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Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
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Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?

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Presentation given at the Friday Harbor Laboratories on August 13th, 2014

Presentation given at the Friday Harbor Laboratories on August 13th, 2014

Published in: Education
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  • 1. Does DNA methylation facilitate phenotypic plasticity in marine invertebrates? Steven Roberts School of Aquatic and Fishery Sciences robertslab.info @sr320
  • 2. Shameless plug onsnetwork.org/eimd @EIMD_fhl
  • 3. Shameless plug onsnetwork.org/eimd @EIMD_fhl
  • 4. Does DNA methylation facilitate phenotypic plasticity in marine invertebrates?
  • 5. Open Science • You are free to Share! • Our lab practices open notebook science • Data, Preprints, Proposals, Slidedecks available FigShare, GitHub, and lab website (robertslab.info) These slides plus links @ robertslab.info
  • 6. commercially important traits Lab Background
  • 7. commercially important traits modified from Lab Background
  • 8. modified from
  • 9. modified from
  • 10. modified from
  • 11. Today modified from 1 2 3
  • 12. Histone Modification Epigenetics short RNAs DNA Methylation
  • 13. Photo credit: Flickr, Creative Commons, he-boden Epigenetics
  • 14. Epigenetics
  • 15. m m DNA Methylation
  • 16. Function?
  • 17. Non- Vertebrates? landscape and function is very different than what is observed in vertebrates
  • 18. Non- Vertebrates? landscape and function is very different than what is observed in vertebrates
  • 19. Non- Vertebrates? landscape and function is very different than what is observed in vertebrates
  • 20. Absent in several model organisms
  • 21. Function?Oysters?
  • 22. mosaic associated with gene bodies
  • 23. Roberts and Gavery 2012 in silico analysis
  • 24. Roberts and Gavery 2012 in silico analysis
  • 25. Roberts and Gavery 2012 in silico analysis
  • 26. Two Lineages - Sperm + Larvae (72h & 120h) Claire Olson Whole Genome BS-Seq
  • 27. Claire Olson Differentially Methylated Loci predominant in Transposable Elements
  • 28. Claire Olson github.com/sr320/olson-dev
  • 29. Summary • Sparsely (~16 %) methylated genome • Gene body methylation • Function specific •TEs are not hypermethylated across genome • Preliminary evidence indicates DMRs are predominant in TEs
  • 30. Role?
  • 31. In species that experience a diverse range of environmental conditions, processes have evolved to increase the number of potential phenotypes in a population in order to improve the chances for an individual’s survival.
  • 32. Roberts and Gavery 2012 in silico analysis
  • 33. Stochastic Variation housekeeping response to change
  • 34. Mackenzie Gavery
  • 35. housekeeping response to change
  • 36. Targeted Regulation
  • 37. Mackenzie Gavery
  • 38. Mackenzie Gavery
  • 39. Transposable Elements providing increased diversity?
  • 40. modified from Beginning to test these Hypotheses
  • 41. Very new data Environment and gene expression stochastic or targeted?
  • 42. Very new data Environmental impact (Estrogens)
  • 43. Very new data Ocean Acidification Selection Environmental Impact Katie Lotterhos
  • 44. Very new data Heritability Plasticity Local Adaptation Genetics versus Epigenetics Common Garden Experiment
  • 45. Acknowledgements Mackenzie Gavery Claire Ellis Sam White Bill Howe Dan Halperin EPA STAR DNA methylation robertslab.infoslides, data & more @

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