Biotechnology:  Recombinant Vaccine Development  Created & Presented by: Brenda & Razina  SBI4UO-B  Dec 2008
History of Vaccines  Thesis/Focus  Definitions (Activity) Persona #1 (GEEK): Brenda  Persona #2 (HEART):  Razina  Persona ...
Vaccines
Thesis/Focus:  <ul><li>Is recombinant technology better than conventional vaccines?  </li></ul><ul><li>Comparison between ...
Definitions  <ul><li>Vaccine </li></ul><ul><li>Antigen </li></ul><ul><li>Virulent </li></ul><ul><li>Proteins </li></ul><ul...
<ul><li>Plasmid: </li></ul><ul><li>Pathogen:  </li></ul><ul><li>Cloning:  </li></ul><ul><li>Vector:  </li></ul><ul><li>Ant...
PERSONA #1: SCIENCE (GEEK)
Types of Vaccines  1. Live, Attenuated (weakened) Vaccines  -Closest to real infection  -Strong antibody response  (T-cell...
Types of Vaccines  2. Inactivated (killed) Vaccines  -Microbes killed with heat  or chemicals  - Alert only B-cells  -Horm...
Types of Vaccines  3. Conjugate Vaccines  -Microbes with protective  capsule (polysaccharides)  HIDE ANTIGENS   -Link poly...
Types of Vaccines  4. Subunit Vaccines  -Antigens of microbes to  stimulate response -Created in 2 ways 1)Chemically break...
Types of Vaccines  5. Recombinant Vaccines  -Genes from disease-causing microbe inserted into a harmless vector -Inject ve...
RECOMBINANT VACCINES  <ul><li>Pros and Cons  </li></ul>-Combination of techniques  -Reliable  and safer  -Control type of ...
Impact on Scientific Research:  DNA VACCINES
FUTURE IMPACT: DNA VACCINES  Pros & Cons  -Improve  recombinant technique  -Control type of vector  AND reduce virus conta...
<ul><li>THE  HEART </li></ul><ul><li>SOCIAL AND MORAL IMPLICATIONS  </li></ul>Persona belief: Recombinant vaccines are eff...
Social & Moral (Heart)  <ul><li>Recombinant vaccines have many pros in its applications.  </li></ul><ul><li>One Advantage ...
How Do Recombinant Vaccines Affect Society? <ul><li>Recombinant vaccine technology can be advantageous to the society as w...
Does it benefit the public? <ul><li>Recombinant vaccines do benefit the public just as it would benefit the society.  </li...
Is it Ethical? <ul><li>The use of Recombinant vaccines are ethical, because they serve a positive purpose- to strengthen t...
Is it Ethical? (Cont’d) <ul><li>There other ethical implications to consider once a safe and effective recombinant vaccine...
 
Does it Interfere With Religious Beliefs?
Does it Interfere With Religious Beliefs? <ul><li>YES! It can interfere with religious beliefs of some people </li></ul><u...
Economic (Bean Counter)
<ul><li>THANK-YOU FOR LISTENING!  </li></ul>
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Biotech Vaccine School

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Biotech Vaccine School

  1. 1. Biotechnology: Recombinant Vaccine Development Created & Presented by: Brenda & Razina SBI4UO-B Dec 2008
  2. 2. History of Vaccines Thesis/Focus Definitions (Activity) Persona #1 (GEEK): Brenda Persona #2 (HEART): Razina Persona #3 (BEAN COUNTER): Sajeeda Conclusion Overview
  3. 3. Vaccines
  4. 4. Thesis/Focus: <ul><li>Is recombinant technology better than conventional vaccines? </li></ul><ul><li>Comparison between different vaccine types </li></ul><ul><li>Advantages & Disadvantages Within 3 Personas </li></ul>RECOMBINANT VACCINES ARE MORE EFFECTIVE THAN CONVENTIONAL VACCINES
  5. 5. Definitions <ul><li>Vaccine </li></ul><ul><li>Antigen </li></ul><ul><li>Virulent </li></ul><ul><li>Proteins </li></ul><ul><li>Gene </li></ul>Any substance that can stimulate the production of antibodies and combine specifically with them <ul><li>A preparation of a pathogen to stimulates antibody </li></ul><ul><li>production or cellular immunity against the pathogen </li></ul><ul><li>but is incapable of causing severe infection. </li></ul>The basic unit of heredity; sequence of nucleotides along a segment of DNA that provides the coded instructions for RNA synthesis Fundamental component of all living things; composed of complex macromolecules that contain hydrogen, oxygen, nitrogen and/or sulfur in chains of amino acids Actively poisonous & disease-causing
  6. 6. <ul><li>Plasmid: </li></ul><ul><li>Pathogen: </li></ul><ul><li>Cloning: </li></ul><ul><li>Vector: </li></ul><ul><li>Antibodies: </li></ul>DNA segments that are chromosome independent & capable of replication in a cell (usually bacteria/yeast) Process of producing a cell, cell product, or organism that is genetically identical to the unit or individual from which it was derived Any disease-producing agent, esp. a virus, bacterium, or other microorganism. Any agent or organism that acts as a carrier or transporter for a pathogen Y-shaped protein molecules produced by B cells as a primary immune defence mechanism
  7. 7. PERSONA #1: SCIENCE (GEEK)
  8. 8. Types of Vaccines 1. Live, Attenuated (weakened) Vaccines -Closest to real infection -Strong antibody response (T-cells & B-cells) -Memory cells created -Risk: attenuated microbes may mutate back into virulent form
  9. 9. Types of Vaccines 2. Inactivated (killed) Vaccines -Microbes killed with heat or chemicals - Alert only B-cells -Hormonal Immunity (1 st dose) & Protective reaction (later doses) -Risk: Not as effective; use adjuvants
  10. 10. Types of Vaccines 3. Conjugate Vaccines -Microbes with protective capsule (polysaccharides) HIDE ANTIGENS -Link polysaccharides to antigens/toxoids that an immature immune system can recognize -Usually used in babies
  11. 11. Types of Vaccines 4. Subunit Vaccines -Antigens of microbes to stimulate response -Created in 2 ways 1)Chemically break microbe apart 2) RECOMBINANT TECH.
  12. 12. Types of Vaccines 5. Recombinant Vaccines -Genes from disease-causing microbe inserted into a harmless vector -Inject vector OR purified antigens (as subunit) -E.g. Hepatitis B (Recombivax HB Hepatitis B Vaccine)
  13. 13. RECOMBINANT VACCINES <ul><li>Pros and Cons </li></ul>-Combination of techniques -Reliable and safer -Control type of vector (safety, ease of growth/storage/cost) -Ability to filter/choose antigens -Strong protective immunity response (proteins expressed on vector is close to a pathogen’s native conformation) <ul><li>-Recombinant DNA technology (in trial) </li></ul><ul><li>-Only one (HBV) approved by FDA </li></ul><ul><li>-Expensive to develop (locate/clone </li></ul><ul><li>desired antigens & express </li></ul><ul><li>efficiently In vector) </li></ul><ul><li>Some require adjuvants </li></ul>
  14. 14. Impact on Scientific Research: DNA VACCINES
  15. 15. FUTURE IMPACT: DNA VACCINES Pros & Cons -Improve recombinant technique -Control type of vector AND reduce virus contamination -Strong AND long-lasting protective immunity to virus <ul><li>-Very new technology </li></ul><ul><li>-Effectiveness & side </li></ul><ul><li>Effects are unknown </li></ul><ul><li>-Not for everyone </li></ul>
  16. 16. <ul><li>THE HEART </li></ul><ul><li>SOCIAL AND MORAL IMPLICATIONS </li></ul>Persona belief: Recombinant vaccines are effective and have many advantages with its uses
  17. 17. Social & Moral (Heart) <ul><li>Recombinant vaccines have many pros in its applications. </li></ul><ul><li>One Advantage of the recombinant vaccine technology is that there is no chance of the host or individual becoming ill from the agent, since it is just a single protein, not the organism itself. </li></ul>
  18. 18. How Do Recombinant Vaccines Affect Society? <ul><li>Recombinant vaccine technology can be advantageous to the society as well as the public. </li></ul><ul><li>Recombinant vaccines can also prevent epidemic diseases from affecting a population of people. </li></ul><ul><li>Every individual in the society and public will be immune to epidemic diseases. Furthermore, recombinant vaccines can cause immunity to diseases last for several years. </li></ul>
  19. 19. Does it benefit the public? <ul><li>Recombinant vaccines do benefit the public just as it would benefit the society. </li></ul><ul><li>Recombinant vaccines and vaccines in general are one of the best means for preventing infectious diseases rather than treating them. </li></ul><ul><li>Recombinant vaccines can also reduce the number of deaths in third war countries who are prone to these deadly diseases </li></ul>
  20. 20. Is it Ethical? <ul><li>The use of Recombinant vaccines are ethical, because they serve a positive purpose- to strengthen the immune system from infectious diseases. </li></ul><ul><li>However, what is not ethical to some individuals is the use of human subjects to test how well these vaccines work. </li></ul><ul><li>The vaccine could have many complications, and cause greater health issues than that individual had from before. There could also be health risks in testing these vaccines. </li></ul>
  21. 21. Is it Ethical? (Cont’d) <ul><li>There other ethical implications to consider once a safe and effective recombinant vaccine has been developed- Who should receive the vaccine first and how much should individuals pay for it? </li></ul><ul><li>Other ethical issues that surround Recombinant Vaccine development include: Ignorance ,Fear, and Lack of Trust </li></ul>
  22. 23. Does it Interfere With Religious Beliefs?
  23. 24. Does it Interfere With Religious Beliefs? <ul><li>YES! It can interfere with religious beliefs of some people </li></ul><ul><li>The fact that the genes for the desired antigens need to be cloned, in order to be expressed efficiently in the new vector; may cause some of those individuals who are religious, and are against gene cloning and cloning in general to feel uncomfortable </li></ul>
  24. 25. Economic (Bean Counter)
  25. 26. <ul><li>THANK-YOU FOR LISTENING! </li></ul>

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