (IL-4): Promotes growth of B-cells, and promotes division of antibody- producing cells.Growth Factors will revolutionise 21st Century Medicine
  9. 9. □ Regenerative MedicineOn 7th January, 2001, Asahi Shimbun, a Japanese newspaper, carried the sensational headline, “CellRegeneration Drug to Begin Clinical Use”. The article discussed the start of treatment using HepatocyteGrowth Factor (HGF), which has a regenerative effect on cells and organs. It declared that the treatmentwould revolutionise 21st century medicine.HGF’s regenerative effect on the liver was first verified in 1984 by a research team led by Dr. ToshikazuNakamura at the Osaka University Graduate School of Medicine’s Biomedical Research Center. Laterresearch revealed the effect was not restricted to liver cells and that it prevents necrosis and regeneratesalmost all organs.Animal testing revealed that “HGF repairs untreatable serious illnesses of the liver and kidneys, heart,blood vessels, and nervous system”. Animals were infected for the purpose the experiment, and whenHGF was injected a wondrous effect was observed whereby cells on the verge of death were revived.Thus, animal testing showed it to be effective for almost all diseases except for cancer. It was such anamazing result that people began to refer to HGF as the “Happy Growth Factor”. • Major Diseases which HGF was Effective against in Animal Testing Liver Diseases: acute hepatitis, hepatitis, cirrhosis of the liver, and liver transplantation. Kidney Diseases: renal failure, kidney transplantation. Lung Diseases: acute pneumonia, and lung fibrosis. Digestive Diseases: gastric ulcers, and diabetes (pancreatic cell regeneration). Cardiovascular Diseases: heart attack, cardiomyopathy, obstructive arteriosclerosis, and prevention of coronary stenosis. Muscular Diseases: muscular dystrophy. Cranial Nerve Diseases: stroke, Parkinson’s Disease, and Lou Gehrigs disease. (Asahi Shimbun, 7th January, 2001)So at last, clinical trials began in earnest to look into whether it would also be effective for humans. Plansfor trials are in progress at Osaka University for obstructive arteriosclerosis and heart attack patients andat Hyogo College of Medicine for cirrhosis of the liver sufferers. Nonetheless, thorough data must beaccumulated on both effectiveness and safety before this research can be considered as practical treatment,so it is expected to take a little more time.However, careful readers will have noticed a wonderful thing. Look again at the previous section onGrowth Factors and you’ll see that HGF is present in placenta. We can make use of the amazing power ofHGF, the Happy Growth Factor, right now by using placenta.□ Discovery of Metastin which Suppresses Progression of Cancer CellsThe wide range of diseases which can be treated using Placenta Extract will be described later, but belowis a press release regarding one particular breakthrough. New Bioactive Peptide “Metastin” Discovered which Suppresses the Spread of CancerAs a result of research into orphan receptors, Takeda has discovered a bioactive peptide which shows acancer suppressant effect. The peptide is created by the cancer suppressant gene “KiSS-1”, and it has beennamed “Metastin” after the word “metastasis”, meaning the spread of cancer.Our pioneering first research facility discovered four new peptides called PrRP, Apelin, GALP, and RFamide, during research into orphan receptors. They were found to be receptors for the bioactive peptidesMCH, Urotensin II, and Neuromedin U. Animal testing at our second medical science facility has alreadyproduced a report in March to the Pharmaceutical Society of Japan that the MCH antagonist shows an
  10. 10. anti-obesity function. The discovery of Metastin is a further result of this continuing research into orphanreceptors.In the current research, ligand peptides of the orphan receptor 0T7T175 are isolated and purified, andfound to be a new peptide produced by the KiSS-1 cancer suppressant gene. Gene KiSS-1 was reportedon in 1997 by a research group led by Professor Welch at Pennsylvania State University, but only nowhave the products and functions of this gene been demonstrated.An experiment was carried out whereby a variety of melanoma in mice was injected subcutaneously, anda tumour allowed to form for five weeks before being transferred to the lungs. There the Metastin receptor0T7T175 was artificially produced. The spread of the melanoma to the lungs was found to be suppressedsignificantly by the continuous administering of Metastin. Additionally, in test tube experiments Metastinwas confirmed to suppress both migrational response and nociceptive response. This indicates thatMetastin inhibits the ability of cells to move, which would explain the cancer suppressant effect withinthe body.Further investigation will be required to determine whether Metastin has a similar cancer suppressanteffect on human cancer cells, however it is hoped that Metastin will suppress the spread of cancer inovarian cancer cases, as this has a relatively high frequency of Metastin receptors. Metastin is also presentin human placenta in large quantities, suggesting that it’s likely that the placenta plays a majorphysiological role. Initially, we believe that a sustained release and low molecular weight compound ofMetastin should be explored with a view to application as a cancer suppressant.Details of this research were published in Nature on 31st May, 2001. 31st May, 2001 Takeda Pharmaceutical Company LimitedCancer Suppressant “Metastin” Discovered in Human PlacentaTakeda Pharmaceuticals announced yesterday they have discovered a bodily substance which suppressesthe spread of cancer, naming it “Metastin”. The gene which produces Metastin was also found. Theresearch was published yesterday in the magazine “Nature”. The company hopes to explain the linkbetween the cancer drug and the spreading process. Metastin exists within the body as peptides which canbe connected to amino acids. The Takeda research team discovered Metastin in the human placenta.While investigating the arrangement of such amino acids, they found Metastin was produced by the“KiSS-1” gene, which is a known skin cancer suppressant. KiSS-1 was discovered by researchers in theUSA in 1997, but it was not known until now that it produced Metastin. In an experiment where skincancer was introduced to the lungs of mice, Metastin reduced the spread of the cancer by approximatelyone third.Asahi Shimbun, 1st June, 2001Cancer Suppressing Material Found in Placenta ProteinsA new peptide has been found which forms inside the placenta when a certain “receptor” is attached tothe cell. The KiSS-1 gene, which suppresses the spread of cancer, was already known, but a new proteinnamed Metastin was discovered which is produced by this gene. In experiments, skin cancer cells in micewere transferred to the lungs, but when Metastin was administered its spread was greatly suppressed.Nikkei Shimbun, 1st June, 2001* Articles about the discovery of a substance which suppresses the spread of cancer appeared in both theAsahi Shimbun and the Nikkei Shimbun on 1st June, 2001. This substance exists in large quantities in theplacenta. It seems likely that further such substances are just waiting to be discovered in the placenta.The Medicinal Properties of the Placenta
  11. 11. Many researchers have found that the placenta possesses a variety of medicinal effects, just like in thearticles above. When you consider the many nutritional properties and growth factors of the placenta, the“all-purpose organ” seems quite an appropriate description.□ Main Medicinal Functions of the Placenta • Nervous System Regulatory Function (specifically the autonomous nervous system) • Endocrine (Hormonal) System Regulatory Function • Immune System Function (raises resistance to illness) • Basal Metabolism Function (energises the metabolism, activating cells, blood vessels and organs) • Active Oxygen Removal Function (prevents oxidation) • Anti-inflammatory Function • Tissue Repair Function • Tranquilising FunctionIt has also been shown to have a number of other functions as follows. • Anti-toxin Function (strengthens the liver) • Lactation Promotion Function • Anti-Allergy Function • Constitution Function • Circulation Function • Blood Production Function • Anti-mutagen Function (suppresses mutations) • Blood Pressure Regulatory Function • Fatigue Recovery Function • Appetite Promotion FunctionIn addition, the following have been reported by many doctors, as diseases which placenta is effectiveagainst. It is clear that the key feature of the placenta is applicability to such a wide variety of conditions.This means that when you treat an illness with placenta it isn’t just one illness which is improved, butthere are often other general improvements in health and beauty such as waking up refreshed, feeling lesstired, or having clearer skin.□ Placenta Can Treat the Following Conditions • Gynaecology: menopausal disorders, menstrual pain, irregular menstruation, failure of lactation, and high prolactin levels, etc. • Internal Medicine: hepatitis, cirrhosis of the liver, chronic pancreatitis, diabetes, chronic gastritis, dyspepsia, gastric ulcers, duodenal ulcer, ulcerative colitis, bronchial asthma, chronic bronchitis, high blood pressure, low blood pressure, habitual constipation, and collagen disease, etc. • Surgery: chronic rheumatoid arthritis, osteoarthritis, arthritis, neuralgia, lumbago, and stiff shoulders, etc. • Dermatology: atopic skin complaints, psoriasis, body odour, eczema, chapped skin, spots, and freckles, etc. • Psychiatry: autonomic ataxia, and sleeplessness, etc. • Urology: enlarged prostate, cystitis, and haemorrhoids, etc. • Ophthalmology: cataracts, allergic conjunctivitis, and vision loss, etc. • Ear, Nose and Throat: allergic rhinitis, Menieres disease, and hay fever, etc. • Dentistry: pyorrhoea, and gum disease, etc.
  12. 12. • Other: fatigue, chills, weak constitution, recovery of strength during and after illness, muscularity, and strength of mind, etc.Effective Use of Placenta for Health and BeautyEssentially, the placenta is a temporary organ formed to develop the embryo and is expelled after birth.In most mammals other than humans the mother actually eats the placenta after birth. You may havenoticed that when a cat or a dog gives birth, the placenta is left with the mother and child. Evenherbivores like cows and horses are known to eat the placenta.Some reports have it that this is to hide the smell of birthing to protect the young from predators, but amore likely explanation is that the mother recovers strength after the delivery by eating the nutrition-richplacenta. The lactation promotion function is an additional reason. There is a great deal of wisdom in thehabits of animals.Until recently, the tradition in Japan was to use the placenta and umbilical cord as an offering on an altar,to pray for the growth of the child. However, in earlier times when medicines were scarce, if a childbecame very ill the umbilical cord would be ground into a powder, boiled, and administered as a specialmedicine.Placenta is an Old and a New MedicineNevertheless, the medicinal properties, nutrients and growth factors of the placenta have been widely usedfor health and beauty, both in the past and today, and in all corners of the globe.The placenta has a history of medicinal use starting more than 2000 years ago. It was used as an elixir ofeternal youth during the Qin Dynasty in China (259 BC to 210 BC). It appears in a medical text entitled“Honzo Syui” from the Tang Dynasty (618 AD to 907 AD) under the names “Jinho” or “Hoi”. It appearsagain in the Ming Dynasty (1368 to 1644) as “Shikasha” in the book “Bencao Gangmu”, where it isprized as a nourishing herbal medicine for physical and mental tiredness and weakness. In Taoism, theelixir used to become a wizard is called “Kasha”. Yang Kwei-Fei is said to have often prescribed“Shikasha”. In modern times, too, it is an essential ingredient in Kampo medicine (the Japanese form oftraditional Chinese herbal medicine).“Shikasha” also appears in a Korean medical text entitled “Dongui Bogam” (1613). In the Edo Period inJapan (1603 to 1868) the same “Shikasha” was one of the three main active agents in a treatment calledKongentan from the town of Kaga in the modern Ishikawa Prefecture.Also in the West, Hippocrates, a doctor in Ancient Greece called “the father of Western medicine”, usedplacenta in his treatments. Cleopatra and Marie Antoinette are also said to have used placenta forrejuvenation and beauty.But somehow, while the use of placenta as a traditional medicine has persisted in the East, it has beenforgotten in the West since the time of the Middle Ages, and it wasn’t until research was done in the1930s in the Soviet Union that the placenta’s usefulness once again saw the light of day.Prof. Filatov, Dr. Kentaro Hieda, and NowProfessor Filatov was a medical school professor in Odessa in the Soviet Union in the 1930s. His use ofplacenta in “Tissue Therapy” brought it back into the realm of science. “Tissue Therapy” is a method oftreating skin complaints whereby placenta or other organs are frozen and stored. There is a similartreatment called “implanted treatment”. Initially, Prof. Filatov performed operations transplanting frozencornea from deceased donors into patients. He noticed that the prognosis was much better with frozencornea than with unfrozen. This was the start of Prof. Filatov’s research, which founded the thinking that
  13. 13. “if the tissues of plants and animals are refrigerated, the stimulus of the cold environment activates thetissue, inducing cell activation factors and bio-stimulation with regenerative abilities”. Later research builton these ideas, leading to the use of frozen tissues such as the placenta for skin conditions and otherillnesses. Thus, “Tissue Therapy” was born. On the effects of the placenta, Prof. Filatov reported that “theplacenta not only activates the functions of the whole body, it is also excellent at promoting recovery ofdiseased areas”. In 1945, Prof. Filatov was awarded the highly influential Lenin Prize for his superbachievements.Shortly afterwards, “Tissue Therapy” came to Japan. In 1950, a group of physicians researching “TissueTherapy” got together and established the “Tissue Therapy Research Institute”. After developing PlacentaExtract injections, in 1956 they founded “Melsmon Pharmaceutical Company Limited” which quicklyobtained government approval, and began manufacture and sale of Melsmon injections as a treatment formenopausal disorders and failed lactation.Meanwhile, Professor Kentaro Hieda propagated “Tissue Therapy” in Japan via a completely separateroute. During World War Two, Prof. Hieda lectured at the Manchurian Medical College, and spent thefirst eight years after the war in China, where he became acquainted with the “Tissue Therapy” ofProfessor Splanski. After returning to Japan he lectured at the Physics Research Institute at KurumeUniversity, where he enthusiastically researched uses of the placenta. That research resulted in thedevelopment of “Refrigerated Placenta Serum Therapy” which employs extract of refrigerated placenta.Later, in 1959, Placenta Extract injections based on Prof. Hieda’s research came to market under thename “Laennec” (*at that time approval was given from the Japanese government for use in the treatmentof hepatitis, but this has now expanded to the treatment of general liver health).However, this “Tissue Therapy” was not the first use of the placenta in Japan. Its use as a traditionalmedicine in China was also passed to Japan, and it was used in the Edo Period appearing as one of thethree active ingredients in the Kongentan remedy from the town of Kaga.Also, both during and after World War Two, the placenta treatment “Vita-X” became well-known as avaluable source of nutrition. It was developed by Dr. Ryukichi Mibayashi, a Professor at the GynaecologyResearch Laboratory of Kyoto University Medical School. When the food situation was poor at the endand shortly after the war, research was launched at the request of the government due to concerns over thehealth of infants and pregnant women, and attention turned to the miraculous effects of placenta. As wellas improving health problems and promoting growth in infants, it was found to be very efficient intreating liver disease, anaemia and other ailments, as well as aiding post-operative recovery. Now, Vita-Xis manufactured and sold as a placenta-based medicine.The Many Ways the Placenta is UsedCurrently, Placenta Extract is available in Japan in the form of injections, as an oral medicine, and ashealth food and beauty products.Although various injections have been offered since the 1950s, at the present time two options areavailable: “Melsmon” injections for menopausal disorders and failed lactation, and “Laennec” injectionsfor improved liver function. The effect of these injections has been approved by the Japanese government,and clinical data and safety tests have been carried out. Needless to say, the practical applications of usingplacenta are far reaching.The drug “Vita-X” is a typical example of an oral placenta-based medicine. In the 1970s, placenta beganto be applied in the field of beauty products, and a range of make-up products were developed. Since thelate 1980s it has also been used in health foods. It is usual for pig placenta to be used in beauty and healthfood products. Its effectiveness when fresh shows very little difference compared to human placenta.Throughout the whole world, more and more new medicines and beauty products contain Placenta Extract.However, recently its effectiveness and safety for use as a medical treatment has been newly confirmed inJapan, and an increasing number of medical institutions across the country are beginning to offerinjections as part of normal range of treatments.
  14. 14. Placenta Extract and SafetyPlacenta Extract injections are extracted as a so called organ preparation, meaning safety issues such asinfection must be addressed. However, there is no cause for concern. The injections are prepared usinghuman placentas from normal births, and all blood and hormones are 100% removed in the manufacturingprocess, meaning no blood or hormones are present in the injection whatsoever. Of course, all medicineswhether injection or oral must pass standards and be approved by the government.Let’s take the example of Melsmon injections, and see what safety measures are taken by themanufacturers in its production. The first aspect is in the control of raw materials. Over many years asystem for the reliable and safe acquisition of placenta has developed involving multiple specialistcontracts between medical organisations. As all mothers will know, blood tests are taken many timesduring pregnancy, and tests for syphilis, AIDS, Hepatitis B, Hepatitis C, and so on are made, ensuringthat only infection-free placentas are selected. This careful management of materials doesn’t only protectthe patient and medical personnel, but prevents infection spreading to those working in the manufacture,and is a critical step in the process. Next, placentas which passed the screening process are refrigeratedfor a fixed period, before being heated in hydrochloric acid and broken down into a water-solublematerial (extract). Then, the hydrochloric acid is evaporated and neutralised to pH 6.8 ~ 7.0 with sodiumhydroxide (the pH of blood), distilled water and benzyl alcohol is added and filtered to prevent pain andtissue damage during the injection. This breakdown and evaporation process involves a total of 15 to 17hours of heat treatment at over 100oC. As a final step, the Placenta Extract is loaded into a sterilisedampoule and high pressure steam sterilization is carried out at 120oC for 30 minutes.Safety is ensured by using materials carefully screened for infection in medical institutions, using heattreatment in the manufacturing process (a total of 15 to 17 hours at over 100oC), and using a sterilisingtreatment on the final product (30 minutes at 120oC), so that any bacterium or virus is denatured. Then, atest to confirm whether proteins are completely broken down into amino acids, sterilisation tests, andanimal testing are carried out as final product checks.There are also minimal concerns regarding side-effects. Melsmon has been licensed under Japanese healthinsurance for 45 years and in the long history of the manufacture and sale of Melsmon injections therehasn’t been a single reported incident of major side-effects. The history of the use of placenta for healthand beauty since ancient times is itself a testimony to the low incidence of side-effects. In my clinic wehave never had a single incident of side-effects due to placenta injections. Only minor side-effects havebeen observed such as “reddening or pain at the point of injection (5% of cases, recovers in 1 to 2 days)”,“heaviness in upper arm (0.1 to 5% of cases, recovers in half a day)”, “nausea or general malaise (veryrare, recovers in half a day)”. However all were quickly cured leading to a revitalised feeling and astrengthened constitution.As there are so few side-effects, patients say they can bathe, exercise, and drink alcohol as normal on theday of the injection.
  15. 15. Section 2Relieving Menopausal Disorders with Placenta
  16. 16. The Perimenopause is the 5 Year Period either side of the MenopauseWhile there are still many people who mistakenly think the perimenopause is the period aftermenstruation ceases, in truth it is the five years either side of the menopause, a total of around 10 years.The exact age depends on the person, but there are those who reach it in their thirties and others whoaren’t affected until their late fifties. In Japan, the average is around 50 or 51, and in this case theperimenopause would be from around 45 to 55.Often you will only know the age you entered the perimenopause after you come to the menopause itself.A disturbed menstrual cycle is a good sign, which happens due to a weakening of the functions of theovaries. In bodily terms, the perimenopause is the “transition period” from regular menstruation to astable state of non-menstruation. In short, as well as a decline in the functions of the ovaries, the ovariessecrete less and less female hormones, before dropping sharply at the menopause, and finally ceasingcompletely and settling down.The changes in hormone production across a woman’s life can be categorised into five phases: childhood,puberty, sexual maturity, the perimenopause, and old age.(1) Childhood: Secretion of female hormones begins from around 8 years.(2) Puberty: Some time before the age of 20 menstruation begins, the reproductive organs and breastsdevelop, and the body becomes more womanly.3) Sexual Maturity: During the 25 year period from 20 to 45 female hormone production peaks, enablingconception, childbirth, and nursing.(4) Perimenopause: The 10 year period from 45 to 55 centres on the menopause and the transition into oldage.(5) Old Age: Production of female hormones in the ovaries ceases.Here we can see that the perimenopause comes in between sexual maturity and old age, so can be thoughtof as a preparatory phase to comfortably entering old age. From this fact alone we can imagine the manyturning points and changes taking place, and the heavy blows taken by the body and mind, which makes itall the more important that the transition is made as smooth as possible.Menopausal Disorders are a General Malaise around the MenopauseDuring the menopause the secretion of female hormones decreases due to a drop in the functions of theovaries, however this shortage of female hormones produces vague bodily disorders or a mental andphysical general malaise, and we call these menopausal disorders. Commonly experienced conditions areas follows.Psychological DisordersHeaviness of the head, headaches, trouble falling asleep, light sleep, early waking, tiredness, fatigue,anxiety, tenseness, irritability, and mild depression.Physical DisordersHot flashes or rushes of blood, dizziness or giddiness, heavy perspiration, palpitations or shortness ofbreath, chills, loss of appetite, nausea, distended abdomen, constipation, diarrhoea, still neck or shoulders,joint pain, hip pain, frequent urination, and eyestrain.It is not unusual for many of these menopausal disorders to manifest together all at once. This is the mainfactor which makes the treatment menopausal disorders difficult.Why Menopausal Disorders Occur
  17. 17. So, why do menopausal disorders occur? In answering that question we must first understand therelationship between menstruation and female hormones (estrogen and progesterone). Estrogen performsmany important functions and progesterone is the hormone which controls estrogen. Menstruation is aphenomenon whereby the membrane which lines the inner surface of the uterus peels off and falls away ata regular cycle, and occurs due to the mutual stimulation of the hypothalamus and pituitary gland in thebrain, and the ovaries [See Figure 2-1].Figure 2-1 – Function of Sexual Functions and Female Hormones[Labels: top 5, left to right] Hypothalamus, Pituitary Gland, Follicle Stimulating Hormone, Progestagen,Gonadotropic Hormone-Releasing Hormone[Labels: bottom 5, left to right] Ovaries, Uterus, Female Hormones, Estrogen, Progesterone□ Cycle of Menstruation [See Figure 2-2](1) The hypothalamus secretes “Gonadotropic Hormone-Releasing Hormone”, which stimulates thepituitary gland. This stimulus causes the pituitary gland to secrete “Follicle Stimulating Hormone”.(2) “Follicle Stimulating Hormone” stimulates the ovarian follicles in the ovaries, one of which begins tomature. Then the ovarian follicle secretes estrogen. Estrogen thickens the lining of the uterus inpreparation for pregnancy.(3) As estrogen builds up in the bloodstream, this information is passed to the hypothalamus and pituitarygland, and secretion of “Follicle Stimulating Hormone” is reduced, and instead “Progestagen” is secreted.This causes one egg to be released or ovulated, by stimulating the matured ovarian follicle.(4) After the egg is released, the ovarian follicle begins to secrete “progesterone” rather than“progestagen”, and this prepares the uterus lining to help the fertilised egg to attach.Figure 2-2 – Periodic Changes in a Normal Menstrual Cycle[Labels: first graph, left to right] Gonadotropic Hormones, Progestagen, Follicle Stimulating Hormone[Labels: second graph, left to right] Ovarian Hormones, Estrogen, Progesterone[Labels: first row of 5 labels] Follicle, Mature Follicle, Released Egg, Corpus Luteum, Corpus Albicans[Labels: second row of 5 labels] Uterus Lining, Menstruation, Proliferation Phase, Secretion Phase,Menstruation[Labels: bottom boxes left to right, top to bottom] Menstrual Cycle (28 Days), 1st Day, Menstruation,Proliferation Phase, Secretion Phase, 28th Day(5) If it is not fertilised, the corpus luteum regresses, secretion of “progesterone” falls, and the thickenedwall of the uterus comes unstuck beginning menstruation. Finally, the hypothalamus once again secretes“Gonadotropic Hormone-Releasing Hormone”, and steps (1) through (5) cycle through again.The menstrual cycle normally takes 28 days. Basal body temperature changes according to a bi-weeklyrhythm, with low temperature for the two weeks when estrogen alone is produced and high temperaturefor the two weeks when progesterone is secreted. So, as we have mentioned, entering the perimenopausemeans a weakening of the ovaries and a reduction in female hormone production. In response to thereduction in female hormone production, the hypothalamus and pituitary gland begin to secreteGonadotropic Hormone-Releasing Hormone and Follicle Stimulating Hormone in large quantities,instructing the ovaries to work harder and harder to secrete female hormones. It is this which has anundesired effect on the nervous system (specifically the autonomous nervous system).This is because the hypothalamus isn’t just the control centre for female hormones. It also controls thenervous system. When the hypothalamus works hard to produce Gonadotropic Hormone-ReleasingHormone and Follicle Stimulating Hormone, the nervous system is also stimulated. Consequently, thenervous system loses its balance, eventually leading to autonomic disorders such as ataxia.
  18. 18. Autonomic nerves are present in various bodily organs where they regulate the organ’s functions. The twomain types of autonomic nerves are sympathetic nerves and parasympathetic nerves, which work intandem against each other to contract and expand blood vessels and trachea, raise and lower bloodpressure, and restrict and stimulate the intestines and digestive tract, thus keeping balance and regulatingthe body [See Figure 2-3]. Therefore, if the balance of the sympathetic and parasympathetic nerves is losta number of general disorders arise such as hot flashes, heavy perspiration, palpitations, shortness ofbreath, constipation, or chills.While there are some factors which cause menopausal disorders which we don’t fully understand, we cangive a summary as follows: “decline in functions of ovaries reduction in female hormones strongstimulation from hypothalamus disorder in nervous system autonomic disorders = general malaise”.Also, the female hormone estrogen has been shown to promote happiness, so if it is reduced apsychological effect causing depression can be expected.Figure 2-3 – Function of the Parasympathetic Nervous System[Labels: left to right, top to bottom]Pupil, Constricted, Secretion of Saliva from the Salivary Gland, Stimulation, Bronchial Tube,Constriction, Lungs, Constriction, Heartbeat, RestrictedLiver, Stomach, Digestion, Stimulation, Secretion of Digestive Fluids, Stimulation, Large Intestines,Small Intestines, Blood Pressure FallsHair Erector Muscle, No Effect, Surface Blood Vessels, No Effect, Bladder, EnlargedCommon Menopausal Disorders: Hot Flashes, Rushes of Blood, Excessive PerspirationThe most common of the menopausal disorders are hot flashes, rushes of blood and excessive perspiration.Hot flashes are a sudden feeling of intense heat lasting from two to thirty minutes which disappears just asquickly. The condition differs from person to person with some experiencing only a flushed face andothers experiencing a hot upper body and cold lower body. The cause of the condition, as mentionedearlier, is thought to be the reduction in estrogen causing the hypothalamus to increase its level ofstimulation, which causes the nervous system to go out of balance.The autonomous nerves in our bodies react to the stimuli of heat and cold. Specifically, sympatheticnerves reduce body temperature by constricting blood vessels and reducing the flow of blood, whereasparasympathetic nerves increase body temperature by widening blood vessels and increasing the flow ofblood. Together they control body temperature by keeping blood flow and body temperature constant.However, when the autonomous nerves are out of balance, this control function is impaired and theconstriction or widening of blood vessels can be extreme, causing hot flashes.Be aware that hot flashes can also occur with conditions like high-blood pressure or hyperthyroidism, soif symptoms are severe you should always get a doctor’s opinion. If it is diagnosed as a menopausaldisorder, it might be several months or even several years before symptoms recede, which is why it isimportant to face such symptoms with a positive attitude. The reason is because many of the conditionscaused by an unbalanced nervous system are also strongly linked to stress, meaning excessive worryingcan worsen the symptoms.As well as hot flashes, or independently of them, excessive perspiration, or night sweats if at night, is alsoa common condition. Excessive perspiration also occurs because of the reduction in estrogen and anunbalanced nervous system.Heavy and Light SufferersOf course, not all people will experience menopausal disorders upon entering the perimenopause. Even ifmenopausal disorders are experienced, they can differ markedly depending on the person, and can be
  19. 19. extremely varied and wide-ranging. You might say there are as many experiences as there are people,from those who experience mild discomfort, to those whose lives are seriously affected. But why is theresuch a range? Of course ones health and body-type have a big influence, but ones environment andlifestyle are also major factors.The perimenopause represents a turning point in the life of many women. Often it is a time when thingslike caring for parents, the retirement of a partner, children’s independence or marriage, all overlap, and ifyou are working as well that just adds a further layer of responsibility. So, when the cerebral limbic cortex,which governs all the emotions, and the cerebral cortex, which governs advanced intelligent activity (seeSection 3), are bombarded with all this environmental stress, the hypothalamus is very susceptible. Peoplewho are easily stressed also tend to be more susceptible, and experience worse menopausal disorders.Perfectionists, as well as introverted or nervous people should take particular care. On the other hand, ifyou are easy-going, always think positively and are often in a good mood, this will be a positive stimulusfor the cerebral cortex and the cerebral limbic cortex, providing a good influence on the hypothalamusand easing any related conditions.Therefore, the secret to relieving menopausal disorders is to practise turning your mood around, and toavoid irritation and worry. In any case, there are many factors which can cause the onset of menopausaldisorders, such as bodily causes due to the reduction in female hormones, a plethora of environmentalcauses at a turning point in life, or psychological causes making the body susceptible to stress”, so it isessential for the treatment to have multiple aspects as well.Placenta as a TreatmentIf symptoms are light it may be best to simply wait and see how things develop, however if menopausaldisorders impact on your day-to-day life, treatment should be sought.In my clinic we use “Melsmon” Placenta Extract injections, a government-approved treatment formenopausal disorders in Japan, combined with herbal medicines depending on the symptoms, and havehad extremely good success.“Melsmon” has been an approved treatment of the Japanese government for 45 years, and itseffectiveness and safety are assured, “showing striking effectiveness at improving various symptoms ofthe transition from the perimenopause to old age.”As described earlier, menopausal disorders arise because of the sudden fall in estrogen levels caused bythe reduction in the functions of the ovaries, which stimulates an organ in the brain which controls femalehormones called the hypothalamus, causing an imbalance in the nervous system which manifests in theform of a general malaise. The role of placenta in treating menopausal disorders has been shown inanimal testing to be a “Secretion Regulatory Function” which creates balance in the hormone system, anda “nervous system regulatory function” which creates balance in the nervous system. In addition to thisregulatory function, placenta demonstrates a wide range of medicinal effects such as “Basal MetabolismFunction”, “Circulation Function”, “Blood Production Function”, “Fatigue Recovery Function”,“Anaemia Improvement Function”, “Immune System Function”, and “Constitution Function”, and asthese effects act in unison they have the power to relieve a wide range of symptoms all at once.Effective Herbal (Kampo) MedicinesThe basic principle for my own treatments is to utilise the wisdom of both Western and Eastern medicine,and use this to offer the optimum treatment to the patient.Since ancient times, Kampo medicines have been known to be useful in treating menopausal disorders.Originally it was said that Kampo medicines worked because they “restore the body’s balance, and thuscure the disease.” Perhaps these Kampo remedies work because many symptoms of menopausal disordersare triggered by an imbalance in the nervous system. In other words, rather than “identifying which part
  20. 20. of the body is malfunctioning” as would be the norm in Western medicine, Kampo medicine emphasises“finding the body’s natural defences and functions and helping the whole body back to health.” In doingthis, you might say that Western medicine examines diseases, and Kampo medicine examines the patient.Therefore, a person with multiple symptoms of menopausal disorders such as chills, stiff shoulders, ormild depression, for example, would require multiple treatments such as internal medicine, orthopaedics,or psychiatry under Western medicine, but under Kampo medicine the “sho” is diagnosed and medicineadministered appropriately based on the patient’s constitution and symptoms. In Kampo medicine, shomeans the patient’s condition in terms of the type, symptoms, state, and stage of the illness. Diagnosis ismade focussing on the sho of each patient, types of which include Jitsu, Kyo, Netsu, and Kan (excess,deficiency, heat and cold). Jitsu and Kyo measure qualitative excesses or deficiencies of the physical body.A Jitsu-Sho diagnosis is a state of illness due to excess bodily strength, and a Kyo-Sho diagnosis is a stateof illness due to deficient bodily strength. Kan and Netsu measure characteristics of the disease. A Kan-Sho diagnosis is a state where the illness mainly lowers the metabolism, and a Kyo-Sho diagnosis is astate where the illness mainly accelerates the metabolism. There is also “Yin-Yang” which measures thestrength or weakness of the body’s resistive power, and “Hyo-Ri” which measures the depth of the illness.The status of an illness is also placed into one of three hypothetical groups relating to the cause: “Ki”,“Ketsu”, and “Mizu,” although menopausal disorders are generally classed as “Ki-Tai” or “O-Ketsu.” “Ki-Tai” means illnesses caused by stagnant energy such as hot flashes, palpitations, shortness of breath,anxiety, bad temper, or depression, whereas “O-Ketsu” means illnesses caused by stagnant blood such aschills, headaches, stiff shoulders, ringing ears, irregular menstruation, or abdominal pain.In Kampo medicine the appropriate herbal medicine is selected based on the analysis of the patient’s Shoand Ki - Ketsu - Mizu state. It stresses the healing power of the body and is a prescription using bothcausal and symptomatic therapies.Kampo remedies also have the effect of stabilising the mind. [Figure 2-4] is a simple chart showingKampo remedies selected according to the Jitsu-Kyo diagnosis of menopausal disorders. Many Kamporemedies are made from natural ingredients such as medicinal roots and bark, meaning there are minimalconcerns over side-effects.Viewed from this perspective, Kampo and placenta remedies have substantial overlap. Indeed, placentahas been used in modern medicine as the Kampo herb “Shikasha,” the only Kampo remedy to be passedto Western medicine. My clinic is proof that menopausal disorders can be effectively treated using acombination of Kampo remedies and placenta to suit the patient. Drug treatments for menopausaldisorders include symptomatic therapies such as tranquilisers, sleeping pills, or sedatives to calm animbalanced nervous system, or supplements such as injections, oral medicine or skin patches to replacethe missing female hormones.Figure 2-4 – Simple Prescription Chart by Diagnosis of Menopausal Disorder[Labels: left column, top to bottom] Jitsu-Sho, Kyo-Sho[Labels: middle column, top to bottom] Tokaku‐jokito, Keishi-bukuryo-gan, Tsu‐do‐san, Kami-shoyo-san,Toki‐shakuyaku‐san, Shimotsu‐to[Labels: right column, top to bottom] Stiff Shoulders / Hot Flashes / Headaches, Constipation, Dizziness /Ringing in the Ears, Stiff Shoulders, Irritability, Chills, Dry SkinHowever, tranquilisers and sleeping pills all have issues with side-effects, and hormone supplements relyon knowing the amount of hormone appropriate to the condition of each patient, as well as having theirown side-effects. This is where placenta and Kampo remedies excel, with next to no worries about side-effects, and relief for both the symptoms and the causes through the regulatory function. This is thereason I use them in my treatments.Clinical Data Shows "Melsmon" Works
  21. 21. This chapter presents some very interesting clinical data from pharmaceutical companies examining theeffectiveness of “Melsmon” for menopausal disorders. It was a comparative clinical test conducted byseven medical organisations which took place between March and December in 1980, with 55 testpatients, 31 of whom were selected at random to receive “Melsmon”, with the remaining 24 receiving aplacebo (a replica treatment with no clinical effect). The dose was a 2ml injection three times per week,for two weeks, a total of six injections.The main complaints at the start of the treatment were as per [Table 2-1]. The group receiving Melsmonsaw improvements as shown below after four and then six treatments.□ General Level of ImprovementAfter four treatments, four cases in the group receiving Melsmon saw “very effective” effects, while nonewere seen in the group receiving the placebo [Table 2-2].Symptom Great Some A Little Total Heavy Head 3 5 18 26 Headache 3 11 17 31Psychological Symptoms Trouble Sleeping 1 7 17 25 Light Sleeping 0 7 18 25 Early Waking 0 9 12 21 Fatigue 1 22 15 38 Washed-Out 0 12 16 28 Anxiety 4 5 15 24 Tension 3 5 18 26 Irritability 3 11 18 32 Depression 2 7 16 25 Hot Flashes 2 16 18 36 Dizziness 2 12 18 32 Heavy Perspiration 0 9 12 21 Palpitations 2 6 23 31 Chills 3 18 8 29Physical Symptoms Loss of Appetite 0 4 11 15 Nausea 0 1 13 14 Abdominal Swelling 0 9 18 27 Diarrhoea 0 0 4 4 Constipation 1 9 14 24 Stiff Neck 6 20 12 38 Stiff Shoulders 6 23 10 39 Joint Pain 1 3 9 13 Hip Pain 2 15 16 33 Frequent Urination 0 1 11 12 Eye Strain 3 5 15 23 Unit: People Table 2-1 – Main Complaints at Start of TreatmentAfter two weeks of treatment a large statistical difference in effectiveness was observed with 77.4%seeing an “effective” or “very effective” effect in the Melsmon group compared to 25.0% in the placebogroup [Table 2-3].□ Level of Improvement by Symptom
  22. 22. (1) Psychological SymptomsA difference could already be seen between the Melsmon and placebo group after just four treatments[Table 2-4]. After two weeks of treatment a large statistical difference was again observed with 67.8%saying “effective” or “very effective” for the Melsmon group compared to 25.0% for the placebo group[Table 2-5].(2) Physical SymptomsAfter four treatments there were 12 cases where Melsmon was more effective, however no significantdifference was yet observed overall [Table 2-6]. After two weeks of treatment a very significantdifference was observed between the Melsmon and placebo groups. The total seeing “effective” or “veryeffective” results was 77.4% for the Melsmon group and only 29.2% for the placebo group, whichrepresents a statistical confirmation [Table 2-7]. Very Very Quite Not Effective Worsened Total Effective + Effective Effective Effective Effective Melsmon 4 8 6 12 1 31 12 (12.9) (25.8) (19.4) (38.7) (3.2) (100) (38.7) Placebo 0 4 3 13 4 24 4 (16.7) (12.5) (54.1) (16.7) (100) (16.7) Total 4 12 9 25 5 55 16 Unit: People, ( ): % Table 2-2 – Overall Level of Improvement after Four Treatments Very Very Quite Not Effective Worsened Total Effective + Effective Effective Effective Effective Melsmon 15 9 3 4 31 24 0 (48.4) (29.0) (9.7) (12.9) (100) (77.4) Placebo 4 2 4 13 1 24 6 (16.7) (8.3) (16.7) (54.1) (4.2) (100) (25.0) Total 19 11 7 17 1 55 30 Unit: People, ( ): % Table 2-3 – Overall Level of Improvement after Two Weeks Very Very Quite Not Effective Worsened Total Effective + Effective Effective Effective Effective Melsmon 5 4 8 13 1 31 9 (16.1) (12.9) (25.8) (41.9) (3.3) (100) (29.0) Placebo 2 2 13 7 24 2 0 (8.3) (8.3) (54.2) (29.2) (100) (8.3) Total 5 6 10 26 8 55 11 Unit: People, ( ): % Table 2-4 – Level of Improvement to Psychological Symptoms after Four Treatments Very Very Quite Not Effective Worsened Total Effective + Effective Effective Effective Effective
  23. 23. Melsmon 12 9 5 5 0 31 21 (38.8) (29.0) (16.1) (16.1) (100) (27.8) Placebo 2 4 4 12 2 24 6 (8.3) (16.7) (16.7) (50.0) (8.3) (100) (25.0) Total 14 13 9 17 2 55 27 Unit: People, ( ): % Table 2-5 – Level of Improvement to Psychological Symptoms after Two Weeks Very Effective Quite Not Worsened Total Very Effective Effective Effective Effective + Effective Melsmon 5 7 6 13 0 31 12 (16.1) (22.6) (19.4) (41.9) (100) (38.7) Placebo 1 2 5 15 1 24 3 (4.2) (8.3) (20.8) (62.5) (4.2) (100) (12.5) Total 6 9 11 28 1 55 15 Unit: People, ( ): % Table 2-6 – Level of Improvement to Physical Symptoms after Four Treatments Very Effective Quite Not Worsened Total Very Effective Effective Effective Effective + Effective Melsmon 13 11 2 5 0 31 24 (41.9) (35.5) (6.5) (16.1) (100) (77.4) Placebo 4 3 8 8 1 24 7 (16.7) (12.5) (33.3) (33.3) (4.2) (100) (29.2) Total 17 14 10 13 1 55 31 Unit: People, ( ): % Table 2-7 – Level of Improvement to Physical Symptoms after Two WeeksThese results show that Melsmon is effective in improving the symptoms of menopausal disorders, andthat improvement is seen for both psychological and physical symptoms, as an overall improvement.Furthermore they show that results are comparatively quick.Using the "Simple Menopause Index"The “Simple Menopause Index” (SMI) is a self-check table for measuring the severity of menopausalsymptoms [Table 2-8]. The table organises menopausal disorders into 10 categories, and the user simplycircles the severity of each symptom in the table and then adds them up. The final evaluation can then belooked up using that total.Menopausal disorder patients in my clinic fill in this SMI table. This way, the severity of the symptoms iscaptured before any treatment begins at the initial examination, and can be referenced later on to assessthe success of the treatment. Presented below are the changes in the SMI of two patients who have used acombination of placenta and Kampo remedies for menopausal disorders.Simple Menopause Index (SMI)Circle the severity of each type of symptom which fits best and enter the number in the box to the right,then add them up and check your evaluation below. Select “Heavy” for whichever of your symptoms isstrongest.
  24. 24. Symptom Heavy Medium Light None Points (1) Flushed Head 10 6 3 0 (2) Heavy Perspiration 10 6 3 0 (3) Cold Hips and Limbs 14 9 5 0 (4) Shortness of Breath, Palpitations 12 8 4 0 (5) Poor or Light Sleep 14 9 5 0 (6) Bad Temper, Irritable 12 8 4 0 (7) Broody, Occasional Depression 7 5 3 0 (8) Headaches, Dizziness, Nausea 7 5 3 0 (9) Fatigue 7 4 2 0 (10) Stiff Shoulders, Hip or Limb Pain 7 5 3 0 Total PointsMenopausal Index Self-Evaluation0~25 Points: You are bearing the menopause well. You should continue with your normal activities.26~50 Points: Pay attention to food and exercise, and take it easy.51~65 Points: Get a doctor’s opinion, and think about guidance, counselling or treatment.66~80 Points: You should be looking at a long-term (6 months or more) course of treatment.81~100 Points: Get detailed checks with a number of specialists, and if it is only menopausal disorders, obtain long-term specialist treatment. Table 2-8 – Simple Menopause Index (SMI) Self-Check Sheet Initial Examination: 20/Nov/2000, Re-Examination: 12/Dec/2000Simple Menopause Index (SMI)Circle the severity of each type of symptom which fits best and enter the number in the box to the right,then add them up and check your evaluation below. Select “Heavy” for whichever of your symptoms isstrongest. (Before Treatment) (After Treatment) Symptom Heavy Medium Light None Points Heavy Medium Light None Points (1) Flushed Head 10 6 3 0 10 10 6 3 0 10 (2) Heavy Perspiration 10 6 3 0 6 10 6 3 0 6 (3) Cold Hips and Limbs 14 9 5 0 14 14 9 5 0 9 (4) Shortness of Breath, Palpitations 12 8 4 0 12 12 8 4 0 8 (5) Poor or Light Sleep 14 9 5 0 14 14 9 5 0 9 (6) Bad Temper, Irritable 12 8 4 0 12 12 8 4 0 4 (7) Broody, Occasional Depression 7 5 3 0 7 7 5 3 0 5 (8) Headaches, Dizziness, Nausea 7 5 3 0 7 7 5 3 0 3 (9) Fatigue 7 4 2 0 7 7 4 2 0 4 (10) Stiff Shoulders, Hip or Limb Pain 7 5 3 0 7 7 5 3 0 7 Total Points 96 Total Points 65Menopausal Index Self-Evaluation
  25. 25. 0~25 Points: You are bearing the menopause well. You should continue with your normal activities.26~50 Points: Pay attention to food and exercise, and take it easy.51~65 Points: Get a doctor’s opinion, and think about guidance, counselling or treatment.66~80 Points: You should be looking at a long-term (6 months or more) course of treatment.81~100 Points: Get detailed checks with a number of specialists, and if it is only menopausal disorders, obtain long-term specialist treatment. Table 2-9 Initial Examination: 13/Nov/2000, Re-Examination: 29/Dec/2000Simple Menopause Index (SMI)Circle the severity of each type of symptom which fits best and enter the number in the box to the right,then add them up and check your evaluation below. Select “Heavy” for whichever of your symptoms isstrongest. (Before Treatment) (After Treatment) Symptom Heavy Medium Light None Points Heavy Medium Light None Points (1) Flushed Head 10 6 3 0 10 10 6 3 0 3 (2) Heavy Perspiration 10 6 3 0 10 10 6 3 0 10 (3) Cold Hips and Limbs 14 9 5 0 14 14 9 5 0 9 (4) Shortness of Breath, Palpitations 12 8 4 0 12 12 8 4 0 12 (5) Poor or Light Sleep 14 9 5 0 14 9 5 0 5 (6) Bad Temper, Irritable 12 8 4 0 12 8 4 0 (7) Broody, Occasional Depression 7 5 3 0 7 7 5 3 0 (8) Headaches, Dizziness, Nausea 7 5 3 0 7 5 3 0 (9) Fatigue 7 4 2 0 7 7 4 2 0 7 (10) Stiff Shoulders, Hip or Limb Pain 7 5 3 0 7 7 5 3 0 7 Total Points 67 Total Points 53Menopausal Index Self-Evaluation0~25 Points: You are bearing the menopause well. You should continue with your normal activities.26~50 Points: Pay attention to food and exercise, and take it easy.51~65 Points: Get a doctor’s opinion, and think about guidance, counselling or treatment.66~80 Points: You should be looking at a long-term (6 months or more) course of treatment.81~100 Points: Get detailed checks with a number of specialists, and if it is only menopausal disorders, obtain long-term specialist treatment. Table 2-10As you can see in [Table 2-9] and [Table 2-10], both patients saw superb results in a comparatively shorttime, providing great evidence of the power of combining placenta and Kampo medicinal treatments.Also, no side-effects were experienced in either case.Illnesses Linked to the MenopauseWhen there is a shortage of the female hormone estrogen due to the reduction in the functions of theovaries, this can lead to diseases such as osteoporosis, hardening of the arteries, or atrophic vaginitis[Table 2-11]. Severe problems caused by a deficiency of estrogen can be split into two broad groups.
  26. 26. There are “acute symptoms of menopausal disorders” which arise from imbalance of the nervous systemduring the menopause, and there are “late onset symptoms of menopausal disorders (also called old agedisorders)” such as osteoporosis, hardening of the arteries, or atrophic vaginitis, which may take timebefore they are identified. Treatment of late-onset symptoms of menopausal disorders is difficult;however, as they can often be protracted it is advisable to stay alert.The development of these late-onset symptoms is not solely due to the role of estrogen in reproduction,but is a result of a variety of functions it performs including preventing calcium from leaking out of bones,reducing cholesterol, and stimulating production of vaginal epithelial cells. To put it simply, the drop inthe production of estrogen reduces all of these functions, which is connected to the development of late-onset symptoms.Age Main Illnesses / Complaints4550 Menopausal Disorders [chills, hot flashes, headaches, menopausal keratosis, skin problems, palpitations, dizziness, ringing in the ears, diarrhoea, constipation, urinary Perimenopause problems, sleeplessness, irritability, forgetfulness] Breast Cancer, Uterine Cancer, Hardening of the Arteries60 Heart Disease, Diabetes, Hyperlipidaemia Liver Disease, Stiff Shoulders, Osteoporosis Old Age Neurosis, Psychosomatic Illness, Masked Depression Hypothyroidism, Bone Fracture Asteatotic Eczema, Collagen Disease70 Dementia Table 2-11 – Common Diseases (Female)□ OsteoporosisRecently, osteoporosis has received a lot of attention as a common post- menopausal disease in women.Osteoporosis is a disease where the calcium inside bones is lost and the bones lose density (bone mass),which causes brittle bones, bending of the spine, and bone fractures. A common location of bone fractureamong sufferers of osteoporosis is the base of the thigh bone, or femoral neck, which often leaves elderlypeople bed-ridden, and at times advances to dementia.However, estrogen has been confirmed to play an important role in preserving bone mass. When estrogenproduction drops sharply following the menopause, there is a sudden reduction in bone mass, which isthought to lead to osteoporosis.□ Hardening of the ArteriesHardening of the arteries, or atherosclerosis, is a disease where the walls of blood vessels grow harder andnarrower. The fundamental cause is an excess of bad cholesterol (LDL Cholesterol – a lipoprotein whichtransports cholesterol to cells and organs) in the blood. Atherosclerosis is the main culprit in the onset ofangina pectoris and myocardial infarction when it spreads to blood vessels in the heart, or stroke when itspreads to blood vessels in the brain. Atherosclerosis can also lead to high-blood pressure by narrowingthe blood vessels.Estrogen not only has the effect of reducing bad cholesterol in the blood stream, but it also increases goodcholesterol (HDL Cholesterol – a lipoprotein which collects excess cholesterol from organs and cells).Estrogen also works to increase the elasticity of blood vessels. This is why atherosclerosis is a commonmenopausal and post-menopausal disease when estrogen levels drop. Indeed, atherosclerosis is reportedmore often in women after the menopause.□ Atrophic Vaginitis
  27. 27. Atrophic vaginitis is a degenerative disorder seen in post-menopausal women. It is an inflammationwhich arises due to the reduction of estrogen, which works to strengthen the epidermal cells of thevagina’s mucous membrane and prevent multiplication of bacteria. This lack of estrogen causes thevagina’s mucous membrane to thin and become more sensitive to external stimulation. It is oftenassociated with a bloody and smelly discharge.Deficiency of estrogen after the menopause can also lead to vaginal dryness and painful intercourse.Essentially, estrogen enables sperm to enter the uterus at the time of ovulation by increasing mucoussecretion from the uterine cervix.Prevention and Treatment of Osteoporosis, Atherosclerosis, and Atrophic VaginitisClearly, promoting the secretion of estrogen is key to the prevention and treatment of diseases likeosteoporosis, atherosclerosis, and atrophic vaginitis, which are caused largely by a lack of estrogen.This is why we look to placenta. Here too, the placenta’s “Secretion Regulatory Function” provides aneffective treatment. The Secretion Regulatory Function regulates the balance of hormones, restrictinghormone secretion when there is excess secretion and promoting it when there is insufficient hormonesecretion.Using placenta to treat the sudden drop in estrogen after the menopause promotes hormone secretion,allowing a gentler decline and alleviating the effects on the body. This is why the placenta shows such abroad effectiveness in treating menopausal disorders. We also know that functions such as the “ActiveOxygen Removal Function” and “Tissue Repair Function” provide even more effectiveness againstatherosclerosis.Below is a simplified explanation of how atherosclerosis develops.(1) Bad cholesterol which has penetrated the lining of blood vessels is oxidised by active oxygen.(2) Macrophages of immuno-competent cells arrive, identify the cholesterol as a foreign body, and ingestthem. This causes them to swell up and transform into foam cells.(3) The number of foam cells increases, raising the membrane of the blood vessel wall and eventuallyrupturing it. The remains of cholesterol and foam cells mix together like a syrup, and this athero (ordeposit) hardens. As a result the blood vessel loses elasticity, hardens, and atherosclerosis develops.At its root, atherosclerosis is the work of bad cholesterol and active oxygen. Recently, the phrase “activeoxygen” has appeared again and again in health magazines and books, but in fact it plays a large role inthe onset of atherosclerosis and in around 90% of modern diseases. So what exactly is active oxygen?Our bodies are composed of six trillion cells, and each one creates energy through a chemical reactionusing oxygen, glucose and fat. However, when this occurs, around 2 to 3% of the oxygen forms into anunstable state, and is transformed into excess active oxygen.The process of oxygen becoming an unstable molecule is a complex physical phenomenon and there aresome difficult to understand aspects to active oxygen. If you were to look it up in a physics textbook youmight find the following explanation: “All materials (including oxygen) are made from molecules andthose molecules are composed of atoms. Normally, electrons spin around the nucleus of atoms in pairs,producing a stable molecular state. However, if a molecule is stimulated and electrons spin individually, itcollapses into an unstable state. In order to become stable again the molecule has to capture an electronfrom another molecule, and this makes it very reactive.” Therefore, if there is an excess of energy, a smallproportion of oxygen molecules will have single, unpaired electrons, and transform into “active oxygen.”This active oxygen is a big problem because it has to react with other materials inside the body in order toretain its stable state. This reaction is called “oxidation”.Nevertheless, active oxygen is not an unhealthy particle. It has the beneficial effect of counteractingviruses and toxins which invade the body. However, if an excess of active oxygen is produced, rather thanbeing beneficial, it rages around the body damaging (oxidising) surrounding cells and organs due to itsstrong oxidising properties.
  28. 28. You probably know the oxidising effect of airborne oxygen from when you leave an iron nail outside andit turns a red rusty colour, or when you leave part of an apple is out and it turns brown. Inside the body,cells and organs can be similarly damaged by active oxygen.Our bodies produce antioxidant enzymes, which are best described as cleaners which remove excessactive oxygen produced in the body. Typical antioxidant enzymes are SOD (Super Oxide Dismutase) orCatalase, however from around the age of 40 the production of these enzymes gradually declines. Thisdecline in antioxidant enzyme production is the trigger for the increased variety of diseases in middle andold age.Going back to our earlier discussion, the culprits for the onset of atherosclerosis were bad cholesterol andactive oxygen. Placenta not only suppresses bad cholesterol in the blood by improving estrogen secretionthrough its “Secretion Regulatory Function”, but also promotes the removal of active oxygen through its“Active Oxygen Removal Function”. In other words it works to remove both of the main causes ofatherosclerosis.Also, atherosclerosis begins when bad cholesterol penetrates weakened blood vessel walls, so theplacenta’s “Tissue Repair Function” also plays a vital role in the prevention of atherosclerosis bypromoting the repair of weakened or damaged tissue.Week Two Week One 1st Month 2nd Month 1st Month 2nd Month A T-CHO 255 239 F T-CHO 303 268 S27 HDL-Cho 55 46 S19 HDL-Cho 54 49(49yrs) Neutral Fats 216 267 (59yrs) Neutral Fats 290 180 1st Month 2nd Month 1st Month 2nd Month B T-CHO 263 250 G T-CHO 234 214 S20 HDL-Cho 62 71 S29 HDL-Cho 81 78(56yrs) Neutral Fats 181 128 (47yrs) Neutral Fats 314 86 1st Month 2nd Month 1st Month 2nd Month C T-CHO 254 221 H T-CHO 256 209 S17 HDL-Cho 83 73 S27 HDL-Cho 103 87(59yrs) Neutral Fats 136 315 (49yrs) Neutral Fats 118 95 1st Month 2nd Month 1st Month 2nd Month D T-CHO 290 265 I T-CHO 290 243 S20 HDL-Cho 45 58 S23 HDL-Cho 95 102(56yrs) Neutral Fats 718 228 (53yrs) Neutral Fats 55 91 1st Month 2nd Month 1st Month 2nd Month E T-CHO 256 251 J T-CHO 234 213 S18 HDL-Cho 78 72 S14 HDL-Cho 67 68 (60yrs) Neutral Fats 76 119 (62yrs) Neutral Fats 144 110T-CHO = Total CholesterolHDL-Cho = Good Cholesterol 1st Month 2nd Month K T-CHO 290 243 S23 HDL-Cho 95 102 (53yrs) Neutral Fats 55 91 Table 2-12 – The Menopause and Hyperlipidemia
  29. 29. In my clinic, there are often cases of patients with a combination of menopausal disorders andhyperlipidemia (excessive fats such as bad cholesterol in the blood). We wanted to find out what thevalues for overall cholesterol, good cholesterol, and neutral fats would be after one or two weeks ofplacenta injections. [Table 2-12] shows the results. The key thing here is that compared to the reduction inoverall cholesterol, good cholesterol tends not to fall but instead is often seen to rise. It is further proof ofplacenta’s beneficial effect that we see such an improvement over such a short time scale.Another process at work here is the placenta’s “growth factors”, specifically the “Epidermal GrowthFactor”, which promotes growth and rejuvenation of the epidermal cells in the vaginal membrane, therebysignificantly alleviating atrophic vaginitis and painful intercourse.Prevention and Treatment of Breast Cancer and Uterine CancerBreast and uterine cancer are cancers which particularly affect women around the time of the menopause.The two main types of uterine cancer are cervical cancer and endometrial cancer. Cervical cancer affectsthe cervical area and is most common in women in their 30s and 40s, while endometrial cancer affects thelining of the uterus and is most common in post-menopausal women in their 50s or 60s. Until recentlycervical cancer was overwhelmingly more common, however rates of endometrial cancer are increasing,and the proportion is now around 70% cervical cancer to 30% endometrial cancer.Those more at risk to endometrial cancer include women in their 50s and 60s, those who had a late firstbirth, those who have never given birth, obese people, and smokers.It is thought that those in their 50s and 60s are more at risk to endometrial cancer due to the imbalance offemale hormones. Specifically, in the 2 to 3 years after the menopause, the functions of the ovariesdecline and ovulation does not occur, but while progesterone production ceases, production of estrogen ismerely reduced. This means there is no progesterone to counter the function of the estrogen, and thisunregulated estrogen makes it easier for endometrial cancer to develop.For breast cancer, however, those at greater risk include women over 40, those whose family has a historyof breast cancer, those who had a late first birth, those who have never given birth, obese people, andsmokers; a demographic which overlaps considerably with those at risk of endometrial cancer. While thecauses of cervical cancer are not yet well understood, there is a clear and substantial influence fromestrogen. The reason obese people are at greater risk of endometrial and breast cancer is the deeprelationship between obesity and estrogen.After the age of 40 the phenomenon of “middle-aged spread” leads to an increase in obesity. It is oftenclaimed to be due to the basal metabolic rate slowing as well as many years of excessive eating and lackof exercise. However in truth, the problem here is that estrogen is created in the subcutaneous fat. Themale hormone androgen is converted into estrogen in the subcutaneous fat, and secreted. This estrogen isthought to play a significant role in breast and endometrial cancers.Similarly, the reason those who first gave birth at a late age and those who have never given birth have ahigher risk is because they have had longer exposure to estrogen. When pregnant the secretion of femalehormones ceases, so their influence is avoided. This is why the risk of cancer is lower in women whohave given birth many times.There are many reasons that smoking is a risk factor for all cancers. Primarily, it is a source of largevolumes of active oxygen. It reacts with and damages oncogenes (cancer-causing genes), and soon thewhole cell is oxidised, increasing the risk of it becoming cancerous.Placenta is a very effective treatment for endometrial and breast cancer. The compound effect of theplacenta’s “Secretion Regulatory Function,” “Anti-mutagen Function,” “Anti-tumour Function,” “GeneRepair Function,” and “Active Oxygen Removal Function,” demonstrates a powerful effect against cancer.Also, the placenta’s various growth factors promote rejuvenation of healthy cells and organs.By being aware of what kind of changes take place in the body and mind when the production of femalehormones suddenly reduces at the time of the menopause, one is better equipped to appropriately handle
  30. 30. menopausal disorders and common diseases in that stage of life. Of the choices available at this time, I’msure you’ll agree that placenta and Kampo remedies are powerful allies.
  31. 31. Section 3 Effective Treatment of Pre-Menopausal Disorders:Menstrual Irregularity, Chills, Stiff Shoulders, Sleeplessness, Constipation, Anaemia, etc.

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