The Heat Shock Protein Response in the Skeletal Muscle of  Untrained Individuals<br />Shaun Guest<br />San Diego State Uni...
Modified from Noble, 2008<br />
INTRODUCTION<br />Magnitude of heat shock response to exercise: <br />Individual characteristics <br /> Training status<br...
INTRODUCTION<br />Exercise training with trained individuals:<br />Maximum volume workloads induces the largest HSP change...
PURPOSE<br />Based on results from acute exercise bouts and training programs, determine whether exercise training in untr...
FINDING THE LITERATURE<br />Data base search:<br />PubMed/Medline (via EBSCO)<br />Biosis Previews<br />SPORTDiscus<br />W...
DISCUSSION<br />With exercise training:<br />Number of physiological adaptations in human skeletal muscle.<br />Ex:  fat ...
CONCLUSIONS<br />Based on results from acute exercise bouts and training programs, it remains unclear whether exercise tra...
FUTURE RESEARCH<br />Examine of role of HSP induction with performance.<br />Continue to use non-damaging exercise protoco...
Questions???<br />
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Heat Shock Protein Response

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Directed readings project for completion of Masters degree from SDSU

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  • Metabolic DisturbancesATP depletionGlycogen deprivationHigh a cidityHypoxiaIncreased Ca2+ concentration Heat shock proteins (HSPs)Family of evolutionary conserved proteinsClassified by size and cellular functionRange from 27 to 110 kDaReview will focus on HSP70 class and HSP72 proteinSensitive to exercise stressHSP72Chaperone proteinFacilitates protein folding/refoldingProtein translocation to membraneDenatured protein reassemblyPrevent protein aggregationPrevent apoptotic pathways and cell death
  • Heat Shock Protein Response

    1. 1. The Heat Shock Protein Response in the Skeletal Muscle of Untrained Individuals<br />Shaun Guest<br />San Diego State University<br />School of Exercise and Nutritional Sciences<br />December 1st, 2009<br />
    2. 2. Modified from Noble, 2008<br />
    3. 3. INTRODUCTION<br />Magnitude of heat shock response to exercise: <br />Individual characteristics <br /> Training status<br /> Age<br /> Sex<br />Absolute workload <br />Intensity <br />Duration<br />Novelty of exercise stress<br /> Noble, 2008<br />
    4. 4. INTRODUCTION<br />Exercise training with trained individuals:<br />Maximum volume workloads induces the largest HSP changes (Liu, 1999).<br />Highest levels of HSP with high intensities <br /> (Liu 1999, 2000). <br />High-intensity resistance exercise and low-intensity endurance exercise<br />Blunted/abolished stress responses (Nething, 2003). <br />HSP response due to increased baseline levels of HSPs pre-exercise (Morton, 2009).<br />
    5. 5. PURPOSE<br />Based on results from acute exercise bouts and training programs, determine whether exercise training in untrained individuals will lead to an attenuated heat shock protein response.<br />
    6. 6. FINDING THE LITERATURE<br />Data base search:<br />PubMed/Medline (via EBSCO)<br />Biosis Previews<br />SPORTDiscus<br />Web of Science<br />Google Scholar<br />Search topics: <br />Heat shock proteins<br />HSP72<br />Skeletal Muscle<br />PEDro Scale.<br />Quality of Evidence Score of 5 (Maher et al, 2003)<br />Inclusion criteria:<br />Male subjects<br />Avg Age: 18-35 yrs<br />Exclusion criteria:<br />Female subjects<br />Age > 35 yrs<br />Musculoskeletal abnormality<br />Neurologic disease<br />
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    12. 12. DISCUSSION<br />With exercise training:<br />Number of physiological adaptations in human skeletal muscle.<br />Ex:  fat oxidation, LA, muscle remodeling<br />The magnitude of the heat shock response is dependent upon: <br />Individual characteristics<br />Exercise Type<br />Frequency<br />Intensity<br />Duration <br />
    13. 13. CONCLUSIONS<br />Based on results from acute exercise bouts and training programs, it remains unclear whether exercise training will lead to an attenuated response in untrained individuals.<br />HSP response shown to be vary greatly between individuals.<br />HSP results reflect genetic variability of skeletal muscle to recover, remodel, and/or adapt to exercise specific stress. <br />
    14. 14. FUTURE RESEARCH<br />Examine of role of HSP induction with performance.<br />Continue to use non-damaging exercise protocols  ‘clean’ results.<br />Compare HSP response with training program in untrained and trained individuals. <br />
    15. 15. Questions???<br />
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