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Autonomic & neuromuscular
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Autonomic & neuromuscular


Autonomic & neuromuscular

Autonomic & neuromuscular

Published in Health & Medicine
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  • 1. Autonomic & Neuromuscular
  • 2. Atenolol Atropine Dobutamine Edrophonium Epinephrine Phenoxybenzamine Phentolamine Phenylephrine Pilocarpine Pralidoxime Propranolol Pseudoephrine Pyridostigmine Rocuronium Sildenafil Succinylcholine Tamsulosin Terazosin
  • 3. Atenolol Sympatholytic, antihypertensive Β1 receptor antagonist β1 receptor antagonist Angina Post MI Hypertension Bronchoconstriction w/ high doses b/c β1 blockade Additive hypotension w/ nitrates
  • 4. Atropine Anticholinergic Muscarinic receptor antagonist Muscarinic receptor blocker Bradycardia IBS Anticholinesterase poisoning Antisecretory agent Mydriasis & cycloplegia Warm, dry, flushed skin Tachycardia Delirium Hallucinations
  • 5. Dobutamine Sympathomimetic, cardiac stimulant β1 receptor agonist Selective β1 receptor agonist β1 > β2 > α1 Cardiac contractility & output Acute heart failure Cardiogenic shock Synergistic on cardiac output w/ nitroprusside Tachycardia Arrhythmia
  • 6. Edrophonium Diagnostic agent Cholinesterase inhibitor Reversible cholinesterase inhibitor Dx myasthenia gravis Muscarinic effects Miosis Salivation
  • 7. Epinephrine Sympathomimetic, bronchodilator, vasopressor Nonselective adrenergic agonist Activates α & β receptors ↑ IP3 & cAMP α1 – vasoconstrict & ↑ BP β1 – ↑ HR, conduction, & contractility β2 – vasodilate, ↓ BP, bronchodilate Cardiac arrest, V fib Shock, asthma COPD HTN Tachycardia Ischemia Hyperglycemia
  • 8. Phenoxybenzamine Vasodilator Irreversible α receptor antagonist α receptor antagonist α1 > α2 Presurgical Tx of HTN d/t pheochromocytoma Postural hypotension Hypotension w/ β blockers & Ca channel blockers
  • 9. Phentolamine Vasodilator α receptor antagonist Blocks α1 & α2 receptors Control BP during surgical removal of pheochromocytoma IV admin only Hypotension Severe hypotension w/ Epi
  • 10. Phenylephrine Vasocontrictor, decongestant Selective α1 receptor agonist Activates α1 receptor Increase IP3 causing contraction of vascular smooth m. Nasal & ocular decongestant Dilate pupil for opthalmoscopy Mydriasis w/o cycloplegia Paralysis of accommodation Rebound nasal congestion HTN MAOI cause severe HTN
  • 11. Pilocarpine Antiglaucoma, sialogogue Muscarinic receptor agonist Activates muscarinic receptors in ciliary m. & salivary gland Sjogren’s syn Glaucoma • Ciliary m. ↑ aqueous humor Xerostomia • Salivary gland ↑ salivation Miosis Blurred vision Accommodative spasm
  • 12. Pralidoxime Organophosphate antidote Cholinesterase reactivator Binds phosphorous & breaks organophosphate bond w/ cholinesterase Organophosphate toxicity Reverses muscle weakness
  • 13. Propranolol Sympatholytic, antihypertensive Nonselective β receptor antagonist Blocks β1 & β2 receptors Angina HTN Benign tremor Migraine prophylaxis thyrotoxicosis Post-MI Highly lipophilic CNS effects Bronchoconstriction Inhibits glycogenolysis Nightmares & depression
  • 14. Pseudoephedrine Decongestant Indirect/direct-acting adrenergic receptor agonist ↑ release NE directly activates adrenergic receptors causing vasoconstriction & cardiac stim. Allergic & viral rhinitis Tachycardia CNS stim. ↑ BP MAOI cause severe HTN
  • 15. Pyridostigmine Antimyasthenic Cholinesterase inhibitor, cholinergic agonist Reversibly inhibits cholinesterase Tx myasthenia gravis Reverse nondepolarizing NM blockers Muscarinic effects Miosis Salivation Prolongs effects of succinylcholine
  • 16. Rocuronium Paralytic agent Nondepolarizing NM blockade Blocks nicotinic receptors in skeletal m. Skeletal m. relaxation for intubation, surgery, ECT Effects reversed by neostigmine & edrophonium Respiratory m. paralysis Apnea
  • 17. Sildenafil Vasodilator Phosphodiesterase inhibitor Inhibits type 5 phosphodiesterase & degradation of cGMP vasodilation in corpus cavernosum d/t Ach release from sacral PNS neurons Erectile dysfunction HA Nasal congestion Back pain Visual disturbances
  • 18. Succinylcholine Paralytic agent Depolarizing NM blockade Binds nicotinic receptors causing prolonged depolarization of skeletal m. & paralysis Skeletal m. relaxation for intubation & surgery Transient m. fasciculations Respiratory m. paralysis Apnea
  • 19. Tamsulosin Urologic agent Uroselective α1 receptor antagonist Blocks α1A receptors in prostate Tx urinary outflow obstruction d/t prostatic hyperplasia Dizziness HA Postural hypotension Cimetidine increases blood levels & effects
  • 20. Terazosin Antihypertensive, urologic agent Selective α1 receptor antagonist Blocks α1 receptors HTN Outflow obstruction d/t prostate hyperplasia 1st dose syncope