•How do we investigate the characteristics of individual ion channels? Voltage clamping the membrane potential 4 pA 10 ms
Whole cell potassium currents at different membrane potentials
• Measuring currents at clamped potentials to determine IV-relationships of either individual ion channels or ion channel populations.• The action potential is a temporary change in membrane potential. This change is caused by the activity of ion channels but..• Voltage gated ion channel activity is regulated by the membrane potential.• The interaction between the microscopic level (ion channels) and macroscopic level (membrane potential) works in two directions, bottom up and top down.
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