Diseases Of Breast

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  • 1. Diseases of Breast
    Pathology-B Lab
    Ravi A Patel
  • 2. M++
    Paget disease
    Fibrocystic change
    Infiltrating/Invasive ductal carcinoma
    Fibroadenoma
    Lipoma
  • 3. There are 2 types of Breast diseases
    Invasive(Infiltrating)
    Invasive ductal carcinoma
    Medullary carcinoma
    Colloid carcinoma
    Tubular carcinoma
    Other types
    Non invasive
    Ductal carcinoma in situ(DCIS – intraductal carcinoma)-includes Paget disease
    Lobular carcinoma in situ(LCIS)
  • 4. Paget disease
    Characterized by extension of ofDuctal carcinoma in situ (DCIS) up to the lactiferous ducts and into the skin of Nipple.
    Clinical appearance- Unilateral crusting exudate over the nipple and areolar skin.
    Its a benign breast lesion
  • 5.
  • 6.
  • 7. Skin of Areola
  • 8. PAGET CELLS WITH
    CLEAR CYTOPLASM AND HYPERCHROMATIC
    PLEOMORPHIC NUCLEI
    WHICH ARE INFILTRATING
    THE DERMIS
    Atypical lining
    cells
  • 9.
  • 10. Paget cells and Atypical ductal lining cells
  • 11.
  • 12. Fibrocystic Change
    The term change is applied to miscellany changes in the female breast that range from harmless to patterns associated with Breast Carcinoma.
    Some of these alteration- Stromal fibrosis and micro/macro cyst produce palpable lumps.
    These changes are the consequence of an exaggeration and distortion of the cystic breast changes that occur normally in menstrual cycle.
  • 13. There are 2 types
    Proliferative- Includes atypical duct or ductal epithelial cell hyperplasias.
    Non proliferative- includes cyst and fibrosis without epithelia hyperplasia..Also known as Simple fibrocystic change.
    It is very common(found in 60-80% of women)
    All these changes tend to rise during the reproductive period of life but may persist after menopause.
  • 14. * Dilated duct with visible lining epithelial cells-LPO
  • 15. Numerous
    Microcysts
    Produced by
    The dilated
    ducts
  • 16. HPO
    Observation
    --- Increased Fibrosis in stroma
    --- Dilated ducts within fibrosis
    --- There is no Epithelial
    hyperplasia of the ductal
    lining cells. If there is
    hyperplasia then the
    whole lumen gets filled
    with heterogenous
    cells.
    ---- So we can conclude that
    that the slide shown falls
    under the most commonly
    found Fibrocystic change
    that is Non proliferative type..
  • 17. HPO
    Non-Proliferative
    Type of Fibrocystic
    Change
    --Fibrosis seen
    but No Hyperplasia
  • 18. HPO
    Fibrosis
    Dilated ducts
  • 19. HPO
  • 20.
  • 21. Infiltrating/Invasive DuctalCarcinoma
    Due to abnormally proliferating ductal lining cells, there is invasion of stroma
    In normal breast tissue
    Ducts= Stroma
    Whereas in Infiltrating ductal carcinoma there is very little stroma
  • 22. Normal Breast tissue is not found
    HPO
    Malignant Ductal lining cells
    Observed to be arranged in
    sheets
    Pleomorphism
    And Hyperchromatic
    nuclei Of the ductal
    lining cells
  • 23.
  • 24.
  • 25.
  • 26. Fibroadenoma
    Proliferating intralobular stroma pushing the epithelium
    There are 2 types of fibroadenoma
    PericanalicularFibroadenoma
    In this kind of Fibroadenoma the ductal space are round/oval and fairly regualar
    2. IntracanalicularFibroadenoma
    Over here there is extensive proliferation of surrounding stroma which compresses the ducts giving them irregular/star shape on cross section.
  • 27. Poliferating Stroma is pushing
    The ducts leading to their irregular
    Shape..
    This signifies of the slide being
    Intracanalicularfibradenoma
    Fibroadenoma
  • 28. Intracanalicular type Pericanalicular type
  • 29.
  • 30. Lipoma
    Lipomas are benign tumours of fat and are most common soft tissue tumour of adulthood.
    Most are solitary lesions.
    Most Lipomas are mobile,slowly enlarging painless masses(angiolipoma can present with local pain)
    Complete excision is usually curative..
  • 31. Subtypes of Lipoma
    Conventional- Most common subtype- they are soft, yellow, well encapsulated masses of mature adipocyytes with considerable varying size.
    Myolipoma
    Spindle cell
    Myelolipoma
    Pleomorphic
    Angiolipoma(locally painful)
  • 32. Fat cells are
    Within a thin fibrous capsule
    Mature Fat cells with
    Scanty stroma
    Remnants
    Of mammary
    Gland
    lobules
    Lipoma
    LPO
  • 33. LPO
  • 34. HPO
    Fibrous capsule
  • 35. HPO
    Scanty stroma and
    Fat cells
  • 36. Thanking to the entire Universe