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Pox herpes
 

Pox herpes

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    Pox herpes Pox herpes Presentation Transcript

    • POX AND HERPES VIRUSES Jaime A. Santos Saturday, May 29, 2010
    • Poxviruses largest viruses complex symmetry double-stranded DNA assembled in inclusion bodies (Guarnieri bodies) Saturday, May 29, 2010
    • Diseases variola (smallpox) vaccinia orf cowpox monkeypox othe animal poxviruses molluscum contagiosum Saturday, May 29, 2010
    • Smallpox only infectious disease to have been eliminated by vaccination 2 forms: variola major (high mortality), variola minor Saturday, May 29, 2010
    • Smallpox vaccination Saturday, May 29, 2010
    • Molluscum contagiosum diagnosis: molluscum bodies treatment: cryotherapy or electrodesication Saturday, May 29, 2010
    • Herpesviridae HSV-1 HSV-2 VZV EBV CMV HHV-6, 7, 8 Saturday, May 29, 2010
    • Characteristics large, enveloped, icosahedral encode DNA polymerase latency, persistence very common causes of infection Saturday, May 29, 2010
    • HSV 1 and 2 HSV-1 more common in oral lesions; HSV-2 in genital lesions majority asymptomatic; skin and mucous membrane lesions, encephalitis, keratitis congenital infection diagnosis: serology, culture treatment: acyclovir and related drugs Saturday, May 29, 2010
    • Herpes simplex 1 and 2 2 different viruses related to each other latency in nerve ganglia reactivation Saturday, May 29, 2010
    • Saturday, May 29, 2010
    • Saturday, May 29, 2010
    • Varicella- zoster virus chickenpox Herpes zoster (reactivation) congenital varicella Saturday, May 29, 2010
    • Varicella (chickenpox) self-limiting; incubation 2 weeks milder in children severe in neonates whoe mothers had chickenpox <5 days prior to delivery, in adults and in immunocompromised diagnosis often clinical but can be cultured treatment: acyclovir Saturday, May 29, 2010
    • Saturday, May 29, 2010
    • Saturday, May 29, 2010
    • Epstein-Barr virus infects B lymphocytes - receptor is complement receptor on B cell B cell infection leads to immortalization and polyclonal B cell stimulation transmitted thru saliva causes infectious mononucleosis possibility of inducing transformation Saturday, May 29, 2010
    • Infectious mononucleosis fever, lymphadenopathy, hepatosplenomegaly atypical lymphocytes (Downey cells) heterophil antibodies Saturday, May 29, 2010
    • Infectious Mononucleosis Epidemiology: different in developing countries Diagnosis: atypical lymphocytes + Monotest for heterophil antibodies serology: + IgM anti-VCA culture: difficult Saturday, May 29, 2010
    • Atypical lymphocytes Saturday, May 29, 2010
    • EBV infection has been associated with endemic type of Burkitt’s lymphoma and nasopharyngeal carcinoma no practical treatment with antiviral Saturday, May 29, 2010
    • Cytomegalovirus very common infection most common cause of congenital viral infection and most common infectious cause of deafness present in body fluids asymptomatic; pneumonia; disseminated in immunocompromised e.g. AIDS Saturday, May 29, 2010
    • CMV Involvement Saturday, May 29, 2010
    • Congenital CMV asymptomatic to full-blown risk in second pregnancy lower Saturday, May 29, 2010
    • Saturday, May 29, 2010
    • CMV Diagnosis cytology serology culture Saturday, May 29, 2010
    • CMV Treatment with ganciclovir limited to life-threatening infection and retinitis Saturday, May 29, 2010
    • HHV 6 Saturday, May 29, 2010
    • Roseola infantum common exanthem of infants relatively benign fever for about three days followed by rashes Saturday, May 29, 2010
    • HHV-8 has been associated with Kaposi’s sarcoma Saturday, May 29, 2010
    • Saturday, May 29, 2010
    • THANK YOU! Saturday, May 29, 2010