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Effector Organs Receptors Action Eye sphincter m. ciliary m. M3 M3 Contraction (meiosis) Contraction (accomodation) Heart SA node AV node Contractility M 2 M 2 M 2 ↓ Heart rate ↓ conduction velocity & ↑ refractory period ↓ contraction Lung bronchial m. M 3 contraction
Effector Organs Receptor Action Blood Vessels most BV skeletal m. - - Small doses – vasodilatation Large doses – vasoconstriction GIT sphincter motility & tone M 3 M 3 Relaxation Increase GUT trigone & sphincter m. bladder wall & detrusor m. Penis, seminal v. M 3 M 3 M Relaxation Contraction Erection
Effector Organs Receptor Action Secretory glands sweat intestinal bronchial lacrimal M M 3 M M Generalized secretion ↑ secretion ↑ secretion Profuse secretion
Dose Effects 0.5 mg Slight cardiac slowing some dryness of mouth inhibition of sweating 1.0 mg Definite dryness of mouth; thirst acceleration of heart, sometimes preceded by slowing mild pupillodilatation
Dose Effects 2.0 mg Rapid HR; palpitations marked dryness of mouth Dilated pupils; some blurring of vision 5.0 mg All of the above symptoms marked; difficulty in speaking and swallowing; Restlessness and fatigue; Headache; dry, hot skin Difficulty in micturition Reduced intestinal peristalsis
Dose Effects 10.0 mg and more Above symptoms more marked Pulse rapid and weak Iris practically obliterated Vision very blurred Skin flushed, hot, dry, and scarlet Ataxia, restlessness and excitement Hallucinations and delirium Coma