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Molecular Biology on Cancer and HIV
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Molecular Biology on Cancer and HIV



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  • 1. Steven Olaya Ramírez Medical Student July 23, 2012
  • 2. STUDY DEMOSTRATES EFFECTIVENESS OF COMBINATION THERAPY FOR BREAST CANCER CELLS IN VITRO A study conducted at Boston University School of Medicine (BUSM) demonstrates an effective combination therapy for breast cancer cells in vitro. News Medical July 3, 2012
  • 3. New therapy testead In Vitro A combination of an epigenetic drug with a protease inhibitor on breast cancer cell linesThat are hormoneresponsive and breastcancer lines, like triplenegative, that are nothormone responsive
  • 4. Histone deacetylasesinhibitors (HDACi) and calpeptin Inhibits calpain, a protein involved in the regulation of signaling proteins
  • 5. HDCAi CALPEPTIN Inhibited cell growth and increased cell death in both cancer cell lines
  • 6. I think that last study is so important for keepmoving forward in the search of a treatment forthe breast cancer that is so devastating for thefemale population. In the article says thatcancer is like a car without brakes, so if thistherapy stop the car with HDACi as brakes forthe cell growth, it could be a brilliant discoverthat deserves attention and a good investment;maybe others researchers would join theresearch.
  • 7. SAFER ALTERNATIVE TO EXPERIMENTALGENE THERAPY AGAINST HIV INFECTION Scientists at The Scripps Research Institute have discovered a surprisingly simple and safe method to disrupt specific genes within cells. The scientists highlighted the medical potential of the new technique by demonstrating its use as a safer alternative to an experimental gene therapy against HIV infection. News Medical July 2, 2012
  • 8. New techniqueemploys zinc finger nuclease (ZFN) proteinsIt can bind and cut DNA at preciselydefined locations in the genome ZFN in DNA
  • 9. So the standard ZFN ZFN proteins cannot delivery method hascross cell membranes been a gene-therapy technique employing a relatively harmless virus to carry a designer ZFN gene into cells Inside, ZFN gene starts producing ZFN proteins, which seek and destroy their target gene
  • 10. Virus delivery method has two basic risks Viral DNA may end up ZFN genes could end up being incorporated producing too many ZFN randomly into cellular proteins, resulting in a DNA, disrupting a high number of "off-valuable gene such as a target" DNA cutstumor-suppressor gene
  • 11. My opinion is that ZFN proteins are a veryinteresting alternative for the treatment of certaindiseases that can be worked with gene therapy,also presents itself as a safer option and accuratethan other types of gene therapy, which deservesto be taken into account in certain researches. Andalthough this method has a transport risk (viraltransport), also has another points that makes thistherapy safest than others.
  • 12.  Theuse of combination therapies that can be prescribed to a patient for treatment of their disease, in this specific case of breast cancer.
  • 13.  Ifthe combination of therapies is successful, it creates the possibility to attack breast cancer and prevent more women continue to die around the world.
  • 14.  Withthe techniques of gene therapy can treat certain diseases (in this specific case of HIV infection) and also prevent others may appear in the course of life, DNA modification opens new doors to medicine.
  • 15.  HIV is in parts of the world an epidemic, for example in parts of africa, this new therapy that comes out gives new hope to combat this virus that has claimed the lives of many people on the planet.
  • 16.  Study demonstrates effectiveness of combination therapy for breast cancer cells in vitro. News medical .(July 3, 2012) Saferalternative to experimental gene therapy against HIV infection. News medical. (July 2,2012) Martínez S, Lina María. Biología Molecular. 7 ed Medellín: UPB. Fac Medicina.