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PROJECT   START
DEVELOPMENT  AND  EVALUATION  OF  XYLOGLUCAN MATRIX RELEASE   TABLETS CONTAINING GLIPIZIDE Project submitted to  Acharya N...
Objective <ul><li>Prepare and evaluate matrix tablets of glipizide using XYLOGLUCAN as a polymer. </li></ul><ul><li>Plan o...
Glipizide <ul><li>Oral anti diabetic agent belonging to  sulphonyl ureas class. </li></ul><ul><li>It is insoluble in water...
Introduction <ul><li>Sustained release theory  : </li></ul><ul><li>Modified release/ non-immediate-release delivery system...
Mechanism of drug release <ul><li>A series of transport phenomena are involved in the release of a drug from a swellable, ...
Effect of rate limiting parameters <ul><li>Polymer hydration </li></ul><ul><li>Drug solubility </li></ul><ul><li>Solution ...
Extraction of Xyloglucan 20 gm of tamarind kernel powder Added to 200ml of cold distilled water to prepare a slurry Slurry...
Preparation of matrix tabs FORMULA :   XGL 1 XGL2 XGL3 XGL4 XGL5 Glipizide 100 100 100 100 100 Xyloglucan 100 150 150 150 ...
Procedure <ul><li>Tablets were prepared by wet granulation technique. </li></ul><ul><li>Starch mucilage as binder, lactose...
Preformulation studies FTIR OF GLIPIZIDE
FTIR OF GLIPIZIDE + XYLOGLUCAN
Estimation <ul><li>Construction of Standard curve of Glipizide </li></ul>Absorbance Concentration (µg/ml) Sl. No Concentra...
Dissolution Studies TIME (In Hours) %Drug  release F1 fomulation exhibits 99 % drug release for prolonged duration .
COMPARISON OF DISSOLUTION RATES TIME  (hr) F1 F2 F3 F4 F5 0 0 0 0 0 0 1 9.321 6.561 9.614 6.514 8.246 2 19.563 13.428 17.3...
Physical parameters DEPARTMENT OF PHARMACEUTICS  VICTORIA COLLEGE OF PHARMACY
Discussion <ul><li>In this study,  glipizide matrix tablets met the pharmacopoeial requirement of uniformity of weight.  <...
Conclusion <ul><li>In the present work efforts have been made to formulate and checking of drug release behavior of xylogl...
Bibliography <ul><li>Nicholas G.lordi,sustained release dosage form in “ the theory and practice of industrial pharmacy” l...
<ul><li>J. Crank,  the mathematics of diffusion,  oxford university press, oxford (1956). </li></ul><ul><li>Agis kydonieus...
THANK YOU !! PROJECT SUBMITTED BY: G. Shanthi Priyanka G. Rajesh J. Vijaya Bhaskar V. Manohar K. Sowjanya P. Sukesh L. V. ...
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Development and evaluation of xyloglucan matrix release tabs contaning glipizide

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  • Development and evaluation of xyloglucan matrix release tabs contaning glipizide

    1. 1. 5
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    6. 6. PROJECT START
    7. 7. DEVELOPMENT AND EVALUATION OF XYLOGLUCAN MATRIX RELEASE TABLETS CONTAINING GLIPIZIDE Project submitted to Acharya Nagarjuna University, Guntur . DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY Under the guidance of Mr. P. Arun Kumar , M.Pharm.,
    8. 8. Objective <ul><li>Prepare and evaluate matrix tablets of glipizide using XYLOGLUCAN as a polymer. </li></ul><ul><li>Plan of work </li></ul><ul><li>Extraction of xyloglucan </li></ul><ul><li>Preparation of matrix release tablets </li></ul><ul><li>Evaluation of prepared matrix tabs </li></ul><ul><li>Results and discussion </li></ul>DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY
    9. 9. Glipizide <ul><li>Oral anti diabetic agent belonging to sulphonyl ureas class. </li></ul><ul><li>It is insoluble in water and alcohols, soluble in 0.1 N NaOH . It is freely soluble in dimethylformamide. </li></ul><ul><li>Dose : 2.5, 5, or 10mg of three times daily </li></ul><ul><li>Effects of glipizide : </li></ul><ul><li>stimulates the release of insulin from the pancreas </li></ul><ul><li>Extrapancreatic effects are increase in insulin sensitivity and a decrease in hepatic glucose production </li></ul>DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY
    10. 10. Introduction <ul><li>Sustained release theory : </li></ul><ul><li>Modified release/ non-immediate-release delivery systems were developed and may be divided into four categories: </li></ul><ul><li>1.Delayed release </li></ul><ul><li>2.Sustained release </li></ul><ul><li>A)Controlled release </li></ul><ul><li>B)Prolonged release </li></ul><ul><li>3.Site-specific release </li></ul><ul><li>4.Receptor release </li></ul><ul><li>For non immediate – release dosage form, K r <<<K a , that is, release of drug from the dosage form is the rate - limiting step. This causes the above kinetic to reduce the following: </li></ul>MATRIX RELEASE TABLETS DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY
    11. 11. Mechanism of drug release <ul><li>A series of transport phenomena are involved in the release of a drug from a swellable, diffusion/erodable matrix : </li></ul><ul><li>Initially, there are steep water concentration gradients at the polymer/water interface, resulting in absorption of water into the matrix </li></ul><ul><li>Due to the absorption of water, the polymer swells, resulting in dramatic changes of drug and polymer concentration, increasing the dimensions of the system and increasing macromolecular mobility </li></ul><ul><li>Upon contact with water the drug dissolves and diffuses out of the device. </li></ul><ul><li>With increasing water content, the diffusion coefficient of the drug increase substantially </li></ul><ul><li>In the case of a poorly water-soluble drug, dissolved and undissolved drug coexist within the polymer-matrix </li></ul><ul><li>Finally, the polymer itself dissolves </li></ul>
    12. 12. Effect of rate limiting parameters <ul><li>Polymer hydration </li></ul><ul><li>Drug solubility </li></ul><ul><li>Solution solubility </li></ul><ul><li>Polymer diffusivity </li></ul><ul><li>a) Polymer particle size </li></ul><ul><li>b) Polymer viscosity </li></ul><ul><li>c) Polymer concentration </li></ul><ul><li>Thickness of polymer diffusional path </li></ul><ul><li>Thickness of hydrodynamic diffusion layer </li></ul><ul><li>Drug loading dose </li></ul><ul><li>Surface area and volume </li></ul><ul><li>Diluent’s effect </li></ul><ul><li>Additives </li></ul>
    13. 13. Extraction of Xyloglucan 20 gm of tamarind kernel powder Added to 200ml of cold distilled water to prepare a slurry Slurry poured into 800 ml of boiled distilled water Solution was boiled for 20 mins in stirred condition Thin clear solution kept over night Centrifuged at 5000 rpm for 20 mins Supernatant liquid was separat ed Poured into excess absolute alcohol and stirred . Precipitate was formed Washed with 200 ml absolute ethanol Dried @ 50 o C
    14. 14. Preparation of matrix tabs FORMULA :   XGL 1 XGL2 XGL3 XGL4 XGL5 Glipizide 100 100 100 100 100 Xyloglucan 100 150 150 150 150 Hydroxyl propyl methyl cellulose - - 100 - - Cellulose acetate phthalate - - - 100 - Ethyl cellulose - - - - 100 Lactose 180 130 30 30 30 Magnesium sterate 8 8 8 8 8 Talc 12 12 12 12 12
    15. 15. Procedure <ul><li>Tablets were prepared by wet granulation technique. </li></ul><ul><li>Starch mucilage as binder, lactose as diluent and mixture of talc and magnesium sterate as lubricant. </li></ul><ul><li>Xyloglucan, HPMC, CAP, EC were included in the formulations containing 100mg of glipizide. </li></ul><ul><li>They were passed through mesh #250 and mixed with starch mucilage (5% w/v) and granulated. </li></ul><ul><li>Wet mass was passed through mesh#10. </li></ul><ul><li>Then subjected for dry screening by passing through mesh#22 which was superimposed on mesh#44. </li></ul><ul><li>Granules were lubricated with talc and magnesium sterate. </li></ul><ul><li>Finally compressed into tablets using tableting machine . </li></ul>.
    16. 16. Preformulation studies FTIR OF GLIPIZIDE
    17. 17. FTIR OF GLIPIZIDE + XYLOGLUCAN
    18. 18. Estimation <ul><li>Construction of Standard curve of Glipizide </li></ul>Absorbance Concentration (µg/ml) Sl. No Concentration (  g/ml) Absorbance in 0.1N HCl 1. 0 0 2. 1 0.012 3. 2 0.025 4. 3 0.036 5. 4 0.048 6. 5 0.06 7. 6 0.071 8. 7 0.081 9. 8 0.092 10. 9 0.103 11 10 0.116
    19. 19. Dissolution Studies TIME (In Hours) %Drug release F1 fomulation exhibits 99 % drug release for prolonged duration .
    20. 20. COMPARISON OF DISSOLUTION RATES TIME (hr) F1 F2 F3 F4 F5 0 0 0 0 0 0 1 9.321 6.561 9.614 6.514 8.246 2 19.563 13.428 17.328 15.321 15.251 3 30.686 23.324 26.412 23.416 25.143 4 42.414 31.656 34.565 32.162 33.359 5 58.512 39.552 40.591 44.814 41.187 6 73.855 46.124 49.56 52.916 49.237 7 84.661 63.768 55.128 61.123 57.591 8 95.622 79.812 64.325 74.752 66.186
    21. 21. Physical parameters DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY
    22. 22. Discussion <ul><li>In this study, glipizide matrix tablets met the pharmacopoeial requirement of uniformity of weight. </li></ul><ul><li>All the tablets conformed to the requirement of assay, as per I.P. hardness, % friability, and thickness were well within acceptable limits. </li></ul><ul><li>It has been observed that the cumulative percent drug release decreases with increasing concentration of gum and swelling index. </li></ul><ul><li>Increasing the amount of gum in the formulation, resulted in slower rate, and decreased amount of drug release from the tablet. </li></ul><ul><li>Stability studies revealed that there was no significant change in hardness, friability, drug content and dissolution profiles of F1. </li></ul><ul><li>So, F1 formulation could be used as an effective matrix former, to retard the release of glipizide for extended period of time. </li></ul>DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY
    23. 23. Conclusion <ul><li>In the present work efforts have been made to formulate and checking of drug release behavior of xyloglucan matrix tablets </li></ul><ul><li>All the formulations were exhibited anomalous diffusion mechanism and F1 formulation was found to be the best formulation on the trail and error method and it was selected for use as sustained matrix release tablets </li></ul><ul><li>Finally, the best formulation F1 drug release in various acidic and basic buffers, the drug release was dependent on only polymer concentrations . </li></ul>
    24. 24. Bibliography <ul><li>Nicholas G.lordi,sustained release dosage form in “ the theory and practice of industrial pharmacy” l. Lachman,h. A. Liberman, and j. L. Kanig, eds, (lea & febiger), philadelphia,pa,(1986), iii rd edition.,430. </li></ul><ul><li>Yie w. Chein, novel drug delivery systems, marcel dekker, inc: 140-142 </li></ul><ul><li>Banker and rhodes, modern pharmaceutics, iii rd edition marcel dekker, inc: 575-588 </li></ul><ul><li>Robinson jr,and lee vhl.(eds) ii nd , new york “ controlled drug delivery fundamentals and applications,” 1987,5-12. </li></ul><ul><li>Gilbert s. Banker, christopher t. Rhodes, ‘sustained and controlled -release drug delivery system,’ chapter-15, in “modern pharmaceutics” second edition, revised and expanded, vol-72, 578-580 </li></ul><ul><li>H. Suhela kas and levent oner chapter 15,in “ the hand book of pharmaceutical controlled release technology” edited by “donald l. Wise,marcel dekker;302. </li></ul>
    25. 25. <ul><li>J. Crank, the mathematics of diffusion, oxford university press, oxford (1956). </li></ul><ul><li>Agis kydonieus, “treatise on controlled drug delivery” marcel dekker, inc: 256-290 </li></ul><ul><li>R.V.Kulkarni, Development and evaluation of xyloglucan matrix tablets of naproxen, asian journal of pharmaceutics (2008) </li></ul><ul><li>Leszek krowczynski , extended-release dosage forms, crp press (1987), chap 6, 106 </li></ul><ul><li>Thomas wai- yip lee, joseph r. Robinson, “controlled release drug-delivery systems,’ chapter-47 in remington: “the science and practice of pharmacy”, 20 th edition, vol-1, 907-910. </li></ul><ul><li>S.p. Vyas, roop.k.khar “controlled drug delivery-concepts and advances,” 155-158. </li></ul><ul><li>Robert e.notari, “biopharmaceutics and clinical pharmacokinetics an introduction ”4 th edition, revised and expanded. 208 </li></ul>DEPARTMENT OF PHARMACEUTICS VICTORIA COLLEGE OF PHARMACY
    26. 26. THANK YOU !! PROJECT SUBMITTED BY: G. Shanthi Priyanka G. Rajesh J. Vijaya Bhaskar V. Manohar K. Sowjanya P. Sukesh L. V. Kishore U.V. Sudheer GUIDED BY: Mr. P. Arun Kumar, M.Pharm. , Victoria college of pharmacy Nallapadu Guntur

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