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  1. 1. Patented HERBULES Technology R Plus Multidimensional Diabetes Management Supplement PRODUCT INFORMATION DESCRIPTION: KARNIM Plus is a formulation composed of medicinal herbs with proven pharmacological actions, which take care of all major complication of diabetes. The pharmacological action of individual herbs indicates that the major ingredients of KARNIM Plus M. charantia and A. indica are anti-hyperglycemic in nature and thereby help to reduce elevated blood glucose levels and induce pancreas to secrete insulin in diabetes. Other herbs like Z. officinale, P. kurroa also possess anti-hyperglycemic activity. O. sanctum enhances uptake of glucose by muscles. Besides this, the immunomodulator activity of the ingredients A. indica and P. kurroa help to potentiate the immune system which usually diminishes in diabetes due to excessive consumption of proteins for energy production. These ingredients also help to lower the incidences of severe infections, a common feature of diabetes due to increased blood glucose levels. Dysfunctioning of liver due to excessive consumption of glycogen and decreased gluconeogenesis is a major complication of diabetes. P. kurroa is a proven hepatoprotective and helps to improve the functioning of liver and maintains the metabolic balance of body. Treatment of diabetes with sulfonyl ureas such as Glibenclamide is known to precipitate cholestasis. Adjuvant therapy with KARNIM Plus in such cases provides protection to liver and prevents toxic influence of allopathic anti-diabetics due to virtue of the presence of P. Kurroa. Precipitation of hyperglycemia due to increased levels of stress is a common feature in diabetes in modern world. O. sanctum is a proven anti-stress agent and helps to prevent the stress-related complications in diabetes. COMPOSITION: Each capsule contains extract derived from: Karela (Momordica charantia) 2.5 gm Neem (Azadirachta indica) 0.2 gm Tulsi (Ocimum sanctum) 0.1 gm Kutki (Picrorhiza kurroa) 0.1 gm Karela Neem Tulsi Kutki Sounth Sounth (Zingiber officinale) 0.1 gm PART USED PART USED PART USED PART USED PART USED FRUIT LEAVES LEAVES & TWIGS ROOT RHIZOME PHARMACOLOGY: Karela (Momordica charantia): Momordica charantia has been found effective in lowering the blood glucose in man. The anti-diabetic activity of M. charantia is due to two active ingredients, Polypeptide -P and Charantin. Polypeptide -P is a 17 amino acid polypeptide, 16 of which are similar to crystalline insulin of bovine origin. This polypeptide has been shown to be ' insulinomimetic.' A number of other polypeptides from M. charantia seeds have been studied in vivo for the insulin like activities of stimulation of lipogenesis and inhibition of corticotropin-induced lipolysis. The mechanism was suggested to involve interaction of peptides with ? -adrenergic or corticotropin receptors. The other active constituent, charantin is a mixture of two steroid glycosides: b -sitosterol-D-glucoside and 5,25-stigmastadien-3- ? -ol-D-glucoside. Charantin has shown anti- hyperglycaemic activity in alloxan treated rabbits and depancreatized cats. Studies performed in vitro with M. charantia fruit extracts indicated a significant enhancement of glucose uptake in muscle tissue and of glycogen accumulation in muscles and hepatic tissue but no effect on glucose uptake or triglyceride synthesis in adipose tissue. Inhibition of glucose uptake by intestinal fragments was also observed and attributed to glycosidic constituent of the fruit extract. M. charantia has been demonstrated to possess a dose dependent increase in the scavenging activity against superoxide radical and hydroxyl radicals. M. charantia is a potent scavenger of superoxide and hydroxy radicals. The antidiabetic effect of the plant is mediated through oxygen radical scavenging mechanism. Indeed the body itself possess enzymes such as superoxide dismutase which routinely protects the ?in pancreas through their scavenging action. The free radical scavenging antidiabetic role of M. charantia supports -cells an additional prophylactic role as many diabetogenic chemicals such as Alloxan, Streptozotocin, Pyrinuron, food nitrosoamines , cynogenic glycosides such as Linamarin and other sources of Dietary cyanide induce diabetes through damage to pancreatic ?via free radical generation. -cells Neem (Azadirachta indica): A. indica has been demonstrated to exert hypoglycemic effect in streptozotocin induced diabetes. It shows its anti-diabetic action by stimulating the insulin secretion by the ?of cells Islets of Langerhans of the pancreas in a manner similar to the sulfonyl ureas like chlorpropamide. Recurrent infections due to high blood glucose levels and slowed down immune responses due to gradual deterioration of immune system because of loss of body proteins is a common feature in diabetes. A. indica has been demonstrated to induce production of interleukin by stimulating specific types of T-cells of the immune system , the lack of which is a common feature of diabetes. So it can be said that A. indica enhances cell-mediated immune responses and thus can normalize the deteriorating immune system in diabetes. Tulsi (Ocimum sanctum): O. sanctum promotes uptake of glucose by peripheral tissue most likely by decreasing peripheral resistance to insulin. O. sanctum has been demonstrated to reduce blood glucose level in diabetic rats and also to promote action of other diabetic medications including oral hypoglycemics and exogenous insulin. O. sanctum is also effective in aggravated hyperglycemia precipitated by stress by virtue of its capacity to normalise stress-induced neurological changes. O. sanctum has been demonstrated to have a normalizing effect on the levels of adrenaline, noradrenaline and monoamine oxidase which are generally decreased in stressed condition and thereby help the body to cope better with stress induced hyperglycemia. Kutki (Picrorhiza kurroa): P. kurroa is useful in treating hyperglycemia. The anti-hyperglycemic activity attributed to the bitter principle ' kutkin'. This principle is known to stimulate secretion of gastrin, secretin and cholecystokinin pancreazymin which then stimulate secretion of insulin by ?of pancreas. -cells Beside anti-hyperglycemic activity, P. kurroa also possess immunomodulator and hepatoprotective activity. The iroid glycoside fraction of the herb is responsible for the immunostimulation and is capable of inducing both antigen-specific and non-specific responses . Thus P. kurroa helps to potentiate the body's immune responses which are usually diminished in diabetes. Increased glycogenolysis and decreased gluconeogenesis in liver due to dysfunctioning of insulin dependent metabolic pathways is a characteristic feature of diabetes. This affects normal functioning of liver ultimately disrupting the metabolic balance of body and may lead to life threatening conditions like ketosis and acidosis. P. kurroa has been demonstrated to posses hepatoprotective action and normalizes the functioning of liver due to presence of active ingredients Picrosides I and II which are glycosidic in nature. So besides lowering blood glucose hepatoprotection in diabetes is an added advantage of P. kurroa.
  2. 2. Sounth (Zingiber officinale): REFERENCES: 1. Baldwa, V.S. , Goyal, R.K., Bhandari, C.M. and Z. officinale exerts its anti-hyperglycemic effect by stimulating the ?to secrete insulin. This action is attributed to its active cells Pangariya, A. (1976), Rajasthan Med. J. 16, 54 constituents 6,8 and 10 gingerols, which cause inhibition of Na+/ K+ pump. Reduced potassium conductance causes membrane 2. Krishnamurthy, T.R. (1962), Antiseptic, 59 , 131 depolarisation and influx of Ca++ ions through voltage sensitive Ca++ channels, which ultimately stimulates insulin secretion by ? 3. Sharma, V.N., Sogani, R.K. and Arora, R.B. cells of pancreas. (1960), Indian J. Med. Res., 48, 471 Elevated fatty acid level and onset of atherosclerosis is a common feature in diabetes due to increased lipolysis. Z. officinale is 4. Gupta, S.S. and Seth, C.B.(1962). J. Indian Med. effective in lowering blood lipid levels and thus circumvents the danger of development of atherosclerosis in diabetic patients. Assoc., 39, 581 INDICATIONS AND USES: 5. Khan, R.A., Gupta, K.P. and Singh, O (1990) ' “ Supplement to be taken as aprophylactic and also therapeutically to improve carbohydrate metabolism and managing blood National Seminar on Unani Medicine' Aligarh, 3 sugar level, reducing weight and complications of diabetes”. 6. Khanna, P., Nag, T.N., Jain, S.C. and Mohan, S. CONTRAINDICATION: (1974). '3rd Int. Cong. Plant Tissue and Cell culture' , Univ. Liecester. KARNIM Plus capsules contain natural herbal ingredients, which are in human consumption from ancient times hence there are no known contraindications. KARNIM Plus can be used safely during pregnancy and lactation. 7. Khanna P., Jain, S.C., Pnagariya, A. and Dixit, V.P. (1981). J. Nat. Prod, 44, 648. SIDE EFFECTS: 8. Feher, H. Cosomos, G. And Vrecjei, A. (1987). ' No side effects have been reported in clinical dosage. Free radical reaction in medicine' Springer Verlag, PRECAUTIONS: Berlin, pp. 48-147 Strict dietary control and regular exercise must accompany KARNIM Plus therapy. Regular monitoring of blood sugar levels is 9. Asayama, K., English D. Slmin, A.E. and Burr, I.M. necessary. (1984). Diabetes, 33,160 DRUG & FOOD INTERACTIONS: 10. Grankvist, K., Marklund, S. and Talhedal, I. (1981). No interactions reported when KARNIM Plus is administered with other medicaments. KARNIM Plus capsules are administered Nature, 294, 158 with oral hypoglycemics for therapeutic and prophylactic use. Various clinical trials indicate that KARNIM Plus capsules have no 11. Gandy, S.E., Buse, M.G. and Crouch, R.K. (0982). interactions with food and other hypoglycemics. J. Clin. Invest., 70, 650 12. Gandhy, S.R., Galbraith, R.A>, Crouch, R.K., DOSAGE : Buse, M.G> and Galbraith, G.M.P. (1981) N. Engl. J. For freshly cases : Med., 304, 1547. 1 capsule 3 times a day. 13. Hegalson, T. and Jonaa, N.R. (1981). Lancet, 2, For chronic cases : 716 2 capsules 3 times a day. 14. Sreejayan, M.N.A. and Roa (1991), Fitoterapia, Should be taken before meals with dietary restrictions and exercise. LXII-N.4, 344 or as directed by physician. 15. Kobberling, J., and Tattersall, R. (eds.) (1983). 'The Genetics of Diabetes Mellitus'. Academic Press, London 16. W.H.O. Technical Report Series (1985). ' Diabetes mellitus', Geneva, 727. THERAPEUTIC EFFECTS OF KARNIM PLUS 17. Apte I.C. (1983) ' Effect of Indegenous Preparatioons on Certain Important Enzymes of KARELA Pathways involved in Diabetes Mellitus' (Ph.D. thesis), Momordica charantia Nagpur University, India. 18. Upadhyay, S.N., Dhawan, S. Garg, S. Wali, N., LACK OF Tucker, L. and Anderson, D.J. (1993). Immunomodulatory properties of Neem (A. indica), INSULIN World Neem Conference, Bangalore. 19. Shoji et al (1984), Planta medica, 56, 186. 20. Giri, J. (1984). Indian J. Nutr. Diete., 21, 433. 21. Chattophadhyay, R.R. (1993). Indian J. Expl. Biol., NEEM Azadiracta indica 31, 891. TULSI 22. Blane, G.D. et al(1980). Nature, 284, 265. SOUNTH Zingiber officinale Ocimum sanctum 23. Reinhardt, J.F. et al (1982). Arch. Pharmacol., 318, 374. 24. Tissari, A.H. et al (1979). Arch. Pharmacol., 308, DECREASED PERIPHERAL 155. INSULIN RESISTANCE 25. Singh, N., et al (1991) Indian J. pharmacol, 23 , SECRETION TO INSULIN 137. 26. Singh, N., Misra, N., Srivastava, A.K., Dixit, K.S. and Gupta, G.P. (1991). Indian J. Pharmacol., 23, 137. DIABETES ATHEROSCLEROSIS DECREASED 27. Verma, P. et al (1991). Indian J. Pharmacol., 23, C.C.F. IMMUNITY 99. 28. Das, A. (1977). Indian Drugs, 14, 8, 168. 29. Simons, J.M. (1989). J. ethnopharacol. , 26, 2, 169. 30. Puri, A., et al (1992). Planta Medica, 58, 6, 528. 31. Aslam, H. (1979), Lancet, 1, 607. SOUNTH NEEM Azadiracta indica 32. Pillai, N.R. et al (1981). Indian J. Med. Res. , 74, Zingiber officinale KUTKI Picrorhiza kurroa 931. 33. Pilanka, P.D. (1980). A study of hepatoprotective effects of some indigenous plants in experimental animals, Ph. D. Thesis, Haffkine's Institure, Mumbai. 34. Wongpaitoon, V. et al (1981). Post Grad. Med. J., PROPHYLACTIC ROLE OF KARNIM PLUS 57, 244. 35. Harris, E.L. (1971). British Med. J., 3, 29. Neem (Azadiracta indica) Karela 36. Res. Indian Med. (1970). 5, 11. (Momordica charantia) 37. Nityanand, S. and Kapoor, N.K. (1973). Indian J. Kutki (Picrorhiza kurroa) Expl. Biol., 11, 395. 38. Husain, S.J. et al (1977). Indian Expl. Bio., 15, DIABETOGENIC 485. INFECTIONS CHEMICALS 39. Mester. I. Mester . M (1979) Planta Medica 37. 367 40. Kohli, K.R, Naik, S. Rajesh, T. Mukund Z and Deepti, K (1993) J. General Med 61, 47 DIABETES STRESS OBESITY TULSI SOUTH (Ocimum sanctum) (Zingiber officinale)