(GCF2008) Biopolis Research Community - " Biopolis"

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  • 1. Biomedical Cluster Map CLINICAL RESEARCH y PHARMACEUTICALS er Bi oi MEDICAL ov m TECHNOLOGY i sc Bioprocessing ag D in ug Chemical Synthesis g r D Genomics & ProteomicsIndustry IndustrySectors Molecular & Cell Biology Sectors C Bioengineering & oh B or Nanotechnology lls io t ce m St HEALTHCARE ar ud Computational em SERVICES & ke ie Biology St rs s BIOTECHNOLOGY DELIVERY TRANSLATIONAL RESEARCH
  • 2. Co-investment, VC funding RISC grants, infrastructure, tax breaks INDUSTRY Pharma MEaT Biotech Clinical Trials Overseas Clinical Trials s ) ev t c ine d s c Singapore Clinical y& vic e / va er e ell s Trials c ov h /d (c g dis tec i cs Dru M ed olo g BiMission-oriented BENCH Translational / Investigational BEDSIDE Research Institutes Medicine NMRC / HSA • IMCB, GIS, BTI Set up by Clinical Research Programmes • IBN, BII, A*STAR / BMRC • Focus, strategy • CMM, SICS Human Capital STN • Development, recruitment Research Consortia SCS Infrastructure • SBIC • SIgN DPF Office • For Clinical Trials • SSCC • Biomarkers SCCS Regulatory Framework MBBS PhD / BMS IF / • IRBs CSI awards Academic BENCH SIgN = Singapore Immunology Network SSCC = Singapore Stem Cell Consortium MEaT = Medical Enginering and Technology IMCB = Institute of Molecular & Cell Biology STN = Singapore Tissue Network GIS = Genome Institute of Singapore SCS = Singapore Cancer Syndicate BTI = Bioprocessing Technical Institute SCCS = Singapore Consortium of Cohort Studies NUS, NTU IBN = Institute of Bioengineering and Nanotechnology BII = Bioinformatics Institute DPF = Data Privacy Framework CMM = Centre for Molecular Medicine BMS IF = Biomedical International Fellowship SICS = Singapore Institute for Clinical Sciences CSI = Clincian Scientist Investigatorship SBIC = Singapore Bioimaging Consortium IRBs = Institutional Review Boards
  • 3. BIOMEDICAL RESEARCH Basic Translational Clinical A*STAR Biomedical Research Council Ministry Of Health Singapore Institute for National Healthcare Group Research Institutes Institute of Medicinal Biology Clinical Sciences (SICS) • National University Hospital (IMB) • The Cancer Institute• Institute of Molecular & • Tan Tock Seng Hospital • Develop programmes in Cell Biology − Singapore Oncogenome Group • Communicable Disease Centre Translational Clinical Medicine − Regenerative Medicine • National Skin Centre• Genome Institute of − Epithelial Biology • Develop critical resources: Singapore - Singapore Tissue Network Singapore Health Services - Singapore Consortium of • Singapore General Hospital• Institute of Cohort Studies • National Cancer Centre Bioengineering & • National Heart Centre Nanotechnology • Develop Clinician Scientists: • Singapore National Eye Centre - Clinician Scientist • KK Women and Children’s Hospital• Bioprocessing Investigatorship (CSI) Awards • National Neuroscience Institute Technology Institute - PhD training for medical doctors Ministry of Health HQ• Bioinformatics Institute Consortia - Biomedical International - Ethical regulations/framework for Fellowships clinical research e.g. IRBs − Singapore Cancer Syndicate − Singapore Bioimaging SICS @ Kent Ridge Consortium - Genetic Medicine National Medical Research Council − Singapore Stem Cell - Virology/Infectious Diseases - Clinical research strategy Consortium - Grant management − Singapore Immunology SICS @ Outram - Manpower development Extramural Network (2008-2010) − Member of Intl Cancer − Cardiovascular Diseases Grants Biomarker Consortium − Eye Diseases Health Sciences Authority - Evaluation capabilities for new technologies UNIVERSITIES
  • 4. Bench to Bedside to Industry Cycle PHARMA INDUSTRY BENCH BEDSIDE Key performers: Key performers:research institutes, Interaction strengthened by new hospitals, specialist universities entities arising from hospital- centres medical school partnerships Grow health Develop strong Be preferred site services, public investigational for early phase health research med capability clinical trials in Asia Establish flagship programmes from bench-to-bedside (heart/ metabolic, neuro, cancer, eye, infectious disease) Build critical mass of human capital, supernumerary to clinical service needs
  • 5. Overall Grant/ Support Framework Research Grants Talent Support [Support research projects/ programmes] Infrastructure [Salary support + [Devt support] research grants] Strategic/ Investigator-led Programmatic ResearchIncreasing seniority and support Singapore Translational Translational & Strategic Research Clinical Research Infra Investigatorship [Research building, Research Grant Individual investigational med Research Grants unit, animal facility] Clinician Scientist Award Academic Programmatic Exploratory/ Research Grants Developmental Organisation Healthcare Research Grants Scholarship
  • 6. Development of Translational/Clinical Research (TCR) Human Capital A new pool of physicians scientists freed of clinical service obligations Singapore Translational Research Clinician Scientist Award. Investigatorship Award. International and Singaporean Young Singapore Physician Scientist Senior Physician Scientist awards awards (70 per year) (15 per year) Full salary and an internationallySimilar to Howard Hughes Medical Institute award – competitive research grant for 3 years full salary and lab support for 5 years)
  • 7. Bench to Bedside Research Funding Programs Funds for teams of basic and clinical scientists Infrastructure to support TCRTranslational/Clinical Research (TCR) flagship Awards *Academic Medical Centers AMCs established through union of medical school and tertiary hospital under a Targeted research programs in common governance each of the following therapeutic areas: cancer, neuroscience, cardiovascular/ *Investigational Medicine Units metabolism, infectious diseases, Clinical research units (2) opthalmology – for early in man clinical investigation S$25 M over 5 years for each program – S$20 M each *Singapore Clinical Research Institute Trans-Singapore clinical research organisations to support therapeutic trials sponsored by pharmaceutical companies – S$6 M per annum
  • 8. Translational Research From Bench to Bedside Institute of Medical Biology (IMB)Executive Director: Prof Birgit LaneIMB studies the mechanisms of human disease in order to discovernew and effective therapeutic strategies for an improved quality oflife.Research Areas:• Singapore Oncogenome Project• Papilloma Virology• Epithelial Biology• Developmental and Regenerative Biology• Regenerative Medicine• Stem Cell Biology• Mesenchymal Stem Cells
  • 9. Translational Research From Bench to Bedside Singapore Institute for Clinical Sciences (SICS)Executive Director: Prof Judith SwainUsing innovative approaches and technologies to enable the efficient andeffective study of human health and diseases Research Areas: • Genetic Medicine • Hepatic Diseases • Metabolic Diseases SICS is headquartered at Biopolis, with labs both at: • The Brenner Centre for Molecular Medicine • Nanos @ Biopolis
  • 10. Translational Research From Bench to Bedside Experimental Therapeutics Centre (ETC)Chief Executive Officer: Prof Sir David Lane • Build up capabilities and resources required for early stage drug discovery and development • Help advance the drug candidates to a stage that is considered commercially more attractive to industry
  • 11. Attracting International Talent (Whales) When physician-scientists Judith Swain and Ed Holmes take up their posts in Singapore…, they will join a star-studded community at one of the world’s most Dr Edward Holmes rapidly developing biomedical research Executive Dy Chmn Sir David Lane centres. …they are the latest of many (TCSG), BMRC & Executive Director, IMCB & Executive Dy Chmn (BSTG), BMRC Chmn, NMRC Western scientists who have headed for the impressive facilities of the tiny city- state. Dr Judith Swain Naturejobs, 5 Jul 06 Executive Director, SICS Dr Birgitte Lane Dr Philippe Kourilsky Executive Chairman, SIgN Sir George Radda Director, IMB Chairman, SBIC Dr Phil Ingham PI, IMCB Dr Jackie Ying Dr Neal Copeland & Dr Edison Liu Dr Yoshiaki Ito Dr Jean Paul Executive Dr Axel Ullrich Dr Nancy JenkinsExecutive Director, PI, IMCB Thiery Director, IBN Director, SOG Lab PIs, IMCB GIS PI, IMCB 2001 2002 2003 2004 2005 2006
  • 12. Human Capital: International Guppies MIT Stanford MIT Physics Chemical Engineering Bio Engineering (Malaysia) (Shanghai) (Hong Kong) MIT Stanford MITChemical Engineering Computer Science Chemical Engineering (Germany) (India) (Vietnam)
  • 13. Human Capital: Singapore GuppiesRockefeller Stanford StanfordBacteriology Biochemistry BiochemistryMedicine/PhD Medicine/PhD Computer Science Duke Camrbidge, London Carnegie-Mellon
  • 14. Nurturing & Developing Human Capital 689 Potential and Completed PhDs NSS(PhD) - 4-5 yrs 193** overseas NSS(BS) - 3 yrs 72 Completed 231* PhDs*** AGS - 4 yrs 193 at partner universitiesCorrect as at 24th September 2007 IF 58*Of which, 68 BS and 1 MBBS are NSFs.**Includes 1 GMS (MD-PhD) scholar. 4 Completed***Includes scholars who are currently attached pending PhDconferment (NUS & NTU takes up to 9 months for conferment.)