Blood cells and hematopoesis
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Blood cells and hematopoesis

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the structure of and formation blood cells, erythrocyte,leucocyte,neutrophil,basophil,eosinophil,lymphocyte T,lymphocyte B, hematopoiesis,......

the structure of and formation blood cells, erythrocyte,leucocyte,neutrophil,basophil,eosinophil,lymphocyte T,lymphocyte B, hematopoiesis, erythropoiesis,leucopoiesis,granulocytopoiesis,agranulocytopoiesis,lymphopoiesis

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  • 1. BLOOD CELLS AND HEMATOPOESIS
    I WAYAN SUGIRITAMA
    http://sugiritama.blogspot.com
    sugiritama@gmail.com
  • 2. COMPONENT OF THE BLOOD
    Blood is specialized connective tissue
    Composed by :
    • Formed elements
    • 3. Fluid component , Plasma (the extracellular(matrix)
  • FORMED ELEMENTS OF BLOOD
    Formed elements : cells and cell fragments (platelets)
    The cells of blood :
    • red blood cells (RBC)
    • 4. white blood cells (WBCs, leukocytes).
  • NEUTROPHILS
    • 60-70% of total leucocytes
    • 5. 9-12 µm in diameter
    • 6. Multilobe nucleus
    • 7. Female : drum stick/Barr Body
    • 8. Granules :
    • 9. Small spesific granules
    • 10. Azurophilic granules (Lysosomes)
    • 11. Tertiary granules (gelatine and cathepsins)
    • 12. Function :
    • 13. Phagocytes
  • EOSINOPHILS
    4% of total leucocyte
    10 - 14 µm in diameter
    Bilobed nucleus
    Many large spesific granules stained by eosin
    Function :
    • Eliminate antibody-antigen complexes
    • 14. Destroy parasitic worms
  • BASOPHILS
    <1% of total leucocyte
    8-10 µm in diameter
    S-shape nucleus (irregular lobes)
    Large spesific granules obscured the nucleus
    Granules (dark blue) contain heparin & histamin
    Surface receptor (Ig E receptors)
    Function :
    As initiator of inflamatory process
  • 15. LYMPHOCYTES
    20%-25% of total leucocyte
    8-10 µm in diameter
    Round nucleus with slight indented, occupies most of the cell
    Contain few azurophilic granules
  • 16. MONOCYTES
    Largest circulating blood cells
    3-8% ot total leucocyte
    Large, acentric, kidney- shape nucleus
    numerous azurophlic granules
    Migrate to the connective tissue  MACROPHAGES (phagocytose antigens and as APC)
  • 17. PLATELETS
    250.000-400.000 platelets/mm3
    2 to 4 µm in diameter
    Display peripheral clear region (hyalomere ) and central darker region (granulomere)
    receptor molecules (glycocalyx) on plasmalemma
    Function : Blood clott
  • 18. HEMATOPOIESIS
    Mature blood cells have a relatively short life span
    Must be continusly replaced by stem cells
    Stem cells produce in HEMATOPOIETIC ORGAN
  • 19. PRENATAL HEMOPOIESIS
    Subdivide into four phases :
    Mesoblastic :
    begin after 2 weeks after conception at yolk sac
    Mesenchymal cells aggregate into blood islands
    Hepatic
    Begins at 6 weeks until end of gestation
    Nucleated erythrocyte
    Appear of leucocyte (8th week)
    Splenic
    Begin at second trimester until end of gestation
    Myeloid
    Begin at the end of second trimester
    Hemopoiesis at bone marrow
  • 20. POSTNATAL HEMOPOIESIS
    Hemopoiesis almost exclusively in BONE MARROW
    Stem cells undergo
    multiple cells divisions
    and differentiation
    Replace the cells that leave the blood stream, die or destroy
  • 21. BONE MARROW
    A gelatinous, vascular connective tissue located in medulary cavity of long bones
    Responsible for hemopoiesis
    Structure :
    Vascular compartment
    Extensive network of sinusoids , arteries and veins form the
    Hemopoietic compartment
    Islands of hematopoietic cells
    Hemopoietic cells in various stage of maturation
  • 22. HEMOPOIETIC GROWTH FACTORSTable 10-6 Gartner colour text histology
    Regulated the hemopoiesis
    Produce by spesific cells
    Acts on spesific stem cells, progenitor cells, and precursor cells
    The route to deliver growth factor :
    Via blood stream
    Secrete near the hemopoietic cells
    Direct cell-cell contact
    Induced rapid mitosis or and differentiation
    Most ot them are glycoproteins
  • 23. HEMATOPOIESIS
  • 24. ERYTHROPOIESIS
    Formation of red blood cells
    Generates 2.5 x 10 11 erythrocytes /day
    By two types of unipotential progenitor cell
    BFU-E
    CFU-E
    Regulate by : erythropoietin
  • 25. PROERYTHROBLAST
    .
  • 26. NORMOBLAST
    .
  • 27. RETICULOCYTE
  • 28. ERYTHROCYTE
    Biconcave-shape disk
    Without nuclei and organelles
    Have soluble enzymes
    Filled with Hemoglobin (Hb)
    Average life span of erythrocyte : 120 days
  • 29. GRANULOCYTOPOIESIS
    Formation of the granulocytes (neuthrophil, eosinophil, and basophil
    CFU-Eo : eosinophil lineage
    CFU-Ba : Basophil lineage
    CFU-GM
    CFH-G : Neutrophil line
    CFU-M : monocyte line
    Influence by G-CSF, GM-CSF
  • 30. GRANULOCYTOPOIESIS
  • 31. EOSINOPHYL STAB
  • 32. NEUTROPHYL STAB
  • 33. BASOPHIL (BONE MARROW)
  • 34. MONOCYTOPOIESIS
  • 35. PROMONOCYTE
  • 36. PLATELET FORMATION
    CFU-Meg, gives rise the Megakaryoblast
    Megakaryoblast differentiate  Megakaryocytes (single lobulated nucleus)
    Megakaryocytes protrude  clusters of proplatelets  platelets
  • 37. MEGAKARYOCYTE
  • 38. LYMPHOPOIESIS
    CFU-Ly divides form the CFU-LyB and CFU-LyT
    CFU-LyB migrate to “bursa-equivalent location”, divided  B lymphocytes
    CFU-LyT undergo mitosis migrate to the Thymus  T lymphocytes
  • 39. LYMPHOBLAST
  • 40. LEARNING TASKS
    Expain the composition of the blood!
    Explain the structure of formed elements of blood!
    How to differentiate the blood cells from a blood-smear?
    Explain the classification and function of leucocyte !
    Explain the maturation of lymphocyte!
    What blood cell would be in abundance during an active parasitic infection? Explain your answer!
    Eplain the structure and function of platelets!
    What blood cell in bone marrow is the earliest recognizable stage of the red blood cell line?
    Describe the structure of erythrocyte if lack of this nutrient: vitamin B12 and iron during the erythrocytopoiesis
  • 41. I WAYAN SUGIRITAMA
    http://sugiritama.blogspot.com
    sugiritama@gmail.com