A syndrome consisting of progressive impairment in to or more areas of cognition (i.e. memory, language, visuo-spatial, and perceptual ability, thinking and problem solving, personality) sufficient to interfere with work, social function or relationships in the absence of delirium or major non-organic psychiatric disorder (eg. Depression, schizophrenia).
It is a progressive irreversible neurodegenerative disorder with no known cause or cure characterized by a progressive deterioration in cognitive and functional abilities, likely as a result of degeneration of the cholinergic neurons in the cortical and limbic areas of the brain.
May be- (a) Early onset type (before age 60)(<10%)
(b) Late onset type
According to progress of disease:
(i) Rapidly progressive
(ii) Slowly progressive
If AD develops rapidly, it is likely to continue to progress rapidly. If it has been slow to progress, it will likely continue on a slow course.
Protect the neurons against excess amounts of glutamate.
The attachment of glutamate to cell surface "docking sites" called N-methyl-D-aspartate (NMDA) receptors permits calcium to flow freely into the cell, which in turn may lead to cell death & degeneration.
Approved by the FDA in 2003 ( MIMENTINE )
Effective for: Moderate to advanced Alzheimer’s disease
Side effects: Dizziness, headache, constipation, confusion
A PERSON IS AT RISK FOR ALZHEIMER, LIFESTYLE CHANGES SHOULD BE MADE
Changing nutritional habits is key. It is very important to limit consumption of red meat and to increase intake of Omega-3 fatty acids , which are found in fish . The regular intake of Vitamin E , and also Vitamin C , is recommended.
Physical exercise and increased consumption of vegetables and fruits should be favored.
Essential fatty acids in the blood and also lipid-peroxidation parameters should be checked every 6-12 months.