Histologic structure of endocrine system
Upcoming SlideShare
Loading in...5
×
 

Like this? Share it with your network

Share

Histologic structure of endocrine system

on

  • 5,831 views

Histologic structure of endocrine system

Histologic structure of endocrine system

Statistics

Views

Total Views
5,831
Views on SlideShare
5,821
Embed Views
10

Actions

Likes
2
Downloads
253
Comments
1

2 Embeds 10

http://www.slideshare.net 9
http://iccstage.blackboard.com 1

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

Histologic structure of endocrine system Presentation Transcript

  • 1. HISTOLOGIC STRUCTURE OF ENDOCRINE SYSTEM DR. I WAYAN SUGIRITAMA,M.Kes HISTOLOGY DEPARTMENT MEDICAL FACULTY OF UDAYANA UNIVERSITY www.sugiritama.blogspot.com [email_address]
  • 2.
    • HORMONE : organic chemical that liberate by endocrine cells into vascular system
    • TARGET ORGAN : tissue/organ on which the hormones act
    • ENDOCRINE GLANDS : Contain cell that produce hormone ( Pituitary, Adrenal, Thyroid, Parathyroid, Islet Langerhan,s, and Pineal)
  • 3. ENDOCRINE
    • GENERAL CHARACTERISTICS
    • COMMONLY SAID THAT THEY HAVE NO DUCTS
    • RICH SUPPLY OF BLOOD VESSELS
    • EACH GLAND SECRETE ONE/MORE HORMONE  SPECIFIC EFFECT UPON ANOTHER TISSUE/ORGAN
  • 4. PITUTIARY/ HYPOPHYSIS GLAND
    • Develop from different embryonic :
      • Adenohypophysis : evagination oral ectoderm
      • Neurohypophysis : neural ectoderm
    • Connected to the brain by neural pathways
    • Hormone secretion controlled by Hypothalamus
  • 5. SUBDIVISION OF HYPOPHYSIS
    • Adenohypophysis (anterior pitutiary)
      • Pars distalis (anterior)
      • Pars intermedia
      • Pars tuberalis
    • Neurohypophysis (posterior pitutiary)
      • Median eminence
      • Infundibulum
      • Pars Nervosa
  • 6. ADENOHYPOPHYSIS (Pars Distalis )
    • Chromophils (have an affinity for histological dyes)
      • Acidhophil (granules stain orange-red with eosin)
        • Somatotrophs  somatotropin (GH)
        • Mammotrophs  Prolactin
      • Basophil (granule stain blue with basic dyes)
        • Corticotrophs  ACTH
        • Thyrothrops  TSH
        • Gonadothrops  LH and FSH
    • Chromophobes (do not take up stain)
      • Degranulated chromophils
  • 7. ADENOHYPOPHYSIS(Pars Intermedia and Pars Tuberalis)
    • PARS INTERMEDIA
      • Between pars distalis-nervosa
      • Cuboidal cell line, colloid containing cysts (Rathke,s cysts)
      • Houses cord of basophils along networl of capillaries  POMC  α -MSH,corticotropin, β -lipoprotein,and β -endorphine
    • PARS TUBERALIS
      • Surround hypophyseal stalk
      • Highly vascularized by arteries and hypophseal portal system along which longitudinal cords of cuboidal-low columnar epith.
      • Cells contain secretory granule (FSH?, LH?)
  • 8. HYPOTHALAMOHYPOPHYSEAL TRACT
    • Unmyelinated axon (cell bodies in supraoptic and paraventricular nuclei of hypothalamus), enter the posterior pitutiary  terminate in vicinity of capillaries
    • Nuclei sythezise  ADH and oxytocin , and also neurohypophysin
  • 9. NEUROHYPOPHYSIS
    • Pars nervosa technically is not endocrine gland
    • Hypothalamohypophyseal tract end in the pars nervosa and store the neurosecretions that are produce by cells bodies (hypothalamus)
    • Axon supported by pituicytes (glial-like cell)
    • Axon contain granule of vasopressin or oxytocin
    • Chrome-alum staining reveal Herring bodies (accumulation of neurosecretory granule)
  • 10. HYPOPHYSIS=MASTER GLAND
  • 11. ADRENAL GLAND
    • Consist of two layer :
      • Adrenal cortex
        • From coelomic intermediate mesoderm
      • Adrenal medulla
        • From neural crest modified sympathetic postganglionic neurons
  • 12. Adrenal cortex
    • Zona glomerulosa
      • Columnar/pyramidal cells are arranged in closely packed, rounded or arched clusters
      • Mineralocorticoids(aldosterone)
    • Zona fasciculata
      • Polyhedral cells arranged in straight cords
      • Glucocorticoids (cortisone &cortisol) and androgens
    • Zona reticularis
      • Cells disposed in irregular cords that form anatomozing network
      • Glucocorticoids and androgens
  • 13. ADRENAL MEDULLA
    • Parenchymal : polyhedral cells arranged in cords/ clumps and supported by reticular fiber network
    • >> capillary supply
    • >> secretory granules
      • epinephrine &
      • norepinephrine
  • 14. THYROID GLAND
    • Thyroid follicle is the structural and functional unit
    • Connective tissue septa derived from the capsule invaded the parenchym
    • Secrete T3 and T4
  • 15. PARENCHYM OF THYROID GLAND
    • FOLLICULAR CELLS
    • Range from squamous-low columnar
    • Numerous short villi that extend into colloid
    • Round, ovoid nucleus,
    • Basophilic cytoplasm, rod-shape mitochondria, supranuclear golgi comp. numerous small vesicle
    • Hormone T4 and T3 stored in colloid, which bound to Thyroglobulin
  • 16. PARENCHYME CELL OF THYROID GLAND
    • PARAFOLLICULAR CELLS
    • Pale staining, lie cluster among the follicular cells
    • 2-3 times larger than follicular cells; 0,1% of epithelium
    • Round nucleus, moderate RER, elongated mithocondria, well developed golgi compl. Small dense granule
    • Secrete calcitonin
  • 17. SYNTHESIS OF THYROID HORMONE
  • 18. PARATHYROIDS GLAND
    • Parenchym : consist of chief cells and oxyphill cells
    • Cells form the cords or cluster surrounded by reticular fiber and rich capillary network
    • Connective tissue in older adult :>> adipose cells (up to 60%)
    • Secrete PTH  calcium metabolism
  • 19. PARENCHYM OF PARATHYROID GLAND
    • CHIEF CELLS
      • Eosinophilic-staining
      • Contain secretory granules (PTH)
      • Juxtanuclear golgi complex, elongated mitochondria and abundant RER
    • OXYPHIL CELLS
      • More deeply stain with eosin
      • Less numerous , appear in group
      • More mitochondria, small golgi app. And little RER
      • The inactive phase of Chief cells
  • 20. PINEAL GLAND
    • Cone-shape midline projection from roof of the diencephalons
    • 5-8 mm X 3-5 mm (120 mg)
    • Covered by pia mater  capsule  septa  incomplete lobules
    • Parenchym composed by : pinealocytes & interstitial cell
    • Melatonine secretion are influenced by light and dark
  • 21. PARENCHYME OF PINEAL GLAND
    • Pinealocytes
      • Basophilic cells, with one. two long processed
      • Nucleus spherical
      • Cytoplasm : SER, RER, small golgi app., mitochondria and small secretory granule
      • Produce Melatonin and serotonin
    • Interstitial cells
      • Scattered trough pinealocytes
      • Deeply staining, with long processed
      • Calcium and carbonate deposite  CORPORA ARENACEA (BRAIN SAND)  >> older
  • 22. ISLET OF LANGERHANS
    • Appear as rounded clusters of cells within exocrine pancreatic tissue
    • Each islet consists of lightly stained polygonal/ rounded cells arranged in cords separated by network of fenestrated blood capillaries
    • Four type cells (A, B, D and F)
    • The B cells have irregular granules (insulin )
    • Type A cell  Glucagons