Eastern-Western Diagnosis & TCM Treatment for NPD Type A

Slide 1: Eastern-Western Diagnosis & TCM Treatment for NPD Type A Lucy G. Hu O.M.D, LAc. (M.D. in China) Five Branches Institute College of Traditional Chinese Medicine Santa Cruz, California, USA Sophia’s Garden Foundation Scientific Advisory Board Palo Alto, California, USA

Slide 2: TCM History in USA • President Nixon’s visit to China in 1972 • California became 1st state to legalize Acupuncture in late 1980’s • Dr. Hu practiced TCM Pediatrics for over 35 years in both China and U.S.

Slide 3: Case Study of NPD Type A • Patient age: 7 1/2 months, Female * • Race: Ashkenazi Jews * • Major complaint: Vomiting, diarrhea * Crying, sleep difficulties * Chronic respiratory and ear infections *

Slide 4: Case Study of NPD Type A Symptoms Jaundice * Large swollen liver and spleen * Malnutrition * Clinical Examinations at Western Hospitals Lucile Packard Children’s Hospital at Stanford (LPCH) * Palo Alto Medical Foundation (PAMF) *

Slide 5: Case Study of NPD Type A NPD Type A background: Most serious of >40 types of lysosomal storage disease * Occurs in Ashkenazi Jews at rate of 1 in 30,000 * Not a single case within 20 years at LPCH * 40 cases in 20 years at Mount Sinai School of Medicine * None of the children survived; Most live only upto 2 or 3 * years NPD Type A: Albert Niemann (Germany) in 1914 * NPD Type B: Ludwig Pick (Germany) in 1927 *

Slide 6: Case Study of NPD Type A Type A has 13 clinical symptoms: A chronic jaundice since birth 2. Abdominal distention 3. Progressive akinesia 4. Difficulty in feeding and swallowing 5. Difficulty in the vertical movement of eyes 6. Hepatosplenomegaly and hepatocirrhosis 7. Developmental delay 8. Sudden loss of muscular tension 9.

Slide 7: Case Study of NPD Type A Type A has 13 clinical symptoms (cont.): Epilepsy 2. Highly sensitive to touch 3. Inflammation in the respiratory system and ears, in 4. complication with pneumonia Breathing only through mouth due to the constant 5. blockage of nose Normal growth of teeth and bones 6.

Slide 8: Case Study of NPD Type A Patient’s test results: Both parents carry the genes for NPD Type A *

Slide 9: Case Study of NPD Type A TCM Bian Zheng Lun Zhi— Clinical Symptoms & Signs (1st Step) Bian Zheng Lun Zhi Symptoms & Signs Liver-gallbladder damp-heat - Jaundice -Large swollen liver Liver Qi stasis -Akinesia -Abnormal vertical eye movement Spleen Qi deficiency - Diarrhea, fatigue Stomach Qi ascending - Vomiting counterflow

Slide 10: Case Study of NPD Type A TCM Treatment (1st step): Modified Yin Chen Hao Formula * Acupuncture * Progress of Patient condition after: 4 days: 95% Jaundice eliminated * 2 weeks: sleeping improved; watery stool softened * 3 weeks: 90% vomiting reduced * 1 month: vomiting completely disappeared *

Slide 11: Case Study of NPD Type A Adjustments to TCM Treatment (2nd step): Patient’s Western * diagnosis confirmed NPD Type A Blood tests showed * storage of fat, cholesterol, and other metabolites, caused cell death

Slide 12: Case Study of NPD Type A TCM Bian Zheng Lun Zhi Clinical Symptoms & Signs (2nd Step) Bian Zheng Lun Zhi Symptoms & Signs Damp-heat brewing internally - Loose stool, irritability, crying, red tongue, abdomen extention Liver Qi & blood stasis - High level of liver enzymes (SGOT, SGPT ) - High levels of cholesterol and glucose - Mega liver & spleen Liver internal wind - Seizures

Slide 13: Case Study of NPD Type A After 3 months: Appetite improved * Sleep increased * Body weight increased * After 4 months: Self-feed, 70% solid foods * Stool more formed * After 5 months: Energy level, mental concentration, appetite increased * Vocalize sounds and able to sit up by herself * Loss of neurological functions slower than other cases *

Slide 14: Case Study of NPD Type A During this time, parents also seek other treatment methods to treat the child: Holistic nutrition * Feldenkrais * Cranial sacral therapy * Chiropractic care * Homeopathy * Aquatic and music therapy * Antibiotic drugs from latest * genetic research Western herbs * Prayer *

Slide 15: Case Study of NPD Type A 3 Severe infections Spring & Fall 2002, Jan * 2003 All were infections of * respiratory system All were controlled by * Chinese herbal formula and acupuncture

Slide 16: Case Study of NPD Type A At 19 months old: Lost neuromuscular ability to clear her own saliva and * swallow food Liver and spleen continued to enlarge * First hospital stay; projected 1-4 week life expectancy * Condition stablized by Dong Fang Gan Kang, * Chinese patented medicine Dong Chong Xia Cao (Cordyceps Sinensis) * Seizures started and controlled by Tien Ma *

Slide 17: Case Study of NPD Type A At 34 months old: Weekly application of herbs, acupuncture, and tuina (massage) * Liquefied fresh organic foods via enteral feeding system * No respiratory infections for 15 months; stronger immune system * Liver and spleen reduced in size * Cholesterol, triglycerides, and other key biochemical indicators * gradually moving into normal ranges Grown 8 teeth and healthy head of hair * Mentally partially acute *

Slide 18: Case Study of NPD Type A At 34 months old (cont.): Reduced seizures, choking, hypersensivity to pain, sound * and light Gained weight * Increased sleep to 7-9 hours/night * Continued TCM Treatment Principles Soothing liver * Dispelling obstruction * Fortifying spleen * Calming spirit * Strengthening immune system *

Slide 19: Case Study of NPD Type A Discussion: Based on Chinese Medicine Theory, physiologically and * pathologically, the Liver plays important role in 3 areas: 1. Emotional activities 2. Digestion and Absorption 3. Flow of Qi and Blood Liver cannot ensure smooth flow of Qi, causing “Wood” (Liver) * to restrain “Earth” (Spleen) Liver stores blood; liver-blood deficiency leads to blurred * vision, muscle spasm, tendon problems, motor impairment

Slide 20: Case Study of NPD Type A Discussion (cont.): Liver dominates tendons * Liver-blood deficiency causes * tendons lack nourishment Eye is window of liver. * Liver-blood deficiency causes abnormal eye movement

Slide 21: Case Study of NPD Type A Traditional Chinese Medicine “New Age Medicine”—Thousands of years old * Jin—Essence Qi—Energy Shen—Spirit