Neoplasia Lab-2 Malignant Tumours
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Neoplasia Lab-2 Malignant Tumours

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Neoplasia Lab-2 Malignant Tumours Neoplasia Lab-2 Malignant Tumours Presentation Transcript

  • Pathology LabMalignant TumoursNeoplasia-2
    5th November
    Ravi A Patel
  • Memory (M++)
    Picture of Metastatic
    Tumour in Liver
    Papillary
    Carcinoma
    Metastasizing
    To Lymph node
    Dermoid
    Cyst
    Gross &
    Microscopic
    Basal Cell CA
    Well pink
    stained
    H-mole
    Gross &
    Microscopic
    Pulmonary
    Embolus
    Hashimoto’s
    Thyroiditis
    Basal
    Cell CA
    Skin
    Infiltrating
    Ductal CA
    Breast
    Squamous
    Cell CA
    Skin
    Adeno
    Carcinoma
    Rectum
    Thyroid
    Hyperplasia
    Amyloid
    Thyroid
    Hemangioma
    Chart demo
  • Malignant tumours
    Basal cell CA-Skin
    Squamous cell CA-Skin
    3. Infiltrating ductal CA
    -Breast
    4. Adenocarcinoma-Rectum
  • Pathways of Spread
    Papillary CA- Metastatic to Lymph node
    2. Tumor Embolus
  • Special Tumour
    H-mole (Microscopic + Gross)
    Dermoid Cyst
  • Immune
    Thyroid Hyperplasia
    Amyloid Thyroid
    Hashimoto’s Thyroidoitis
  • Cellular Features of Malignant Tumours
    Anaplasia- No differentiation
    Pleomorphism (Size,shape and nucleus)
    Mitosis increases(Atypical increase in mitosis)
    Increase in N:C ratio
    Hyperchromatic nucleus(highly stained)
  • Malignant Tumours
  • Basal cell CA-Skin
    Non-Invasive (No metastasis)
    Epidermis + Nest of tumour cells
    Peripherally arranged in Palisading/Picket Fence
  • Nests are formed by downward growth of
    Basal cells deep into dermis
    Nests are Formed in columns
    and sheets of basophilic cells
    Stroma around tends to seperate
    And forms well defined space
    Nests of Tumour cells
  • Well stained section of Basal cell CA
    Palisading formation/Picket fencing is clear
  • Infiltrating Ductal Carcinoma of Breast
    Due to abnormally proliferating ductal lining cells, there is invasion of stroma
    In normal breast tissue
    Ducts= Stroma
    Whereas in Infiltrating ductal carcinoma there is very little stroma
  • Normal Breast tissue is not found
    HPO
    Malignant Ductal lining cells
    Observed to be arranged in
    sheets
    Pleomorphism
    And Hyperchromatic
    nuclei Of the ductal
    lining cells
  • LPO
  • LPO
  • HPO
  • Squamous cell carcinoma-Skin
    Most common tumour arising from sun-exposed sites in older people.
    Locating the area where epidermis show atypical cells
    Keratinization of the squamous cells
    Cells show Keratin pearls like structure within
    Rest of cellular changes would be same as those manifested by all malignant tumours.
  • Keratin pearl
    Within squamous cell
    Atypical epidermal
    cells
    Hyperchromatic
    Nuclei
  • Observing keratinization
    Within the squamous cells
    Seen in HPO
    Next slide
  • Keratin pearls
  • Adencarcinoma of Rectum
    More differentiated
    There is abnormal proliferation of the rectal glands
  • Usually arising from
    Adenomatous polyps
    Atypical Gland
    in mucosa layer
    Well differentiated slide
    Goblet cells are numerous
  • Pathways of Spread
  • Papillary Carcinoma metastatic to lymph node
    From Thyroid gland Lyphoid follicle with germinal center
    It metastasize evenly
  • LPO
    Psamomma Body
  • HPO
    Psamomma Body
  • Orphan Annie- Nuclei
    HPO
  • Tumour Embolus-Lung
    Hematogenous spread of cancer cells result to embolization of the cells to distant site from the primary tumour
    There are neoplastic cells with in the blood vessel which will lead to congestion caused by the obstruction in blood flow.
  • Special Tumours
  • Hydatidiform Mole
    It is a benign tumour but can be converted to chorio carcinoma
    Occurs in pregnancy, uterus becomes large..
    3 Microscopic Changes Occurs
    Hydrophic degeneration- stroma enlarges due to accumulation of water.
    Cystic swelling
    Proliferation of trophoblastic cells.
  • Gross Description
    Endometrial cavity is occupied by grayish irregular to nodular tissues.
    Nodules resemble – small,cystic,translucent structures similar to small FISH EGGS.
    These are actually swollen chorionic villi which have undergone hydrophic degeneration.
  • Grayish Nodular Tissue
    FISH EGGS- they are enlarged
    Chorionic villi which have undergone
    Hydrophic degeneration
  • At the pointer
    Enlarged Chorionic VIlli
    Syncitio-Trophoblast
    Proliferation
  • Syncitio-Trophoblast
    Proliferation
  • HPO
    At the pointer
    Enlarged Chorionic VIlli
    Syncitio-Trophoblast
    Proliferation
  • Mature Cystic Teratoma-DermoidCyst,Ovary
    A.K.A Mature Benign teratoma of totipotent cells.
    Things to observe under microscope
    Cystic wall & Ectodermal elements as stratified squamous epithelium with underlying hair follicles and sweat glands.
  • Gross
    Ovary opened
    Revelaing Inner lining epithelium of the cystic wall
    Hair shafts and protruding incisor tooth from the wall.
  • Hair Shafts &
    Protruding incisor
    Tooth from the wall
  • Cystic Wall
    Ectodermal stratified
    Sqamous epithelium
    Sweat glands
    Hair Follicle
  • Immune
  • Thyroid Hyperplasia
    It is an Autoimmune disease
    A.K.A Grave’s Disease
    Body produces Antibodies
    There is increased thyroid hormones-Hyperthyroidism
    Metabolism:-
    Increased Thyroid function
    Tremors
    Weight loss after eating.
  • Increase in number of thyroid
    follicular cells surrounding the
    Acini.
  • Amyloid Thyroid
    Amyloid is a proteinaceous substance deposited between the adjacent cells.
    Amyloid is pink hyalinized material.
    Amyloid is seen to be compressing the thyroid acini.
  • Deposition of amyloid
    Around the acini
  • Hashimoto’s Throiditis
    It is a disease occuring due to T-lymphocyte defect, b lymphocyte also produces antibodies against the thyroid antigens.
    There is replacement of thyroid parenchyma by Lymphocytic infiltrates.
    In some areas lymphoid follicles are found.
    Remnants of thyroid follicles show atrophy but some are swollen with pinkish,granular cytoplasm– Hurthle cells
  • Hurthle cells
    Lymphocyte infiltrates
    At the pointer
  • Thanking to the entire Universe