08b growth regulation-2010 update-stacy

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  • 1.  
  • 2. Anterior Pituitary
    • responsible for physical growth
    • growth hormone ( GH ) – levels dictate amount of growth in developing organism
      • peptide hormone
  • 3. Growth Hormone Regulation hypothalamus growth hormone releasing hormone (GHRH) growth hormone inhibiting hormone (GHIH) anterior pituitary growth hormone (GH) GH half-life is 20 – 30 min
  • 4. Growth Hormone Effects
    • cartilage & bone – increased length and width of skeleton
    • muscle cells – increased cell number ( hyperplasia ) and cell size ( hypertrophy )
    • ribosome function – increased protein production
    • fat metabolism – fatty acids as energy source
  • 5. Growth Hormone Abnormalities
    • Dwarfism
    • Gigantism
    • Acromegaly
  • 6. Dwarfism
    • Cause:
      • decreased GH secretion during childhood
    • Result:
      • limited height (4 feet tall)
      • normal proportions
  • 7. Dwarfism
  • 8. Gigantism
    • Cause:
      • increased GH secretion during childhood
    • Symptom:
      • height much taller than average
    • Treatment:
      • surgery if hypersecretion due to tumor growth on pituitary
  • 9. Gigantism Robert Wadlow World’s tallest man at 8 feet 11.1 inches
  • 10. Size 12 Size 25
  • 11. Tallest person alive
    • Sultan Kosen, born in Turkey
    • 8 feet 1 inch
    http://www.youtube.com/watch?v=ODFHC2XCtjU
  • 12. Acromegaly
    • Cause:
      • increased GH secretion as an adult
    • Symptom:
      • bone lengthening has stopped
        • bone width increases
    • Treatment:
      • surgery if hypersecretion due to tumor growth on pituitary
  • 13.  
  • 14. Professional Sports