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McGovern Institute

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McGovern Institute

McGovern Institute

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  • Note that the scale is logarithmic. Next generation sequencing technolgy causes massive acceleration starting in 2008.Illumina announced $1000 genome in Jan 2014 but they are probably not accounting for all costs.
  • Redcay et al Neuroimage. 2010 May 1;50(4):1639-47. doi: 10.1016/j.neuroimage.2010.01.052. Epub 2010 Jan 22.
  • http://clarityresourcecenter.com
  • http://eapsweb.mit.edu/about/visitor
  • http://www.theatlanticcities.com/neighborhoods/2012/05/bostons-highway-went-nowhere-look-back-inner-belt-fight-40-years-later/1884/ Cambridge historical society
  • Alternative to previous slide
  • https://www.rikenresearch.riken.jp/eng/hom/7114.html
  • Milky way contains 100-400 billion starsUniverse contains at least 100 billion galaxies extrapolating from hubble deep space images http://www.physics.org/facts/sand-galaxies.asp
  • Transcript

    • 1. Robert Desimone, Ph.D. Director, McGovern Institute for Brain Research Doris and Don Berkey Professor of Neuroscience desimone@mit.edu http://mcgovern.mit.edu
    • 2. • Founded in 2000 by Patrick & Lore Harp McGovern • Mission is to understand brain and to discover ways to prevent and treat brain disorders • 19 faculty members and >200 researchers • Faculty include Nobel Laureate and 5 members of National Academy of Sciences • Part of MIT neuroscience complex, among the largest in the world • Many collaborations within and outside MIT, including Picower Institute, Broad Institute, Harvard-affiliated hospitals, and many other institutions worldwide
    • 3. Our founders: Patrick & Lore Harp McGovern
    • 4. McGovern Institute Faculty Members
    • 5. Our mission: Understanding the brain in health and disease
    • 6. Disorders once thought to be distinct….
    • 7. ……are now known to overlap
    • 8. President Obama’s BRAIN Initiative White House, April 2, 2013
    • 9. A technology revolution: genome sequencing
    • 10. Tracing connections in the living human brain Zeynep Saygin (MIT)
    • 11. Imaging human brain activity during social interactions Rebecca Saxe (MIT)
    • 12. CLARITY: a new method for visualizing the brain Kwanghun Chung (MIT)
    • 13. Optogenetics: controlling brain activity with light Ed Boyden (MIT)
    • 14. A unique environment: MIT and Kendall Square MIT
    • 15. What’s the road map?
    • 16. NHGRI Mice are the most common genetic model….
    • 17. • Inflated self-esteem or grandiosity • More talkative than usual • Flight of ideas • Distractibility • Feelings of worthlessness • Recurrent thoughts of death …but it is not easy to model brain disorders in mice
    • 18. CRISPR: a new technology for genome editing Feng Zhang (MIT and Broad Institute)
    • 19. Jiahao Sha, Nanjing Medical University (Cell, Jan 2014) CRISPR used to make targeted gene mutations in monkeys
    • 20. RIKEN The common marmoset as a genetic model for brain research
    • 21. A brain-inspired computer vision system Tomaso Poggio; Center for Brains, Minds & Machines (MIT)
    • 22. Italian Institute of Technology A learning humanoid robot
    • 23. Understanding ourselves and our place in the universe
    • 24. Robert Desimone, Ph.D. Director, McGovern Institute for Brain Research Doris and Don Berkey Professor of Neuroscience desimone@mit.edu http://mcgovern.mit.edu

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