3. There are 2 types of Breast diseases Invasive(Infiltrating) Invasive ductal carcinoma Medullary carcinoma Colloid carcinoma Tubular carcinoma Other types Non invasive Ductal carcinoma in situ(DCIS – intraductal carcinoma)-includes Paget disease Lobular carcinoma in situ(LCIS)
4. Paget disease Characterized by extension of ofDuctal carcinoma in situ (DCIS) up to the lactiferous ducts and into the skin of Nipple. Clinical appearance- Unilateral crusting exudate over the nipple and areolar skin. Its a benign breast lesion
12. Fibrocystic Change The term change is applied to miscellany changes in the female breast that range from harmless to patterns associated with Breast Carcinoma. Some of these alteration- Stromal fibrosis and micro/macro cyst produce palpable lumps. These changes are the consequence of an exaggeration and distortion of the cystic breast changes that occur normally in menstrual cycle.
13. There are 2 types Proliferative- Includes atypical duct or ductal epithelial cell hyperplasias. Non proliferative- includes cyst and fibrosis without epithelia hyperplasia..Also known as Simple fibrocystic change. It is very common(found in 60-80% of women) All these changes tend to rise during the reproductive period of life but may persist after menopause.
16. HPO Observation --- Increased Fibrosis in stroma --- Dilated ducts within fibrosis --- There is no Epithelial hyperplasia of the ductal lining cells. If there is hyperplasia then the whole lumen gets filled with heterogenous cells. ---- So we can conclude that that the slide shown falls under the most commonly found Fibrocystic change that is Non proliferative type..
21. Infiltrating/Invasive DuctalCarcinoma Due to abnormally proliferating ductal lining cells, there is invasion of stroma In normal breast tissue Ducts= Stroma Whereas in Infiltrating ductal carcinoma there is very little stroma
22. Normal Breast tissue is not found HPO Malignant Ductal lining cells Observed to be arranged in sheets Pleomorphism And Hyperchromatic nuclei Of the ductal lining cells
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26. Fibroadenoma Proliferating intralobular stroma pushing the epithelium There are 2 types of fibroadenoma PericanalicularFibroadenoma In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar 2. IntracanalicularFibroadenoma Over here there is extensive proliferation of surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.
27. Poliferating Stroma is pushing The ducts leading to their irregular Shape.. This signifies of the slide being Intracanalicularfibradenoma Fibroadenoma
30. Lipoma Lipomas are benign tumours of fat and are most common soft tissue tumour of adulthood. Most are solitary lesions. Most Lipomas are mobile,slowly enlarging painless masses(angiolipoma can present with local pain) Complete excision is usually curative..
31. Subtypes of Lipoma Conventional- Most common subtype- they are soft, yellow, well encapsulated masses of mature adipocyytes with considerable varying size. Myolipoma Spindle cell Myelolipoma Pleomorphic Angiolipoma(locally painful)
32. Fat cells are Within a thin fibrous capsule Mature Fat cells with Scanty stroma Remnants Of mammary Gland lobules Lipoma LPO
