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Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
Blood pH Measurement
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Blood pH Measurement

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Instrumentation based on measurement of Blood pH

Instrumentation based on measurement of Blood pH

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  • http://ccforum.com/content/4/1/6
  • W. Vonau,"pH Monitoring: a review," J Solid State Electrochem (2006) 10: 746–752
  • www.ph-meter.info/pH-electrode-construction 
  • Danny O’Hare, Kim H.Parker, C.PeterWinlove,"Metal–metal oxide pH sensors for physiological application," Medical Engineering & Physics 28 pp 982–988, 2006
  • Peter Kurzweil, "Metal Oxides and Ion-Exchanging Surfaces as pH Sensors in Liquids: State-of-the-Art and Outlook," Sensors 2009
  • B. Palan, K. Roubik, M. Husak and B. Courtois, "CMOS ISFET-based structures for biomedical applications," Microtechnologies in Medicine and Biology, 1st Annual International, Conference on. 2000, pp. 502-506, 2000.
  • Peter Kurzweil, "Metal Oxides and Ion-Exchanging Surfaces as pH Sensors in Liquids: State-of-the-Art and Outlook," Sensors 2009
  • E. I. Gill, A. Arshak, K. Arshak and O. Korostynska, "Investigation of Thick-Film Polyaniline-Based Conductimetric pH Sensors for Medical Applications," Sensors Journal, IEEE, vol. 9, pp. 555-562, 2009.
  • N. Sheppard, "Microfabricatedconductimetric pH sensor," Sensors and Actuators.B, Chemical, vol. 28, pp. 95, 1995.
  • T. Lumsden, "The PB3300 intraarterial blood gas monitoring system," J. Clin. Monit., vol. 10, pp. 59, 1994http://www.oceanoptics.com/Products/phsensor.asp
  • A. Sohanghpurwala, "Optical replacement of pH electrode," IEEE Sensors Journal, vol. 9, pp. 219, 2009.
  • Peter Kurzweil, "Metal Oxides and Ion-Exchanging Surfaces as pH Sensors in Liquids: State-of-the-Art and Outlook," Sensors 2009
  • http://www.oroboros.at/index.php?id=mipnetanalyzer
  • http://www.oroboros.at/index.php?id=mipnetanalyzer
  • Transcript

    • 1. Blood pH Measurement<br />SuhasDeshpande<br />EE506 <br />Dr. Druzgalski<br />
    • 2. Outline<br />pH<br />Blood and pH<br />pH Monitoring<br />Glass Electrodes<br />Metal-metal oxide electrodes<br />pH sensitive FETs<br />Conductimetric pH sensors<br />Fiber optic pH sensors<br />Temperature dependence<br />Calibration<br /> Model G pH meter<br /> (Beckman Coulter, Inc. 1936)<br />http://www.ph-meter.info/pH-meter-history<br />
    • 3. pH Defined<br />Chemically: measure of acidity or basicity of a fluid<br />Physically: Measure of concentration of H+ ions<br />Mathematically: pH = -log10[H+] <br />Technically: Power or Potential of hydrogen ions in the fluid. <br />
    • 4. Blood pH<br />Importance in medical field<br /><ul><li>Diagnosis of major acid base disorders, cancers renal failures, ischemia
    • 5. Diagnosis of patients in ICU
    • 6. Major surgeries like open heart surgery
    • 7. Diagnosis of effect of a particular drug on the patient</li></ul>Blood pH is very tightly regulated in human body generally lies between 7.3-7.5<br />Acute changes in blood pH induce powerful regulatory effects at the level of the cell, organ, and organism<br />The pH of blood plasma and various other body solutions is tightly regulated variables in human physiology<br />
    • 8. pH monitoring<br />
    • 9. pH measurement<br />Glass Electrodes<br />Metal-metal oxide electrodes<br />pH sensitive FETs<br />Conductimetric pH sensors<br />Fiber optic pH sensors<br />
    • 10. Glass Electrodes<br />EMF is developed between the measuring electrode and reference electrode <br />Time consuming<br />Needs blood sample to be taken<br />www.ph-meter.info/pH-electrode-construction <br />
    • 11. Metal-metal oxide electrodes<br />Working on similar principle<br />Rhodium-iridium can be used as electrode<br />Chemical equilibrium between salt-salt solution cause potential between the electrodes <br />Easy to miniaturize and CMOS compatible<br />
    • 12. Comparing MMO Electrodes<br />
    • 13. pH sensitive FETs<br />Based on MOSFET device can be manufactured using CMOS technology<br />Various gate materials used SiO2, Si3N4, Al2O3 <br />
    • 14. Compare different ISFETs<br />
    • 15. Conductimetric sensors<br />Based on the change in the conductivity upon contact with changing pH<br />Polymers such as Polyaniline (PANI) show wide range of conductivities with varying pH for different dopings.<br />
    • 16. Conductimetric sensors<br />
    • 17. Fiberoptic pH sensors<br />Safe small can be placed in patient’s arteries<br />Based on absorption or fluorescence<br />In-vitro analysis makes continuous monitoring possible<br />Indicator dye Phenol red can be used for the range 7.0-7.5<br />http://www.oceanoptics.com/Products/phsensor.asp<br />
    • 18. Optical pH Sensor System<br />Two LEDs with different wavelenths<br />Florescence measured using photo detector<br />Amount of florescence determines the pH<br />Result of optical sensor linear, with max error of 0.18 and avg error 0.061<br />
    • 19. Comparing different electrodes<br />
    • 20. Temperature dependence<br />Temperature dependence of pH increases with increase in bascicity<br />For basic solutions pH depends on autoprotolysisof water which is temperature dependent<br />
    • 21. Calibration<br />Two point calibration<br />pH = (6.0,8.0)<br />Signal pH = 6.0 brought to base zero<br />Slope(gain) adjusted using ∆pH = 2.0 (i.e 8.0-6.0)<br />Base zero adjusted to pH signal = 6<br />
    • 22. Industrial pH Meters<br />Thermo-Fisher: http://www.thermofisher.com/global/en/home.asp<br />Siemens (Tel.: 1-800-SIEMENS)<br />http://www.usa.siemens.com/entry/en/<br />
    • 23. References<br />http://www.ph-meter.info<br />www.ph-meter.info/pH-electrode-construction <br />http://ccforum.com/content/4/1/6<br />http://www.oroboros.at/index.php?id=mipnetanalyzer<br />W. Vonau,"pH Monitoring: a review," J Solid State Electrochem (2006) 10: 746–752 <br />Danny O’Hare, Kim H.Parker, C.PeterWinlove,"Metal–metal oxide pH sensors for physiological application," Medical Engineering & Physics 28 pp 982–988, 2006 <br />Peter Kurzweil, "Metal Oxides and Ion-Exchanging Surfaces as pH Sensors in Liquids: State-of-the-Art and Outlook," Sensors 2009<br />E. I. Gill, A. Arshak, K. Arshak and O. Korostynska, "Investigation of Thick-Film Polyaniline-Based Conductimetric pH Sensors for Medical Applications," Sensors Journal, IEEE, vol. 9, pp. 555-562, 2009. <br />N. Sheppard, "Microfabricatedconductimetric pH sensor," Sensors and Actuators.B, Chemical, vol. 28, pp. 95, 1995. <br />T. Lumsden, "The PB3300 intraarterial blood gas monitoring system," J. Clin. Monit., vol. 10, pp. 59, 1994.<br /> B. Palan, K. Roubik, M. Husak and B. Courtois, "CMOS ISFET-based structures for biomedical applications," Microtechnologies in Medicine and Biology, 1st Annual International, Conference on. 2000, pp. 502-506, 2000.<br />A. Sohanghpurwala, "Optical replacement of pH electrode," IEEE Sensors Journal, vol. 9, pp. 219, 2009.<br />

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