probiotic lactobacillus rhamnosus GG

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  • 1. THERAPY SOLO CAT
  • 2. CONTENT • WHAT QUESTION DIDTHE STUDY ASK? • ARETHE RESULTS OFTHE STUDYVALID (STEP 1) • WHAT WERETHE RESULTS (STEP 2) • APPLICABILITY OFTHE RESULTS ( STEP 3)
  • 3. WHAT QUESTION DIDTHE STUDY ASK? CATEGORY ANSWER POPULATION Children ( 2-6 years) with respiratory illnesses INTERVENTION Using normal milk containing probiotic lactobacillus rhamnosus GG COMPARISON Normal milk only OUTCOME Primary : measure the respiratory symptoms improvement by using probiotic GG milk Secondary: measure the gastrointestinal symptoms improvement by using probiotic GG milk
  • 4. ARETHE RESULTS OFTHE STUDYVALID Was the assignment of patients to treatment randomized?
  • 5. ARETHE RESULTS OFTHE STUDYVALID Was the randomization list concealed?
  • 6. ARETHE RESULTS OFTHE STUDYVALID Was follow-up of patients sufficiently long and complete?
  • 7. ARETHE RESULTS OFTHE STUDYVALID Were patients analyzed in the groups which they were randomized?
  • 8. ARETHE RESULTS OFTHE STUDYVALID Were patients and clinician kept ‘blind’ to treatment? yes, blinding both the clinician and children *parent* to the treatment.
  • 9. ARETHE RESULTS OFTHE STUDYVALID Were the groups treated equally, apart from the experimental treatment?
  • 10. ARETHE RESULTS OFTHE STUDYVALID Were the groups similar at the start of the trial?
  • 11. ARETHEVALID RESULTS OFTHIS RCT IMPORTANT? What is the magnitude of the treatment effect?
  • 12. Odd Ratio REGARDINGTO PRIMARYOUTCOME ( RESPIRATORY SYMPTOMS ) GG group OR of 5.03 (95% CI 4.92-5.15 ) Placebo group OR of 5.17 (95% CI 5.05-5.29)
  • 13. ARETHEVALID RESULTS OFTHIS RCT IMPORTANT? How precise is this estimate of the treatment effect?
  • 14. Odd Ratio REGARDINGTO PRIMARYOUTCOME ( RESPIRATORY SYMPTOMS ) GG group OR of 5.03 (95% CI 4.92-5.15 ) Significant and precise Placebo group OR of 5.17 (95% CI 5.05-5.29) Significant and precise
  • 15. ARETHESEVALID, IMPORTANT RESULTS APPLICABLETO MY PATIENTS? Is our patient so different from those in the study that its results cannot apply ? The patients in the study are similar to our patients, mainly similar Demographic and clinical characteristics ( which the author provides) So, we can apply the results in our setting
  • 16. Is the treatment feasible in my setting ? Milk containing probiotic Lactobacillus rhamnosus GG is available in our market 0000000 ARETHESEVALID, IMPORTANT RESULTS APPLICABLE TO MY PATIENTS?
  • 17. What are our patient’s potential benefits and harms form the therapy ? Benefits 0 Harms 0 ARETHESEVALID, IMPORTANT RESULTS APPLICABLETO MY PATIENTS?
  • 18. What are our patients values and expectations for both the outcome we are trying to prevent and the treatment that we are offering ? Decrease respiratory symptoms as a primary outcome of the study, also decrease gastrointestinal symptoms Find an alternative method to decrease the illness with effectively with less side effects and easy administration not like the chemical drugs ARETHESEVALID, IMPORTANT RESULTS APPLICABLE TO MY PATIENTS?