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Rotavirus
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Rotavirus

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  • 1. RO TA RUS V CCI E VI A NT E T SAVE YOUR K IM O IDS DR.SMRUTIRANJAN PATANAIK
  • 2. RO TA RUS VI A VIRUS OF THE FAMILY REOVIRIDAE WHEEL SHAPED APPEARANCE – ROTA MAJOR CAUSE OF DIARRHEA AND GASTROENTERITIS UNDER THE AGE OF FIVE MORTALITY 6 LAKHS ACROSS THE GLOBE (29 TO 45 % OF ALL DIARRHEAL DEATHS) OVER 2 MILLION HOSPITALIZED EACH YEAR
  • 3. STRUCTURECLASSIFICATIONBASIS :- IMMUNOLOGICAL REACTIVITIES OF VARIOUS COMPONENTS OF PARTICLES & FROM GENOMIC COMPOSITION INTO GROUPS A-G:-GROUP A HAVING SEROTYPES & GENOTYPES
  • 4. REPLI TI N CA OSITE- CYTOPLASM OF ENTEROCYTES REMOVAL OF OUTER CAPSID mRNA SYNTHESIS mRNA (CYTOPLASM) TRANSLATION VIRAL PROTEINS VIROPLASM REPLICATION ds RNA DOUBLE SHELLED PARTICLES FORMED VIRUS RELEASED
  • 5. ROUTE OF TRANSMISSION-FAECO ORAL ROUTE (1012 VIRIONS PER GM. OF EXCRETA IN ACUTE INFECTION)INFECTIVE DOSE-LOW (100-1000 VIRAL PARTICLES)INCUBATION PERIOD-2 TO 3 DAYSIMMUNITY:- IgA ANTIBODIES CTL
  • 6. NEED FO R AV CCI E A N NATURALLY ACQUIRED IMMUNITY AFTER THE DISEASE. TRANSMISSION RATES UNAFFECTED BY IMPROVING SANITATION. UNAVAILABILITY OF LIFE SAVING I.V. TREATMENT TO ALL PATIENTS. COST EFFECTIVE METHODS. HISTORYOF VACCINE DEVELOPMENT• 1993-94—LIVE ATTENUATED ROTAVIRUS VACCINE FROM RHESUS MONKEY.• 1996-COCKTAIL VACCINE (RRV-TV).• 1998-ROTASHIELD
  • 7. PRESEN V CCI ES A ALA LE T A N VI B
  • 8. CHALLEN GES FO R V CCI E A N I TRO DUCTI N& FUTURE PRO SPECTS N OUNCERTAIN DEMAND, INSUFFICIENT SUPPLY AND HIGH PRICES OF THE VACCINE.LACK OF INFORMATION ON BURDEN OF DISEASE IN SOME COUNTRIES.NEW EMERGING MUTANT & RECOMBINANT STRAINS OF VIRUS.
  • 9. I AN N UTSHELLTHE 2 VACCINES ROTATEQ AND ROTARIXLAUNCHED IN THE YEAR 2006 HELP INPREVENTION OF ROTAVIRUS INFECTION AT THEENTEROCYTE LEVEL HAVING A PROMISINGEFFICACY OF AROUND 95 TO 100%.