Your SlideShare is downloading. ×
  • Like
Autonomic & neuromuscular
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×

Now you can save presentations on your phone or tablet

Available for both IPhone and Android

Text the download link to your phone

Standard text messaging rates apply

Autonomic & neuromuscular

  • 170 views
Published

Autonomic & neuromuscular

Autonomic & neuromuscular

Published in Health & Medicine
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Be the first to comment
    Be the first to like this
No Downloads

Views

Total Views
170
On SlideShare
0
From Embeds
0
Number of Embeds
6

Actions

Shares
Downloads
8
Comments
0
Likes
0

Embeds 0

No embeds

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
    No notes for slide

Transcript

  • 1. Autonomic & Neuromuscular
  • 2. Atenolol Atropine Dobutamine Edrophonium Epinephrine Phenoxybenzamine Phentolamine Phenylephrine Pilocarpine Pralidoxime Propranolol Pseudoephrine Pyridostigmine Rocuronium Sildenafil Succinylcholine Tamsulosin Terazosin
  • 3. Atenolol Sympatholytic, antihypertensive Β1 receptor antagonist β1 receptor antagonist Angina Post MI Hypertension Bronchoconstriction w/ high doses b/c β1 blockade Additive hypotension w/ nitrates
  • 4. Atropine Anticholinergic Muscarinic receptor antagonist Muscarinic receptor blocker Bradycardia IBS Anticholinesterase poisoning Antisecretory agent Mydriasis & cycloplegia Warm, dry, flushed skin Tachycardia Delirium Hallucinations
  • 5. Dobutamine Sympathomimetic, cardiac stimulant β1 receptor agonist Selective β1 receptor agonist β1 > β2 > α1 Cardiac contractility & output Acute heart failure Cardiogenic shock Synergistic on cardiac output w/ nitroprusside Tachycardia Arrhythmia
  • 6. Edrophonium Diagnostic agent Cholinesterase inhibitor Reversible cholinesterase inhibitor Dx myasthenia gravis Muscarinic effects Miosis Salivation
  • 7. Epinephrine Sympathomimetic, bronchodilator, vasopressor Nonselective adrenergic agonist Activates α & β receptors ↑ IP3 & cAMP α1 – vasoconstrict & ↑ BP β1 – ↑ HR, conduction, & contractility β2 – vasodilate, ↓ BP, bronchodilate Cardiac arrest, V fib Shock, asthma COPD HTN Tachycardia Ischemia Hyperglycemia
  • 8. Phenoxybenzamine Vasodilator Irreversible α receptor antagonist α receptor antagonist α1 > α2 Presurgical Tx of HTN d/t pheochromocytoma Postural hypotension Hypotension w/ β blockers & Ca channel blockers
  • 9. Phentolamine Vasodilator α receptor antagonist Blocks α1 & α2 receptors Control BP during surgical removal of pheochromocytoma IV admin only Hypotension Severe hypotension w/ Epi
  • 10. Phenylephrine Vasocontrictor, decongestant Selective α1 receptor agonist Activates α1 receptor Increase IP3 causing contraction of vascular smooth m. Nasal & ocular decongestant Dilate pupil for opthalmoscopy Mydriasis w/o cycloplegia Paralysis of accommodation Rebound nasal congestion HTN MAOI cause severe HTN
  • 11. Pilocarpine Antiglaucoma, sialogogue Muscarinic receptor agonist Activates muscarinic receptors in ciliary m. & salivary gland Sjogren’s syn Glaucoma • Ciliary m. ↑ aqueous humor Xerostomia • Salivary gland ↑ salivation Miosis Blurred vision Accommodative spasm
  • 12. Pralidoxime Organophosphate antidote Cholinesterase reactivator Binds phosphorous & breaks organophosphate bond w/ cholinesterase Organophosphate toxicity Reverses muscle weakness
  • 13. Propranolol Sympatholytic, antihypertensive Nonselective β receptor antagonist Blocks β1 & β2 receptors Angina HTN Benign tremor Migraine prophylaxis thyrotoxicosis Post-MI Highly lipophilic CNS effects Bronchoconstriction Inhibits glycogenolysis Nightmares & depression
  • 14. Pseudoephedrine Decongestant Indirect/direct-acting adrenergic receptor agonist ↑ release NE directly activates adrenergic receptors causing vasoconstriction & cardiac stim. Allergic & viral rhinitis Tachycardia CNS stim. ↑ BP MAOI cause severe HTN
  • 15. Pyridostigmine Antimyasthenic Cholinesterase inhibitor, cholinergic agonist Reversibly inhibits cholinesterase Tx myasthenia gravis Reverse nondepolarizing NM blockers Muscarinic effects Miosis Salivation Prolongs effects of succinylcholine
  • 16. Rocuronium Paralytic agent Nondepolarizing NM blockade Blocks nicotinic receptors in skeletal m. Skeletal m. relaxation for intubation, surgery, ECT Effects reversed by neostigmine & edrophonium Respiratory m. paralysis Apnea
  • 17. Sildenafil Vasodilator Phosphodiesterase inhibitor Inhibits type 5 phosphodiesterase & degradation of cGMP vasodilation in corpus cavernosum d/t Ach release from sacral PNS neurons Erectile dysfunction HA Nasal congestion Back pain Visual disturbances
  • 18. Succinylcholine Paralytic agent Depolarizing NM blockade Binds nicotinic receptors causing prolonged depolarization of skeletal m. & paralysis Skeletal m. relaxation for intubation & surgery Transient m. fasciculations Respiratory m. paralysis Apnea
  • 19. Tamsulosin Urologic agent Uroselective α1 receptor antagonist Blocks α1A receptors in prostate Tx urinary outflow obstruction d/t prostatic hyperplasia Dizziness HA Postural hypotension Cimetidine increases blood levels & effects
  • 20. Terazosin Antihypertensive, urologic agent Selective α1 receptor antagonist Blocks α1 receptors HTN Outflow obstruction d/t prostate hyperplasia 1st dose syncope