Overall Perspective

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    Overall Perspective - Presentation Transcript

    1.  
    2. Alisa’s Story Picture of Alisa taken on the 14th of October 2006
      • Picture of Alisa taken on the 14th of September 2006
      Alisa’s Story
    3. On the 23rd of October 2006 Alisa started her nutritional supplement under the watchful eye of c aretaker Tarrah Hildreth in Hammanskraal Alisa’s CD4 count on 4 Alisa’s Story
    4. Alisa’s Story A picture of Alisa on the 4th of November 2006
      • -----Original Message----- From: Hildreth family
      • Sent: 05 November 2006 01:29 PM To: Daleen Slabbert Subject: pictures of Alisa
      •  
      • Alisa is improving by leaps and bounds. We take her CD4 count on Thursday and are excited to see how much it has gone up. She is not on ARV's so her progress is all from Imuniti and prayer! She has a huge appetite. tell your husband I have given out the boxes that Rudy left with me to some people that really needed it. This product has been a blessing. Thanks again for everything.
      • Love,
      • Tarrah Hildreth
      Alisa’s Story
    5. Alisa’s Story A picture of Alisa on the 10th of November 2006
    6. Alisa’s Story 19th of November 2006
    7. Alisa’s Story 24th of November 2006
      • 5th of
      • December
      • 2006
      Alisa’s Story
    8. Alisa’s Story 27th of January 2007
    9. Alisa’s Story 1-2 Months
    10. The Imuniti Wellness Month Pack
    11. IMUNITI Wellness Pack
      • Immune booster
      • @
      • Anti-oxidants
      • Sutherlandia
      • African Potato
      • Rooibos Se.Zn
      • Spirulina
      • Chinese Green Tea
      • Aloe Vera juice
      • BlueGold –a natural water sterilizing agent
      High Protein Imuniti Meal 3 by 1 kg’s
    12. Manufacturing Process
    13. Manufacturing Accreditations
      • Nutritional Foods
        • Pre-audit for ISO
        • 9000/2000
        • Pre-audit HACCP
      • SPP
        • ISO 9000/2000
        • HACCP
        • ISO 14001
        • Organic Processing
        • Certification
        • Halaal & Kosher
    14. Manufacturing Accreditations
      • Impilo Drugs
        • Medicines Control Council accreditation (MCC)
        • Good Manufacturing Practice (GMP)
      • Blue Gold
        • SABS
        • CSIR
        • Rand Water
        • ERWAT
        • SGS
        • Univ of KZN
        • WITS
        • Van Drimmelin Lab
        • Inst of Water Studies
        • Dept of Health of SA
    15. Core Business
      • Nutritional Foods
      • Core business is:
        • Formulation & Manufacturing of
        • Food related
        • Products for
        • Catering market segment
      • Product portfolio :
        • 16 product groups
        • 354 NF product
        • formulas
      • Impilo Drugs
      • Core business is:
        • Formulation & Manufacturing of
        • Products for
        • Pharmaceutical &
        • Complementary
        • Medicines market
      • Product portfolio :
        • 3 product groups
        • 25 product formulas
        • 382 formulas
      • SPP
      • Core business is:
        • Formulation & Manufacturing of
        • Soy Food related
        • Products
    16. The Brands
      • Nutritional Foods :
      • Impilo:
        • Includes 25 different products
      • Contract manufacturing
      • and packing for
        • ASPEN
        • ENALENI
        • DISCHEM
        • PD PHARMACEUTICALS
        • HERBOLOGY etc
      • SPP:
    17. Spesialised Protein Products (Pty) Ltd 1. Based in Potchefstroom in North West Province in South Africa. 2 . The SPP Manufacturing advantages : A World Class First; All expertise in-house to duplicate; Unique IP From basic food to bio-tech
    18. Spesialised Protein Products
      • 3 . SPP products have important advantages :
      • a. Bland in taste - “non-soy beanie”;
      • b. No chemical use in process a natural cold water extraction process the Potchefstroom Process® ;
      • c. Lactose and Cholesterol free products;
          • d. Products with a very high PDI (90%+) - functional
          • e. Products with a very high P.E.R. (90%+) – Nutritional
      • f. Whole soy bean “goodness”.
    19.  
    20.  
      • 1. Composition of the Soybean
      Spesialised Protein Products Soy Nutrition & Health a. Excellent source of good quality protein. b. Rich in polyunsaturated fatty acids – contains no cholesterol. c. Protein content of the soybean is one of highest among all legumes. d. Amino acid structure - close to that of mothers milk 2. Ten Food Based Dietary Guidelines - Nutrition Society of Southern Africa - 2001 Eat dry beans, peas, lentils and soy regularly
    21. Spesialised Protein Products 3. Heart Disease Soy Nutrition & Health a. 25g soy protein/day - lower total and LDL cholesterol levels. b. Reduced LDL cholesterol reduced risk of CHD. FDA Health Claim Approval As of October 26th 1999, the United States Federal Drug Administration allowed certain foods containing at least 6.25g of soy protein per serving to carry a label including information on soy’s role in reducing the risk of coronary heart disease (CHD). 4. Phytochemicals and Soy Isoflavones Phytochemicals - biologically active plant substances - include phyto-oestrogens . Of interest for health reasons are classes of phyto-oestrogens called lignans and Isoflavones . Soybeans contain significant amounts of Isoflavones daidzein and genistein
    22. Spesialised Protein Products Soy Nutrition & Health 5. Soy and Cancer
      • a. Common cancers strongly associated with environmental factors including diet. For example high fat intake associated with breast, colon and womb cancer.
      • b. Isoflavones and other compounds in soybeans may act as anti-carcinogens.
      • Consumption of soy foods may be linked to reduced rates of certain types of cancer, for example :
      • Breast Cancer Prostate Cancer Colon Cancer
      6. Soy and Menopausal Symptoms During menopause oestrogen levels fall , resulting in hot flushes as the most common symptom. It has been found that Asian women, whose soy intake is high, experience these symptoms much less often than Western women. This may be due to the phyto-oestrogen content of soy.
    23. Spesialised Protein Products Soy Nutrition & Health 7. Soy and Bone Health Osteoporosis is a condition of low bone density which may be due to the loss of calcium from bone tissue via the urine. Soy protein may help preserve the structure of bones as replacing animal protein with vegetable protein may reduce the level of urinary calcium excretion and therefore reduce the risk of the development of osteoporosis. Also, soy phyto-oestrogen may increase bone strength. 8. Soy and Diabetes Mellitus Soybeans may be useful in diabetes control . The complex carbohydrates found in soy are slowly digested and produce low glycaemic and insulin responses. This means that the glucose is released gradually into the blood, assisting in keeping the blood sugar level within normal ranges.
    24. Nutritional Meal or Drinks 22% protein 55% protein 32% protein
    25. Nutritional Foods Established in 1944 by Suzman and Rose families in Klerksdorp Manufactures powdered foodstuffs, food ingredients and dry blended products
    26. Nutritional Foods
    27. NF’s Products Soup Powders Milk Blends and Replacers Dehydrated Stews and Minces Powdered Soft drinks Hot Drink Powders Deserts
    28. Impilo Drugs Established in 1940 in KZN 1
    29. IMPILO’s Products
    30. Impilo Drugs
    31. The Imuniti Wellness Monthly Pack
      • A holistic solution including :-
      • nutritional supplementation ( vitamin and mineral supplements – micro- nutrient balanced )
      • immune boosting ( Natural unique plant sterols )
      • nutritious meal ( highly digestible soy protein – macro - nutrients )
      • natural water sterilising agent
    32. THE IMUNITI NUTRITIONAL PACK®
      • IMUNITI-SPP INSTAMEAL FORTIFIED SOY-MAIZE PORRIDGE
      • Description:
      • An instant ( pre-cooked ) cereal made from a mix of instant extruded maize and full fat soy powder sweetened with sucrose , fortified with vitamins and minerals. Add hot or cold water. May be used with sour milk , milk , fruit juice , yoghurt or sugar.
      • Labeling:
      • High protein – High fibre – High vitamins and minerals –Non genetically modified products – Non dairy –Contains prebiotics –LOW GLYCEMIC INDEX –SUITABLE FOR DIABETICS – LACTOSE FREE
      • Ingredients:
      • Maize, soy, sucrose, soy fibre, vitamins and minerals – (dicalcium phosphate, sodium chloride, magnesium oxide, zinc oxide, ferrous fumarate, chromium citrate ,Vit A, Vit D, Vit E, Vit B1, Vit B2, Vit B6, Vit B12, folic acid, biotin, nicotinamide, pantothenic acid, ascorbic acid, potasium iodide, sodium selenite
    33. THE IMUNITI NUTRITIONAL PACK®
      • Dosage
      • Take 100grams daily or 50grams twice daily – Product may also be used as an instant nutritious meal drink or protein supplement drink/shake or sprinkled onto food or cereal – product suitable for children above 12 months of age- Approved by the Diabetic Association of South Africa
      • Storage Conditions:
      • Store in a cool < 25 celcius , dry place – Keep away from direct sunlight- shelf life if sealed 4-6 months- if opened product should be used in 1 month
      • BENEFITS OF SOY
      • Anti-carcinogenic (Cancer fighting compounds)
        • Isoflavones
        • Protease ( enzyme ) inhibitors
        • Saponins
        • Phytic acid
      • Anti-thrombotic and Anti-platelet aggregating effects
        • prevents dangerous clots from forming which may cause heart attacks
        • Anti-hypertensive
        • Some clinical research indicating soy protein reduces blood pressure, thereby potentially reducing the risk of strokes
      • Geniatein (the main isoflavone in soybeans)
        • Beneficial to men with untreated Prostrate cancer
      • Solya oil contains Omega 3 Essential Fatty Acids
        • Omega 3 (EPA and DHA ) is necessary for normal cell functioning , normal functioning of the brain and nervous system , normal immune system functioning , “bad “ LDL cholesterol lowering , lowering of heart disease risk , normal functioning of the hormonal system , reduces platelet stickiness ( reduces risk of clot formation ) and plays a role in the maintenance of healthy skin , organ functioning and the reduction of inflammation in the body
      • Diminishes the risk of Breast cancer , especially in estrogen sensitive women. The phytoestrogens in soy are only 1/10 000 the potency of human estrogen or the oestrogen used for HRT (hormone replecement therapy). The phytoestrogens bind to estrogens receptors on the cells thereby reducing the number of binding sites for human or synthetic estrogen diminish the negative effects of Post Menopausal Syndrome.
      • Reduces the risk of Osteoporosis
      • The isoflavones in soya inhibit bone re-absorption and stimulate bone formation. The soya proteins reduce levels of calcium excretion thereby helping to prevent osteoporoseis
      • Regulates Blood Sugar levels by keeping blood glucose levels stable and preventing excessive secretion of insulin, promoting diabetes. Soya beans have a GI (glycaemic index) = 18 (i.e. very low).
      • High in Fibre
      • High fibre diets reduce the risk of Colon Cancer, Heart disease and constipation.
      • Pre-biotics
      • Non-digestible oligosaccharides present in soya beans promote the growth of normal healthy bowel flora (e.g.. Lactobacillus spp. And Bifido bacteria) that are responsible for bowel health and for good general health and maintenance of a healthy immune system.
    34. Micro Nutrients
      • Sutherlandia
      • African Potato
      • Rooibos plus Selenium and Zinc
      • Pure Spirulina (Certified safe and Non-Toxic)
      • Aloe Vera (Liquid concentrate Plus Vitamin C)
      • Chinese Green Tea
      • SCIENTIFIC DATA ON SUTHERLANDIA
      • Sutherlandia frutescens is regarded as the most profound and multipurpose of the medicinal plants in Southern Africa.
      • Scientifically isolated active ingredients:
        • L-Canavanine (L- arginine antagonist with documented anti-viral , anti-bacterial , anti-
        • fungal and anti-cancer activity)
        • Pinitol (documented anti-diabetic activity)
        • GABA ( gamma amino butyric acid – essential for normal brain functioning , anti-anxiety and
        • anti-epileptic)
        • Dosage: Take one in the morning and one in the evening.
        • Warning: Do not use during pregnancy or while breastfeeding.
      • Sutherlandia has been shown to be beneficial for the following conditions:
      • Diabetes – Anxiety – Liver disorders – Wasting diseases ( significant anecdotal evidence of weight gain ) – Anti HIV properties ( significant anecdotal evidence of vital load lowering ) – anti-inflammatory and analgesic – cancer
      • Sutherlandia has been traditionally used for the following conditions:
      • Diarrhea – constipation – candidiasis– thrush—cystitis—detoxification—depression—heartburn—osteo/rheumatoid arthritis—gout—TB—cancers--influenza
      • AFRICAN POTATO
        • HYPOXIS hemerocallidea:
        • Main activity = immune boosting
        • High in sterols and sterolins natural immune boosters
        • The main constituent is the glycoside hypoxoside , which on hydrolysis yields an aglycone rooperol
        • Beta-sitosterol is a phytosterol with a chemical structure similar to cholesterol. Alone and in combination with similar phytosterols it reduces blood cholesteril levels.
        • Phytosterols and sterolins have been scientifically demonstrated to have anti-inflamatory , anti-allergic , anti-tumor and immune enhancing properties.
        • Beta-sitosterol also have anti-prostatic adenoma activity ( inhibits 5 alpha-reductase )
        • Recent biomedical evidence suggest that the corns of african potato have antidiabetic potential for type 2 non insulin dependant diabetis.
        • Phytosterols attributes to a general immunomodulatory effect
      • Hypoxoside and its glycone rooperol have been shown to possess antimutagenic and cytotoxic proprties. People with BPH (benign prostatic hyperplasia) have reported a decrease in symptoms after using african potato.
      • Dosage: Take on tablet in the morning.
      • Warning: Do not use during pregnancy or while breastfeeding.
      • African potato or phytosterols are or may be beneficial in the following conditions:
      • Weak immune system—diabetes—allergies—chronic inflammation—rheumatoid arthritis—certain cancers—side effects of chemotherapy and radiotherapy—benign prostatic hyperplasia.
      • African potato has also been traditionally used in the following indications:
      • Asthma—bladder disorders—dizziness—testicular tumors—urinary infections—chronic infections—convalescent and strengthening tonic in adults and children with wasting disease– TB and cancer—anxiety and depression—prostatic hypertrophy
      • ROOIBOS plus SELENIUM and ZINC
      • (ASPALATHUS linearis)
        • Scientifically isolated active ingredients:
          • Flavanoids ( anti-oxidants )
          • Aspalathin ( potent anti-oxidant )
          • Vitex
          • Orientin
          • Iso-orientin
          • Luteolin
          • Quercetin (anti-oxidant)
          • Nothofagin
          • Minerals – iron-calcium -- potassium – magnesium—zinc—sodium
          • Trace Elements – copper—manganese—fluoride
        • The active anti-oxidants and nutrients in Rooibos plus Selenium and Zinc have been shown to be beneficial for the following conditions:
          • Weak immune system
          • Prevention of certain cancers
          • Viral infections
          • poor wound healing
          • Skin disorders and rashes
          • Colic and muscle spasms
          • General well-being
          • HIV/Aids
          • Helps to prevent heart disease
      • Dosage: Take one tablet at night with food
      • Warning:
        • Do not use during pregnancy or while breastfeeding—This tablet should be taken at night and not at the same time as the others because it is caffeine free and tannin free (tannin impairs the absorption of iron and protein in the body)
      • PURE SPIRULINA (Certified safe & Non-Toxic)
      • (Spirulina platensis)
        • Spirulina is a well known and researched “ Super Food “ blue-green algae
        • Scientifically isolated active ingredients:
        • More than 100 nutrients;
          • 19 Amino acids including 9 essential amino acids
          • Essential Amino Acids – leucine-lysine-isoleucine-histidine-methionine-phenylalanine-threonine-tryptophan-valine
          • Non-Essentiale Amin Acids—alanine-arginine-aspartic acid-cysteine-glutamic acid-glycine-proline-serine-tyrosine-lysine
          • Minerals—calcium ( 26x more than milk ) chloride-magnesium-iron-potassium-zinc-sodium-manganese
          • Enzymes including- SOD (super oxide dismutase)
          • Total lipids: --louric –palmitic—palmitolinoleic-stearic-linoleic-alpha-linolenic-myristic-palmitoleic-heptadecamoic-oleic-gamma-linolenic-sulfolipids
          • Vitamins including: carotenoids ( alpha,beta) –xanthophyllis-cryptoxanthin-echinenane-echinenane-zeaxanthin-lutein-euglenanone- Vit B1,2,3,4,5,6,12 – Vit C, D,E,H – inositol – folic acid
          • Carbohydrates – glucosamine—glycogen—rhamnose—muramic acid
          • Sterols:- cholesterol- sitosterol- stigmasterol
          • Chlorophyll and Phycocyanin
          • Essential Fatty Acid (Omega 6) GLA
          • Linoleic and Arachidonic Acid
          • Protein 60-70% ( 20x more than SOYA and 400x more than beef by weight in the same farming area of farming production )
          • Nucleic acids: RNA and DNA
          • Salic acid
        • Owing to Spirulina’s multi-nutrient and multi-antioxidant content , it has been shown to be beneficial in the following conditions:
          • Chronic Mental and Physical fatigue– chronic illness – pure nutritional status – HIV?AIDS – sport training – obesity ( helps stabilize blood glucose levels ) – elevated cholesterol – detoxification ( liver , kidneys , blood ) – promotes the growth of healthy Lactobacillus spp. ( intestinal microflara ) – weal immune system – hypoglycemia – stress – diabetes – wound healing – natures richest vegerables source of iron – 26x more calcium than milk per equivalent quantity
      • Dosage : Take one tablet daily
      • CHINESE GREEN TEA
      • (Camellia sinensis)
        • Three types of tea come from the Camellia sinensis plant (Green , oolong and black ) their chemical content and flavors are different due to their respective fermentation processes. All 3 types have antibacterial and free radical capturing activities. However the efficacy decreases the darker the tea. This is due to the lower contents of anti oxidising polyphenols remaining in the leaves due to fermentation processes. Green tea is the least fermented of the 3.
        • Scientifically isolated active ingredients and other phytochemicals :
          • Apigenin, astragalin, beta-carotene,beta-ionine,beta-sitosterol,caffeic acid, caffeine ( very low 3.5%) carvacrol , catechins, chlorogenic acid , cinnamic acid, cryptoxanthin,chlorophyll, epicatechin,epigallocatechin,eugenol, farnesol,gallic acid,geraniol, hyperoside, indole, isoquercitrin ,kaempferol, lutein, lycopene , lignins , myrcene,myricetin,myristic acid , naringenin , polyphenols , procyanidins ,quercetin , quercitrin ,rutin , salicylic acid , tannic acid , thymol , vitexin , zeaxanthin
        • NUTRIENTS:
          • Amino acids , Minerals ( calcium, iron , magnesium , manganese , phosphorous , potassium , zinc ) Viatamins ( Vit B1 , 2,3,5, Vit C ) Protein
      • Dosage: Take one tablet daily
      • The potent anti-oxidants and phyto-chemicals in Chinese Green Tea have shown the following benefits:
        • Help to protect against cancer
        • Lower cholesterol levels
        • Reduce clotting tendency in blood
        • Stimulate the immune system
        • Fight tooth decay
        • Help regulate blood sugar levels
        • Help regulate blood insulin levels
        • Combats mental fatigue
        • May delay the onset of atherosclerosis
        • Prevention of free radical damage
        • Beneficial for asthma
        • May help prevent enlargement of the prostrate gland
        • Promotes the burning of fat in obesity
        • Anti-viral properties
      • Note:
        • The polyphenol epigallocatechin gallate (EGCG) is able to penetrate the body’s cells and shield DNA from hydrogen peroxide, a potent free radical, capable of causing molecular damage
      • ALOE VERA (liquid concentrate plus Vitamin C)
      • Extensive research and clinical and traditional usage of Aloe Vera has shown the following benefits:
        • Acts as an astringent and emollient
        • Anti-bacterial
        • Anti-fungal
        • Anti-viral
        • Topically , promotes the healing of – burns – wounds – infections – acne – eczema – psoriasis – insect bites – sprains – bruises- sunburn – and ulcers
        • Anti-tumor properties
        • Promotes the healing process
        • Beneficial for hemorrhoids and constipation
        • Varicose veins improvement
        • Detoxification
        • Stimulates cell regeneration
        • If ingested , helps to: - lower cholesterol – reduces inflammation including post radiation therapy inflammation – increases blood vessel generation in lower extremities in patients with poor peripheral circulation , soothes stomach irritation
      • Beneficial to the following conditions:
        • Thrush (candidiasis)
        • diabetes
        • weak immune system
        • improves disorders of the gastrointestinal / digestive system (e.g. Inflammation of the mouth , tongue . Esophagus , stomach , colon , rectum )
        • and vaginal inflammation
    35. Quality of Life Trials (anecdotal)
      • QUALITY OF LIFE (QOL) TRIALS ON PEOPLE LIVING WITH AIDS
      • The IMUNITI Wellness Pack has been used on thousands of sick individuals (HIV positive with or without full blown AIDS and other disorders e.g., TB, diabetes, chronic fatigue, wasting) in 4 countries in Southern Africa, namely, South Africa, Namibia , Botswana and Lesotho , with outstanding results with respect to health improvement.
      • One Quality of Life ( QOL ) Pilot study was performed in Namibia on 36 patients with a 100% success rate in the adult individuals in terms of mass gain ( 6 – 10 kg on average after 4 weeks).
      •  
      • QUALITY OF LIFE (QOL) TRIALS ON PEOPLE LIVING WITH AIDS
      • Another QOL trial on 100 patients was performed in Maseru, Lesotho . The trial was conducted over a period of three months to determine the outcomes based on QOL parameters ( Weight, mood, appetite, mobility, physical strength, ability to take care of oneself, be able to work and general well being ). Excellent results were achieved to the QOL parameters measured. There was an average mass gain of 2 – 4 kg per month, significant improvement in mood and general well being, increased strength, less fatigue, decreased symptoms of diarrhea, nausea and opportunistic infections . The trial participants have been able to work and perform household duties, with overall improvement in health and general productivity levels .
      Quality of Life Trials (anecdotal)
      • QUALITY OF LIFE (QOL) TRIALS ON PEOPLE LIVING WITH AIDS
      • The IMUNITI Wellness Pack was tested by the Occupational Health Clinic at Independent Newspapers , in Durban with excellent results in terms of increased energy, well-being and quality of life. The product was further tested by Ms Liz Clarke , the former chief HIV/AIDS reporter for Independent Newspapers, on an AIDS sufferer in KwaZulu Natal. Ms Clarke received the USA-South Africa award for the best HIV/AIDS reporter in South Africa for the year (2002-2003). The results of this trial test on a dying HIV/AIDS sufferer after 8 weeks were remarkable (see attached article).
      • Various patients with a CD4 count of less than 10 have recovered, some over a period of 8 weeks , to such an extent that they were able to return to work .
      •  
      Quality of Life Trials (anecdotal)
    36. Quality of Life Trials (clinical trials) The Medicines Control Council of SA is conducting clinical trials on the Imuniti Supplement Combo Pack in SA. It is anticipated that the first phase of the clinical trial will be published by October 2008. Trial protocols were designed in accordance with World Health Organization’s guidelines and were approved by the peer review committee of the Medicines Control Council of SA. Due to the extremely positive nature of the anecdotal evidence gathered over a four year period, Imuniti Holdings Ltd and Edge2Edge Global Investments Ltd are extremely confident that the trial will pass the Quality of Life parameters. This outcome could make the product unique in the world and due to the fact that the product is natural, any HIV and AIDS patient could then use the product. It is foreseen that the product will become the lunchbox of industry. Ongoing trials could result that the product be classified in a new category namely a natural &quot;Anti Retroviral”.
    37. Articles:
    38.  
    39. Imuniti Wellness Pack ® Benefits
      • Increased - on the job concentration (productivity)
      • Reduced – on the job incidents (concentration)
      • Reduced - accident related absenteeism
      • Improved - 8 hour energy levels (“filling-ness”)
      • Reduced - sick leave (immune boosting)
      • Improved - self esteem (back at work)
    40. IMUNITI Wellness Pack ® anecdotal test results
      • Most significant results:
        • Mouth and body sores disappeared
        • Diarrhea disappeared almost immediately
        • Gained weight (20% lean body mass)
        • Gained strength and energy
        • Quality of life improved dramatically
    41. Pricing ONE USD PER DAY
    42. IMUNITI Conclusion The IMUNITI WELLNESS PACK ® contains everything which was discussed and more, to help any person that is sick or healthy to improve and enhance their Quality of Life
    43. The Fight against Immune Deficiency Disorders (IDD)
    44. Setting the perspective
      • 3 billion people worldwide are suffering from malnutrition
      • and immune deficiencies - Global Alliance For Improved
      • Nutrition (GAIN)
      • 15 million people in Southern Africa are affected by
      • malnutrition and poverty
      • 26 million people in the SADC region are infected with HIV
      • and AIDS
      “ The progress of opportunistic diseases can be significantly retarded with appropriate nutrition and immune enhancing nutrients ” World Health Organisation (WHO)
    45. What is Immunity and The Immune System
    46. What is Immunity?
      • Active natural (contact with infection): develops slowly, is long term, and antigen specific.
      • Active artificial (immunization): develops slowly, lasts for several years, and is specific to the antigen for which the immunization was given.
      • Passive natural (trans-placental = mother to child): develops immediately, is temporary, and affects all antigens to which the mother has immunity.
      • Passive artificial (injection of gamma globulin): develops immediately, is temporary, and affects all antigens to which the donor has immunity.
      Immunity can be either natural or artificial , innate or acquired=adaptive , and either active or passive:
    47. Immune System - organs
      • primary organs : bone marrow (in the hollow center of bones) and the thymus gland (located behind the breastbone above the heart), and
      • secondary organs at or near possible portals of entry for pathogens: adenoids, tonsils, spleen (located at the upper left of the abdomen), lymph nodes (along the lymphatic vessels with concentrations in the neck, armpits, abdomen, and groin), Peyer's patches (within the intestines), and the appendix.
    48. Immune system / organ functioning
    49. Major cells and proteins of the Immune system
      • The immune system isn't located in just one part of the body . The thymus, liver, bone marrow, tonsils, lymph nodes, spleen, and blood all have a role in the immune response. These organs help make, store and transport the cells and proteins that fight foreign invaders.
      • The major cells and proteins of the immune system are:
        • B-cells (also called B-lymphocytes)
        • T-cells (also called T-lymphocytes)
        • Phagocytes — &quot;Eater Cells&quot;
        • Complement —Special Proteins
    50. T lymphocytes – the cell
      • T lymphocytes become CD4+ or helper T cells, or they can become CD8+ cells, which in turn can become killer T cells, also called cytotoxic T cells.
      • Immune system process
    51. T lymphocytes – the cell activated
      • Activation of
      • helper T cells
      Activation of cytotoxic T cells
    52. B lymphocytes – the cell
      • Activation of B cells
      • to make antibody
      B cells become plasma cells, which produce antibodies when a foreign antigen triggers the immune response
    53. Integrated working of the Immune system
    54. What is Immunodeficiency disorder?
    55. Immunodeficiency Disorders
      • A primary immune deficiency occurs when the abnormalities of the immune system develop from an inborn defect in the cells.  Affected cells include T-cells , B-cells , phagocytic cells or the complement system .
      There is overwhelming evidence that the majority of secondary immune deficiency disorders have as part of their cause some type of external environmental infection. This can be viral, bacterial, fungal, protozoa and various other types of parasites.
    56. Primary Immunodeficiency disorders
      • The most primary immune deficiencies are inherited diseases. Examples are:
      • a include X-linked agammaglobulinemia (XLA),
      • severe combined immunodeficiency (SCID), and
      • variable immunodeficiency (CVID), etc.
      The causes of the defects are unknown and genetic factors cannot be ruled out
    57. Secondary Immunodeficiency disorders
      • Alternative examples of secondary immune deficiencies are:
      • Flu Tuberculosis (TB)
      • Pneumonia AIDS (HIV)
      • Bird Flu (virus H5N1) Congo Fever (Ebola Virus )
      Secondary immune deficiencies occur when damage is caused by environmental factors. Such as: Radiation Chemotherapy Burns and furthermore infections contribute to the many causes of secondary immune deficiencies.
    58. Immunodeficiency disorders A Summary
    59. IMMUNODEFICIENCY AND MALNUTRITION
      • Malnutrition with immunodeficiency and infection is the World’s leading cause of infant and child deaths
      • Ref: The Merck Manual 16 th Edition Pg. 317
    60. MARASMUS OR KWASHIOKOR
      • Malnutrition is caused due to a deficiency of all nutrient’s ( MARASMUS ) or primarily of protein deficiency ( KWASHIOKOR ), usually with superimposed vitamin and mineral deficiencies. e.g. ( vitamin A , Iron , Zinc )
      • When malnutrition is severe enough to reduce your weight to < 80% of the expected mean, impairment of the immune function is noted.
      • Ref: Merck Manual Pg 317
    61. IMMUNE IMPAIRMENT
      • The degree of immune impairment depends on the degree and duration of malnutrition, and on underlying illness e.g. Infection and other nutritional deficiencies
      • With nutritional rehabilitation , the immunologic defect reverses rapidly
      • Ref: Merck Manual Pg 318
    62. Nutritional Supplementation
      • An organism as complex as the human body is an ordered aggregation of cells . Each cell obtains the nutrients essential for its well-being from the circulating extra cellular interstitial fluid in which it is bathed
      • Sound nutrition depends on a proper dietary regimen, or food intake. This must include the six major components of the diet namely:
      Carbohydrates Proteins Fats Vitamins Minerals Water Reference : Biochemistry . A case – orientated Approach pg. 1&2
    63. HOMEOSTASIS
      • The internal cellular composition must be kept constant within narrow limits , otherwise the human dies
      • The maintenance of this stable internal environment is termed Homeostasis
      • It can thus clearly be seen that in order for the human body to be in Homeostasis it needs a fully balanced diet consisting of all six the principal food components
      • Reference: Biochemistry A Case – orientated approach pg. 3
    64. IMMUNE NETWORKS
      • The immune system consists of individual components and it operates as a whole, not one of the components operates autonomously.
      • In any given immune response, the components function in concert, tandem or are in conflict
      • Ref: The Merck Manual 16 th Editiopg.288
    65. CONCLUSION
      • With reference to the above it is clear that that the Immune System is complex
      • One or two supplements is NOT enough to boost the whole immune system
      • One needs to supplement the whole diet to enhance the body to maintain and obtain Homeostasis
    66. HOMEOSTASIS AND THE IMMUNE SYSTEM
      • Simplistically we can say that Homeostasis = Immune system = CD4 = Correct diet
      • A body in homeostasis produces 1-2 billion CD4 cells in 24 hours
    67. HIV VIRUS
      • HIV can produce up to 10 Billion viruses in 24 hours
      • An important cause for a CD4 decline over time is failure of the body to regenerate enough CD4 cells (2 billion against 10 billion HIV) resulting in an impaired immune system
      • If the body is fed correctly it can produce more CD4 cells, thus enhancing its immune system and fight HIV over a longer period of time
    68. A generalized graph of the relationship between HIV copies (viral load) and CD4 counts over the average course of untreated HIV infection; any particular individual's disease course may vary considerably. ----  CD4+ T cell count (cells per µL)  ----- HIV RNA copies per mL of plasma Wikipedia ® Encyclopedia .
    69. Edge to Edge Global Investments Ltd (UAE)
    70. Who is Edge to Edge Global Investments Ltd (UAE)?
      • Edge to Edge is representative of the founder members of IMUNITI Holdings Ltd and Edge to Edge Global Investments Ltd (SA) – E2E (UAE) – 100% subsidiary of Edge to Edge Global Investments Ltd (Cayman);
      • Edge to Edge owns the Intellectual Property and Trademark of the IMUNITI Nutritional Combo Pack;
      • Edge to Edge drives and facilitates the International roll-out of the IMUNITI Wellness Combo Pack as well as the AF/E2E Feeding Scheme Product and other nutritional and wellness products.
    71. Edge to Edge Vision:
      • The provision of affordable and sustainable wellness services and products through the roll- out of the Imuniti wellness products and services
      • The promotion of the socio-economic wellbeing of all people from developing countries
      • To become the preferred provider and distributor of Nutritional and Wellness products on a Global scale
    72. Africa’s Partners of Edge to Edge: AGRICULTURAL AND NUTRITION PROJECT FOR FUTURE SELF-RELIANCE IN AFRICA (ASRP) Post Conflict Reconstruction and Development: Towards Building Developmental Capable States in Africa
    73. Africa’s Partners of Edge to Edge: ASRP The ASRP focuses on ten African countries emerging from conflicts, which includes: the Republic of Burundi; the Republic of Cote d’Ivoire; the Democratic Republic of Congo, (DRC); the Republic of Guinea Bissau; the Republic of Liberia; the Republic of Kenya; the Republic of Sierra Leone; the Somali Republic; the Republic of Sudan and the Republic of Uganda (Northern Uganda).
    74. Africa’s Partners of Edge to Edge: Members of the Africa Forum 2007
    75. The Agriculture for Self reliance project (ASRP) is designed to tackle the food security’s most important aspects including food availability, food access and food adequacy. ASRP consists of three components namely: agriculture, nutrition and capacity development. The primary target beneficiaries of this project benefiting from all the components will be the vulnerable groups. The objectives to be achieved with this project are to provide structured and coordinated processes of delivery for products and services to be delivered to the malnourished and HIV/AIDS infected people of the African, which will assist in the fight against the HIV/AIDS pandemic in Africa. Africa’s Partners of Edge to Edge: ASRP
    76. Africa’s Partners of Edge to Edge: ASRP Nutrition intervention at a relatively lower price through technology available to E2E is divided into two categories of which the first is “Food for Africa’s vulnerable groups” – to supply one million people per month with basic nutrition initially and to increase the supply to ten million people per month by 2012 . The nutrition will comprise of a three course per day solution at a mere cost of USD 8 per month per person (product detail to follow).
    77. FUNA PUZAMANDHLA
    78. FUNA PUZAMANDHLA
    79. FUNA SUPER 40 POWDERED SOFT DRINK
    80. FUNA GENERAL STEW
    81. Africa’s Partners of Edge to Edge: ASRP The second project “Enhanced Product Response to HIV and AIDS in Southern Africa” will be to supply the Imuniti nutritional supplement combo pack to the HIV/AIDS infected groups in each region. This product comprises natural immune modulators, a high protein fortified food and a natural water sterilization agent and is a monthly pack at a cost of USD 30 per person . The aim is to use this pack as a first line of defense once an individual has been tested HIV positive especially where the patient is not able to receive ARV treatment. This pack will form the nutritional supplementation part to the treatment of the patient. In essence the Imuniti pack will become the MAINTENANCE pack of the patient and will help to build the quality of life in all regions. The initial rollout of this project will be to reach and supply 1million people in year one and increasing to 8.5million people in year 2012.
    82. Africa’s Partners of Edge to Edge: ASRP Both farming and food production components of this program will contribute to the vision of the Africa Forum to deploy its best efforts to contribute to the creation of a continent which is stable, secure and prosperous. The vision and its objectives are shared by the African Union and its initiative NEPAD (New Partnership for Africa’s Development), to place African countries, both individually and collectively on a path to sustainable development, to halt economic and political marginalization of Africa and to enhance the continent’s full and beneficial integration into the global economy . This project will serve as the general template and baseline for all future projects to be put in place in Africa and will be deemed to be the turn key solution for delivery and logistics, service providing and control of fortified foods and supplementation to the malnourished as well as HIV/AIDS infected people of Africa.
    83. Summary of the Core Business of E2E
      • E2E’s strategic intent is to promote the right to life and its sustenance through food and nutritional supplementation, clean water and the provision of primary health care services.
      • E2E do provide the holistic solution, which is:-
      • a wellness pack (vitamin and minerals supplements)
      • a nutritious meal (high digestible protein)
      • a natural water sterilizing agent AND
      • a range of professional primary health care services
      • supported by manufacturing facilities, products and a network of distribution and wellness centres to be rolled out
    84. Wellness Centre - Model SERVICES a) Primary Health Care b) Occupational Health Care c) Dental Care d) Optometry E2E / AF WELLNESS CENTRE HUMAN RESOURCES a) Staff Selection / Recruitment b) Management c) Accredited Training BUSINESS STRUCTURE a) Doctor/Dentist/Optometrist b) Turnkey operations SOFTWARE /Manage a) Clinical 1. Protocols 2. Stock File 3. Referrals 4. Follow-ups b) Administration 1. Navigator 2. Accounting Package FINANCIAL a) Projections & Budgets b) Cash Flow c) Debtors d) Creditors PROPERTY a) Site Selection b) Centre Lay-out c) Architects / Project Managers d) Equipment & Furniture INFORMATION TECHNOLOGY a) Communications – Central Server b) Data Mining Protocols (HIV / AIDS) a) Software Protocols b) Health Care Workers c) Imuniti Combo Pack MARKETING a) Marketing Processes b) Radio as Medium E2E MANAGEMENT a) Head Office Systems & Controls b) IWS Systems & Controls
    85. Distribution Facility - Layout
    86. Distribution Facility - Layout
    87. Wellness Centre - Layout
      • Specialised Services
      • Sonar
      • Occupational Health
      • Optometry
      • Dental
      Pharmacy Manager Reception Area Consulting Rooms
      • IMUNITI Holdings Ltd:
      • an introduction to the Group of companies
      • www.imuniti.co.za
    88. IMUNITI Listing Process
      • Market need for products and services overwhelming
      • Completion of the Private Placement process IMUNITI Holdings Ltd:
        • Achievement of R 83 million
      • The benefits of listing on the ALT ×:
        • Raise IMUNITI company profile, and
        • To raise additional expansion capital if required
    89. Linkages to Global Programmes
      • IMUNITI is in the process of formalising several International Strategic Alliances through E2E and will focus on the following arenas:
      • Occupational Health and Safety i.e. impact of malnutrition, HIV and AIDS and related illnesses on productivity, staff turnover and absenteeism;
      • World-Wide Support Programs for indigent households suffering from malnutrition, food insecurity and without access to clean water;
      • People living with HIV and Aids in South Africa, the rest of Africa and Globally; and
      • People challenged by opportunistic illnesses such as TB, Malaria and Bilharzia.

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