Pox herpes

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Pox herpes

  1. 1. POX AND HERPES VIRUSES Jaime A. Santos Saturday, May 29, 2010
  2. 2. Poxviruses largest viruses complex symmetry double-stranded DNA assembled in inclusion bodies (Guarnieri bodies) Saturday, May 29, 2010
  3. 3. Diseases variola (smallpox) vaccinia orf cowpox monkeypox othe animal poxviruses molluscum contagiosum Saturday, May 29, 2010
  4. 4. Smallpox only infectious disease to have been eliminated by vaccination 2 forms: variola major (high mortality), variola minor Saturday, May 29, 2010
  5. 5. Smallpox vaccination Saturday, May 29, 2010
  6. 6. Molluscum contagiosum diagnosis: molluscum bodies treatment: cryotherapy or electrodesication Saturday, May 29, 2010
  7. 7. Herpesviridae HSV-1 HSV-2 VZV EBV CMV HHV-6, 7, 8 Saturday, May 29, 2010
  8. 8. Characteristics large, enveloped, icosahedral encode DNA polymerase latency, persistence very common causes of infection Saturday, May 29, 2010
  9. 9. HSV 1 and 2 HSV-1 more common in oral lesions; HSV-2 in genital lesions majority asymptomatic; skin and mucous membrane lesions, encephalitis, keratitis congenital infection diagnosis: serology, culture treatment: acyclovir and related drugs Saturday, May 29, 2010
  10. 10. Herpes simplex 1 and 2 2 different viruses related to each other latency in nerve ganglia reactivation Saturday, May 29, 2010
  11. 11. Saturday, May 29, 2010
  12. 12. Saturday, May 29, 2010
  13. 13. Varicella- zoster virus chickenpox Herpes zoster (reactivation) congenital varicella Saturday, May 29, 2010
  14. 14. Varicella (chickenpox) self-limiting; incubation 2 weeks milder in children severe in neonates whoe mothers had chickenpox <5 days prior to delivery, in adults and in immunocompromised diagnosis often clinical but can be cultured treatment: acyclovir Saturday, May 29, 2010
  15. 15. Saturday, May 29, 2010
  16. 16. Saturday, May 29, 2010
  17. 17. Epstein-Barr virus infects B lymphocytes - receptor is complement receptor on B cell B cell infection leads to immortalization and polyclonal B cell stimulation transmitted thru saliva causes infectious mononucleosis possibility of inducing transformation Saturday, May 29, 2010
  18. 18. Infectious mononucleosis fever, lymphadenopathy, hepatosplenomegaly atypical lymphocytes (Downey cells) heterophil antibodies Saturday, May 29, 2010
  19. 19. Infectious Mononucleosis Epidemiology: different in developing countries Diagnosis: atypical lymphocytes + Monotest for heterophil antibodies serology: + IgM anti-VCA culture: difficult Saturday, May 29, 2010
  20. 20. Atypical lymphocytes Saturday, May 29, 2010
  21. 21. EBV infection has been associated with endemic type of Burkitt’s lymphoma and nasopharyngeal carcinoma no practical treatment with antiviral Saturday, May 29, 2010
  22. 22. Cytomegalovirus very common infection most common cause of congenital viral infection and most common infectious cause of deafness present in body fluids asymptomatic; pneumonia; disseminated in immunocompromised e.g. AIDS Saturday, May 29, 2010
  23. 23. CMV Involvement Saturday, May 29, 2010
  24. 24. Congenital CMV asymptomatic to full-blown risk in second pregnancy lower Saturday, May 29, 2010
  25. 25. Saturday, May 29, 2010
  26. 26. CMV Diagnosis cytology serology culture Saturday, May 29, 2010
  27. 27. CMV Treatment with ganciclovir limited to life-threatening infection and retinitis Saturday, May 29, 2010
  28. 28. HHV 6 Saturday, May 29, 2010
  29. 29. Roseola infantum common exanthem of infants relatively benign fever for about three days followed by rashes Saturday, May 29, 2010
  30. 30. HHV-8 has been associated with Kaposi’s sarcoma Saturday, May 29, 2010
  31. 31. Saturday, May 29, 2010
  32. 32. THANK YOU! Saturday, May 29, 2010

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